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The map label for this gene is holA [H]

Identifier: 114331416

GI number: 114331416

Start: 1506702

End: 1507775

Strand: Reverse

Name: holA [H]

Synonym: Neut_1427

Alternate gene names: 114331416

Gene position: 1507775-1506702 (Counterclockwise)

Preceding gene: 114331417

Following gene: 114331415

Centisome position: 56.66

GC content: 48.04

Gene sequence:

>1074_bases
ATGCGACTAGATCCGAAGCCTGTGACCAGTCAACCTGGTGAAGGTGTTGCCTCTCTGTATGTTGTGCTGGGGGATGAGTT
ACTGTTGGTCACGGAAGCAACCGACCGGATTCGTGCCCATGCCAAAGATCAGGGTTACATTGCGCGTGAAATCTTTACGA
TTGATCAGCGATTTGAATGGATAAACCTGTTTCATTGGGGACGTCAATCCTCCCTGTTCAGCGAACGTCGCATACTTGAT
TTACGTATTCCATCCGGTAAACCGGGCAGGGAAGGCAGTATGATTATCGAAAAATTTTGTCAGCATCTGCCGCGCGATAC
CGTGACCATTGTGACGTTACCGGAAATTGATAAACAGGGACGTGCCAGCAAGTGGTTCAAGGCATTCGAACGTACCGGCC
GGATCACCGAAATAAAACCGGTCAGGCGTGATCAGTTGCCCCACTGGATCAAACAGCGTCTTGGGCAGCAGAAGCAAACA
ACGGATCGGGATACATTGCAATTCTTTGCGGATAAGGTTGAAGGTAATCTGCTGGCAGCTCATCAGGAAATAAAAAAGCT
GGGATTACTCTATCCTGTCGGTAAATTAACTTTTGAGCAGATCAGGAATGCCATTCTGGATGTTACACGCTTTGATGTGC
TGCAGCTGCCGGAAGCTATGCTGACAGCCGATATGGTACGTTATAACCGTATTCTGGAGGGGTTGCAGGGGGAGGGGGTA
GCTCCGCCACTGATACTGGCTATTTTGTCAGAGCAGATTCGTTTGCTGATAAAAATCCACCTGACCAAGAACTCCAGTCG
GGGTATGACGCTGGAACAAGCCATGGCAGCATTGCGCGTGTGGCCTTCAAGGCAAAAACTGATTGCAGGTATCTTTCACC
GTACTCACTATCAATTGCTGGTGCGGGCTTTGCTGCAGGCGGCTGCCATTGATCGAATGATCAAGGGAGTCACGAAAGGA
GATATCTGGGAAGCGCTTTTAAAGCTCGGGATGTATTTTGCTGTTGATGACAATCGTTGTAAGGCAATCGAAAGGAATAG
TTTTCTATTTACGATCAACTTATCTCTAAAATAA

Upstream 100 bases:

>100_bases
CAGAGGAAGAAATGCTGTACAAGGATATGCAGAAAGATGCCGTACAACAGATTCTTCGCCAGATTACGGCTGTTACCCTC
GGGTGAGATGTGTATAACGC

Downstream 100 bases:

>100_bases
ATGAAAGTAAAAATTGCATGGCAGGAAGGAGTCAGTTTTCTCGGACAGGTTGGGAGCGGGCATTCTGTACTCATGGATGG
CGCACCGGAAGCAGGCGGGA

Product: DNA polymerase III, delta subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MRLDPKPVTSQPGEGVASLYVVLGDELLLVTEATDRIRAHAKDQGYIAREIFTIDQRFEWINLFHWGRQSSLFSERRILD
LRIPSGKPGREGSMIIEKFCQHLPRDTVTIVTLPEIDKQGRASKWFKAFERTGRITEIKPVRRDQLPHWIKQRLGQQKQT
TDRDTLQFFADKVEGNLLAAHQEIKKLGLLYPVGKLTFEQIRNAILDVTRFDVLQLPEAMLTADMVRYNRILEGLQGEGV
APPLILAILSEQIRLLIKIHLTKNSSRGMTLEQAMAALRVWPSRQKLIAGIFHRTHYQLLVRALLQAAAIDRMIKGVTKG
DIWEALLKLGMYFAVDDNRCKAIERNSFLFTINLSLK

Sequences:

>Translated_357_residues
MRLDPKPVTSQPGEGVASLYVVLGDELLLVTEATDRIRAHAKDQGYIAREIFTIDQRFEWINLFHWGRQSSLFSERRILD
LRIPSGKPGREGSMIIEKFCQHLPRDTVTIVTLPEIDKQGRASKWFKAFERTGRITEIKPVRRDQLPHWIKQRLGQQKQT
TDRDTLQFFADKVEGNLLAAHQEIKKLGLLYPVGKLTFEQIRNAILDVTRFDVLQLPEAMLTADMVRYNRILEGLQGEGV
APPLILAILSEQIRLLIKIHLTKNSSRGMTLEQAMAALRVWPSRQKLIAGIFHRTHYQLLVRALLQAAAIDRMIKGVTKG
DIWEALLKLGMYFAVDDNRCKAIERNSFLFTINLSLK
>Mature_357_residues
MRLDPKPVTSQPGEGVASLYVVLGDELLLVTEATDRIRAHAKDQGYIAREIFTIDQRFEWINLFHWGRQSSLFSERRILD
LRIPSGKPGREGSMIIEKFCQHLPRDTVTIVTLPEIDKQGRASKWFKAFERTGRITEIKPVRRDQLPHWIKQRLGQQKQT
TDRDTLQFFADKVEGNLLAAHQEIKKLGLLYPVGKLTFEQIRNAILDVTRFDVLQLPEAMLTADMVRYNRILEGLQGEGV
APPLILAILSEQIRLLIKIHLTKNSSRGMTLEQAMAALRVWPSRQKLIAGIFHRTHYQLLVRALLQAAAIDRMIKGVTKG
DIWEALLKLGMYFAVDDNRCKAIERNSFLFTINLSLK

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=295, Percent_Identity=29.8305084745763, Blast_Score=115, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 40927; Mature: 40927

Theoretical pI: Translated: 10.37; Mature: 10.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLDPKPVTSQPGEGVASLYVVLGDELLLVTEATDRIRAHAKDQGYIAREIFTIDQRFEW
CCCCCCCCCCCCCCCHHHHHEEECCCEEEEECCHHHHHHHCCCCCCHHHHHHHHHHHHHH
INLFHWGRQSSLFSERRILDLRIPSGKPGREGSMIIEKFCQHLPRDTVTIVTLPEIDKQG
HHHHHCCCHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCC
RASKWFKAFERTGRITEIKPVRRDQLPHWIKQRLGQQKQTTDRDTLQFFADKVEGNLLAA
CHHHHHHHHHHCCCCCEECCCHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHH
HQEIKKLGLLYPVGKLTFEQIRNAILDVTRFDVLQLPEAMLTADMVRYNRILEGLQGEGV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCC
APPLILAILSEQIRLLIKIHLTKNSSRGMTLEQAMAALRVWPSRQKLIAGIFHRTHYQLL
CHHHHHHHHHHHHHEEEEEEEECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
VRALLQAAAIDRMIKGVTKGDIWEALLKLGMYFAVDDNRCKAIERNSFLFTINLSLK
HHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEECCCCCCEEECCCEEEEEEEEEC
>Mature Secondary Structure
MRLDPKPVTSQPGEGVASLYVVLGDELLLVTEATDRIRAHAKDQGYIAREIFTIDQRFEW
CCCCCCCCCCCCCCCHHHHHEEECCCEEEEECCHHHHHHHCCCCCCHHHHHHHHHHHHHH
INLFHWGRQSSLFSERRILDLRIPSGKPGREGSMIIEKFCQHLPRDTVTIVTLPEIDKQG
HHHHHCCCHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCC
RASKWFKAFERTGRITEIKPVRRDQLPHWIKQRLGQQKQTTDRDTLQFFADKVEGNLLAA
CHHHHHHHHHHCCCCCEECCCHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHH
HQEIKKLGLLYPVGKLTFEQIRNAILDVTRFDVLQLPEAMLTADMVRYNRILEGLQGEGV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCC
APPLILAILSEQIRLLIKIHLTKNSSRGMTLEQAMAALRVWPSRQKLIAGIFHRTHYQLL
CHHHHHHHHHHHHHEEEEEEEECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
VRALLQAAAIDRMIKGVTKGDIWEALLKLGMYFAVDDNRCKAIERNSFLFTINLSLK
HHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEECCCCCCEEECCCEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]