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The map label for this gene is gmk

Identifier: 113476420

GI number: 113476420

Start: 4405803

End: 4406363

Strand: Reverse

Name: gmk

Synonym: Tery_2834

Alternate gene names: 113476420

Gene position: 4406363-4405803 (Counterclockwise)

Preceding gene: 113476421

Following gene: 113476416

Centisome position: 56.86

GC content: 39.93

Gene sequence:

>561_bases
ATGCAAACTGGTAAATTAATTGTTTTAACTGGACCGAGTGGTGTAGGTAAGGGAACTTTGTTAAGCTGTTTGTTACATCG
CCATCCCGGATTGGCTTTTTCTGTATCTGTTACGACTCGTTCTCCTCGACCAGGGGAGGTGGAGGGAAAGAGCTATTTTT
TTGTAGACCATGATCAATTTCGAGAAATGATTGAAAGTGAAGAATTATTGGAGTGGGCAGAATATGCAGGTAATTTTTAT
GGTACACCACGTGTTCCTGTGATTGAAAATATTGAACAAGGTAGATCAATGATCTTAGAAATTGAGCTACAGGGTGCACG
ACAAATTCAAAGGACTTTTCCTGATGCCTTACGCATATTTATTTTACCACCTTCGATGGCTGAATTGGAAGAACGATTAT
GGGGTAGGGGACAAGATTCGGAGGAGGCGATCACTAAACGTCTACAACGGGCGACTGAAGAGCTTGAGGCTGCTACAGAG
TTTGATATCCAATTGGTGAATGATAGTATAGAGGATACTTTGCAAAATTTGGATAAAATATTATTTCATTTTAGGGAGTA
A

Upstream 100 bases:

>100_bases
CTACCCAGAACTCAGAAGTGAAATTCACAAGAGATAAGAAATTTGAGAACTTGAGGATATCTTAAAATGTTTTGGCGACT
ACTTTACTATAAGCAAAATT

Downstream 100 bases:

>100_bases
GGAGTAGTTAAATTGGATTAAAAATCGGTCATGAAAGGATCAATAATTGTTTATTGAATATGGACGGGTTGACGAATTTC
TTGCCATAATTTTTGGTACT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 186; Mature: 186

Protein sequence:

>186_residues
MQTGKLIVLTGPSGVGKGTLLSCLLHRHPGLAFSVSVTTRSPRPGEVEGKSYFFVDHDQFREMIESEELLEWAEYAGNFY
GTPRVPVIENIEQGRSMILEIELQGARQIQRTFPDALRIFILPPSMAELEERLWGRGQDSEEAITKRLQRATEELEAATE
FDIQLVNDSIEDTLQNLDKILFHFRE

Sequences:

>Translated_186_residues
MQTGKLIVLTGPSGVGKGTLLSCLLHRHPGLAFSVSVTTRSPRPGEVEGKSYFFVDHDQFREMIESEELLEWAEYAGNFY
GTPRVPVIENIEQGRSMILEIELQGARQIQRTFPDALRIFILPPSMAELEERLWGRGQDSEEAITKRLQRATEELEAATE
FDIQLVNDSIEDTLQNLDKILFHFRE
>Mature_186_residues
MQTGKLIVLTGPSGVGKGTLLSCLLHRHPGLAFSVSVTTRSPRPGEVEGKSYFFVDHDQFREMIESEELLEWAEYAGNFY
GTPRVPVIENIEQGRSMILEIELQGARQIQRTFPDALRIFILPPSMAELEERLWGRGQDSEEAITKRLQRATEELEAATE
FDIQLVNDSIEDTLQNLDKILFHFRE

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=185, Percent_Identity=41.0810810810811, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI4504221, Length=185, Percent_Identity=41.0810810810811, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI226874831, Length=185, Percent_Identity=41.0810810810811, Blast_Score=141, Evalue=3e-34,
Organism=Homo sapiens, GI186700627, Length=180, Percent_Identity=30, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI186700629, Length=180, Percent_Identity=30, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI186972120, Length=180, Percent_Identity=30, Blast_Score=87, Evalue=6e-18,
Organism=Homo sapiens, GI262118263, Length=176, Percent_Identity=31.25, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI262118255, Length=176, Percent_Identity=31.25, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI4505237, Length=176, Percent_Identity=31.25, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI262118259, Length=176, Percent_Identity=31.25, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI38570142, Length=178, Percent_Identity=28.6516853932584, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI14780902, Length=189, Percent_Identity=29.1005291005291, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI21361598, Length=190, Percent_Identity=25.2631578947368, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1790080, Length=183, Percent_Identity=47.5409836065574, Blast_Score=174, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI193203132, Length=170, Percent_Identity=47.0588235294118, Blast_Score=152, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17508835, Length=180, Percent_Identity=45, Blast_Score=150, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71988041, Length=180, Percent_Identity=31.1111111111111, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71988048, Length=180, Percent_Identity=31.1111111111111, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17557440, Length=182, Percent_Identity=31.3186813186813, Blast_Score=70, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6320662, Length=181, Percent_Identity=43.0939226519337, Blast_Score=153, Evalue=2e-38,
Organism=Drosophila melanogaster, GI21356141, Length=173, Percent_Identity=43.3526011560694, Blast_Score=129, Evalue=9e-31,
Organism=Drosophila melanogaster, GI281362232, Length=181, Percent_Identity=28.1767955801105, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24648808, Length=181, Percent_Identity=28.1767955801105, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI281362230, Length=181, Percent_Identity=28.1767955801105, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI161078487, Length=178, Percent_Identity=28.6516853932584, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI161078485, Length=181, Percent_Identity=28.1767955801105, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24648810, Length=181, Percent_Identity=28.1767955801105, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI85816106, Length=130, Percent_Identity=33.0769230769231, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI85816281, Length=130, Percent_Identity=33.0769230769231, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45551002, Length=130, Percent_Identity=33.0769230769231, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45554489, Length=173, Percent_Identity=24.8554913294798, Blast_Score=63, Evalue=1e-10,
Organism=Drosophila melanogaster, GI221330166, Length=192, Percent_Identity=28.125, Blast_Score=63, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_TRIEI (Q110R6)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_722481.1
- ProteinModelPortal:   Q110R6
- SMR:   Q110R6
- STRING:   Q110R6
- GeneID:   4245137
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_2834
- NMPDR:   fig|203124.1.peg.4767
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   EWAEFAG
- PhylomeDB:   Q110R6
- ProtClustDB:   PRK00300
- BioCyc:   TERY203124:TERY_2834-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 21177; Mature: 21177

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTGKLIVLTGPSGVGKGTLLSCLLHRHPGLAFSVSVTTRSPRPGEVEGKSYFFVDHDQF
CCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCEEEEECHHHH
REMIESEELLEWAEYAGNFYGTPRVPVIENIEQGRSMILEIELQGARQIQRTFPDALRIF
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCEEEEEEEECCHHHHHHHCHHHEEEE
ILPPSMAELEERLWGRGQDSEEAITKRLQRATEELEAATEFDIQLVNDSIEDTLQNLDKI
EECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LFHFRE
HHHHCC
>Mature Secondary Structure
MQTGKLIVLTGPSGVGKGTLLSCLLHRHPGLAFSVSVTTRSPRPGEVEGKSYFFVDHDQF
CCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCEEEEECHHHH
REMIESEELLEWAEYAGNFYGTPRVPVIENIEQGRSMILEIELQGARQIQRTFPDALRIF
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCEEEEEEEECCHHHHHHHCHHHEEEE
ILPPSMAELEERLWGRGQDSEEAITKRLQRATEELEAATEFDIQLVNDSIEDTLQNLDKI
EECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LFHFRE
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA