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The map label for this gene is dxs

Identifier: 114331489

GI number: 114331489

Start: 1571324

End: 1573168

Strand: Direct

Name: dxs

Synonym: Neut_1501

Alternate gene names: 114331489

Gene position: 1571324-1573168 (Clockwise)

Preceding gene: 114331488

Following gene: 114331490

Centisome position: 59.05

GC content: 47.7

Gene sequence:

>1845_bases
ATGTATCCATTACTCGATCGCATTGAGATACCCGCACAATTACGTAACCTGAAACGCAGCCAATTGCCACAATTAGCAGA
TGAACTGCGAAGCTTTCTGATCGAATCGGTAGCGAAGACCGGTGGACATTTGTCTTCCAATCTCGGGACGATCGAACTGA
CCATTGCGCTGCACTATATATTTGATACACCCTTTGATCGACTGGTATGGGATGTCGGACATCAAACCTATGCACATAAA
ATACTTACAGGTCGACGAACGGGAATGGCTCATCTGCGCATGCAGGGAGGTATTGCAGGATTCCCCAGAAGAGATGAGAG
TGAATATGACGCTTTCGGCACAGCACATTCCAGTACATCTATTAGTGCCGCACTAGGTATGGCTGTCGCAGCACGAATCA
ATAAAATAAAACAGCACGCAATTGCAATTATTGGTGATGGCGCAATGAGTGCGGGAATGGCTTTTGAGGCGCTGAACAAT
GCCGGTGTAATGGATGCGGACTTGCTGGTTATCCTGAATGACAATGACATGTCTATTTCCCCCCCTGTGGGAGCACTCAA
TCACTATCTGGCCAAACTGATGTCAGGCCGTTTTTATGCCACTGCAAGACGTGCAGGAGAAAGAATGCTGGGCGTAGTTC
CTCCGGTATTGGAGCTGGCGAAACGTGCCGAGGAACATGTTAAAGGTATGGTAACTCCGGGCACGTTATTTGAGGAATTC
GGTTTCAACTATATTGGCCCAATTGATGGCCACGATCTGGATATCCTGCTTACTACGCTAAATAACATCAAGCAGCTTGA
TGGGCCGCAATTCCTGCACATTGTGACGCGCAAGGGCAAAGGCTACAAACCGGCAGAAGAAGATCCTGTTTTGTATCACG
GGGTTGGAAAATTCGAACCGGGGAAGGGAGTTATACCGAAACCATCTACCAGGCCAGCTTATACCCAAATATTTGGTGAC
TGGTTATGTGATATGGCGGCCAAAGATTCGCGGCTAATCGGCATAACGCCCGCTATGAGAGAAGGCTCTGGACTTATCCG
TTTTTCAAAAGAATACCCGGATCGCTATTTTGATGTAGGAATTGCTGAACAACATGCCGTGACATTCGCTGCCGGTGCAG
CCTGTGAAGGATTGAAACCAGTTGTGGCGATTTACTCAACTTTTCTGCAGCGTGCCTATGATCAGCTGATTCATGATGTG
GCTATTCAGAATTTACCCGTTGTTTTCGCTATTGACCGAGCCGGGCTTGTCGGTGCAGACGGTCCGACACATGCCGGAAG
TTTTGATTTGAGTTATCTGCGTTGTATTCCCAATATCACAGTGATGATGCCTGCTGATGAGAATGAGTGTCGTCAAATGC
TCTATACTGCTTTCCAGCTCGATACCCCTACTGCCGTCCGGTATCCGCGTGGTACAGGACCCGGCGTGCAAATAAAGCAG
GAAATGCAGATTGTTCCACTGGGTAAGGGTGAGATTCGCCGCCAGGGCACACGCATTGCATTACTTGCGTTTGGTAGTAT
GCTGTCCCCCTGTCTTGAAGCTGGAGATGAATTGGATGCCACGGTCGTCAATATGCGTTTTGTAAAGCCACTGGATCAGG
AACTGGTTATGACACTTGCGGCCGAACACGAATTACTGGTGACTGTTGAAGAAAATACAATTATGGGAGGGGCAGGCAGT
GCTGTACTGGAATGCCTAGCCAGTCAGGGCGTGAATATCAGATTACTGCAATTAGGTTTGTCAGACAACTTCCTTGATCA
GGGTGATCCTGCTCAAATGTTATCTGACTGCGGATTGGATAAAACCGGGATTATTAAATCAGTAAAAGAAAGACTTTCTC
TATAG

Upstream 100 bases:

>100_bases
AGCAAATCACTGATTTCATTGTACAGCGTGAGTTTTAGTTTTACGCTACCAATCCAATCTTTACCAATCTTTACGTTACC
CACTCTTAGCTACAATTCGC

Downstream 100 bases:

>100_bases
CGTTCGCATATGTAACAAATCAGCAGCAAAGTTGGCGAGCTCTATTCCTTACCGGTTGCTCCAATATTTTTATACAGCTT
CACAGCCAGATAATCTGGAC

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 614; Mature: 614

Protein sequence:

>614_residues
MYPLLDRIEIPAQLRNLKRSQLPQLADELRSFLIESVAKTGGHLSSNLGTIELTIALHYIFDTPFDRLVWDVGHQTYAHK
ILTGRRTGMAHLRMQGGIAGFPRRDESEYDAFGTAHSSTSISAALGMAVAARINKIKQHAIAIIGDGAMSAGMAFEALNN
AGVMDADLLVILNDNDMSISPPVGALNHYLAKLMSGRFYATARRAGERMLGVVPPVLELAKRAEEHVKGMVTPGTLFEEF
GFNYIGPIDGHDLDILLTTLNNIKQLDGPQFLHIVTRKGKGYKPAEEDPVLYHGVGKFEPGKGVIPKPSTRPAYTQIFGD
WLCDMAAKDSRLIGITPAMREGSGLIRFSKEYPDRYFDVGIAEQHAVTFAAGAACEGLKPVVAIYSTFLQRAYDQLIHDV
AIQNLPVVFAIDRAGLVGADGPTHAGSFDLSYLRCIPNITVMMPADENECRQMLYTAFQLDTPTAVRYPRGTGPGVQIKQ
EMQIVPLGKGEIRRQGTRIALLAFGSMLSPCLEAGDELDATVVNMRFVKPLDQELVMTLAAEHELLVTVEENTIMGGAGS
AVLECLASQGVNIRLLQLGLSDNFLDQGDPAQMLSDCGLDKTGIIKSVKERLSL

Sequences:

>Translated_614_residues
MYPLLDRIEIPAQLRNLKRSQLPQLADELRSFLIESVAKTGGHLSSNLGTIELTIALHYIFDTPFDRLVWDVGHQTYAHK
ILTGRRTGMAHLRMQGGIAGFPRRDESEYDAFGTAHSSTSISAALGMAVAARINKIKQHAIAIIGDGAMSAGMAFEALNN
AGVMDADLLVILNDNDMSISPPVGALNHYLAKLMSGRFYATARRAGERMLGVVPPVLELAKRAEEHVKGMVTPGTLFEEF
GFNYIGPIDGHDLDILLTTLNNIKQLDGPQFLHIVTRKGKGYKPAEEDPVLYHGVGKFEPGKGVIPKPSTRPAYTQIFGD
WLCDMAAKDSRLIGITPAMREGSGLIRFSKEYPDRYFDVGIAEQHAVTFAAGAACEGLKPVVAIYSTFLQRAYDQLIHDV
AIQNLPVVFAIDRAGLVGADGPTHAGSFDLSYLRCIPNITVMMPADENECRQMLYTAFQLDTPTAVRYPRGTGPGVQIKQ
EMQIVPLGKGEIRRQGTRIALLAFGSMLSPCLEAGDELDATVVNMRFVKPLDQELVMTLAAEHELLVTVEENTIMGGAGS
AVLECLASQGVNIRLLQLGLSDNFLDQGDPAQMLSDCGLDKTGIIKSVKERLSL
>Mature_614_residues
MYPLLDRIEIPAQLRNLKRSQLPQLADELRSFLIESVAKTGGHLSSNLGTIELTIALHYIFDTPFDRLVWDVGHQTYAHK
ILTGRRTGMAHLRMQGGIAGFPRRDESEYDAFGTAHSSTSISAALGMAVAARINKIKQHAIAIIGDGAMSAGMAFEALNN
AGVMDADLLVILNDNDMSISPPVGALNHYLAKLMSGRFYATARRAGERMLGVVPPVLELAKRAEEHVKGMVTPGTLFEEF
GFNYIGPIDGHDLDILLTTLNNIKQLDGPQFLHIVTRKGKGYKPAEEDPVLYHGVGKFEPGKGVIPKPSTRPAYTQIFGD
WLCDMAAKDSRLIGITPAMREGSGLIRFSKEYPDRYFDVGIAEQHAVTFAAGAACEGLKPVVAIYSTFLQRAYDQLIHDV
AIQNLPVVFAIDRAGLVGADGPTHAGSFDLSYLRCIPNITVMMPADENECRQMLYTAFQLDTPTAVRYPRGTGPGVQIKQ
EMQIVPLGKGEIRRQGTRIALLAFGSMLSPCLEAGDELDATVVNMRFVKPLDQELVMTLAAEHELLVTVEENTIMGGAGS
AVLECLASQGVNIRLLQLGLSDNFLDQGDPAQMLSDCGLDKTGIIKSVKERLSL

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=624, Percent_Identity=24.5192307692308, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI4507521, Length=624, Percent_Identity=24.5192307692308, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI133778974, Length=421, Percent_Identity=24.9406175771971, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI156564403, Length=259, Percent_Identity=27.7992277992278, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI225637461, Length=424, Percent_Identity=24.2924528301887, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI225637459, Length=424, Percent_Identity=24.2924528301887, Blast_Score=84, Evalue=6e-16,
Organism=Homo sapiens, GI225637463, Length=424, Percent_Identity=24.2924528301887, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI291084858, Length=251, Percent_Identity=26.6932270916335, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI1786622, Length=614, Percent_Identity=57.9804560260586, Blast_Score=768, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=676, Percent_Identity=25, Blast_Score=109, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17538422, Length=282, Percent_Identity=26.241134751773, Blast_Score=76, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6319698, Length=316, Percent_Identity=26.2658227848101, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI45551847, Length=616, Percent_Identity=25, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI45550715, Length=616, Percent_Identity=25, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24645119, Length=509, Percent_Identity=25.147347740668, Blast_Score=105, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24666278, Length=638, Percent_Identity=26.0188087774295, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21358145, Length=265, Percent_Identity=27.9245283018868, Blast_Score=76, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24650940, Length=265, Percent_Identity=27.9245283018868, Blast_Score=76, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_NITEC (Q0AFY6)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_747711.1
- ProteinModelPortal:   Q0AFY6
- SMR:   Q0AFY6
- STRING:   Q0AFY6
- GeneID:   4273854
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_1501
- NMPDR:   fig|335283.3.peg.98
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- PhylomeDB:   Q0AFY6
- ProtClustDB:   PRK05444
- BioCyc:   NEUT335283:NEUT_1501-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 66832; Mature: 66832

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYPLLDRIEIPAQLRNLKRSQLPQLADELRSFLIESVAKTGGHLSSNLGTIELTIALHYI
CCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEH
FDTPFDRLVWDVGHQTYAHKILTGRRTGMAHLRMQGGIAGFPRRDESEYDAFGTAHSSTS
HCCCHHHHHHHHCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCHHHCCCCCCCCH
ISAALGMAVAARINKIKQHAIAIIGDGAMSAGMAFEALNNAGVMDADLLVILNDNDMSIS
HHHHHHHHHHHHHHHHHHHEEEEEECCCHHHCHHHHHHCCCCCCCCEEEEEECCCCCCCC
PPVGALNHYLAKLMSGRFYATARRAGERMLGVVPPVLELAKRAEEHVKGMVTPGTLFEEF
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHC
GFNYIGPIDGHDLDILLTTLNNIKQLDGPQFLHIVTRKGKGYKPAEEDPVLYHGVGKFEP
CCCEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCEEEECCCCCCC
GKGVIPKPSTRPAYTQIFGDWLCDMAAKDSRLIGITPAMREGSGLIRFSKEYPDRYFDVG
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEECHHCCCHHEECC
IAEQHAVTFAAGAACEGLKPVVAIYSTFLQRAYDQLIHDVAIQNLPVVFAIDRAGLVGAD
CCCHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEECCC
GPTHAGSFDLSYLRCIPNITVMMPADENECRQMLYTAFQLDTPTAVRYPRGTGPGVQIKQ
CCCCCCCCCHHHHHHCCCCEEEECCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEC
EMQIVPLGKGEIRRQGTRIALLAFGSMLSPCLEAGDELDATVVNMRFVKPLDQELVMTLA
CCEEEECCCCHHHHCCCEEEEEHHHHHHHHHHHCCCCCCCEEEEEHHHCCHHHHHHHHHH
AEHELLVTVEENTIMGGAGSAVLECLASQGVNIRLLQLGLSDNFLDQGDPAQMLSDCGLD
CCCEEEEEEECCEEECCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHCCCC
KTGIIKSVKERLSL
HHHHHHHHHHHHCC
>Mature Secondary Structure
MYPLLDRIEIPAQLRNLKRSQLPQLADELRSFLIESVAKTGGHLSSNLGTIELTIALHYI
CCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEH
FDTPFDRLVWDVGHQTYAHKILTGRRTGMAHLRMQGGIAGFPRRDESEYDAFGTAHSSTS
HCCCHHHHHHHHCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCHHHCCCCCCCCH
ISAALGMAVAARINKIKQHAIAIIGDGAMSAGMAFEALNNAGVMDADLLVILNDNDMSIS
HHHHHHHHHHHHHHHHHHHEEEEEECCCHHHCHHHHHHCCCCCCCCEEEEEECCCCCCCC
PPVGALNHYLAKLMSGRFYATARRAGERMLGVVPPVLELAKRAEEHVKGMVTPGTLFEEF
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHC
GFNYIGPIDGHDLDILLTTLNNIKQLDGPQFLHIVTRKGKGYKPAEEDPVLYHGVGKFEP
CCCEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCEEEECCCCCCC
GKGVIPKPSTRPAYTQIFGDWLCDMAAKDSRLIGITPAMREGSGLIRFSKEYPDRYFDVG
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEECHHCCCHHEECC
IAEQHAVTFAAGAACEGLKPVVAIYSTFLQRAYDQLIHDVAIQNLPVVFAIDRAGLVGAD
CCCHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEECCC
GPTHAGSFDLSYLRCIPNITVMMPADENECRQMLYTAFQLDTPTAVRYPRGTGPGVQIKQ
CCCCCCCCCHHHHHHCCCCEEEECCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEC
EMQIVPLGKGEIRRQGTRIALLAFGSMLSPCLEAGDELDATVVNMRFVKPLDQELVMTLA
CCEEEECCCCHHHHCCCEEEEEHHHHHHHHHHHCCCCCCCEEEEEHHHCCHHHHHHHHHH
AEHELLVTVEENTIMGGAGSAVLECLASQGVNIRLLQLGLSDNFLDQGDPAQMLSDCGLD
CCCEEEEEEECCEEECCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHCCCC
KTGIIKSVKERLSL
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA