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The map label for this gene is ispD

Identifier: 113474465

GI number: 113474465

Start: 986538

End: 987218

Strand: Reverse

Name: ispD

Synonym: Tery_0609

Alternate gene names: 113474465

Gene position: 987218-986538 (Counterclockwise)

Preceding gene: 113474467

Following gene: 113474463

Centisome position: 12.74

GC content: 38.91

Gene sequence:

>681_bases
ATGAATCTATTAATTCCTGCTGCTGGTATAGGGCGACGCATGGGAGGTTCCCGAAATAAGCTTTTGTTAACTCTATTGGG
CAAGTCTTTATTGAGTTGGACTCTTGAAGCTGCGGTAAAATCTGATCATATCACTTGGATTGGTATTATTGGACAACCTA
TTGATTTTCCTGATTTTCAAAAAAATATTTCAGATTTATCTACTGACAAGCACATAGAGCTAATTGAGGGTGGAGCTACT
CGTCAGGAGTCGGTTTATAATGGTTTACAGGCTTTACCATCCGCAGCAGAACGAGTTTTAATTCACGATGGGGCTAGGTG
TTTAGCTACTCCTGAACTGTTGGACAGATGTGCGGTGGAGATTCTCAAATGCCCTGGTATAATTGCTTCTGTGCCAGTTA
AAGACACAATTAAGGTTGTTGACCCTTCAGGTATAATTCAGGATACACCAAATCGTCGCAATTTATGGGCTGCTCAAACA
CCCCAAGGATTTGATGTTAAGCTGTTGAAAGAATGCCATAAAAAGGGGCAAATTTTAGGTTGGGAAGTTACTGATGATGC
TGCTTTATTTGAAAAATGTGGTTTACCTGTAAAAATTTTGGAGGGAGAGGAAACTAATTTAAAGGTGACAACTCCTCTAG
ATTTAAAAATAGCAGAATTTATTTTGCTTAAAGCCTTATAG

Upstream 100 bases:

>100_bases
AGGAATAAGGAAATTTACCAAAATTTGCAAATTTTTCAGTGTCAGAGTTTTGTTAAACTCTAATTAAATATCTGGTTTAA
TATGATTGCTTGAGGAAAAA

Downstream 100 bases:

>100_bases
GAAGTATTAATATAATGTCCTCTTCAATAATTATAAATAAATTTTTATTTTCAGGAGTTAGAAGTTCACAGGAGAACAAA
AGCCAACCATAACCATAATT

Product: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MNLLIPAAGIGRRMGGSRNKLLLTLLGKSLLSWTLEAAVKSDHITWIGIIGQPIDFPDFQKNISDLSTDKHIELIEGGAT
RQESVYNGLQALPSAAERVLIHDGARCLATPELLDRCAVEILKCPGIIASVPVKDTIKVVDPSGIIQDTPNRRNLWAAQT
PQGFDVKLLKECHKKGQILGWEVTDDAALFEKCGLPVKILEGEETNLKVTTPLDLKIAEFILLKAL

Sequences:

>Translated_226_residues
MNLLIPAAGIGRRMGGSRNKLLLTLLGKSLLSWTLEAAVKSDHITWIGIIGQPIDFPDFQKNISDLSTDKHIELIEGGAT
RQESVYNGLQALPSAAERVLIHDGARCLATPELLDRCAVEILKCPGIIASVPVKDTIKVVDPSGIIQDTPNRRNLWAAQT
PQGFDVKLLKECHKKGQILGWEVTDDAALFEKCGLPVKILEGEETNLKVTTPLDLKIAEFILLKAL
>Mature_226_residues
MNLLIPAAGIGRRMGGSRNKLLLTLLGKSLLSWTLEAAVKSDHITWIGIIGQPIDFPDFQKNISDLSTDKHIELIEGGAT
RQESVYNGLQALPSAAERVLIHDGARCLATPELLDRCAVEILKCPGIIASVPVKDTIKVVDPSGIIQDTPNRRNLWAAQT
PQGFDVKLLKECHKKGQILGWEVTDDAALFEKCGLPVKILEGEETNLKVTTPLDLKIAEFILLKAL

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family

Homologues:

Organism=Homo sapiens, GI157412259, Length=231, Percent_Identity=27.2727272727273, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1789104, Length=225, Percent_Identity=34.6666666666667, Blast_Score=116, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPD_TRIEI (Q118M1)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_720526.1
- ProteinModelPortal:   Q118M1
- SMR:   Q118M1
- STRING:   Q118M1
- GeneID:   4241980
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_0609
- NMPDR:   fig|203124.1.peg.3553
- eggNOG:   COG1211
- HOGENOM:   HBG672839
- OMA:   SKVIVVC
- PhylomeDB:   Q118M1
- ProtClustDB:   PRK00155
- BioCyc:   TERY203124:TERY_0609-MONOMER
- HAMAP:   MF_00108
- InterPro:   IPR001228
- InterPro:   IPR018294
- TIGRFAMs:   TIGR00453

Pfam domain/function: PF01128 IspD

EC number: =2.7.7.60

Molecular weight: Translated: 24660; Mature: 24660

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLIPAAGIGRRMGGSRNKLLLTLLGKSLLSWTLEAAVKSDHITWIGIIGQPIDFPDFQ
CCEEECCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHH
KNISDLSTDKHIELIEGGATRQESVYNGLQALPSAAERVLIHDGARCLATPELLDRCAVE
HHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHEEEEECCCHHEECHHHHHHHHHH
ILKCPGIIASVPVKDTIKVVDPSGIIQDTPNRRNLWAAQTPQGFDVKLLKECHKKGQILG
HHHCCCCEEECCCCCEEEEECCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHCCCEEE
WEVTDDAALFEKCGLPVKILEGEETNLKVTTPLDLKIAEFILLKAL
EEECCHHHHHHHCCCCEEEECCCCCCEEEECCCCHHHHHHHHHHCC
>Mature Secondary Structure
MNLLIPAAGIGRRMGGSRNKLLLTLLGKSLLSWTLEAAVKSDHITWIGIIGQPIDFPDFQ
CCEEECCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHH
KNISDLSTDKHIELIEGGATRQESVYNGLQALPSAAERVLIHDGARCLATPELLDRCAVE
HHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHEEEEECCCHHEECHHHHHHHHHH
ILKCPGIIASVPVKDTIKVVDPSGIIQDTPNRRNLWAAQTPQGFDVKLLKECHKKGQILG
HHHCCCCEEECCCCCEEEEECCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHCCCEEE
WEVTDDAALFEKCGLPVKILEGEETNLKVTTPLDLKIAEFILLKAL
EEECCHHHHHHHCCCCEEEECCCCCCEEEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA