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The map label for this gene is hisI [H]

Identifier: 113476109

GI number: 113476109

Start: 3836241

End: 3836726

Strand: Reverse

Name: hisI [H]

Synonym: Tery_2490

Alternate gene names: 113476109

Gene position: 3836726-3836241 (Counterclockwise)

Preceding gene: 113476110

Following gene: 113476108

Centisome position: 49.51

GC content: 42.8

Gene sequence:

>486_bases
ATGAATCCCCTATTTAGTACCAGAAATTCAGTAGAACAAGTAGAAGAAGGTTTGCTCCTTGCTCCCAAATTTGACTGCAA
TGGTTTGATTCCAGTCGTTACCACCGATGCCAACACGGGTGAAGTGCTGATGCACGCTTATATGAACGAAGAGGCTTTAG
TTAAAACCATTGAAACGGGAGAAGGTCACTATTACAGTCGCAGTCGTCAGCAACTATGGCATAAAGGTCAATCTAGTGGA
CTGGTGCAAAAAGTACAGCAGTTAGCTATTGATGACGACCAAGATTGTCTGTGGATGCAGGTTGAAGTAGCTGGTTCGGG
AGCTAGTTGTCACGTGGGTTATCGTTCTTGTTTTTATCGCTGTATTCCTACGGGAAAAAGTGCTATTGATTCCCAAGAAC
CAATTCAGTTAACTTTTACCGAAACGGAGAAAACTTTTGACCCGAAAACAGTGTATGGTAATGCTCCCAACCCAACACAA
TTGTAA

Upstream 100 bases:

>100_bases
AATGATTTGAGCGATCTATGACCGTCTAACTATATTGCTTTACAATTAGTTGGGATACTTCACAGGATAATGATTATTAA
AATTGAAAAGTTGAGCTAAT

Downstream 100 bases:

>100_bases
ATTTACTTCAATCCTTTAACACCTATAGGAATTACGCAAATGCACTATATATAACATATAGTGCATTATTAACAGGGCGA
TCGCTACTTTTTTTTTCAGC

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 161; Mature: 161

Protein sequence:

>161_residues
MNPLFSTRNSVEQVEEGLLLAPKFDCNGLIPVVTTDANTGEVLMHAYMNEEALVKTIETGEGHYYSRSRQQLWHKGQSSG
LVQKVQQLAIDDDQDCLWMQVEVAGSGASCHVGYRSCFYRCIPTGKSAIDSQEPIQLTFTETEKTFDPKTVYGNAPNPTQ
L

Sequences:

>Translated_161_residues
MNPLFSTRNSVEQVEEGLLLAPKFDCNGLIPVVTTDANTGEVLMHAYMNEEALVKTIETGEGHYYSRSRQQLWHKGQSSG
LVQKVQQLAIDDDQDCLWMQVEVAGSGASCHVGYRSCFYRCIPTGKSAIDSQEPIQLTFTETEKTFDPKTVYGNAPNPTQ
L
>Mature_161_residues
MNPLFSTRNSVEQVEEGLLLAPKFDCNGLIPVVTTDANTGEVLMHAYMNEEALVKTIETGEGHYYSRSRQQLWHKGQSSG
LVQKVQQLAIDDDQDCLWMQVEVAGSGASCHVGYRSCFYRCIPTGKSAIDSQEPIQLTFTETEKTFDPKTVYGNAPNPTQ
L

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=92, Percent_Identity=46.7391304347826, Blast_Score=82, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319819, Length=72, Percent_Identity=43.0555555555556, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 17892; Mature: 17892

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPLFSTRNSVEQVEEGLLLAPKFDCNGLIPVVTTDANTGEVLMHAYMNEEALVKTIETG
CCCCCCCHHHHHHHHCCEEECCCCCCCCEEEEEEECCCCCHHHHHHHCCCHHHEEEEECC
EGHYYSRSRQQLWHKGQSSGLVQKVQQLAIDDDQDCLWMQVEVAGSGASCHVGYRSCFYR
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEEEEECCCCCEEEECHHHHHHH
CIPTGKSAIDSQEPIQLTFTETEKTFDPKTVYGNAPNPTQL
HCCCCCCCCCCCCCEEEEEECCCCCCCCCEEECCCCCCCCC
>Mature Secondary Structure
MNPLFSTRNSVEQVEEGLLLAPKFDCNGLIPVVTTDANTGEVLMHAYMNEEALVKTIETG
CCCCCCCHHHHHHHHCCEEECCCCCCCCEEEEEEECCCCCHHHHHHHCCCHHHEEEEECC
EGHYYSRSRQQLWHKGQSSGLVQKVQQLAIDDDQDCLWMQVEVAGSGASCHVGYRSCFYR
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEEEEECCCCCEEEECHHHHHHH
CIPTGKSAIDSQEPIQLTFTETEKTFDPKTVYGNAPNPTQL
HCCCCCCCCCCCCCEEEEEECCCCCCCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA