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The map label for this gene is parC [H]

Identifier: 113475568

GI number: 113475568

Start: 2928042

End: 2930663

Strand: Reverse

Name: parC [H]

Synonym: Tery_1901

Alternate gene names: 113475568

Gene position: 2930663-2928042 (Counterclockwise)

Preceding gene: 113475570

Following gene: 113475562

Centisome position: 37.81

GC content: 37.34

Gene sequence:

>2622_bases
ATGGCCAAAAAATTAAATTTACTTTCCGGAAAAGTTATTACTACATCACTCCATACAGAAATGCAACAATCATATCTTGA
ATATGCCATGAGTGTGATTGTTGGCCGAGCTTTGCCAGATGTTAGAGATGGACAAAAACCAGTTCATCGTCGAATAATAT
ACGCTATGCACGAACTTGGTCTCACTCCAGATAGACCATTTCGCAAATGCGCCAGAGTAGTTGGTGACGTTCTCGGAAAA
TACCATCCCCACGGCGACCAGGCTGTTTATGATGCTATGGTGCGGATGATTCAAAATTTTTCTAGTCGTTATCCATTACT
AGATGGCCACGGTAACTTTGGCTCCATTGACAATGACCCTGCCGCTGCTATGCGTTACACAGAAAGTCGCTTGGCATCAA
TTGGCAATGAAGGTTTATTAACCCAAATTAGTGAAGCTATAGTTGACTTTACCAACAACTTTGATGGTTCCCAACAAGAG
CCTAAAGTATTACCGGCACAATTACCATTTTTATTACTAAATGGTTCTTCTGGAATTGCTGTAGGAATGGCAACTAATGT
TCCACCGCATAATTTAGGTGAGGTCGTAGATGGCCTCATTGCTTTAATTGACAATCCTAATATTTCTGATCAAAAGTTAT
TTGAATTAATTCCTGGGCCTGACTTTCCCACTGGAGGAGAAATTGTTAGCACAGATGGAATTATTGATACTTATACTAAG
GGTCGAGGTAGCATCCCCATGAGGGGTGTGGCAACTATTGAGCAAGTGCCTACAGGTCGTGGACGACGGACAAAAACAGC
TATTGTGGTCACAGAGTTACCTTTCCAAGTTAATAAAGCAGGCTGGATAGAAAAAACAGCAGACTTAGTTAATGCAGGCA
AGATCGAAGGTATTGCTGATTTGCGAGATGAGAGCGATCGCTCTGGTATTAGAGTTGTTATTGAGCTAAAACGTGAAGCT
GACCCTAGTGTTGTACTTCACCATCTCTACCGAAATACTGACTTACTTTCTAAATTTGGTGCAATTATGCTAGCTTTGGT
TAATGGACAACCACAGCAATTATCTTTGCGAACACTTTTACAAGAATTTCTCAATTTTAGAGAAGAGACTCTCACCCGTC
ACTATACCCATGAGCTACAAATAGCTCAAGCTAGAAGTCACATTGTTGCAGGTTTACTAACTGCTCTAAAAGAATTGGAT
AGAGTAATTGATATTCTCAGAAATGCACCGGATGGTAATACTGCTAAAGTTAGCTTCCAAGAAAGTTTGGGTTTAAGCGA
AAATCAAGCTGATGCTATCCTAGCAATGCCAATGCGAAGACTAACTGGTTTGGAAAAACAAAAGTTAGAGGAAGAACATG
AGCAACTCATGGGAAAAATACAAGAGCTAGAAAATTTATTAGGCGATCGCCATCAACTTCTCAAAGCCCTCAAAAAAGAA
TTGCGAACCCTAAAGCGTAAATATAACGACCCTAGACGTACTCGAATTATCGACCAAATAAAATTAAAAAATGCTGATGA
TTTTGCATCTATTTCTCAACAGAAAAAATATCTAGAAGCTGGAAATAAAGAAATAGATATAAAAACAAAAGGTAGAGTAA
TAAAATCAAAAAATATAACAGTTAAATCGCCAATTTTGACTTTGGAAGCTGCTCCGCCACCTACAGAAAAAGTTGTTATA
GAATTTAGCCACCGAGGATATGTAAGACGAATTCCTGCTAAAGGATTTGAGAAGTATAAAATTGATAAAAAATCTCATAT
AACTATGGAAAATAGTGAGGATTTTACTACTAATATAATTGAGGCAACTACTGACAAAACTTTAGTATTACTAACTCGTA
CTGGTAAAGCATATCCTTTGAAAGTCAATAATATTCCTTCTGCTTCTAACCGTTCGACAATACGGAATGAAAATAAAGGG
GTACCTTTAGTAACTTTACTACCCCCATCAGCTACAAAAGAAATTACTGATGCTCGTAAAGAAATTATTATTGGTCAATT
TATTTTAAATGAAGCTAAGGAGAATAAAGACTTAATTATGTTGACTCAAAATGGCAAAATTAAACGTTTATGTTTGTCTG
ATTTGAGTGATATGAGAAATCGTGGAGTGACAGTAATTAAGCTTAAAGAAGATGATGAATTACGTTATGTTAGTTTGGGT
AAAACTGGAGAACAAGTGGTTTTGGCTACTTCTGGTGGGCGATTATTAAGATTACAAATAGATGACGAAAAATTACCATT
AATGGGGCGTGCTGCTCAAGGTTCTCAAGCAACTAGGTTAAGGAAACAAGAAGAGTTAGTTGGTTGTGTGACTTTGGATA
TAGGAAGTAATTTATTGTTAGTTTCTCAACACAGTTATGGTAAGCAAATTCCTGTTACTGCTTTGCGAGTAGCTAATCGT
GGTGGTATTGGTCAAAATGTTTTTCAGTTTACCAGACAAGATGATATTTTAGCGGGGATAGTTGCTAGTAGTTCAAATGT
TCTGGTTCAGGTGTTGACAACTGATGGTAGAGTTTTTGGAATGATTGCTGACAGGGTAAAAGTTGATCAACAAGATGATC
ACGGCCATCGTCTACTGAAGTTGGGTGCCAAAGAAAAAATTATTAAAGTGGTTGGTTATTAA

Upstream 100 bases:

>100_bases
GGATGGTGAGGTATAGTTTAATACTAATTTATATTCCCTATTCCCATTTATATTCTCTATTCCATATTCCCTCCCTATTC
CCTATCTAAAATACTAACTC

Downstream 100 bases:

>100_bases
TCAGTTATCAGTTACAGCAAATTTCCAGTATATGAGGTACAGATATTAAAACTTCTATCTTGCTATTGCGGGCATATTGC
CCGCACAAGTGTACCTTAGT

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 873; Mature: 872

Protein sequence:

>873_residues
MAKKLNLLSGKVITTSLHTEMQQSYLEYAMSVIVGRALPDVRDGQKPVHRRIIYAMHELGLTPDRPFRKCARVVGDVLGK
YHPHGDQAVYDAMVRMIQNFSSRYPLLDGHGNFGSIDNDPAAAMRYTESRLASIGNEGLLTQISEAIVDFTNNFDGSQQE
PKVLPAQLPFLLLNGSSGIAVGMATNVPPHNLGEVVDGLIALIDNPNISDQKLFELIPGPDFPTGGEIVSTDGIIDTYTK
GRGSIPMRGVATIEQVPTGRGRRTKTAIVVTELPFQVNKAGWIEKTADLVNAGKIEGIADLRDESDRSGIRVVIELKREA
DPSVVLHHLYRNTDLLSKFGAIMLALVNGQPQQLSLRTLLQEFLNFREETLTRHYTHELQIAQARSHIVAGLLTALKELD
RVIDILRNAPDGNTAKVSFQESLGLSENQADAILAMPMRRLTGLEKQKLEEEHEQLMGKIQELENLLGDRHQLLKALKKE
LRTLKRKYNDPRRTRIIDQIKLKNADDFASISQQKKYLEAGNKEIDIKTKGRVIKSKNITVKSPILTLEAAPPPTEKVVI
EFSHRGYVRRIPAKGFEKYKIDKKSHITMENSEDFTTNIIEATTDKTLVLLTRTGKAYPLKVNNIPSASNRSTIRNENKG
VPLVTLLPPSATKEITDARKEIIIGQFILNEAKENKDLIMLTQNGKIKRLCLSDLSDMRNRGVTVIKLKEDDELRYVSLG
KTGEQVVLATSGGRLLRLQIDDEKLPLMGRAAQGSQATRLRKQEELVGCVTLDIGSNLLLVSQHSYGKQIPVTALRVANR
GGIGQNVFQFTRQDDILAGIVASSSNVLVQVLTTDGRVFGMIADRVKVDQQDDHGHRLLKLGAKEKIIKVVGY

Sequences:

>Translated_873_residues
MAKKLNLLSGKVITTSLHTEMQQSYLEYAMSVIVGRALPDVRDGQKPVHRRIIYAMHELGLTPDRPFRKCARVVGDVLGK
YHPHGDQAVYDAMVRMIQNFSSRYPLLDGHGNFGSIDNDPAAAMRYTESRLASIGNEGLLTQISEAIVDFTNNFDGSQQE
PKVLPAQLPFLLLNGSSGIAVGMATNVPPHNLGEVVDGLIALIDNPNISDQKLFELIPGPDFPTGGEIVSTDGIIDTYTK
GRGSIPMRGVATIEQVPTGRGRRTKTAIVVTELPFQVNKAGWIEKTADLVNAGKIEGIADLRDESDRSGIRVVIELKREA
DPSVVLHHLYRNTDLLSKFGAIMLALVNGQPQQLSLRTLLQEFLNFREETLTRHYTHELQIAQARSHIVAGLLTALKELD
RVIDILRNAPDGNTAKVSFQESLGLSENQADAILAMPMRRLTGLEKQKLEEEHEQLMGKIQELENLLGDRHQLLKALKKE
LRTLKRKYNDPRRTRIIDQIKLKNADDFASISQQKKYLEAGNKEIDIKTKGRVIKSKNITVKSPILTLEAAPPPTEKVVI
EFSHRGYVRRIPAKGFEKYKIDKKSHITMENSEDFTTNIIEATTDKTLVLLTRTGKAYPLKVNNIPSASNRSTIRNENKG
VPLVTLLPPSATKEITDARKEIIIGQFILNEAKENKDLIMLTQNGKIKRLCLSDLSDMRNRGVTVIKLKEDDELRYVSLG
KTGEQVVLATSGGRLLRLQIDDEKLPLMGRAAQGSQATRLRKQEELVGCVTLDIGSNLLLVSQHSYGKQIPVTALRVANR
GGIGQNVFQFTRQDDILAGIVASSSNVLVQVLTTDGRVFGMIADRVKVDQQDDHGHRLLKLGAKEKIIKVVGY
>Mature_872_residues
AKKLNLLSGKVITTSLHTEMQQSYLEYAMSVIVGRALPDVRDGQKPVHRRIIYAMHELGLTPDRPFRKCARVVGDVLGKY
HPHGDQAVYDAMVRMIQNFSSRYPLLDGHGNFGSIDNDPAAAMRYTESRLASIGNEGLLTQISEAIVDFTNNFDGSQQEP
KVLPAQLPFLLLNGSSGIAVGMATNVPPHNLGEVVDGLIALIDNPNISDQKLFELIPGPDFPTGGEIVSTDGIIDTYTKG
RGSIPMRGVATIEQVPTGRGRRTKTAIVVTELPFQVNKAGWIEKTADLVNAGKIEGIADLRDESDRSGIRVVIELKREAD
PSVVLHHLYRNTDLLSKFGAIMLALVNGQPQQLSLRTLLQEFLNFREETLTRHYTHELQIAQARSHIVAGLLTALKELDR
VIDILRNAPDGNTAKVSFQESLGLSENQADAILAMPMRRLTGLEKQKLEEEHEQLMGKIQELENLLGDRHQLLKALKKEL
RTLKRKYNDPRRTRIIDQIKLKNADDFASISQQKKYLEAGNKEIDIKTKGRVIKSKNITVKSPILTLEAAPPPTEKVVIE
FSHRGYVRRIPAKGFEKYKIDKKSHITMENSEDFTTNIIEATTDKTLVLLTRTGKAYPLKVNNIPSASNRSTIRNENKGV
PLVTLLPPSATKEITDARKEIIIGQFILNEAKENKDLIMLTQNGKIKRLCLSDLSDMRNRGVTVIKLKEDDELRYVSLGK
TGEQVVLATSGGRLLRLQIDDEKLPLMGRAAQGSQATRLRKQEELVGCVTLDIGSNLLLVSQHSYGKQIPVTALRVANRG
GIGQNVFQFTRQDDILAGIVASSSNVLVQVLTTDGRVFGMIADRVKVDQQDDHGHRLLKLGAKEKIIKVVGY

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=175, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1788562, Length=896, Percent_Identity=36.4955357142857, Blast_Score=545, Evalue=1e-156,
Organism=Escherichia coli, GI1789396, Length=737, Percent_Identity=35.5495251017639, Blast_Score=389, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI212645845, Length=453, Percent_Identity=24.5033112582781, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=181, Percent_Identity=28.7292817679558, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.3

Molecular weight: Translated: 96887; Mature: 96756

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKKLNLLSGKVITTSLHTEMQQSYLEYAMSVIVGRALPDVRDGQKPVHRRIIYAMHELG
CCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCC
LTPDRPFRKCARVVGDVLGKYHPHGDQAVYDAMVRMIQNFSSRYPLLDGHGNFGSIDNDP
CCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCH
AAAMRYTESRLASIGNEGLLTQISEAIVDFTNNFDGSQQEPKVLPAQLPFLLLNGSSGIA
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCEE
VGMATNVPPHNLGEVVDGLIALIDNPNISDQKLFELIPGPDFPTGGEIVSTDGIIDTYTK
EEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCEEECCCCEECCCC
GRGSIPMRGVATIEQVPTGRGRRTKTAIVVTELPFQVNKAGWIEKTADLVNAGKIEGIAD
CCCCCCCCCCHHHHHCCCCCCCCEEEEEEEEECCCEECCCCCHHHHHHHHCCCCCCCHHH
LRDESDRSGIRVVIELKREADPSVVLHHLYRNTDLLSKFGAIMLALVNGQPQQLSLRTLL
HCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCHHHHHHHHHHHHHEECCCCCHHHHHHHH
QEFLNFREETLTRHYTHELQIAQARSHIVAGLLTALKELDRVIDILRNAPDGNTAKVSFQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEH
ESLGLSENQADAILAMPMRRLTGLEKQKLEEEHEQLMGKIQELENLLGDRHQLLKALKKE
HHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRTLKRKYNDPRRTRIIDQIKLKNADDFASISQQKKYLEAGNKEIDIKTKGRVIKSKNIT
HHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCEEEECCCEE
VKSPILTLEAAPPPTEKVVIEFSHRGYVRRIPAKGFEKYKIDKKSHITMENSEDFTTNII
EECCEEEEECCCCCCCEEEEEECCCCCEEECCCCCCCCEECCCCCEEEECCCCCCHHHHH
EATTDKTLVLLTRTGKAYPLKVNNIPSASNRSTIRNENKGVPLVTLLPPSATKEITDARK
EECCCCEEEEEEECCCEEEEEECCCCCCCCCCHHCCCCCCCCEEEEECCCCHHHHHHHHH
EIIIGQFILNEAKENKDLIMLTQNGKIKRLCLSDLSDMRNRGVTVIKLKEDDELRYVSLG
HHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEEC
KTGEQVVLATSGGRLLRLQIDDEKLPLMGRAAQGSQATRLRKQEELVGCVTLDIGSNLLL
CCCCEEEEEECCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHEEEEEEECCCCEEE
VSQHSYGKQIPVTALRVANRGGIGQNVFQFTRQDDILAGIVASSSNVLVQVLTTDGRVFG
EECCCCCCCCCHHHEEECCCCCCCHHHHHHHCCCCCEEEEEECCCCEEEEEEECCCEEEE
MIADRVKVDQQDDHGHRLLKLGAKEKIIKVVGY
EEHHHHCCCCCCCCCCHHHHCCCHHHHHEECCC
>Mature Secondary Structure 
AKKLNLLSGKVITTSLHTEMQQSYLEYAMSVIVGRALPDVRDGQKPVHRRIIYAMHELG
CCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCC
LTPDRPFRKCARVVGDVLGKYHPHGDQAVYDAMVRMIQNFSSRYPLLDGHGNFGSIDNDP
CCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCH
AAAMRYTESRLASIGNEGLLTQISEAIVDFTNNFDGSQQEPKVLPAQLPFLLLNGSSGIA
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCEE
VGMATNVPPHNLGEVVDGLIALIDNPNISDQKLFELIPGPDFPTGGEIVSTDGIIDTYTK
EEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCEEECCCCEECCCC
GRGSIPMRGVATIEQVPTGRGRRTKTAIVVTELPFQVNKAGWIEKTADLVNAGKIEGIAD
CCCCCCCCCCHHHHHCCCCCCCCEEEEEEEEECCCEECCCCCHHHHHHHHCCCCCCCHHH
LRDESDRSGIRVVIELKREADPSVVLHHLYRNTDLLSKFGAIMLALVNGQPQQLSLRTLL
HCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCHHHHHHHHHHHHHEECCCCCHHHHHHHH
QEFLNFREETLTRHYTHELQIAQARSHIVAGLLTALKELDRVIDILRNAPDGNTAKVSFQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEH
ESLGLSENQADAILAMPMRRLTGLEKQKLEEEHEQLMGKIQELENLLGDRHQLLKALKKE
HHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRTLKRKYNDPRRTRIIDQIKLKNADDFASISQQKKYLEAGNKEIDIKTKGRVIKSKNIT
HHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCEEEECCCEE
VKSPILTLEAAPPPTEKVVIEFSHRGYVRRIPAKGFEKYKIDKKSHITMENSEDFTTNII
EECCEEEEECCCCCCCEEEEEECCCCCEEECCCCCCCCEECCCCCEEEECCCCCCHHHHH
EATTDKTLVLLTRTGKAYPLKVNNIPSASNRSTIRNENKGVPLVTLLPPSATKEITDARK
EECCCCEEEEEEECCCEEEEEECCCCCCCCCCHHCCCCCCCCEEEEECCCCHHHHHHHHH
EIIIGQFILNEAKENKDLIMLTQNGKIKRLCLSDLSDMRNRGVTVIKLKEDDELRYVSLG
HHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEEC
KTGEQVVLATSGGRLLRLQIDDEKLPLMGRAAQGSQATRLRKQEELVGCVTLDIGSNLLL
CCCCEEEEEECCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHEEEEEEECCCCEEE
VSQHSYGKQIPVTALRVANRGGIGQNVFQFTRQDDILAGIVASSSNVLVQVLTTDGRVFG
EECCCCCCCCCHHHEEECCCCCCCHHHHHHHCCCCCEEEEEECCCCEEEEEEECCCEEEE
MIADRVKVDQQDDHGHRLLKLGAKEKIIKVVGY
EEHHHHCCCCCCCCCCHHHHCCCHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Isomerization [C]

Inhibitor: CJ-12, 371; CJ-12, 372; Coumermycin; Doxorubicin; Sitafloxacin [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]