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The map label for this gene is csd [H]

Identifier: 114331234

GI number: 114331234

Start: 1293968

End: 1295239

Strand: Reverse

Name: csd [H]

Synonym: Neut_1238

Alternate gene names: 114331234

Gene position: 1295239-1293968 (Counterclockwise)

Preceding gene: 114331235

Following gene: 114331233

Centisome position: 48.67

GC content: 43.87

Gene sequence:

>1272_bases
ATGAAAATTGTTGACACATTAGTGACTTCATCTGCACAGCAAACAACTACTGTACCTGGAATAGGGCAATTTCGTGCAGA
TTTTCCGATTCTTGATATCAAGGTAGATGACAAACCGCTGATTTATCTTGACAACGCTGCTTCTAGCCAAATGCCGCAGG
CAGTCATTGATTGTCTGGTTCGTTACCAGAAAACTCAGCATGCAAATATTCATCGTGCGGTACATTATTTATCCAACCTG
GCTACACAGGAATATGAAGCAGCACGGTGTAAACTGCAAAATTTTATCGGTGCGCGTGAAGATAGAGAGGTGATATTTAC
TAGTGGTACAACTGACAGTATCAATCTGGTGATGCATGGGTATGGACGTAAATTCATTCAGCGTGGCGATGAAATTATTT
TGTCCGAGCTCGAACATCATTCCAATATTGTGCCTTGGCAGATGTTGGCCGAGGAAAGAGGTGCGCATATCCGGGTAGCC
CCAATTAATGATGCAGGTGAGCTTCTGGTGGAGGAATATGAAAAACTTTTTAATTCCAAGACCCGATTTGTAGCTTTGTC
GCATGTTTCCAATGCACTTGGTAGCATCAATCCGATCAAACGCATGATTGCCATAGCACATCAGCATGATGTTCCTGTTT
TGATTGATGGCGCCCAGGCAGCGCCTCATTTGAAAATAGATGTGCAGGATCTCGATTGCGATTTTTATGCTTTCTCGGCG
CACAAAATGTGCGGGCCCACCGGGATTGGTATTTTGTACGGAAAGGCGCATTTGCTTGAATCTATGCAACCATTCAAAGG
AGGAGGGGACATGATTGCTTCAGTTTCCTTTGAAAAAACAACATATAACGAGATACCATATAAATTTGAGGCAGGTACTC
CTCCTATTGCGGCGGCCATAGGTTTTGGTGCGGCAATTGATTATCTGGAACAGATCGGCCTTGATGCTATTGCTGATTAT
GAACATGAGCTGCTGCTTTATGCTTCTGAGCAAATCAGAATGATCCCAGGCGTGAAAATCATAGGCGATTGCCCGGATAA
GGTTGCGGTGATATCGTTTGTTATTGATGGTATTCATCCGCATGATGTTGGTACTTTACTGAACCAGGAAGGTATAGCTG
TGCGCACAGGGCATCATTGTGCACAACCGATTATGCAGCGTTTTAATGTGGCGGCAACGTCGCGTGCCTCATTTTCTTTT
TATAATACTAAAAAAGAGATCGATGCTCTGGTGGCAGGTATTCGGTCTGTACAAAAGGTTTTCGCACAATGA

Upstream 100 bases:

>100_bases
ATACGCATTCGGAGGCGAAATTATTAACCGCGTTATAGTGGCTTCACTCAGGCAACGGCTTGAAGAATATATTCTTGTAA
GAACACGCATTAGCTAAATC

Downstream 100 bases:

>100_bases
GTTTGAAATCAATTTATCAAGAAGTTATTCTTGATCATAATCGCAAGCCGCGTAACTATGGTTCTCTTAGCCATCCTACC
CACCATGCGACAGGACATAA

Product: SufS subfamily cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MKIVDTLVTSSAQQTTTVPGIGQFRADFPILDIKVDDKPLIYLDNAASSQMPQAVIDCLVRYQKTQHANIHRAVHYLSNL
ATQEYEAARCKLQNFIGAREDREVIFTSGTTDSINLVMHGYGRKFIQRGDEIILSELEHHSNIVPWQMLAEERGAHIRVA
PINDAGELLVEEYEKLFNSKTRFVALSHVSNALGSINPIKRMIAIAHQHDVPVLIDGAQAAPHLKIDVQDLDCDFYAFSA
HKMCGPTGIGILYGKAHLLESMQPFKGGGDMIASVSFEKTTYNEIPYKFEAGTPPIAAAIGFGAAIDYLEQIGLDAIADY
EHELLLYASEQIRMIPGVKIIGDCPDKVAVISFVIDGIHPHDVGTLLNQEGIAVRTGHHCAQPIMQRFNVAATSRASFSF
YNTKKEIDALVAGIRSVQKVFAQ

Sequences:

>Translated_423_residues
MKIVDTLVTSSAQQTTTVPGIGQFRADFPILDIKVDDKPLIYLDNAASSQMPQAVIDCLVRYQKTQHANIHRAVHYLSNL
ATQEYEAARCKLQNFIGAREDREVIFTSGTTDSINLVMHGYGRKFIQRGDEIILSELEHHSNIVPWQMLAEERGAHIRVA
PINDAGELLVEEYEKLFNSKTRFVALSHVSNALGSINPIKRMIAIAHQHDVPVLIDGAQAAPHLKIDVQDLDCDFYAFSA
HKMCGPTGIGILYGKAHLLESMQPFKGGGDMIASVSFEKTTYNEIPYKFEAGTPPIAAAIGFGAAIDYLEQIGLDAIADY
EHELLLYASEQIRMIPGVKIIGDCPDKVAVISFVIDGIHPHDVGTLLNQEGIAVRTGHHCAQPIMQRFNVAATSRASFSF
YNTKKEIDALVAGIRSVQKVFAQ
>Mature_423_residues
MKIVDTLVTSSAQQTTTVPGIGQFRADFPILDIKVDDKPLIYLDNAASSQMPQAVIDCLVRYQKTQHANIHRAVHYLSNL
ATQEYEAARCKLQNFIGAREDREVIFTSGTTDSINLVMHGYGRKFIQRGDEIILSELEHHSNIVPWQMLAEERGAHIRVA
PINDAGELLVEEYEKLFNSKTRFVALSHVSNALGSINPIKRMIAIAHQHDVPVLIDGAQAAPHLKIDVQDLDCDFYAFSA
HKMCGPTGIGILYGKAHLLESMQPFKGGGDMIASVSFEKTTYNEIPYKFEAGTPPIAAAIGFGAAIDYLEQIGLDAIADY
EHELLLYASEQIRMIPGVKIIGDCPDKVAVISFVIDGIHPHDVGTLLNQEGIAVRTGHHCAQPIMQRFNVAATSRASFSF
YNTKKEIDALVAGIRSVQKVFAQ

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=311, Percent_Identity=26.6881028938907, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI156713448, Length=241, Percent_Identity=28.6307053941909, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1787970, Length=403, Percent_Identity=48.3870967741936, Blast_Score=412, Evalue=1e-116,
Organism=Escherichia coli, GI1789175, Length=392, Percent_Identity=41.3265306122449, Blast_Score=320, Evalue=1e-88,
Organism=Escherichia coli, GI48994898, Length=215, Percent_Identity=28.8372093023256, Blast_Score=93, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI25143064, Length=213, Percent_Identity=30.9859154929577, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI193211090, Length=385, Percent_Identity=25.4545454545455, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6319831, Length=229, Percent_Identity=29.6943231441048, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI20129463, Length=298, Percent_Identity=26.1744966442953, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 46625; Mature: 46625

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVDTLVTSSAQQTTTVPGIGQFRADFPILDIKVDDKPLIYLDNAASSQMPQAVIDCLV
CCHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCHHHHHHHHH
RYQKTQHANIHRAVHYLSNLATQEYEAARCKLQNFIGAREDREVIFTSGTTDSINLVMHG
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEEC
YGRKFIQRGDEIILSELEHHSNIVPWQMLAEERGAHIRVAPINDAGELLVEEYEKLFNSK
CCHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCC
TRFVALSHVSNALGSINPIKRMIAIAHQHDVPVLIDGAQAAPHLKIDVQDLDCDFYAFSA
CEEEEHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEEEEECCCCEEEECC
HKMCGPTGIGILYGKAHLLESMQPFKGGGDMIASVSFEKTTYNEIPYKFEAGTPPIAAAI
CCCCCCCCCEEEEHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCEEEECCCCCHHHHH
GFGAAIDYLEQIGLDAIADYEHELLLYASEQIRMIPGVKIIGDCPDKVAVISFVIDGIHP
HHHHHHHHHHHCCCHHHHCCCCEEEEEECCCEEECCCEEEECCCCCHHHHHHHHHCCCCC
HDVGTLLNQEGIAVRTGHHCAQPIMQRFNVAATSRASFSFYNTKKEIDALVAGIRSVQKV
HHHHHHHCCCCCEEECCCHHHHHHHHHHCCHHCCCCCEEECCCHHHHHHHHHHHHHHHHH
FAQ
HCC
>Mature Secondary Structure
MKIVDTLVTSSAQQTTTVPGIGQFRADFPILDIKVDDKPLIYLDNAASSQMPQAVIDCLV
CCHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCHHHHHHHHH
RYQKTQHANIHRAVHYLSNLATQEYEAARCKLQNFIGAREDREVIFTSGTTDSINLVMHG
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEEC
YGRKFIQRGDEIILSELEHHSNIVPWQMLAEERGAHIRVAPINDAGELLVEEYEKLFNSK
CCHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCC
TRFVALSHVSNALGSINPIKRMIAIAHQHDVPVLIDGAQAAPHLKIDVQDLDCDFYAFSA
CEEEEHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEEEEECCCCEEEECC
HKMCGPTGIGILYGKAHLLESMQPFKGGGDMIASVSFEKTTYNEIPYKFEAGTPPIAAAI
CCCCCCCCCEEEEHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCEEEECCCCCHHHHH
GFGAAIDYLEQIGLDAIADYEHELLLYASEQIRMIPGVKIIGDCPDKVAVISFVIDGIHP
HHHHHHHHHHHCCCHHHHCCCCEEEEEECCCEEECCCEEEECCCCCHHHHHHHHHCCCCC
HDVGTLLNQEGIAVRTGHHCAQPIMQRFNVAATSRASFSFYNTKKEIDALVAGIRSVQKV
HHHHHHHCCCCCEEECCCHHHHHHHHHHCCHHCCCCCEEECCCHHHHHHHHHHHHHHHHH
FAQ
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]