Click here to switch to the map view.

The map label for this gene is ubiE [H]

Identifier: 114331425

GI number: 114331425

Start: 1517077

End: 1517808

Strand: Direct

Name: ubiE [H]

Synonym: Neut_1436

Alternate gene names: 114331425

Gene position: 1517077-1517808 (Clockwise)

Preceding gene: 114331424

Following gene: 114331431

Centisome position: 57.01

GC content: 46.31

Gene sequence:

>732_bases
ATGAATGCCACACACTTTGGTTTTACAACTGTTTCAGAAACAGAAAAAGCTCGTAAGGTTGCAGAAGTCTTCCATTCGGT
AGCAGCACGTTATAACCTGATGAATGACCTGATGTCCATGGGATTGCATCGTCTGTGGAAAAAATTTGCAATCGATGTCA
GCGGTGCGAGAAGAGGTGACAAGGTATTGGATATTGCCGGTGGAACCGCTGATTTAACCGCTTTATTCCGGGAGAAAGTA
GGTGACGCAGGGGAAGTCTGGCTGACCGACATCAACAATTCCATGCTGTCAATTGGCCGTGATCGTATGCTGAATGATGG
TAAAAGCGTACCGGTTGCTCAATGTGATGCTGAAAAACTACCCTTCCCGGATAATTATTTTGATCGGGTTTGTGTCGCTT
TTGGTTTGAGGAACATGACACATAAAGATATTGCTCTCCGGGAAATGTGGCGTGTGTTATCCCCGGGTGGTTCGCTCATC
GTGCTGGAGTTTTCCAAGGTGTGGAAACCACTGCAGCCTTTGTATGACACTTACTCATTTAAGGCTCTCCCGTTTATGGG
GAAAATTGTTACCCGTGACGATGCCAGTTACCGCTATCTCGCAGAATCTATTCGGATGCATCCCTCCCAGGAAGATCTGA
AACAGCTCATGCAACAGGTTGGATTTGAACGGGTTGAATATTTCAATCTGACAGCGGGCGTTGTAGCACTGCATCGCGGA
TATAAATTCTGA

Upstream 100 bases:

>100_bases
TACCTGCAACGACTGGGAGCTTCCGGCAGTAGCCGCGAAGTAAAATAGCAATACTTTCCGCTAAACATTAATTACTCATT
CGGAATATATCCTCAGAATA

Downstream 100 bases:

>100_bases
TCTTGCTGTTTGGTACGGAACACATGAATCTGTCCACATATTCAAGCAGGATTTACAACAGCCCGTCAGCTTTGCGTTTT
GCCAGCAGACAAATCAAGTC

Product: ubiquinone/menaquinone biosynthesis methyltransferases

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MNATHFGFTTVSETEKARKVAEVFHSVAARYNLMNDLMSMGLHRLWKKFAIDVSGARRGDKVLDIAGGTADLTALFREKV
GDAGEVWLTDINNSMLSIGRDRMLNDGKSVPVAQCDAEKLPFPDNYFDRVCVAFGLRNMTHKDIALREMWRVLSPGGSLI
VLEFSKVWKPLQPLYDTYSFKALPFMGKIVTRDDASYRYLAESIRMHPSQEDLKQLMQQVGFERVEYFNLTAGVVALHRG
YKF

Sequences:

>Translated_243_residues
MNATHFGFTTVSETEKARKVAEVFHSVAARYNLMNDLMSMGLHRLWKKFAIDVSGARRGDKVLDIAGGTADLTALFREKV
GDAGEVWLTDINNSMLSIGRDRMLNDGKSVPVAQCDAEKLPFPDNYFDRVCVAFGLRNMTHKDIALREMWRVLSPGGSLI
VLEFSKVWKPLQPLYDTYSFKALPFMGKIVTRDDASYRYLAESIRMHPSQEDLKQLMQQVGFERVEYFNLTAGVVALHRG
YKF
>Mature_243_residues
MNATHFGFTTVSETEKARKVAEVFHSVAARYNLMNDLMSMGLHRLWKKFAIDVSGARRGDKVLDIAGGTADLTALFREKV
GDAGEVWLTDINNSMLSIGRDRMLNDGKSVPVAQCDAEKLPFPDNYFDRVCVAFGLRNMTHKDIALREMWRVLSPGGSLI
VLEFSKVWKPLQPLYDTYSFKALPFMGKIVTRDDASYRYLAESIRMHPSQEDLKQLMQQVGFERVEYFNLTAGVVALHRG
YKF

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=276, Percent_Identity=42.0289855072464, Blast_Score=214, Evalue=5e-56,
Organism=Escherichia coli, GI48994983, Length=243, Percent_Identity=62.5514403292181, Blast_Score=315, Evalue=2e-87,
Organism=Caenorhabditis elegans, GI17557039, Length=244, Percent_Identity=44.672131147541, Blast_Score=217, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6323526, Length=256, Percent_Identity=38.671875, Blast_Score=158, Evalue=7e-40,
Organism=Drosophila melanogaster, GI24641702, Length=257, Percent_Identity=45.5252918287938, Blast_Score=222, Evalue=1e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 27584; Mature: 27584

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: PS01183 UBIE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCC
>Mature Secondary Structure
MNATHFGFTTVSETEKARKVAEVFHSVAARYNLMNDLMSMGLHRLWKKFAIDVSGARRGD
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KVLDIAGGTADLTALFREKVGDAGEVWLTDINNSMLSIGRDRMLNDGKSVPVAQCDAEKL
CEEEECCCHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
PFPDNYFDRVCVAFGLRNMTHKDIALREMWRVLSPGGSLIVLEFSKVWKPLQPLYDTYSF
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHCCCC
KALPFMGKIVTRDDASYRYLAESIRMHPSQEDLKQLMQQVGFERVEYFNLTAGVVALHRG
CCCHHHHHHEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCC
YKF
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]