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The map label for this gene is ygcW [C]

Identifier: 114331533

GI number: 114331533

Start: 1615081

End: 1615917

Strand: Reverse

Name: ygcW [C]

Synonym: Neut_1546

Alternate gene names: 114331533

Gene position: 1615917-1615081 (Counterclockwise)

Preceding gene: 114331534

Following gene: 114331531

Centisome position: 60.72

GC content: 48.39

Gene sequence:

>837_bases
ATGAATCAACCTTACAAAGGTACCCCTTTCGATTTGACCGGCCGCGCGGTACTTATCAGCGGTGCAACCGGGCTTCTTGG
CACGGAATTCGCGCTTGCAGCAGCTTCAGCTGGTGCGGACCTGGTACTGGGTGATCTGGATGGTGACAAGCTGAAATCAT
TGGAAAATGAAATAACTGCTTCATACCCGGATACACGAATCCTGGTGCGGACTCTGGATGTCACTTGTACGGATTCATGC
CAGTCCATCGCGCAGTCATGTGAAAACTGGTTTGGCCGGCTCGATGCAGTGATCCACAGCGCTGCAATCGACCCAAAATT
TGAGAAAGATTCTGATACTTCCCGTTTTTCAAAGTTTACTGAATTTCCTTTGGCACTTTGGCAGACGTCACTGGATGTTA
ATTTGACCGGTGCGTTTCAGCTGGCTCAGGCTACATGCCGCATCATGGAGAAATCCGGCAAGGGATCCATCGTTTTTCTT
GGATCCAATTACGGTCTCGTTGGGCCGGATCAGCGTATCTACAAAAAGGCAGGGCAGGAGATACAGACGTATAAACCGGC
AGTCTATTCGGTGTGTAAGGCAGGATTGCTGGGACTCACAAAATTTCTTGCCGCCTATTACATGTATACGTCGATTCGTA
TCAATCTGCTTACGCCCAGTGGAGTTTGGAACAAACATGACCCCGAGTTTATCGGTAGCTATTCGTCGCGAACCATTCTG
GGACGTATGTCAGAAAAAGATGAGTATCGAGGAGCAATTATTTTTTTGCTTTCGGATGCATCCAGTTATATGACGGGTGC
AAATCTGGTCATTGATGGAGGGTGGACAGCATTGTAG

Upstream 100 bases:

>100_bases
GCGGATCGATTCCGCGAGTCACTTTACAGGAGGGTATGGATGTGCTGAATATAGCGCTTGCAGCCAGAAAATCTCTTCAG
ACCGGACGGCAGGTCAGATT

Downstream 100 bases:

>100_bases
GTATTTCTCTGTATATCCATTTCAGTTATTTCTAGATTATCCTCCACACTACCCCGGTTTTCTTTTATTGATCCGAACCA
CATATATGCACAGCTAAATC

Product: short-chain dehydrogenase/reductase SDR

Products: 3-dehydro-2-deoxy-D-gluconate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MNQPYKGTPFDLTGRAVLISGATGLLGTEFALAAASAGADLVLGDLDGDKLKSLENEITASYPDTRILVRTLDVTCTDSC
QSIAQSCENWFGRLDAVIHSAAIDPKFEKDSDTSRFSKFTEFPLALWQTSLDVNLTGAFQLAQATCRIMEKSGKGSIVFL
GSNYGLVGPDQRIYKKAGQEIQTYKPAVYSVCKAGLLGLTKFLAAYYMYTSIRINLLTPSGVWNKHDPEFIGSYSSRTIL
GRMSEKDEYRGAIIFLLSDASSYMTGANLVIDGGWTAL

Sequences:

>Translated_278_residues
MNQPYKGTPFDLTGRAVLISGATGLLGTEFALAAASAGADLVLGDLDGDKLKSLENEITASYPDTRILVRTLDVTCTDSC
QSIAQSCENWFGRLDAVIHSAAIDPKFEKDSDTSRFSKFTEFPLALWQTSLDVNLTGAFQLAQATCRIMEKSGKGSIVFL
GSNYGLVGPDQRIYKKAGQEIQTYKPAVYSVCKAGLLGLTKFLAAYYMYTSIRINLLTPSGVWNKHDPEFIGSYSSRTIL
GRMSEKDEYRGAIIFLLSDASSYMTGANLVIDGGWTAL
>Mature_278_residues
MNQPYKGTPFDLTGRAVLISGATGLLGTEFALAAASAGADLVLGDLDGDKLKSLENEITASYPDTRILVRTLDVTCTDSC
QSIAQSCENWFGRLDAVIHSAAIDPKFEKDSDTSRFSKFTEFPLALWQTSLDVNLTGAFQLAQATCRIMEKSGKGSIVFL
GSNYGLVGPDQRIYKKAGQEIQTYKPAVYSVCKAGLLGLTKFLAAYYMYTSIRINLLTPSGVWNKHDPEFIGSYSSRTIL
GRMSEKDEYRGAIIFLLSDASSYMTGANLVIDGGWTAL

Specific function: Unknown

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=278, Percent_Identity=27.6978417266187, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI19923817, Length=279, Percent_Identity=24.7311827956989, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI66933014, Length=281, Percent_Identity=26.6903914590747, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI40254992, Length=239, Percent_Identity=29.7071129707113, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI32483357, Length=194, Percent_Identity=27.8350515463918, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI59889578, Length=252, Percent_Identity=25.3968253968254, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI87082160, Length=275, Percent_Identity=26.5454545454545, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI87082100, Length=277, Percent_Identity=27.4368231046931, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1790717, Length=275, Percent_Identity=24, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787335, Length=271, Percent_Identity=24.7232472324723, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1787526, Length=214, Percent_Identity=28.5046728971963, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789208, Length=277, Percent_Identity=23.4657039711191, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1789057, Length=278, Percent_Identity=25.5395683453237, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25147288, Length=271, Percent_Identity=25.830258302583, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17560676, Length=282, Percent_Identity=26.241134751773, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17561402, Length=277, Percent_Identity=24.187725631769, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560150, Length=280, Percent_Identity=24.6428571428571, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17555706, Length=267, Percent_Identity=23.2209737827715, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17562910, Length=283, Percent_Identity=25.7950530035336, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=211, Percent_Identity=31.7535545023697, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21355319, Length=277, Percent_Identity=24.9097472924188, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.125

Molecular weight: Translated: 30202; Mature: 30202

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQPYKGTPFDLTGRAVLISGATGLLGTEFALAAASAGADLVLGDLDGDKLKSLENEITA
CCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCC
SYPDTRILVRTLDVTCTDSCQSIAQSCENWFGRLDAVIHSAAIDPKFEKDSDTSRFSKFT
CCCCCEEEEEEECCEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
EFPLALWQTSLDVNLTGAFQLAQATCRIMEKSGKGSIVFLGSNYGLVGPDQRIYKKAGQE
HCHHHHHHCCCCEEEEHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHCCH
IQTYKPAVYSVCKAGLLGLTKFLAAYYMYTSIRINLLTPSGVWNKHDPEFIGSYSSRTIL
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCHHHHCCCCCCEEE
GRMSEKDEYRGAIIFLLSDASSYMTGANLVIDGGWTAL
ECCCCCCCCCCEEEEEEECCCHHCCCCCEEEECCCCCC
>Mature Secondary Structure
MNQPYKGTPFDLTGRAVLISGATGLLGTEFALAAASAGADLVLGDLDGDKLKSLENEITA
CCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCC
SYPDTRILVRTLDVTCTDSCQSIAQSCENWFGRLDAVIHSAAIDPKFEKDSDTSRFSKFT
CCCCCEEEEEEECCEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
EFPLALWQTSLDVNLTGAFQLAQATCRIMEKSGKGSIVFLGSNYGLVGPDQRIYKKAGQE
HCHHHHHHCCCCEEEEHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHCCH
IQTYKPAVYSVCKAGLLGLTKFLAAYYMYTSIRINLLTPSGVWNKHDPEFIGSYSSRTIL
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCHHHHCCCCCCEEE
GRMSEKDEYRGAIIFLLSDASSYMTGANLVIDGGWTAL
ECCCCCCCCCCEEEEEEECCCHHCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-deoxy-D-gluconate; NAD+

Specific reaction: 2-deoxy-D-gluconate + NAD+ = 3-dehydro-2-deoxy-D-gluconate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]