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The map label for this gene is metR [H]

Identifier: 114331541

GI number: 114331541

Start: 1624799

End: 1625734

Strand: Reverse

Name: metR [H]

Synonym: Neut_1554

Alternate gene names: 114331541

Gene position: 1625734-1624799 (Counterclockwise)

Preceding gene: 114331543

Following gene: 114331539

Centisome position: 61.09

GC content: 51.5

Gene sequence:

>936_bases
ATGCTTGAATTACGACATCTTCGCACATTGAATGCCTTAGATGAGACTGGCAGTATTTCACTGGCAGCGCAGCGTGTGCA
TTTGACTCAATCTGCGGTATCGCACCAGATCAAGGCGCTGCAAGAGCACTACCAGTTGCCGATTATTCAGCGCAGTGGCC
ATGCAGTACAGTTGACCGATGCAGGTAAGCGTCTGGTGCAACTGGCGGGGAAGATACTTGGCGAGGTTCAGTCAGCAGAG
CGGGATCTGGCAAAAATATCGCAGCAGGCGGCAGGGAGTTTGCGGATTGTGCTGGAGTGTCATACCTGTTTCGACTGGCT
GATGCCAATCATGGATGATTTCCGTCAACACTGGCCGGAAGTGGAGCTTGACCTGGTTTCTGGTTTTCATAGTGATCCGG
TGTCGTTGCTTCGGCAGCAGGTTGCTGACGTGGTGATCGGTTCAGAGAACAAGCCACAGCAGGGGATCATTCATTTTCCA
TTATTCCGTTTTGAAATCCTGGCTGTGCTGGCCCCGGGGCATGTACTCGGGAGCAAACGAGTACTTGAAGCTGCTGATTT
TGCGCAGGACGTACTGATTACTTATCCGGTTCCGGAAGAGCGGATAGATTTGATCCGGCAAGTGCTGATGCCTGCGGGTG
TCAGCTGGCAGCGCCGAACAACCGAATTAACCGTGGCCATTTTGCAGCTGGTAGCAAGCCGGCGGGGGATTGCTGCACTG
CCGGGATGGGGAATCAAAAATTATCTGGATTACGAGTATGTGATTGCCCGGCGTATCGGTACGAGTGGACTGTGGAGTGA
TTTGTATCTTTCAGTGCGGGAGCAAGATGCTTCGCTGCGTTATTTACGGGATTTTCTGGAAACGATTGACCAGGTTTGTT
TTGCCAGACTGGATGGAATTAAGCCATTGAGCAAAAAAGGAACGAGGAAAAACTGA

Upstream 100 bases:

>100_bases
TTATATTTTCTCTGCATGATCGGAAAACCATCATTGTGTGGAATGCTCTATAATGAATCAAATGAAATGTTTTACAGATA
ATTATGAATAATTTTCATAT

Downstream 100 bases:

>100_bases
GAGCAAAGCGGGAAAAATAAGGGACTCAAGAAATCGGGCAATCCCCCTTAAACTGGGGATGATTGCCCGGCGTAAACTGT
TGTAATCAGGCCAATATGGG

Product: transcriptional regulator, LysR family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MLELRHLRTLNALDETGSISLAAQRVHLTQSAVSHQIKALQEHYQLPIIQRSGHAVQLTDAGKRLVQLAGKILGEVQSAE
RDLAKISQQAAGSLRIVLECHTCFDWLMPIMDDFRQHWPEVELDLVSGFHSDPVSLLRQQVADVVIGSENKPQQGIIHFP
LFRFEILAVLAPGHVLGSKRVLEAADFAQDVLITYPVPEERIDLIRQVLMPAGVSWQRRTTELTVAILQLVASRRGIAAL
PGWGIKNYLDYEYVIARRIGTSGLWSDLYLSVREQDASLRYLRDFLETIDQVCFARLDGIKPLSKKGTRKN

Sequences:

>Translated_311_residues
MLELRHLRTLNALDETGSISLAAQRVHLTQSAVSHQIKALQEHYQLPIIQRSGHAVQLTDAGKRLVQLAGKILGEVQSAE
RDLAKISQQAAGSLRIVLECHTCFDWLMPIMDDFRQHWPEVELDLVSGFHSDPVSLLRQQVADVVIGSENKPQQGIIHFP
LFRFEILAVLAPGHVLGSKRVLEAADFAQDVLITYPVPEERIDLIRQVLMPAGVSWQRRTTELTVAILQLVASRRGIAAL
PGWGIKNYLDYEYVIARRIGTSGLWSDLYLSVREQDASLRYLRDFLETIDQVCFARLDGIKPLSKKGTRKN
>Mature_311_residues
MLELRHLRTLNALDETGSISLAAQRVHLTQSAVSHQIKALQEHYQLPIIQRSGHAVQLTDAGKRLVQLAGKILGEVQSAE
RDLAKISQQAAGSLRIVLECHTCFDWLMPIMDDFRQHWPEVELDLVSGFHSDPVSLLRQQVADVVIGSENKPQQGIIHFP
LFRFEILAVLAPGHVLGSKRVLEAADFAQDVLITYPVPEERIDLIRQVLMPAGVSWQRRTTELTVAILQLVASRRGIAAL
PGWGIKNYLDYEYVIARRIGTSGLWSDLYLSVREQDASLRYLRDFLETIDQVCFARLDGIKPLSKKGTRKN

Specific function: Control of the last step in methionine biosynthesis; metR is a positive activator of the metA, metE and metH genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790262, Length=274, Percent_Identity=38.3211678832117, Blast_Score=207, Evalue=6e-55,
Organism=Escherichia coli, GI157672245, Length=121, Percent_Identity=34.7107438016529, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI87082024, Length=284, Percent_Identity=24.2957746478873, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1786401, Length=184, Percent_Identity=27.1739130434783, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788706, Length=170, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790208, Length=172, Percent_Identity=27.3255813953488, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788296, Length=183, Percent_Identity=30.0546448087432, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787530, Length=198, Percent_Identity=24.2424242424242, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1787589, Length=124, Percent_Identity=28.2258064516129, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787601, Length=204, Percent_Identity=26.9607843137255, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI145693105, Length=242, Percent_Identity=22.7272727272727, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI145693193, Length=211, Percent_Identity=26.5402843601896, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1787879, Length=195, Percent_Identity=24.6153846153846, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34996; Mature: 34996

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLELRHLRTLNALDETGSISLAAQRVHLTQSAVSHQIKALQEHYQLPIIQRSGHAVQLTD
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEHH
AGKRLVQLAGKILGEVQSAERDLAKISQQAAGSLRIVLECHTCFDWLMPIMDDFRQHWPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCC
VELDLVSGFHSDPVSLLRQQVADVVIGSENKPQQGIIHFPLFRFEILAVLAPGHVLGSKR
CEEHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEECHHHHHHHHHHHCCCHHHCCHH
VLEAADFAQDVLITYPVPEERIDLIRQVLMPAGVSWQRRTTELTVAILQLVASRRGIAAL
HHHHHHHHCCCEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
PGWGIKNYLDYEYVIARRIGTSGLWSDLYLSVREQDASLRYLRDFLETIDQVCFARLDGI
CCCCCHHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
KPLSKKGTRKN
CCHHCCCCCCC
>Mature Secondary Structure
MLELRHLRTLNALDETGSISLAAQRVHLTQSAVSHQIKALQEHYQLPIIQRSGHAVQLTD
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEHH
AGKRLVQLAGKILGEVQSAERDLAKISQQAAGSLRIVLECHTCFDWLMPIMDDFRQHWPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCC
VELDLVSGFHSDPVSLLRQQVADVVIGSENKPQQGIIHFPLFRFEILAVLAPGHVLGSKR
CEEHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEECHHHHHHHHHHHCCCHHHCCHH
VLEAADFAQDVLITYPVPEERIDLIRQVLMPAGVSWQRRTTELTVAILQLVASRRGIAAL
HHHHHHHHCCCEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
PGWGIKNYLDYEYVIARRIGTSGLWSDLYLSVREQDASLRYLRDFLETIDQVCFARLDGI
CCCCCHHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
KPLSKKGTRKN
CCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]