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The map label for this gene is hisG [H]

Identifier: 113474435

GI number: 113474435

Start: 929569

End: 930585

Strand: Direct

Name: hisG [H]

Synonym: Tery_0578

Alternate gene names: 113474435

Gene position: 929569-930585 (Clockwise)

Preceding gene: 113474434

Following gene: 113474436

Centisome position: 11.99

GC content: 33.53

Gene sequence:

>1017_bases
ATGACAAAAGATCAAACTTTAAGAATAGCCTTACCAAGTAAAGGTGCTTTGGCAAAGGGAACAATGAACTTATTGTCAGC
CTGTGGTTTGGGTGTATCTAGACCCAATGAAAGACAATATTTTGGTTCAATTCCTGCTTTACCACAAGTAAAAGTTTTAT
TTCAAAGAGCAGCAGATATTTTTACAAAGGTAGAAGAAGGAAGTGTAGATTTAGGAATTACAGGTTATGATGTGGTTTGT
GAAGAAGGTCAATCACATGATGATGTAATAGTAATTTGGGATAAGTTGGGTTATGGTAAATGTAAATTAGTCTTAGCTGT
TCCTGAAAGTTGGGTTGATGTTTCTTCTATAGAAGATTTAGCAGAGTTAACTCTCTTATTTAGAGATAAAGGAAAAAATT
TGAGAATTGCGACTAAATATCATCATCTAACTCAAAAATGGCTCTATGAAAAGTTAATTGTACATTTTTCTTTAGTGGCA
GTTCAAGGTGCAATGGAAGCCGCACCAAGTATGGGATATGCTGATATGATTGCTGATATAACTAGCACTGGTACAACTCT
CAGAGAAAATCGTTTAAAACAAATTGAAGGAGGTACACTTATAGAATCTCAAGCTTGTTTAATTGGTAATAAACGCTTGT
TACAAGAAAATAAAATTAAATTAGAAACAACTCAAGTATTTTTAGAGTTGCTCGAGGCACAAATGGAGTCGAAAAAGTAT
GTTTCAATAACAGCAAATGTAGATGGAAAATCACTAGATGAAATAGGCGATCGCCTCATGTATAAAAGTCAATTAACTGG
TATTGCTGGTCTACAAGGACCAACTATTGCTAAAGTATATTCTAGGGAAAAAAATAGCTTGTATGCTGTGACAATTGTAG
TTAAACAAAGTATGTTATTGCCAGCAATTAACCATCTGAGAAATGTAGGTGGTACAGATATGACAGTTTCTTCTCCTAGT
TATGTTTTTGGTTCCCAGTCTCAAATTTATGAGTCATTTTTGTCAAAGCTAAAATAA

Upstream 100 bases:

>100_bases
TAGATTTCAATTTACCCCCTTTCAAGGGATGAGAAAAATATTAAATTCAGTATTTGAATACTTATAATTTAGCAGGTAAT
ACTAATAACTAATAACTGAA

Downstream 100 bases:

>100_bases
TCTTTTATCCCTGGATAAATGAGCTCTTTTTAAGGAAAAATATTTACTTGATCTAGCCTATCTTTCATACCATTTATAAA
AAAATTCTACATTTTATTTA

Product: ATP phosphoribosyltransferase regulatory subunit / ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MTKDQTLRIALPSKGALAKGTMNLLSACGLGVSRPNERQYFGSIPALPQVKVLFQRAADIFTKVEEGSVDLGITGYDVVC
EEGQSHDDVIVIWDKLGYGKCKLVLAVPESWVDVSSIEDLAELTLLFRDKGKNLRIATKYHHLTQKWLYEKLIVHFSLVA
VQGAMEAAPSMGYADMIADITSTGTTLRENRLKQIEGGTLIESQACLIGNKRLLQENKIKLETTQVFLELLEAQMESKKY
VSITANVDGKSLDEIGDRLMYKSQLTGIAGLQGPTIAKVYSREKNSLYAVTIVVKQSMLLPAINHLRNVGGTDMTVSSPS
YVFGSQSQIYESFLSKLK

Sequences:

>Translated_338_residues
MTKDQTLRIALPSKGALAKGTMNLLSACGLGVSRPNERQYFGSIPALPQVKVLFQRAADIFTKVEEGSVDLGITGYDVVC
EEGQSHDDVIVIWDKLGYGKCKLVLAVPESWVDVSSIEDLAELTLLFRDKGKNLRIATKYHHLTQKWLYEKLIVHFSLVA
VQGAMEAAPSMGYADMIADITSTGTTLRENRLKQIEGGTLIESQACLIGNKRLLQENKIKLETTQVFLELLEAQMESKKY
VSITANVDGKSLDEIGDRLMYKSQLTGIAGLQGPTIAKVYSREKNSLYAVTIVVKQSMLLPAINHLRNVGGTDMTVSSPS
YVFGSQSQIYESFLSKLK
>Mature_337_residues
TKDQTLRIALPSKGALAKGTMNLLSACGLGVSRPNERQYFGSIPALPQVKVLFQRAADIFTKVEEGSVDLGITGYDVVCE
EGQSHDDVIVIWDKLGYGKCKLVLAVPESWVDVSSIEDLAELTLLFRDKGKNLRIATKYHHLTQKWLYEKLIVHFSLVAV
QGAMEAAPSMGYADMIADITSTGTTLRENRLKQIEGGTLIESQACLIGNKRLLQENKIKLETTQVFLELLEAQMESKKYV
SITANVDGKSLDEIGDRLMYKSQLTGIAGLQGPTIAKVYSREKNSLYAVTIVVKQSMLLPAINHLRNVGGTDMTVSSPSY
VFGSQSQIYESFLSKLK

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=323, Percent_Identity=28.7925696594427, Blast_Score=109, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320896, Length=310, Percent_Identity=28.3870967741935, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 37244; Mature: 37112

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKDQTLRIALPSKGALAKGTMNLLSACGLGVSRPNERQYFGSIPALPQVKVLFQRAADI
CCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHH
FTKVEEGSVDLGITGYDVVCEEGQSHDDVIVIWDKLGYGKCKLVLAVPESWVDVSSIEDL
HHHHCCCCEEEEECCHHHEECCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHHHH
AELTLLFRDKGKNLRIATKYHHLTQKWLYEKLIVHFSLVAVQGAMEAAPSMGYADMIADI
HHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
TSTGTTLRENRLKQIEGGTLIESQACLIGNKRLLQENKIKLETTQVFLELLEAQMESKKY
HHCCCHHHHHHHHHCCCCCEEECCHHHHCCHHHHHCCCEEHHHHHHHHHHHHHHHCCCEE
VSITANVDGKSLDEIGDRLMYKSQLTGIAGLQGPTIAKVYSREKNSLYAVTIVVKQSMLL
EEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCEEEEEEEHHHHHHH
PAINHLRNVGGTDMTVSSPSYVFGSQSQIYESFLSKLK
HHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TKDQTLRIALPSKGALAKGTMNLLSACGLGVSRPNERQYFGSIPALPQVKVLFQRAADI
CCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHH
FTKVEEGSVDLGITGYDVVCEEGQSHDDVIVIWDKLGYGKCKLVLAVPESWVDVSSIEDL
HHHHCCCCEEEEECCHHHEECCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHHHH
AELTLLFRDKGKNLRIATKYHHLTQKWLYEKLIVHFSLVAVQGAMEAAPSMGYADMIADI
HHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
TSTGTTLRENRLKQIEGGTLIESQACLIGNKRLLQENKIKLETTQVFLELLEAQMESKKY
HHCCCHHHHHHHHHCCCCCEEECCHHHHCCHHHHHCCCEEHHHHHHHHHHHHHHHCCCEE
VSITANVDGKSLDEIGDRLMYKSQLTGIAGLQGPTIAKVYSREKNSLYAVTIVVKQSMLL
EEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCEEEEEEEHHHHHHH
PAINHLRNVGGTDMTVSSPSYVFGSQSQIYESFLSKLK
HHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA