Click here to switch to the map view.

The map label for this gene is 114331536

Identifier: 114331536

GI number: 114331536

Start: 1617931

End: 1620180

Strand: Direct

Name: 114331536

Synonym: Neut_1549

Alternate gene names: NA

Gene position: 1617931-1620180 (Clockwise)

Preceding gene: 114331532

Following gene: 114331537

Centisome position: 60.8

GC content: 49.69

Gene sequence:

>2250_bases
ATGCGTATTGAAAAAAGGATCAAGGACTATCTGGTTTTTTCTGGGGATAGTATTCTCGATGCCCTGAAACACATCAATGA
TAACCAGTCCCGGATCGTTTTCGTTGTGCAGGATAACGGCGTATTAATCGGGGCAGTCAGCGACGGTGACGTGCGACGCT
GGATGACCCAGGCGACCGAATTTGATCTGAATCTGCCGATCGATCATGTGATGAATCGTAATTTCATCGCCCGGCCCGTT
GCCGAATCCCAGAATCAGATTGCAGACTATTTTGATCACAAACGCGACATCATCCCGCTGATCGACGAACAAGGGCGTTT
TGTCGCCCTGGCACGAAAATCAGCTACAGGGCTCCAGATCGGGGATTTCCTGATTGCCGACCAAAACCCCACATTTATCA
TCGCCGAAGTCGGTAACAATCATAATGGGGATATCGGCCTTGCGAAAGAACTGGTAAACCTAGCGGTGGAAGCCGGGGCC
GATTGTGTCAAATTCCAGATGCGTGATCTTTCCTCGTTGTATTCGAATCAGGGCAGGAATGCAGAGGTGGGTTATGACCT
GGGATCACAATACACGCTGGATCTGCTCAATAAATTCCAGTTGAGCCATGATGCACTTTGTCAGATATTCGATTATTGCA
GGCAGCAGGATATTCTGCCCTTGTGCACGCCTTGGGATATGGTGAGTGTCCGTGTATTGGAAGAATACGGACTGGAAGCC
TTTAAAGTGGCTTCAGCCGATTTTACCAACTATGAAATGCTGGAAGCGCTGGCTAAAACAGGTAAACCGCTGATCTGCTC
CACGGGCATGAGTTCAGAAGCAGAGATCAAGGGCTCGGTGAGTCTGCTGCGCCGGTTGGGTGCCCCCTTTGCCTTGCTGC
ACTGCAATTCGACCTATCCTGCCCCCTTCAAGGATGTAAACCTCAACTACCTGCCGCATTTAAAGCAGCTGGCAGGTACG
GTGGTCGGCTATTCGGGCCATGAACGCGGGTTTGCGGTGCCTCTGGCTGCCGTTGCCCTTGGAGCGCGCATCGTGGAAAA
ACATTTTACTGTCAACCGTGGTATGGAAGGCAATGACCATAAAGTCAGTTTATTACCAGCAGAATTTACGGAAATGGTGC
AACAGATTCGCAATATTGAAGAGGCCATGGGACAAGGTGGTGAACGGGCACTGACCCAGGGGGAAATGATCAATCGTGAA
AATCTGGCTAAAAGCCTGGTAATCAATTGCGATCTTTCGCAAGGACAACTCATCAAACGCAGCATGATCGTGGTGAAAAG
CCCCGGGCAGGGTCTGCAACCCAATCGCATTGATGAGCTGGCAGGCAAAGTGGCACAGCACGATTTTAAGGCCGGGGATT
TCTTCTTTGAAACAGATATCACGCCACAATCAGCTAAAAAACAACACTATACCTTTTCACGTCCCTACGGAATCCCAGCA
CGTTATCACGATTACCAGGCACTGACCGAAGGAATGAAAATCGATTTCATTGAGTTTCATCTGAGTTACCACGATCTGGA
TGTGAAGCTCTCTGACTATTTCTCTGATCCATTGCCAATCGGTTATGCCGTGCACAGTCCGGAATTGTTCGCTGGTGATC
ATATTCTCGATCTGGCAAACGACGATGAAGATTACCGGGCACATTCCATTACCGAACTGAAACGTACAACAGCGGTAGCG
AGCGAGTTGCGTCAGTATTTTCCGTCGACACCCAGACCGGTACTGGTACTCAATGCCGGAGGCTGGTCACCGCAGAATTT
CCTGCCAGTTGAAGCACGCACGAAACTTTACGACAGGGTGGCCAAAGCGCTGGGCGAAATCGACCTGAATTCCATTCGAC
TGGCCATTCAGACCATGCCCCCTTTTCCCTGGCACTTTGGGGGGCAGAGTCACCATAATCTCTTTGTCGATCCGGATGAG
ATCGCGGTATTTTGCGAGAAAACTGGCCATCATATCTGCCTCGACGTTTCACACTCCATGATGGCCTGCAACTATTATCA
GTGGGATTTCAGCGCATTCCTCAAGAAAGTTCTGCCTCATACTATCCATCTGCACATAGTCGATGCCAAGGGAATAGATG
GTGAAGGAGTGCAGATTGGCCATGGTGATGTGGATTTCGCCTTGCTGCACGATCAGTTGAACCAACATGCTCCCGGAATA
CAGTTCATACCTGAAATCTGGCAGGGCCATAAAAATAAAGGAGAAGGGTTCTGGTCAGCATTGGCGTTTCTGGAAAAAAC
CGGTTTCTAG

Upstream 100 bases:

>100_bases
AAGCCTCAAGTAGTATTGACATACTCCATCGGTATAATTCTTTATATCCCCTGTCATACAGACCCGGCAATCATAATCTT
CACCGAACAGGATTTGCAGC

Downstream 100 bases:

>100_bases
GTAGATTCAGAACCGATTCAAAGCTGGTAATAATCATTCCTCTCGGCTTCCGAATATTTGATATATGATCAATTCTCCCA
GGTAAATTACCTGCTGATTC

Product: N-acylneuraminate-9-phosphate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 749; Mature: 749

Protein sequence:

>749_residues
MRIEKRIKDYLVFSGDSILDALKHINDNQSRIVFVVQDNGVLIGAVSDGDVRRWMTQATEFDLNLPIDHVMNRNFIARPV
AESQNQIADYFDHKRDIIPLIDEQGRFVALARKSATGLQIGDFLIADQNPTFIIAEVGNNHNGDIGLAKELVNLAVEAGA
DCVKFQMRDLSSLYSNQGRNAEVGYDLGSQYTLDLLNKFQLSHDALCQIFDYCRQQDILPLCTPWDMVSVRVLEEYGLEA
FKVASADFTNYEMLEALAKTGKPLICSTGMSSEAEIKGSVSLLRRLGAPFALLHCNSTYPAPFKDVNLNYLPHLKQLAGT
VVGYSGHERGFAVPLAAVALGARIVEKHFTVNRGMEGNDHKVSLLPAEFTEMVQQIRNIEEAMGQGGERALTQGEMINRE
NLAKSLVINCDLSQGQLIKRSMIVVKSPGQGLQPNRIDELAGKVAQHDFKAGDFFFETDITPQSAKKQHYTFSRPYGIPA
RYHDYQALTEGMKIDFIEFHLSYHDLDVKLSDYFSDPLPIGYAVHSPELFAGDHILDLANDDEDYRAHSITELKRTTAVA
SELRQYFPSTPRPVLVLNAGGWSPQNFLPVEARTKLYDRVAKALGEIDLNSIRLAIQTMPPFPWHFGGQSHHNLFVDPDE
IAVFCEKTGHHICLDVSHSMMACNYYQWDFSAFLKKVLPHTIHLHIVDAKGIDGEGVQIGHGDVDFALLHDQLNQHAPGI
QFIPEIWQGHKNKGEGFWSALAFLEKTGF

Sequences:

>Translated_749_residues
MRIEKRIKDYLVFSGDSILDALKHINDNQSRIVFVVQDNGVLIGAVSDGDVRRWMTQATEFDLNLPIDHVMNRNFIARPV
AESQNQIADYFDHKRDIIPLIDEQGRFVALARKSATGLQIGDFLIADQNPTFIIAEVGNNHNGDIGLAKELVNLAVEAGA
DCVKFQMRDLSSLYSNQGRNAEVGYDLGSQYTLDLLNKFQLSHDALCQIFDYCRQQDILPLCTPWDMVSVRVLEEYGLEA
FKVASADFTNYEMLEALAKTGKPLICSTGMSSEAEIKGSVSLLRRLGAPFALLHCNSTYPAPFKDVNLNYLPHLKQLAGT
VVGYSGHERGFAVPLAAVALGARIVEKHFTVNRGMEGNDHKVSLLPAEFTEMVQQIRNIEEAMGQGGERALTQGEMINRE
NLAKSLVINCDLSQGQLIKRSMIVVKSPGQGLQPNRIDELAGKVAQHDFKAGDFFFETDITPQSAKKQHYTFSRPYGIPA
RYHDYQALTEGMKIDFIEFHLSYHDLDVKLSDYFSDPLPIGYAVHSPELFAGDHILDLANDDEDYRAHSITELKRTTAVA
SELRQYFPSTPRPVLVLNAGGWSPQNFLPVEARTKLYDRVAKALGEIDLNSIRLAIQTMPPFPWHFGGQSHHNLFVDPDE
IAVFCEKTGHHICLDVSHSMMACNYYQWDFSAFLKKVLPHTIHLHIVDAKGIDGEGVQIGHGDVDFALLHDQLNQHAPGI
QFIPEIWQGHKNKGEGFWSALAFLEKTGF
>Mature_749_residues
MRIEKRIKDYLVFSGDSILDALKHINDNQSRIVFVVQDNGVLIGAVSDGDVRRWMTQATEFDLNLPIDHVMNRNFIARPV
AESQNQIADYFDHKRDIIPLIDEQGRFVALARKSATGLQIGDFLIADQNPTFIIAEVGNNHNGDIGLAKELVNLAVEAGA
DCVKFQMRDLSSLYSNQGRNAEVGYDLGSQYTLDLLNKFQLSHDALCQIFDYCRQQDILPLCTPWDMVSVRVLEEYGLEA
FKVASADFTNYEMLEALAKTGKPLICSTGMSSEAEIKGSVSLLRRLGAPFALLHCNSTYPAPFKDVNLNYLPHLKQLAGT
VVGYSGHERGFAVPLAAVALGARIVEKHFTVNRGMEGNDHKVSLLPAEFTEMVQQIRNIEEAMGQGGERALTQGEMINRE
NLAKSLVINCDLSQGQLIKRSMIVVKSPGQGLQPNRIDELAGKVAQHDFKAGDFFFETDITPQSAKKQHYTFSRPYGIPA
RYHDYQALTEGMKIDFIEFHLSYHDLDVKLSDYFSDPLPIGYAVHSPELFAGDHILDLANDDEDYRAHSITELKRTTAVA
SELRQYFPSTPRPVLVLNAGGWSPQNFLPVEARTKLYDRVAKALGEIDLNSIRLAIQTMPPFPWHFGGQSHHNLFVDPDE
IAVFCEKTGHHICLDVSHSMMACNYYQWDFSAFLKKVLPHTIHLHIVDAKGIDGEGVQIGHGDVDFALLHDQLNQHAPGI
QFIPEIWQGHKNKGEGFWSALAFLEKTGF

Specific function: Unknown

COG id: COG2089

COG function: function code M; Sialic acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis spsE [H]

Homologues:

Organism=Homo sapiens, GI12056473, Length=323, Percent_Identity=35.2941176470588, Blast_Score=202, Evalue=8e-52,
Organism=Drosophila melanogaster, GI21357081, Length=342, Percent_Identity=30.1169590643275, Blast_Score=153, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006190
- InterPro:   IPR013785
- InterPro:   IPR013132
- InterPro:   IPR013974 [H]

Pfam domain/function: PF03102 NeuB; PF08666 SAF [H]

EC number: NA

Molecular weight: Translated: 83798; Mature: 83798

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS50844 AFP_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIEKRIKDYLVFSGDSILDALKHINDNQSRIVFVVQDNGVLIGAVSDGDVRRWMTQATE
CCHHHHHHHHEEECCHHHHHHHHHCCCCCCEEEEEEECCCEEEEEECCCHHHHHHHHHHC
FDLNLPIDHVMNRNFIARPVAESQNQIADYFDHKRDIIPLIDEQGRFVALARKSATGLQI
CCCCCCHHHHHCCCCEECCHHHHHHHHHHHHHCCCCCCCEECCCCCEEEEEECCCCCCEE
GDFLIADQNPTFIIAEVGNNHNGDIGLAKELVNLAVEAGADCVKFQMRDLSSLYSNQGRN
CCEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCC
AEVGYDLGSQYTLDLLNKFQLSHDALCQIFDYCRQQDILPLCTPWDMVSVRVLEEYGLEA
CEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCE
FKVASADFTNYEMLEALAKTGKPLICSTGMSSEAEIKGSVSLLRRLGAPFALLHCNSTYP
EEEECCCCCCHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCC
APFKDVNLNYLPHLKQLAGTVVGYSGHERGFAVPLAAVALGARIVEKHFTVNRGMEGNDH
CCCCCCCCCCCHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KVSLLPAEFTEMVQQIRNIEEAMGQGGERALTQGEMINRENLAKSLVINCDLSQGQLIKR
EEEEECHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHCCEEEEEECCCCCCEEEE
SMIVVKSPGQGLQPNRIDELAGKVAQHDFKAGDFFFETDITPQSAKKQHYTFSRPYGIPA
EEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCC
RYHDYQALTEGMKIDFIEFHLSYHDLDVKLSDYFSDPLPIGYAVHSPELFAGDHILDLAN
CCCCHHHHHCCCEEEEEEEEEEEEEEEEEHHHHCCCCCCCCEEECCCCEECCCEEEECCC
DDEDYRAHSITELKRTTAVASELRQYFPSTPRPVLVLNAGGWSPQNFLPVEARTKLYDRV
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEECHHHHHHHHHHH
AKALGEIDLNSIRLAIQTMPPFPWHFGGQSHHNLFVDPDEIAVFCEKTGHHICLDVSHSM
HHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEECHHHEEEEEECCCCEEEEEECCCE
MACNYYQWDFSAFLKKVLPHTIHLHIVDAKGIDGEGVQIGHGDVDFALLHDQLNQHAPGI
EEEEEEEECHHHHHHHHCCCEEEEEEEECCCCCCCCEEECCCCCCHHHHHHHHHCCCCCC
QFIPEIWQGHKNKGEGFWSALAFLEKTGF
HHHHHHHCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MRIEKRIKDYLVFSGDSILDALKHINDNQSRIVFVVQDNGVLIGAVSDGDVRRWMTQATE
CCHHHHHHHHEEECCHHHHHHHHHCCCCCCEEEEEEECCCEEEEEECCCHHHHHHHHHHC
FDLNLPIDHVMNRNFIARPVAESQNQIADYFDHKRDIIPLIDEQGRFVALARKSATGLQI
CCCCCCHHHHHCCCCEECCHHHHHHHHHHHHHCCCCCCCEECCCCCEEEEEECCCCCCEE
GDFLIADQNPTFIIAEVGNNHNGDIGLAKELVNLAVEAGADCVKFQMRDLSSLYSNQGRN
CCEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCC
AEVGYDLGSQYTLDLLNKFQLSHDALCQIFDYCRQQDILPLCTPWDMVSVRVLEEYGLEA
CEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCE
FKVASADFTNYEMLEALAKTGKPLICSTGMSSEAEIKGSVSLLRRLGAPFALLHCNSTYP
EEEECCCCCCHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCC
APFKDVNLNYLPHLKQLAGTVVGYSGHERGFAVPLAAVALGARIVEKHFTVNRGMEGNDH
CCCCCCCCCCCHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KVSLLPAEFTEMVQQIRNIEEAMGQGGERALTQGEMINRENLAKSLVINCDLSQGQLIKR
EEEEECHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHCCEEEEEECCCCCCEEEE
SMIVVKSPGQGLQPNRIDELAGKVAQHDFKAGDFFFETDITPQSAKKQHYTFSRPYGIPA
EEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCC
RYHDYQALTEGMKIDFIEFHLSYHDLDVKLSDYFSDPLPIGYAVHSPELFAGDHILDLAN
CCCCHHHHHCCCEEEEEEEEEEEEEEEEEHHHHCCCCCCCCEEECCCCEECCCEEEECCC
DDEDYRAHSITELKRTTAVASELRQYFPSTPRPVLVLNAGGWSPQNFLPVEARTKLYDRV
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEECHHHHHHHHHHH
AKALGEIDLNSIRLAIQTMPPFPWHFGGQSHHNLFVDPDEIAVFCEKTGHHICLDVSHSM
HHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEECHHHEEEEEECCCCEEEEEECCCE
MACNYYQWDFSAFLKKVLPHTIHLHIVDAKGIDGEGVQIGHGDVDFALLHDQLNQHAPGI
EEEEEEEECHHHHHHHHCCCEEEEEEEECCCCCCCCEEECCCCCCHHHHHHHHHCCCCCC
QFIPEIWQGHKNKGEGFWSALAFLEKTGF
HHHHHHHCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]