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The map label for this gene is lktA [H]

Identifier: 113477138

GI number: 113477138

Start: 5623544

End: 5625580

Strand: Reverse

Name: lktA [H]

Synonym: Tery_3664

Alternate gene names: 113477138

Gene position: 5625580-5623544 (Counterclockwise)

Preceding gene: 113477140

Following gene: 113477136

Centisome position: 72.59

GC content: 41.88

Gene sequence:

>2037_bases
ATGGAGTCACCCTTACAACAACAGCCAATTCCGAATCATGGAAAATTTAACCATATACATCCTATCCTCAACCCTGAAGT
CCCAGTTGTCACACCTGAAAATCCTTTGCCTACTATTTCACGACTATGGGATGAACTAGCCCAAGAAGCAGTCATAAACT
CCGTCTCCGGTCCAACCATTGCCTCTCGTGCTTATGCAATGGTACATACAGCCATGTATGATGCCTGGAGTGCCTATGAT
CCATTAGCTATAGGAACTCAGTTGGGAGATGACTTACAACGCCCCCTATCCGAAAACACCAACTTTAATAAAACTCAAGC
CATGAGTTTTGCTGCTTACCGGGTATTGTCAGAATTATTCCCCGCTCAAGTAGAAACTTTCAATGAATTAATGGTCAAAT
TAGACCTAGAAACCAACAATACTACTACTGATACTACTACCCCTGCTGGTATTGGTAACGTCTCTGCCGAAGCACTATTA
AGATTCCGGTCCAACGACGGTTCAAATCAACTCGGGGATGATCCCAATGGCGACGGTACCCCCTATTCTGATATTAGCAG
CTATGAACCTATTAATTTTCCAGGAAGTTCCATTAATATAGAGCGCTGGACCCCAGAACCAGTTCCCATTGATGCCGAGC
CCGGTGAAGAAGATCGAATACAAACATTCCTCACACCTCAATGGGGAAAAGTCATCCCCTTCAGTTCTATATCAGTTGAA
AAAATACGACCCCAACCACCAAAACCATTCTTGCTTGTAGATGGCGAGGTTGACTTAGATGCAAGTACAATTACATTACC
AGATGGCTCTGTTGTCGCAATTAGCAAAGATATTGTTGGAACTATTATCAACCCTGAATTTATCGCACAAGCAGAAAATA
TTGCCAACGTTCGCGCCAACTTAACTGATGAGCAAAAATTAATTGCTGAATTTTGGGAAGACGGCCATGGTACATCTTAC
CCTCCGGGAACCTGGATGAATTTTGGAGAATTTATCTCAGCCAGAGATAATCATACTTTAGATGAAGATGTGAAACTCTT
CTTTAGTTTGGGCAATGCATTATTTGATGCTGGCATTGCTGCCTGGGGATCTAAAGTTTTCTACGACTATGCTCGTCCCG
TGCGAGTAGTACGGGAACTCGGAGCACAAGGTTTAATTGGAGAATTTAATCCAGAGCTTGGTGGTTTTGCTATTGATAGT
TGGAAGGATCCTACAGAAGGAACTGCAACTATTCTTGCAACTAATTTCCTTACTTATCAAGCCCCTGGAGAGGAGCCTTC
ACCTCCTTTTGCTGAGTATATATCAGGTCATAGCAGTTTCAGTGCTGCAGGAGCTGAAATTCTCAAACGGTTTACTGGTA
GCGATGATTTTGGTGGTGGCATAACTTTTGAGGTAGGCGAGTCTGTTTTTGAACCAGGTATCACACCTAAAGTGCCTGTA
ACTCTTGAGTGGAATACTTTTAGCGAAGCTTCTGATCAGGCTGGTATATCTCGTATTTACGGCGGTATCCACTTTGAAGA
TGGGGATCTCAATGGGAGGGCACTAGGGCGAGAAGTCGCAGAACATGTTTGGGAAAAAACTCAAGGAGTAATTACTCCCA
ATACTATTATTGCTACTAATGAAAAGGATAATTTAATTGGCTCTGTCACTAACGACTTAATATATAGCAACCGCAGTGAT
GATATTGTTTTTGGTAACGAGGGCAATGATATGCTTTGTGGAGGCAAGGGTAACGACATCGTCAATGGTGGTGCAGGAGC
AGACCTGATATACGGTGATTTTGGCGATGATATTCTCATTGGTGGAGTTGGTGGCGATAACTTTCATTTCAGGTCTAATG
ATGGGAACAATATTATTACTGATTTTGAAGATGGAATAGATGTTATTGGTTTAGGTGATGGTTTAAGTTTCCAGCAGTTA
ACTATTTCTCAAATAGGTAATGATACTCGAATTAGTGCCAACCAACTTTCAATTACATTGCAGGGCGTCGAAGAAAGTGC
CATAAATATTGAAGATTTTAGGGATTGTAAAATATAA

Upstream 100 bases:

>100_bases
ATATTATTGTAATATAAAAGGTGTTAATAGCAAGCTTTCAAACATTCTGAACTGCAAGCCCTAATTAAAATCATTTATTC
TTTATACTAAAAACAAAATC

Downstream 100 bases:

>100_bases
GTTCCTAGCCTATTTTCCAGCCAAATTCAGAAGTTGAAAAAGAGAAGTTTTTTTGGACAAAAATAACTTTGTAGAAATGT
TGGATGCAACATTCCTACAT

Product: hemolysin-type calcium-binding protein

Products: NA

Alternate protein names: Lkt [H]

Number of amino acids: Translated: 678; Mature: 678

Protein sequence:

>678_residues
MESPLQQQPIPNHGKFNHIHPILNPEVPVVTPENPLPTISRLWDELAQEAVINSVSGPTIASRAYAMVHTAMYDAWSAYD
PLAIGTQLGDDLQRPLSENTNFNKTQAMSFAAYRVLSELFPAQVETFNELMVKLDLETNNTTTDTTTPAGIGNVSAEALL
RFRSNDGSNQLGDDPNGDGTPYSDISSYEPINFPGSSINIERWTPEPVPIDAEPGEEDRIQTFLTPQWGKVIPFSSISVE
KIRPQPPKPFLLVDGEVDLDASTITLPDGSVVAISKDIVGTIINPEFIAQAENIANVRANLTDEQKLIAEFWEDGHGTSY
PPGTWMNFGEFISARDNHTLDEDVKLFFSLGNALFDAGIAAWGSKVFYDYARPVRVVRELGAQGLIGEFNPELGGFAIDS
WKDPTEGTATILATNFLTYQAPGEEPSPPFAEYISGHSSFSAAGAEILKRFTGSDDFGGGITFEVGESVFEPGITPKVPV
TLEWNTFSEASDQAGISRIYGGIHFEDGDLNGRALGREVAEHVWEKTQGVITPNTIIATNEKDNLIGSVTNDLIYSNRSD
DIVFGNEGNDMLCGGKGNDIVNGGAGADLIYGDFGDDILIGGVGGDNFHFRSNDGNNIITDFEDGIDVIGLGDGLSFQQL
TISQIGNDTRISANQLSITLQGVEESAINIEDFRDCKI

Sequences:

>Translated_678_residues
MESPLQQQPIPNHGKFNHIHPILNPEVPVVTPENPLPTISRLWDELAQEAVINSVSGPTIASRAYAMVHTAMYDAWSAYD
PLAIGTQLGDDLQRPLSENTNFNKTQAMSFAAYRVLSELFPAQVETFNELMVKLDLETNNTTTDTTTPAGIGNVSAEALL
RFRSNDGSNQLGDDPNGDGTPYSDISSYEPINFPGSSINIERWTPEPVPIDAEPGEEDRIQTFLTPQWGKVIPFSSISVE
KIRPQPPKPFLLVDGEVDLDASTITLPDGSVVAISKDIVGTIINPEFIAQAENIANVRANLTDEQKLIAEFWEDGHGTSY
PPGTWMNFGEFISARDNHTLDEDVKLFFSLGNALFDAGIAAWGSKVFYDYARPVRVVRELGAQGLIGEFNPELGGFAIDS
WKDPTEGTATILATNFLTYQAPGEEPSPPFAEYISGHSSFSAAGAEILKRFTGSDDFGGGITFEVGESVFEPGITPKVPV
TLEWNTFSEASDQAGISRIYGGIHFEDGDLNGRALGREVAEHVWEKTQGVITPNTIIATNEKDNLIGSVTNDLIYSNRSD
DIVFGNEGNDMLCGGKGNDIVNGGAGADLIYGDFGDDILIGGVGGDNFHFRSNDGNNIITDFEDGIDVIGLGDGLSFQQL
TISQIGNDTRISANQLSITLQGVEESAINIEDFRDCKI
>Mature_678_residues
MESPLQQQPIPNHGKFNHIHPILNPEVPVVTPENPLPTISRLWDELAQEAVINSVSGPTIASRAYAMVHTAMYDAWSAYD
PLAIGTQLGDDLQRPLSENTNFNKTQAMSFAAYRVLSELFPAQVETFNELMVKLDLETNNTTTDTTTPAGIGNVSAEALL
RFRSNDGSNQLGDDPNGDGTPYSDISSYEPINFPGSSINIERWTPEPVPIDAEPGEEDRIQTFLTPQWGKVIPFSSISVE
KIRPQPPKPFLLVDGEVDLDASTITLPDGSVVAISKDIVGTIINPEFIAQAENIANVRANLTDEQKLIAEFWEDGHGTSY
PPGTWMNFGEFISARDNHTLDEDVKLFFSLGNALFDAGIAAWGSKVFYDYARPVRVVRELGAQGLIGEFNPELGGFAIDS
WKDPTEGTATILATNFLTYQAPGEEPSPPFAEYISGHSSFSAAGAEILKRFTGSDDFGGGITFEVGESVFEPGITPKVPV
TLEWNTFSEASDQAGISRIYGGIHFEDGDLNGRALGREVAEHVWEKTQGVITPNTIIATNEKDNLIGSVTNDLIYSNRSD
DIVFGNEGNDMLCGGKGNDIVNGGAGADLIYGDFGDDILIGGVGGDNFHFRSNDGNNIITDFEDGIDVIGLGDGLSFQQL
TISQIGNDTRISANQLSITLQGVEESAINIEDFRDCKI

Specific function: Pasteurella leukotoxins are exotoxins that attack host leukocytes and especially polymorphonuclear cells, by causing cell rupture. The leukotoxin binds to the host LFA-1 integrin and induces a signaling cascade leading to many biological effects, includin

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted. Host cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 5 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018511
- InterPro:   IPR013550
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF02382 RTX; PF08339 RTX_C [H]

EC number: NA

Molecular weight: Translated: 73456; Mature: 73456

Theoretical pI: Translated: 3.98; Mature: 3.98

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESPLQQQPIPNHGKFNHIHPILNPEVPVVTPENPLPTISRLWDELAQEAVINSVSGPTI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCH
ASRAYAMVHTAMYDAWSAYDPLAIGTQLGDDLQRPLSENTNFNKTQAMSFAAYRVLSELF
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
PAQVETFNELMVKLDLETNNTTTDTTTPAGIGNVSAEALLRFRSNDGSNQLGDDPNGDGT
HHHHHHHCEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHEECCCCCCCCCCCCCCCCCC
PYSDISSYEPINFPGSSINIERWTPEPVPIDAEPGEEDRIQTFLTPQWGKVIPFSSISVE
CCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCHH
KIRPQPPKPFLLVDGEVDLDASTITLPDGSVVAISKDIVGTIINPEFIAQAENIANVRAN
HCCCCCCCCEEEECCCCCCCCCEEECCCCCEEEEECCHHHEECCHHHHHHHHHHHHHHCC
LTDEQKLIAEFWEDGHGTSYPPGTWMNFGEFISARDNHTLDEDVKLFFSLGNALFDAGIA
CCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
AWGSKVFYDYARPVRVVRELGAQGLIGEFNPELGGFAIDSWKDPTEGTATILATNFLTYQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEEEEEEEEE
APGEEPSPPFAEYISGHSSFSAAGAEILKRFTGSDDFGGGITFEVGESVFEPGITPKVPV
CCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHCCCCCCCCEE
TLEWNTFSEASDQAGISRIYGGIHFEDGDLNGRALGREVAEHVWEKTQGVITPNTIIATN
EEECCCCCCCHHHHCHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEC
EKDNLIGSVTNDLIYSNRSDDIVFGNEGNDMLCGGKGNDIVNGGAGADLIYGDFGDDILI
CCCCHHHHHHHHHHCCCCCCCEEECCCCCEEEECCCCCCEECCCCCCEEEEECCCCCEEE
GGVGGDNFHFRSNDGNNIITDFEDGIDVIGLGDGLSFQQLTISQIGNDTRISANQLSITL
ECCCCCCCEEECCCCCEEEEECCCCCEEEECCCCCCHHEEHHHHCCCCCEEECCEEEEEE
QGVEESAINIEDFRDCKI
EECCCCCCCHHHHCCCCC
>Mature Secondary Structure
MESPLQQQPIPNHGKFNHIHPILNPEVPVVTPENPLPTISRLWDELAQEAVINSVSGPTI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCH
ASRAYAMVHTAMYDAWSAYDPLAIGTQLGDDLQRPLSENTNFNKTQAMSFAAYRVLSELF
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
PAQVETFNELMVKLDLETNNTTTDTTTPAGIGNVSAEALLRFRSNDGSNQLGDDPNGDGT
HHHHHHHCEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHEECCCCCCCCCCCCCCCCCC
PYSDISSYEPINFPGSSINIERWTPEPVPIDAEPGEEDRIQTFLTPQWGKVIPFSSISVE
CCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCHH
KIRPQPPKPFLLVDGEVDLDASTITLPDGSVVAISKDIVGTIINPEFIAQAENIANVRAN
HCCCCCCCCEEEECCCCCCCCCEEECCCCCEEEEECCHHHEECCHHHHHHHHHHHHHHCC
LTDEQKLIAEFWEDGHGTSYPPGTWMNFGEFISARDNHTLDEDVKLFFSLGNALFDAGIA
CCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
AWGSKVFYDYARPVRVVRELGAQGLIGEFNPELGGFAIDSWKDPTEGTATILATNFLTYQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEEEEEEEEE
APGEEPSPPFAEYISGHSSFSAAGAEILKRFTGSDDFGGGITFEVGESVFEPGITPKVPV
CCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHCCCCCCCCEE
TLEWNTFSEASDQAGISRIYGGIHFEDGDLNGRALGREVAEHVWEKTQGVITPNTIIATN
EEECCCCCCCHHHHCHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEC
EKDNLIGSVTNDLIYSNRSDDIVFGNEGNDMLCGGKGNDIVNGGAGADLIYGDFGDDILI
CCCCHHHHHHHHHHCCCCCCCEEECCCCCEEEECCCCCCEECCCCCCEEEEECCCCCEEE
GGVGGDNFHFRSNDGNNIITDFEDGIDVIGLGDGLSFQQLTISQIGNDTRISANQLSITL
ECCCCCCCEEECCCCCEEEEECCCCCEEEECCCCCCHHEEHHHHCCCCCEEECCEEEEEE
QGVEESAINIEDFRDCKI
EECCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3040588; 2707120; 11157953; 2185213; 2914876; 8483936; 11750142 [H]