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The map label for this gene is 113477599

Identifier: 113477599

GI number: 113477599

Start: 6444890

End: 6445951

Strand: Reverse

Name: 113477599

Synonym: Tery_4182

Alternate gene names: NA

Gene position: 6445951-6444890 (Counterclockwise)

Preceding gene: 113477600

Following gene: 113477598

Centisome position: 83.17

GC content: 35.4

Gene sequence:

>1062_bases
ATGCAGTTCGATCACATTCATTTCTACGTTGAAAATGCTATAGAGTCCAGAGACTGGTTTAGAGAAAAATTAGGTTTTAA
AGCCATTGCTTCTAAAACCAGTCAACATACCCAGAAGGAAATTATTAACAGGGGTCAAGTATATTTTGCCTTATCTTCTG
CCATCACACCAGCAAGTCCTGTTACCAATTTTCTGAGCTTACATCCTCCCGGAGTCGCTGATGTAGCTTTTCGAGTTCGA
GATATTACCTCAGTTGTGGCAAATGCGGCAGCTAATGGAGCAGAAATTTTGCAACCTATTCAGGAAAACTTAAACGGTTT
AAAATGGGCGAAAATTTCTGGATGGGGAGACTTAACTCATACTTTGATAGAAAAAATTGATGATGCAAAAATTTTGAATT
CTACTTCTCAACTTTCTACGGATCTTATGGTGATCGATCATGTAGTTTTAAATGTAGCTAAAGACAATTTAGAACCTGCT
TTCAATTGGTATCATCAAATTTTCAATTTCCAACCCCATCAAAATTTTGACATTCAGACAAATAAATCAGGTTTGCGTAG
TCTAGTGATGATACACCCAGAGGGAGAAGTCAAATTTCCTATTAATGAGCCTACATCTGATAGTTCTCAAATTCAGGAAT
TTTTGGATGCTAATTCTGGTGCGGGAATACAACACATTGCTTTACATACAGAAAATATTTTGGGGGTGGTCGGAGAGTTG
CGATCGCTTGGTTTACCTTTTTTACAAGTTCCAAAAACATATTACTATAGTCTACAAACAGAAGCATTAAGTCATCTATC
AGAAACTGACTGGCAGAAAGTTCAAAATTGTCAAATTTTGGTAGACTGGCAAGAAAAAATACCAGGAGCAATGTTACTAC
AAATTTTTACACAACCAATATTTAACCAACCAACAGTATTTTTTGAGTTTATTGAACGTAAAGTTGTTTGGGTAAATGGT
AAACAAATTCAGACACCAGGTTTTGGTCAAGGTAATTTTCAAGCTTTATTTGAAGCTATTGAAAGGGAACAAATGAAACG
AGGTAGTTTAAGAAAAAATTAA

Upstream 100 bases:

>100_bases
GAGGAATCTCAAAATGTCATAACGTTAGCAGGTAGCGCTATACTTGTAACAATATTTATTTTCTCCAAATAATATTTTGA
TTGAATAATAAAAGTTGATT

Downstream 100 bases:

>100_bases
AAATTAAAGGTAGGATGGATTAATAGAACCCCATATAAATTTACTATATAACCCTTGAAAATCTATTTATCAATGCTTTA
AATTACACTAATTAAGATGG

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: homogentisate; CO2

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MQFDHIHFYVENAIESRDWFREKLGFKAIASKTSQHTQKEIINRGQVYFALSSAITPASPVTNFLSLHPPGVADVAFRVR
DITSVVANAAANGAEILQPIQENLNGLKWAKISGWGDLTHTLIEKIDDAKILNSTSQLSTDLMVIDHVVLNVAKDNLEPA
FNWYHQIFNFQPHQNFDIQTNKSGLRSLVMIHPEGEVKFPINEPTSDSSQIQEFLDANSGAGIQHIALHTENILGVVGEL
RSLGLPFLQVPKTYYYSLQTEALSHLSETDWQKVQNCQILVDWQEKIPGAMLLQIFTQPIFNQPTVFFEFIERKVVWVNG
KQIQTPGFGQGNFQALFEAIEREQMKRGSLRKN

Sequences:

>Translated_353_residues
MQFDHIHFYVENAIESRDWFREKLGFKAIASKTSQHTQKEIINRGQVYFALSSAITPASPVTNFLSLHPPGVADVAFRVR
DITSVVANAAANGAEILQPIQENLNGLKWAKISGWGDLTHTLIEKIDDAKILNSTSQLSTDLMVIDHVVLNVAKDNLEPA
FNWYHQIFNFQPHQNFDIQTNKSGLRSLVMIHPEGEVKFPINEPTSDSSQIQEFLDANSGAGIQHIALHTENILGVVGEL
RSLGLPFLQVPKTYYYSLQTEALSHLSETDWQKVQNCQILVDWQEKIPGAMLLQIFTQPIFNQPTVFFEFIERKVVWVNG
KQIQTPGFGQGNFQALFEAIEREQMKRGSLRKN
>Mature_353_residues
MQFDHIHFYVENAIESRDWFREKLGFKAIASKTSQHTQKEIINRGQVYFALSSAITPASPVTNFLSLHPPGVADVAFRVR
DITSVVANAAANGAEILQPIQENLNGLKWAKISGWGDLTHTLIEKIDDAKILNSTSQLSTDLMVIDHVVLNVAKDNLEPA
FNWYHQIFNFQPHQNFDIQTNKSGLRSLVMIHPEGEVKFPINEPTSDSSQIQEFLDANSGAGIQHIALHTENILGVVGEL
RSLGLPFLQVPKTYYYSLQTEALSHLSETDWQKVQNCQILVDWQEKIPGAMLLQIFTQPIFNQPTVFFEFIERKVVWVNG
KQIQTPGFGQGNFQALFEAIEREQMKRGSLRKN

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=380, Percent_Identity=35.5263157894737, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI285002264, Length=357, Percent_Identity=36.1344537815126, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI14249394, Length=374, Percent_Identity=22.4598930481283, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17555220, Length=381, Percent_Identity=35.6955380577428, Blast_Score=211, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17550752, Length=371, Percent_Identity=30.188679245283, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24667510, Length=379, Percent_Identity=36.1477572559367, Blast_Score=205, Evalue=4e-53,
Organism=Drosophila melanogaster, GI21356105, Length=307, Percent_Identity=38.7622149837134, Blast_Score=180, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 1.13.11.27

Molecular weight: Translated: 39927; Mature: 39927

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFDHIHFYVENAIESRDWFREKLGFKAIASKTSQHTQKEIINRGQVYFALSSAITPASP
CCCCCEEHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHH
VTNFLSLHPPGVADVAFRVRDITSVVANAAANGAEILQPIQENLNGLKWAKISGWGDLTH
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEECCCHHHHH
TLIEKIDDAKILNSTSQLSTDLMVIDHVVLNVAKDNLEPAFNWYHQIFNFQPHQNFDIQT
HHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEE
NKSGLRSLVMIHPEGEVKFPINEPTSDSSQIQEFLDANSGAGIQHIALHTENILGVVGEL
CHHCCCEEEEECCCCCEEECCCCCCCCHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHH
RSLGLPFLQVPKTYYYSLQTEALSHLSETDWQKVQNCQILVDWQEKIPGAMLLQIFTQPI
HHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHCCHHHHHHHHHHHH
FNQPTVFFEFIERKVVWVNGKQIQTPGFGQGNFQALFEAIEREQMKRGSLRKN
CCCCHHHHHHHCCEEEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQFDHIHFYVENAIESRDWFREKLGFKAIASKTSQHTQKEIINRGQVYFALSSAITPASP
CCCCCEEHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHH
VTNFLSLHPPGVADVAFRVRDITSVVANAAANGAEILQPIQENLNGLKWAKISGWGDLTH
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEECCCHHHHH
TLIEKIDDAKILNSTSQLSTDLMVIDHVVLNVAKDNLEPAFNWYHQIFNFQPHQNFDIQT
HHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEE
NKSGLRSLVMIHPEGEVKFPINEPTSDSSQIQEFLDANSGAGIQHIALHTENILGVVGEL
CHHCCCEEEEECCCCCEEECCCCCCCCHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHH
RSLGLPFLQVPKTYYYSLQTEALSHLSETDWQKVQNCQILVDWQEKIPGAMLLQIFTQPI
HHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHCCHHHHHHHHHHHH
FNQPTVFFEFIERKVVWVNGKQIQTPGFGQGNFQALFEAIEREQMKRGSLRKN
CCCCHHHHHHHCCEEEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-hydroxyphenylpyruvate; O2

Specific reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]