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The map label for this gene is serA [H]

Identifier: 114331558

GI number: 114331558

Start: 1646834

End: 1648051

Strand: Reverse

Name: serA [H]

Synonym: Neut_1571

Alternate gene names: 114331558

Gene position: 1648051-1646834 (Counterclockwise)

Preceding gene: 114331559

Following gene: 114331557

Centisome position: 61.93

GC content: 45.65

Gene sequence:

>1218_bases
ATGTCTGAAGATATTCAGAAAATCTGCAAAGTTCTTACGCTAAACTCGATTGCTTCGGTCGGACTCAAGCGTTTACCTGC
CAATATTTTTCAGATCAGTAGTGATATTTCCGATCCTGATGTGATACTGGTACGTTCCCATAACATGCACGATATGGACA
TACCCGTAAGTGTGATTGCAATCGGTCGTGCCGGTGCTGGAACAAACAATATTCCCGTCAACCAGATGAGTGCACGCGGT
ATCCCAGTTTTTAATACACCTGGGGCTAATGCTAATGCAGTCAAGGAACTCGTGCTGGCAGGGATGTTAATGGCATCACG
TAATCTGATACCGGCTTTGCGTTTTGTTGAAGCGCTGGAAGGAGATGATCAATCCTTTCATTTGCAGGTTGAAGCAGGTA
AAAAACAGTTTTCCGGACTGGAGCTGCCAGGGCGGACATTGGGTGTTATTGGCCTTGGCAAGATCGGGCGACCTGTGGCG
GATGCTGCAATCAAACTCGGGATGAAGGTGTTGGGCTATGACCCGAAAATCACGATCGATTCAGCATGGAGCTTGTCTGC
AGAAGTACAAAGAGCTAATCAGATTGAAGATTTGGTGCGCCGCAGCAATTTTATTTCATTACATGTGCCGCTTAATGAAT
CTACTCGGCATCTGATCAACGGCCCACTGATATCTCATATGCAGAAAAATACAATTCTGCTTAATTTTTCGCGTAATGCC
ATCGTTGATGAAGATGCTGTACTGGCTGGTATCAAGAGTGGAATTATCAAAAATTATGTTTGTGATTTTCCTGATCAGAA
ATTGAAGCAGCAACCGGCAGTTATCACCTTACCTCACCTGGGCGCCTCTACGCATGAAGCGGAGGAAAATTGCGCCATGA
TGATTGCTGACCAGATCATGGATTATATAGCTCACGGTAATATCAGTTATACCGTCAATTTTCCGGATGTTGTCATGGAG
CGTGGAACTCCGTTCCGGGTTGCCGTGGCTAATGCCAATGTCCCTAATCTGCTGGGGCAAATATCAACCCGCATGGCGGA
TATCGGCCTAAATATTCATAATATGATCAATAAATCCCGTGGGGAAATGGCTTATACACTGGTCGATACTGACAGGGCTG
TTCCGCCGGAAATCATTAATGCAATTGCCCAGATTACGGGTGTGTTAATGGTTCGTTATCTGCCTGTTTCAGTACCTTCC
GAGCCTGAACGAGTGTAA

Upstream 100 bases:

>100_bases
CACCGATCAGTCGGTGGCATGCGTGCTTCAATCTATAATGCCATGCCATTGGAAGGGGTGCAGACACTGGCGACATTCAT
GCGGGAATTTGAGAAAAACC

Downstream 100 bases:

>100_bases
AGCAGAAAATCCAGCCGCAATCTTATTAAATCCCTATTGATGACGGAACAGCTTACACAACTGCGCAATGAAATCGATGC
AATCGACGATGAATTGCTCC

Product: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MSEDIQKICKVLTLNSIASVGLKRLPANIFQISSDISDPDVILVRSHNMHDMDIPVSVIAIGRAGAGTNNIPVNQMSARG
IPVFNTPGANANAVKELVLAGMLMASRNLIPALRFVEALEGDDQSFHLQVEAGKKQFSGLELPGRTLGVIGLGKIGRPVA
DAAIKLGMKVLGYDPKITIDSAWSLSAEVQRANQIEDLVRRSNFISLHVPLNESTRHLINGPLISHMQKNTILLNFSRNA
IVDEDAVLAGIKSGIIKNYVCDFPDQKLKQQPAVITLPHLGASTHEAEENCAMMIADQIMDYIAHGNISYTVNFPDVVME
RGTPFRVAVANANVPNLLGQISTRMADIGLNIHNMINKSRGEMAYTLVDTDRAVPPEIINAIAQITGVLMVRYLPVSVPS
EPERV

Sequences:

>Translated_405_residues
MSEDIQKICKVLTLNSIASVGLKRLPANIFQISSDISDPDVILVRSHNMHDMDIPVSVIAIGRAGAGTNNIPVNQMSARG
IPVFNTPGANANAVKELVLAGMLMASRNLIPALRFVEALEGDDQSFHLQVEAGKKQFSGLELPGRTLGVIGLGKIGRPVA
DAAIKLGMKVLGYDPKITIDSAWSLSAEVQRANQIEDLVRRSNFISLHVPLNESTRHLINGPLISHMQKNTILLNFSRNA
IVDEDAVLAGIKSGIIKNYVCDFPDQKLKQQPAVITLPHLGASTHEAEENCAMMIADQIMDYIAHGNISYTVNFPDVVME
RGTPFRVAVANANVPNLLGQISTRMADIGLNIHNMINKSRGEMAYTLVDTDRAVPPEIINAIAQITGVLMVRYLPVSVPS
EPERV
>Mature_404_residues
SEDIQKICKVLTLNSIASVGLKRLPANIFQISSDISDPDVILVRSHNMHDMDIPVSVIAIGRAGAGTNNIPVNQMSARGI
PVFNTPGANANAVKELVLAGMLMASRNLIPALRFVEALEGDDQSFHLQVEAGKKQFSGLELPGRTLGVIGLGKIGRPVAD
AAIKLGMKVLGYDPKITIDSAWSLSAEVQRANQIEDLVRRSNFISLHVPLNESTRHLINGPLISHMQKNTILLNFSRNAI
VDEDAVLAGIKSGIIKNYVCDFPDQKLKQQPAVITLPHLGASTHEAEENCAMMIADQIMDYIAHGNISYTVNFPDVVMER
GTPFRVAVANANVPNLLGQISTRMADIGLNIHNMINKSRGEMAYTLVDTDRAVPPEIINAIAQITGVLMVRYLPVSVPSE
PERV

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=292, Percent_Identity=32.8767123287671, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI61743967, Length=238, Percent_Identity=31.0924369747899, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI4557497, Length=238, Percent_Identity=31.0924369747899, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI145580578, Length=248, Percent_Identity=30.6451612903226, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI4557499, Length=248, Percent_Identity=30.6451612903226, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI145580575, Length=236, Percent_Identity=31.3559322033898, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI6912396, Length=244, Percent_Identity=24.5901639344262, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789279, Length=380, Percent_Identity=30, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI87082289, Length=249, Percent_Identity=26.5060240963855, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787645, Length=188, Percent_Identity=29.2553191489362, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=248, Percent_Identity=35.4838709677419, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI25147481, Length=286, Percent_Identity=24.8251748251748, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320925, Length=365, Percent_Identity=27.9452054794521, Blast_Score=140, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6322116, Length=346, Percent_Identity=28.3236994219653, Blast_Score=137, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6324055, Length=265, Percent_Identity=28.3018867924528, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6324964, Length=227, Percent_Identity=28.1938325991189, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19921140, Length=296, Percent_Identity=32.7702702702703, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24646446, Length=268, Percent_Identity=29.8507462686567, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24646448, Length=268, Percent_Identity=29.8507462686567, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24646452, Length=268, Percent_Identity=29.8507462686567, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24646450, Length=268, Percent_Identity=29.8507462686567, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI62472511, Length=268, Percent_Identity=29.8507462686567, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28574286, Length=252, Percent_Identity=23.4126984126984, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24585514, Length=327, Percent_Identity=22.0183486238532, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI28574282, Length=327, Percent_Identity=22.0183486238532, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI45551003, Length=327, Percent_Identity=22.0183486238532, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI28574284, Length=327, Percent_Identity=22.0183486238532, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI45552429, Length=312, Percent_Identity=22.7564102564103, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24585516, Length=245, Percent_Identity=21.6326530612245, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 43925; Mature: 43793

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEDIQKICKVLTLNSIASVGLKRLPANIFQISSDISDPDVILVRSHNMHDMDIPVSVIA
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEEECCCCCCCCCCEEEEE
IGRAGAGTNNIPVNQMSARGIPVFNTPGANANAVKELVLAGMLMASRNLIPALRFVEALE
EECCCCCCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHC
GDDQSFHLQVEAGKKQFSGLELPGRTLGVIGLGKIGRPVADAAIKLGMKVLGYDPKITID
CCCCEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCHHHCCCCCCEEEC
SAWSLSAEVQRANQIEDLVRRSNFISLHVPLNESTRHLINGPLISHMQKNTILLNFSRNA
CCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHCCHHHHHHCCCEEEEEECCCC
IVDEDAVLAGIKSGIIKNYVCDFPDQKLKQQPAVITLPHLGASTHEAEENCAMMIADQIM
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHH
DYIAHGNISYTVNFPDVVMERGTPFRVAVANANVPNLLGQISTRMADIGLNIHNMINKSR
HHHHCCCEEEEEECHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHCCCC
GEMAYTLVDTDRAVPPEIINAIAQITGVLMVRYLPVSVPSEPERV
CCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SEDIQKICKVLTLNSIASVGLKRLPANIFQISSDISDPDVILVRSHNMHDMDIPVSVIA
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEEECCCCCCCCCCEEEEE
IGRAGAGTNNIPVNQMSARGIPVFNTPGANANAVKELVLAGMLMASRNLIPALRFVEALE
EECCCCCCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHC
GDDQSFHLQVEAGKKQFSGLELPGRTLGVIGLGKIGRPVADAAIKLGMKVLGYDPKITID
CCCCEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCHHHCCCCCCEEEC
SAWSLSAEVQRANQIEDLVRRSNFISLHVPLNESTRHLINGPLISHMQKNTILLNFSRNA
CCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHCCHHHHHHCCCEEEEEECCCC
IVDEDAVLAGIKSGIIKNYVCDFPDQKLKQQPAVITLPHLGASTHEAEENCAMMIADQIM
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHH
DYIAHGNISYTVNFPDVVMERGTPFRVAVANANVPNLLGQISTRMADIGLNIHNMINKSR
HHHHCCCEEEEEECHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHCCCC
GEMAYTLVDTDRAVPPEIINAIAQITGVLMVRYLPVSVPSEPERV
CCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]