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The map label for this gene is shc [H]

Identifier: 114331495

GI number: 114331495

Start: 1577628

End: 1579640

Strand: Reverse

Name: shc [H]

Synonym: Neut_1507

Alternate gene names: 114331495

Gene position: 1579640-1577628 (Counterclockwise)

Preceding gene: 114331496

Following gene: 114331494

Centisome position: 59.36

GC content: 50.32

Gene sequence:

>2013_bases
ATGTCTATTTCACAGGCGTTTTTCAGAACCTTGATACAAAAATCTTCTCTGTCGGATAGCTCGCTGGTTTCAGAAAACTT
TCCGGCGGATGATGTGGCTGGGAATGAGGCAAACGAGATTTCTGCGGTTACACTGGATGAAGCTATCACCCGCGCATACA
CAGCTTTACTGGCACAGCAGCGAGAAGATGGCCACTGGTGCTTTCCACTGGAAGCAGATTGCACAATTCCGGCTGAATAT
ATCCTGATGATGCATTTCATGGATGAAGTGGACACTGTACTGGAGCGCAAAATTGCAAATTTCTTGCGTACCCGGCAGGT
AACCGATGGGCATGGTGGCTGGCCACTATACTATGGTGGTGATTTTGATATGAGTTGCAGTGTCAAGACCTATTACGCTT
TGAAGCTGGCTGGAGACTCGCCGGAAGCAGCGCATATGGTTCATGCCCGTAACGCCATACTGGAACGGGGGGGTGCGGCG
CGCTCGAATGTATTTACCCGTTTGTTGCTTGCTATGTATCGGCAGATTCCATGGCGTGGAGTACCATTTGTTCCAGCTGA
GATCATGCTGTTGCCGCGCTGGTTTCCTTTTCACCTGAGCAAAGTGGCGTACTGGTCGCGTACAGTGATGGTGCCGCTTT
CTATTCTATGTACGCTGAAAGCCAAGGCAATCAATCCTCGCAATGTGCATGTACAAGAACTATTTGTTGTTGATCCGGTG
AAGGAAAAAAACTACTTCCCGGTACGTACTTCTCTTAATCGCTTGTTGCTGTATGTGGAGCGGTTGGCTTCAAAGCTGGA
ACCATTTATTCCGTCATTCATCCGTCGCCGGGCTGTGAAAAAGGCTGAACAATGGGTAATCGAACGTCTTAATGGTAACG
ATGGTCTGGGGGCAATTTTTCCGGCGATGGTTAATGCCTATGAGGCATTAACATTGCTGGGTCACGACCGTGATCACCCG
CTACTTCAGCAATGTCGCCAATCTTTACGTGAGCTGCTGGTGGATGAAGGAGAAGAGATTACCTGGTGTCAGCCTTGTGT
ATCTCCCGTGTGGGATACTGTGCTGGCCACCTTGGCGCTGCAGGAGGATAAACAGGCTGATAGCGAGCCGATTCGTCGTG
CACTTGACTGGATTGTGCCTCTACAGATACTCGATGAACCCGGTGACTGGCGCGATAGCCGGCCTAATCTGTTAGGAGGA
GGCTGGGCGTTCCAGTACGCTAATCCGCATTATCCGGATCTGGATGATACAGCTGCTGTAGCGTGGGCATTAATTCAGAC
TGGAGCGGAAGATTACCGTGTCAGCATTACCCGGGCAGCAGACTGGCTAGCGGGTATGCAATCGAGTAATGGAGGCTTTG
CTGCATTTGATATAGACAATGCGTATTACTACCTGAATGAAATTCCATTCGCAGATCATGGCGCATTGCTGGACCCGCCC
ACAAGCGATGTATCAGCACGTTGTGTAGGCCTGCTTGCCTTGAATGGCGAGGTGAGACATCAGGAAGCCGTGAAGCGCGG
TCTGGATTTTTTGTTCAATGAACAGGAATCATCCGGGGCATGGTTTGGACGCTGGGGCAGTAACTACATTTATGGCACCT
GGTCCGTACTGGAAGCATTTAGGCTGGCGCGTGTGGATAAAGGCCATCAGGCAGTGCAGCGTGCTATTCAATGGCTGGAA
TCGGTGCAGCGCGCCGACGGCGGATGGGGAGAAACCAATGATTCATATCTTGATCCACAATTGGCTGGACAACTGGAAGC
CAGTACTTCCTTCCAGACCGCATGGGCTGTGCTCGGACTGATGGCTGCTGGAGAGGTGGAAAATACAGCAGTGAGAAAAG
GAATTGATTATTTGCTGCGTACCCAGATTGCTACCGGGTTATGGGAAGAACCATGGTTCACCGCACCCGGTTTCCCAAGG
GTTTTCTACCTGAAATATCACGGTTACTCCAAATATTTTCCATTGTGGGCACTGAATCGATATCGTACACTAAGTAGCAA
ATCTGCCGTATGA

Upstream 100 bases:

>100_bases
CAAGAAATACAATTCTATAATATAAGTGATTGGACTATCTCCTGGAAGATCGCTGTACAATCATTTCATGCAGATTTATC
AAACGAGGGCTTTGCATTTT

Downstream 100 bases:

>100_bases
ATAGTCGTGTTGGCATCATTGTTGCCTTGCGAGCAGAAGCCAGATGTATCACACAGCGCCGTTTGACTTTTGATCGAGCA
GTAGCACTGGATGAAAATCT

Product: squalene-hopene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 670; Mature: 669

Protein sequence:

>670_residues
MSISQAFFRTLIQKSSLSDSSLVSENFPADDVAGNEANEISAVTLDEAITRAYTALLAQQREDGHWCFPLEADCTIPAEY
ILMMHFMDEVDTVLERKIANFLRTRQVTDGHGGWPLYYGGDFDMSCSVKTYYALKLAGDSPEAAHMVHARNAILERGGAA
RSNVFTRLLLAMYRQIPWRGVPFVPAEIMLLPRWFPFHLSKVAYWSRTVMVPLSILCTLKAKAINPRNVHVQELFVVDPV
KEKNYFPVRTSLNRLLLYVERLASKLEPFIPSFIRRRAVKKAEQWVIERLNGNDGLGAIFPAMVNAYEALTLLGHDRDHP
LLQQCRQSLRELLVDEGEEITWCQPCVSPVWDTVLATLALQEDKQADSEPIRRALDWIVPLQILDEPGDWRDSRPNLLGG
GWAFQYANPHYPDLDDTAAVAWALIQTGAEDYRVSITRAADWLAGMQSSNGGFAAFDIDNAYYYLNEIPFADHGALLDPP
TSDVSARCVGLLALNGEVRHQEAVKRGLDFLFNEQESSGAWFGRWGSNYIYGTWSVLEAFRLARVDKGHQAVQRAIQWLE
SVQRADGGWGETNDSYLDPQLAGQLEASTSFQTAWAVLGLMAAGEVENTAVRKGIDYLLRTQIATGLWEEPWFTAPGFPR
VFYLKYHGYSKYFPLWALNRYRTLSSKSAV

Sequences:

>Translated_670_residues
MSISQAFFRTLIQKSSLSDSSLVSENFPADDVAGNEANEISAVTLDEAITRAYTALLAQQREDGHWCFPLEADCTIPAEY
ILMMHFMDEVDTVLERKIANFLRTRQVTDGHGGWPLYYGGDFDMSCSVKTYYALKLAGDSPEAAHMVHARNAILERGGAA
RSNVFTRLLLAMYRQIPWRGVPFVPAEIMLLPRWFPFHLSKVAYWSRTVMVPLSILCTLKAKAINPRNVHVQELFVVDPV
KEKNYFPVRTSLNRLLLYVERLASKLEPFIPSFIRRRAVKKAEQWVIERLNGNDGLGAIFPAMVNAYEALTLLGHDRDHP
LLQQCRQSLRELLVDEGEEITWCQPCVSPVWDTVLATLALQEDKQADSEPIRRALDWIVPLQILDEPGDWRDSRPNLLGG
GWAFQYANPHYPDLDDTAAVAWALIQTGAEDYRVSITRAADWLAGMQSSNGGFAAFDIDNAYYYLNEIPFADHGALLDPP
TSDVSARCVGLLALNGEVRHQEAVKRGLDFLFNEQESSGAWFGRWGSNYIYGTWSVLEAFRLARVDKGHQAVQRAIQWLE
SVQRADGGWGETNDSYLDPQLAGQLEASTSFQTAWAVLGLMAAGEVENTAVRKGIDYLLRTQIATGLWEEPWFTAPGFPR
VFYLKYHGYSKYFPLWALNRYRTLSSKSAV
>Mature_669_residues
SISQAFFRTLIQKSSLSDSSLVSENFPADDVAGNEANEISAVTLDEAITRAYTALLAQQREDGHWCFPLEADCTIPAEYI
LMMHFMDEVDTVLERKIANFLRTRQVTDGHGGWPLYYGGDFDMSCSVKTYYALKLAGDSPEAAHMVHARNAILERGGAAR
SNVFTRLLLAMYRQIPWRGVPFVPAEIMLLPRWFPFHLSKVAYWSRTVMVPLSILCTLKAKAINPRNVHVQELFVVDPVK
EKNYFPVRTSLNRLLLYVERLASKLEPFIPSFIRRRAVKKAEQWVIERLNGNDGLGAIFPAMVNAYEALTLLGHDRDHPL
LQQCRQSLRELLVDEGEEITWCQPCVSPVWDTVLATLALQEDKQADSEPIRRALDWIVPLQILDEPGDWRDSRPNLLGGG
WAFQYANPHYPDLDDTAAVAWALIQTGAEDYRVSITRAADWLAGMQSSNGGFAAFDIDNAYYYLNEIPFADHGALLDPPT
SDVSARCVGLLALNGEVRHQEAVKRGLDFLFNEQESSGAWFGRWGSNYIYGTWSVLEAFRLARVDKGHQAVQRAIQWLES
VQRADGGWGETNDSYLDPQLAGQLEASTSFQTAWAVLGLMAAGEVENTAVRKGIDYLLRTQIATGLWEEPWFTAPGFPRV
FYLKYHGYSKYFPLWALNRYRTLSSKSAV

Specific function: Catalyzes the cyclization of squalene into hopene. Probably part of an operon y4aABCD involved in the synthesis of an isoprenoid compound [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 3 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI47933395, Length=674, Percent_Identity=25.9643916913947, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI47933397, Length=674, Percent_Identity=25.9643916913947, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI224177558, Length=661, Percent_Identity=26.0211800302572, Blast_Score=157, Evalue=4e-38,
Organism=Homo sapiens, GI224177556, Length=584, Percent_Identity=26.541095890411, Blast_Score=143, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6321863, Length=595, Percent_Identity=24.3697478991597, Blast_Score=118, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006400
- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR002365
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 75569; Mature: 75438

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSISQAFFRTLIQKSSLSDSSLVSENFPADDVAGNEANEISAVTLDEAITRAYTALLAQQ
CCHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHH
REDGHWCFPLEADCTIPAEYILMMHFMDEVDTVLERKIANFLRTRQVTDGHGGWPLYYGG
CCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECC
DFDMSCSVKTYYALKLAGDSPEAAHMVHARNAILERGGAARSNVFTRLLLAMYRQIPWRG
CCCCEECEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCC
VPFVPAEIMLLPRWFPFHLSKVAYWSRTVMVPLSILCTLKAKAINPRNVHVQELFVVDPV
CCCCCHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCC
KEKNYFPVRTSLNRLLLYVERLASKLEPFIPSFIRRRAVKKAEQWVIERLNGNDGLGAIF
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
PAMVNAYEALTLLGHDRDHPLLQQCRQSLRELLVDEGEEITWCQPCVSPVWDTVLATLAL
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHH
QEDKQADSEPIRRALDWIVPLQILDEPGDWRDSRPNLLGGGWAFQYANPHYPDLDDTAAV
HHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCEEEECCCCCCCCCCHHHHH
AWALIQTGAEDYRVSITRAADWLAGMQSSNGGFAAFDIDNAYYYLNEIPFADHGALLDPP
HHHHHHCCCCHHEEEHHHHHHHHHHCCCCCCCEEEEEECCEEEEEECCCCCCCCCCCCCC
TSDVSARCVGLLALNGEVRHQEAVKRGLDFLFNEQESSGAWFGRWGSNYIYGTWSVLEAF
CCCCHHHEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCEEEEHHHHHHHH
RLARVDKGHQAVQRAIQWLESVQRADGGWGETNDSYLDPQLAGQLEASTSFQTAWAVLGL
HHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHH
MAAGEVENTAVRKGIDYLLRTQIATGLWEEPWFTAPGFPRVFYLKYHGYSKYFPLWALNR
HHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHH
YRTLSSKSAV
HHHCCCCCCC
>Mature Secondary Structure 
SISQAFFRTLIQKSSLSDSSLVSENFPADDVAGNEANEISAVTLDEAITRAYTALLAQQ
CHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHH
REDGHWCFPLEADCTIPAEYILMMHFMDEVDTVLERKIANFLRTRQVTDGHGGWPLYYGG
CCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECC
DFDMSCSVKTYYALKLAGDSPEAAHMVHARNAILERGGAARSNVFTRLLLAMYRQIPWRG
CCCCEECEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCC
VPFVPAEIMLLPRWFPFHLSKVAYWSRTVMVPLSILCTLKAKAINPRNVHVQELFVVDPV
CCCCCHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCC
KEKNYFPVRTSLNRLLLYVERLASKLEPFIPSFIRRRAVKKAEQWVIERLNGNDGLGAIF
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
PAMVNAYEALTLLGHDRDHPLLQQCRQSLRELLVDEGEEITWCQPCVSPVWDTVLATLAL
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHH
QEDKQADSEPIRRALDWIVPLQILDEPGDWRDSRPNLLGGGWAFQYANPHYPDLDDTAAV
HHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCEEEECCCCCCCCCCHHHHH
AWALIQTGAEDYRVSITRAADWLAGMQSSNGGFAAFDIDNAYYYLNEIPFADHGALLDPP
HHHHHHCCCCHHEEEHHHHHHHHHHCCCCCCCEEEEEECCEEEEEECCCCCCCCCCCCCC
TSDVSARCVGLLALNGEVRHQEAVKRGLDFLFNEQESSGAWFGRWGSNYIYGTWSVLEAF
CCCCHHHEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCEEEEHHHHHHHH
RLARVDKGHQAVQRAIQWLESVQRADGGWGETNDSYLDPQLAGQLEASTSFQTAWAVLGL
HHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHH
MAAGEVENTAVRKGIDYLLRTQIATGLWEEPWFTAPGFPRVFYLKYHGYSKYFPLWALNR
HHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHH
YRTLSSKSAV
HHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]