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The map label for this gene is cya [H]

Identifier: 113477363

GI number: 113477363

Start: 6054014

End: 6055195

Strand: Reverse

Name: cya [H]

Synonym: Tery_3919

Alternate gene names: 113477363

Gene position: 6055195-6054014 (Counterclockwise)

Preceding gene: 113477364

Following gene: 113477361

Centisome position: 78.13

GC content: 36.8

Gene sequence:

>1182_bases
ATGGCAAATATTTTAGGAGATGACAATAATAACTTCTTAATAGGTTCTCCAGAACCTGACCTTATGGAAGGTTTTGGTGG
AAATGACACTATTTTTGGTGAAAAAGGAGATGATACTCAAAGCGGAGGAGATGGAGTCGACGAAATTTTTGGTGGCATTG
GATCTGATTCTTTAATTGGTGGTGAAGATAACGATTTTCTAAAAGCAGAAGATGGACGCGACTTAGCATTTGGAGGTCCT
GGAGATGATAGTATTGAAGGTGGTCCCGGAAATGATACCCTAACAGGAGAAAATGGCAACGACTCTTTATTTGGAGAAAC
TGGAGATGACCTTATAATAGGTAGCCAAGGACTTGATTATATTATTGGAGGAGGAGGTAACGATACATTAAGAGGTAATC
AAGGGAATGATAGTCTAGTTGGAAATGTTGATGATGATCTAATATTTGGGGACCAAGGAAACGATACTGGCAGTGGAGGT
ACAGGTAATGATTCTCTTTTAGGTGGTGATGGTGATGACTCTTTAGACGGAGGTAGTGGTAATGATACTATATTTGGTGA
ATCAGGTAACGATTCTCTATTTGGCATTATTGGCAGTGATTTTATTAATGGTAATAGGGGTAACGATCAAGTTTTTGGTG
GAGAAAATGCAGATAATCTTCGTGGTGGAAAAGGTAATGATACAATATTTGGAGAACTTGAGAATGACTCTCTCTTCGGT
GACTCAAACAACGACCTAGTTATTGGTGGTATTGGTGATGATACATTGTTTGGTGGAAAGAATAATGATACCCTTCAAGG
TAGTGATGGTAATGACTCTTTGTTAGGGGATCTAGGCAACGATATATTATTTGGAGGTGGGGGAGAAGATACATTAACTG
GTGGTGAGGGAGAAGACACTTTTGTACTACCTGGAGAACTAGGTAGTATTGATATAATTAATGATTTTAATCCCTTAGAA
GATTTCTTAGCTTTAAGTGGTAATTTAACTTTTGAGGATTTAAGTTTTCAACAACAAACTGGCTTAAACTTCAGAGATAC
ATTAATCACTATTAATAATGACAGATTATTAGCCATATTAGTAAATGTTCCAGCCTCCATAATTTCAGAGAAAGACTTCA
TAGATGTTAGCCAACCTTTACTTGATTTTGATTCTAAGTATACTGGCAATGAAGTTTTATAA

Upstream 100 bases:

>100_bases
AAAAAATACAATCCTTAAACTTAGAATCTTTGTATATTTTTCTCCAAACCTTACTTTTTCTATAATCAAACTAATAACAC
CATAGGAGCATCCAAATAAT

Downstream 100 bases:

>100_bases
TTCTTCAGTATCATCAAGATAGTTTTCCAACAAATACCGTAATTTTAACCTACCTCCATAATTTCAGAGAAAGACTTCAT
AGATGTTAGCCAACCTTTAC

Product: hemolysin-type calcium-binding protein

Products: NA

Alternate protein names: AC-HLY; ACT; Cyclolysin; ATP pyrophosphate-lyase; Adenylyl cyclase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MANILGDDNNNFLIGSPEPDLMEGFGGNDTIFGEKGDDTQSGGDGVDEIFGGIGSDSLIGGEDNDFLKAEDGRDLAFGGP
GDDSIEGGPGNDTLTGENGNDSLFGETGDDLIIGSQGLDYIIGGGGNDTLRGNQGNDSLVGNVDDDLIFGDQGNDTGSGG
TGNDSLLGGDGDDSLDGGSGNDTIFGESGNDSLFGIIGSDFINGNRGNDQVFGGENADNLRGGKGNDTIFGELENDSLFG
DSNNDLVIGGIGDDTLFGGKNNDTLQGSDGNDSLLGDLGNDILFGGGGEDTLTGGEGEDTFVLPGELGSIDIINDFNPLE
DFLALSGNLTFEDLSFQQQTGLNFRDTLITINNDRLLAILVNVPASIISEKDFIDVSQPLLDFDSKYTGNEVL

Sequences:

>Translated_393_residues
MANILGDDNNNFLIGSPEPDLMEGFGGNDTIFGEKGDDTQSGGDGVDEIFGGIGSDSLIGGEDNDFLKAEDGRDLAFGGP
GDDSIEGGPGNDTLTGENGNDSLFGETGDDLIIGSQGLDYIIGGGGNDTLRGNQGNDSLVGNVDDDLIFGDQGNDTGSGG
TGNDSLLGGDGDDSLDGGSGNDTIFGESGNDSLFGIIGSDFINGNRGNDQVFGGENADNLRGGKGNDTIFGELENDSLFG
DSNNDLVIGGIGDDTLFGGKNNDTLQGSDGNDSLLGDLGNDILFGGGGEDTLTGGEGEDTFVLPGELGSIDIINDFNPLE
DFLALSGNLTFEDLSFQQQTGLNFRDTLITINNDRLLAILVNVPASIISEKDFIDVSQPLLDFDSKYTGNEVL
>Mature_392_residues
ANILGDDNNNFLIGSPEPDLMEGFGGNDTIFGEKGDDTQSGGDGVDEIFGGIGSDSLIGGEDNDFLKAEDGRDLAFGGPG
DDSIEGGPGNDTLTGENGNDSLFGETGDDLIIGSQGLDYIIGGGGNDTLRGNQGNDSLVGNVDDDLIFGDQGNDTGSGGT
GNDSLLGGDGDDSLDGGSGNDTIFGESGNDSLFGIIGSDFINGNRGNDQVFGGENADNLRGGKGNDTIFGELENDSLFGD
SNNDLVIGGIGDDTLFGGKNNDTLQGSDGNDSLLGDLGNDILFGGGGEDTLTGGEGEDTFVLPGELGSIDIINDFNPLED
FLALSGNLTFEDLSFQQQTGLNFRDTLITINNDRLLAILVNVPASIISEKDFIDVSQPLLDFDSKYTGNEVL

Specific function: This adenylate cyclase belongs to a special class of bacterial toxin. It causes whooping cough by acting on mammalian cells by elevating cAMP-concentration and thus disrupts normal cell function [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 17 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005165
- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF03497 Anthrax_toxA; PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 40400; Mature: 40269

Theoretical pI: Translated: 3.22; Mature: 3.22

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANILGDDNNNFLIGSPEPDLMEGFGGNDTIFGEKGDDTQSGGDGVDEIFGGIGSDSLIG
CCCCCCCCCCCEEEECCCCHHHHCCCCCCEEECCCCCCCCCCCCCHHHHHCCCCCCCEEC
GEDNDFLKAEDGRDLAFGGPGDDSIEGGPGNDTLTGENGNDSLFGETGDDLIIGSQGLDY
CCCCCEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCE
IIGGGGNDTLRGNQGNDSLVGNVDDDLIFGDQGNDTGSGGTGNDSLLGGDGDDSLDGGSG
EEECCCCCCCCCCCCCCCEECCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
NDTIFGESGNDSLFGIIGSDFINGNRGNDQVFGGENADNLRGGKGNDTIFGELENDSLFG
CCEEEECCCCCCEEEEEECCCCCCCCCCCCEECCCCCCCCCCCCCCCCEEEEECCCEEEC
DSNNDLVIGGIGDDTLFGGKNNDTLQGSDGNDSLLGDLGNDILFGGGGEDTLTGGEGEDT
CCCCCEEEEECCCCCEECCCCCCEEECCCCCCHHHHHCCCCEEECCCCCCCCCCCCCCCE
FVLPGELGSIDIINDFNPLEDFLALSGNLTFEDLSFQQQTGLNFRDTLITINNDRLLAIL
EEECCCCCCEEEECCCCHHHHHHHHCCCCEEHHCCCHHHHCCCEEEEEEEECCCEEEEEE
VNVPASIISEKDFIDVSQPLLDFDSKYTGNEVL
EECCHHHHCCCCCCCCHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
ANILGDDNNNFLIGSPEPDLMEGFGGNDTIFGEKGDDTQSGGDGVDEIFGGIGSDSLIG
CCCCCCCCCCEEEECCCCHHHHCCCCCCEEECCCCCCCCCCCCCHHHHHCCCCCCCEEC
GEDNDFLKAEDGRDLAFGGPGDDSIEGGPGNDTLTGENGNDSLFGETGDDLIIGSQGLDY
CCCCCEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCE
IIGGGGNDTLRGNQGNDSLVGNVDDDLIFGDQGNDTGSGGTGNDSLLGGDGDDSLDGGSG
EEECCCCCCCCCCCCCCCEECCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
NDTIFGESGNDSLFGIIGSDFINGNRGNDQVFGGENADNLRGGKGNDTIFGELENDSLFG
CCEEEECCCCCCEEEEEECCCCCCCCCCCCEECCCCCCCCCCCCCCCCEEEEECCCEEEC
DSNNDLVIGGIGDDTLFGGKNNDTLQGSDGNDSLLGDLGNDILFGGGGEDTLTGGEGEDT
CCCCCEEEEECCCCCEECCCCCCEEECCCCCCHHHHHCCCCEEECCCCCCCCCCCCCCCE
FVLPGELGSIDIINDFNPLEDFLALSGNLTFEDLSFQQQTGLNFRDTLITINNDRLLAIL
EEECCCCCCEEEECCCCHHHHHHHHCCCCEEHHCCCHHHHCCCEEEEEEEECCCEEEEEE
VNVPASIISEKDFIDVSQPLLDFDSKYTGNEVL
EECCHHHHCCCCCCCCHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7557410; 12910271 [H]