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The map label for this gene is lktA [H]

Identifier: 113474267

GI number: 113474267

Start: 600305

End: 603121

Strand: Direct

Name: lktA [H]

Synonym: Tery_0387

Alternate gene names: 113474267

Gene position: 600305-603121 (Clockwise)

Preceding gene: 113474266

Following gene: 113474268

Centisome position: 7.75

GC content: 47.07

Gene sequence:

>2817_bases
ATGAAACTAAACACAAAAAGTATAGTAATAATAGATGCTAGTGTAGAGAACTACCAGCAATTATTAAACGGAGTCATTCC
CGGAGTTAAACCTTTTCTCCTCGGCGGCGACACTGACGGTATCCAACAGATAGGGGATATCCTCCAAAAACATCCAGAAA
CGGATACTCTTCATATTATCTCCCACGGTTCTCCTGGTTGTCTGTATCTGGGAAATAGCCAATTGAGTTTGGATACTCTC
AAAGGCTATGAGCCCCAACTACAACAATGGCAACTGGACAACCTTCTGCTCTATGGTTGTAACGTCGCTGCCGGGGATGG
GGGAGAAGAGTTTATTGATAAGTTGCATCGGTTGACGGGGGCTGAGATAGCGGCTTCTAAGTCTTTGACTGGGGCGGCAG
TTAAAGGGGGGAACTGGGAGTTGGAGGTGAGGACGGGCCAAACCAAACCCTCTCTGGCATTGCAAGTAGAAGCGATGGCT
AGCTACTCTGATACTCTTGAACTGCAATTTGAATGGGCTAAACATATCGGCGGTCAAGGTTTGACCTATGTTTATCGCAT
AACCACAGATAGCATCGGCAATGTTTTGGTGGCGGGTGTTTTTGATGACAATATTGATATCGATGGCGACGGGAACAATG
ATTTTACCTCTAATAAGGATAGCAGCACCCGGGATGCTTATGTAGCCAAGTTCGACAGCAATGGCAATTGGATCTGGGCT
AAACAGATCGGCGGTAGGGGTTCTGAGGATATTAAAACGATAACCACAGACAGCAGCGGCAATGTCTTGGTGGCGGGTGG
TTTTGGTGGCAACATTGATATCGACGGCGATGGAAACAATGATTTTTCCTCTAATAATGATTCCTCTAATAATGATGCTT
TTGCGGCTAAGTTAGACAGCAATGGCAATTTGGTCTGGGCTAAACAGATCGGCGGTAGCGTCACTACAGGTAACTATATT
TCTGGCATAATCACAGACAGCAGTGGCAATGCCTTGGTGGCGGGTACTTTTAAGGGCAACATTGACATCGACGGCGATGG
GAACAATGATTTTACCTCTAATAATGATGGCAGCAACGATTCTTATGTAGCTAAGTTTGACAGCAATGGCAATTTGGTCT
GGGCTAAACGTATTGGCGGTAGCAATGGTAACTCTTCTGGTGCCATAACCATAGACAGCAGTGACAATGTCTTGGTGGCG
GGTGGTTTTAAGGGCAACATTGATATCGACGATGATGGGAACAATAATTTTACCTCTAATGGGGAGGCGGATAGTTATGT
AGCCAAGTTCGACAGCAATGGCAATTTTGTCTGGGCTAAACAGTTCGGCAGTATCCGTGCTGACTATATTAATAGCATAA
CCACAGACAGCAACGGCAATGTCTTGGTGGGGGGTCTTTTTAATAGCTACATTGACATCGACGGCGATGGGAACAATGAT
TTTACCTCAATTAGCGACATCGATGGTTATGTAGCCAAGTTAGACAGCAATGGCAATTTGGTCTGGGCTAAACAGTTCGG
CAGTAGCCTTGGTGGGGTTGTTAGGAGCCTGACCACAGACAGCAGCGGCAATGTCTTGGTGGTGGGTAATTTTAGTGGTG
ACGTTGACATCGACGGCGATGGGAACAATGATTTTACCTCTAATGGTAATGGTAACCATACTTTTACAGCCAAGTACGAC
AGCAATGGCAATTTGGTCTGGGTTAAACATAATCTACACAACGCCTACACCATAACCACAGACAGCAGCGGCAATGTCTT
GATGGTGAGTGATTTTAATGGCAACATTGACATTGACGGCGATGGGGACAATGATTTTACCTCTAATGGGGACAGGAATG
GTTTGGTGGTGAAGTTCTCGGACGATACTAACTCCCCTCCCACGGATATCGCCCTCAGCAACAACACCATCGACGAAAAC
GTAGCAGCGAATACCCCGATAGGCAATCTCTCCAGCACAGACCCCGATACTGGAGATACCTTTACCTACAGTTTAGTCTC
AGGTGCCGGAGACACCGACAACGGAACCTTCAACATCAGCGGAGACGAACTAACAATTAAAAGTTCCCCCGACTACGAAA
ACAAACCGAGTTACAGCATCAGAGTTGAAACCACCGATGCAGCAGGAGAAACTTATCAGAAGGAATTAACGATTAACGTT
AACGACCTTTTTGACGGTAACAGCGGCAACGACATCCTCCGAGGCACCGCTGCCGCTGATTCCATCTACGGTTTAGAAGG
GCGCGACAAGTTGTACGGCAAAGGCGGTAACGATATCATATCTGGAGGAGCAGACAGCGATATCGTTAAAGGTGACAGCG
GTGACGACCAACTCAACGGCGATGATGGTCGGGACAGGCTTTATGGTGGTACCGGTAACGATATCATATCTGGAGGAGAA
GACAAAGACATCGTTAAAGGTGACAGCGGCGACGACCAACTTAACGGTGATGCTGGTCCAGACAGGCTTTACGGTGGCAC
CGGCAACGACATTTTACTCGGAGGAGACGGCAACGACTTACTTTATGGTCAAGGCGGAGACGACGAGCTTAATGGCGGAC
CTGGCATGGACAGACTTTACGGCAGTGACGGTATTGATACCTTTGTCTTAGGGGAGGGCCAGGAACGCGATAGCATCTAC
AATTTCGCGGTCGGTACAGATAAAATCAAGTTAGAGGGCAGTCTGAGTTTTGGCCAATTGCAGATTTTCCCAAGGGGTTC
TTCTAGTTTAATTGAAGTCACTGCTACTGGAGAAGAATTGGCTATTGTGTTGGGGGTTAATGCGGCGGATATTAACGACG
GCAGCGTATTTATCTAG

Upstream 100 bases:

>100_bases
CACTGTTGTATTTGTACTACAATAAGTGTCTTTGGGTAAGTCCTAATATTTCAATATCAGGCAAGCATTTATCTATTAAC
CTATTTCCTACAAAAAAACT

Downstream 100 bases:

>100_bases
TAGCTAGTGAACTGTTTTATCTCAAATATTTAGGGCCTGCTGAGAAAGTCTTTAATGCTAGGAAATCCCGCGCTGTCTCC
TAAGAGCAGCGCCGGGAGGA

Product: cadherin

Products: NA

Alternate protein names: Lkt [H]

Number of amino acids: Translated: 938; Mature: 938

Protein sequence:

>938_residues
MKLNTKSIVIIDASVENYQQLLNGVIPGVKPFLLGGDTDGIQQIGDILQKHPETDTLHIISHGSPGCLYLGNSQLSLDTL
KGYEPQLQQWQLDNLLLYGCNVAAGDGGEEFIDKLHRLTGAEIAASKSLTGAAVKGGNWELEVRTGQTKPSLALQVEAMA
SYSDTLELQFEWAKHIGGQGLTYVYRITTDSIGNVLVAGVFDDNIDIDGDGNNDFTSNKDSSTRDAYVAKFDSNGNWIWA
KQIGGRGSEDIKTITTDSSGNVLVAGGFGGNIDIDGDGNNDFSSNNDSSNNDAFAAKLDSNGNLVWAKQIGGSVTTGNYI
SGIITDSSGNALVAGTFKGNIDIDGDGNNDFTSNNDGSNDSYVAKFDSNGNLVWAKRIGGSNGNSSGAITIDSSDNVLVA
GGFKGNIDIDDDGNNNFTSNGEADSYVAKFDSNGNFVWAKQFGSIRADYINSITTDSNGNVLVGGLFNSYIDIDGDGNND
FTSISDIDGYVAKLDSNGNLVWAKQFGSSLGGVVRSLTTDSSGNVLVVGNFSGDVDIDGDGNNDFTSNGNGNHTFTAKYD
SNGNLVWVKHNLHNAYTITTDSSGNVLMVSDFNGNIDIDGDGDNDFTSNGDRNGLVVKFSDDTNSPPTDIALSNNTIDEN
VAANTPIGNLSSTDPDTGDTFTYSLVSGAGDTDNGTFNISGDELTIKSSPDYENKPSYSIRVETTDAAGETYQKELTINV
NDLFDGNSGNDILRGTAAADSIYGLEGRDKLYGKGGNDIISGGADSDIVKGDSGDDQLNGDDGRDRLYGGTGNDIISGGE
DKDIVKGDSGDDQLNGDAGPDRLYGGTGNDILLGGDGNDLLYGQGGDDELNGGPGMDRLYGSDGIDTFVLGEGQERDSIY
NFAVGTDKIKLEGSLSFGQLQIFPRGSSSLIEVTATGEELAIVLGVNAADINDGSVFI

Sequences:

>Translated_938_residues
MKLNTKSIVIIDASVENYQQLLNGVIPGVKPFLLGGDTDGIQQIGDILQKHPETDTLHIISHGSPGCLYLGNSQLSLDTL
KGYEPQLQQWQLDNLLLYGCNVAAGDGGEEFIDKLHRLTGAEIAASKSLTGAAVKGGNWELEVRTGQTKPSLALQVEAMA
SYSDTLELQFEWAKHIGGQGLTYVYRITTDSIGNVLVAGVFDDNIDIDGDGNNDFTSNKDSSTRDAYVAKFDSNGNWIWA
KQIGGRGSEDIKTITTDSSGNVLVAGGFGGNIDIDGDGNNDFSSNNDSSNNDAFAAKLDSNGNLVWAKQIGGSVTTGNYI
SGIITDSSGNALVAGTFKGNIDIDGDGNNDFTSNNDGSNDSYVAKFDSNGNLVWAKRIGGSNGNSSGAITIDSSDNVLVA
GGFKGNIDIDDDGNNNFTSNGEADSYVAKFDSNGNFVWAKQFGSIRADYINSITTDSNGNVLVGGLFNSYIDIDGDGNND
FTSISDIDGYVAKLDSNGNLVWAKQFGSSLGGVVRSLTTDSSGNVLVVGNFSGDVDIDGDGNNDFTSNGNGNHTFTAKYD
SNGNLVWVKHNLHNAYTITTDSSGNVLMVSDFNGNIDIDGDGDNDFTSNGDRNGLVVKFSDDTNSPPTDIALSNNTIDEN
VAANTPIGNLSSTDPDTGDTFTYSLVSGAGDTDNGTFNISGDELTIKSSPDYENKPSYSIRVETTDAAGETYQKELTINV
NDLFDGNSGNDILRGTAAADSIYGLEGRDKLYGKGGNDIISGGADSDIVKGDSGDDQLNGDDGRDRLYGGTGNDIISGGE
DKDIVKGDSGDDQLNGDAGPDRLYGGTGNDILLGGDGNDLLYGQGGDDELNGGPGMDRLYGSDGIDTFVLGEGQERDSIY
NFAVGTDKIKLEGSLSFGQLQIFPRGSSSLIEVTATGEELAIVLGVNAADINDGSVFI
>Mature_938_residues
MKLNTKSIVIIDASVENYQQLLNGVIPGVKPFLLGGDTDGIQQIGDILQKHPETDTLHIISHGSPGCLYLGNSQLSLDTL
KGYEPQLQQWQLDNLLLYGCNVAAGDGGEEFIDKLHRLTGAEIAASKSLTGAAVKGGNWELEVRTGQTKPSLALQVEAMA
SYSDTLELQFEWAKHIGGQGLTYVYRITTDSIGNVLVAGVFDDNIDIDGDGNNDFTSNKDSSTRDAYVAKFDSNGNWIWA
KQIGGRGSEDIKTITTDSSGNVLVAGGFGGNIDIDGDGNNDFSSNNDSSNNDAFAAKLDSNGNLVWAKQIGGSVTTGNYI
SGIITDSSGNALVAGTFKGNIDIDGDGNNDFTSNNDGSNDSYVAKFDSNGNLVWAKRIGGSNGNSSGAITIDSSDNVLVA
GGFKGNIDIDDDGNNNFTSNGEADSYVAKFDSNGNFVWAKQFGSIRADYINSITTDSNGNVLVGGLFNSYIDIDGDGNND
FTSISDIDGYVAKLDSNGNLVWAKQFGSSLGGVVRSLTTDSSGNVLVVGNFSGDVDIDGDGNNDFTSNGNGNHTFTAKYD
SNGNLVWVKHNLHNAYTITTDSSGNVLMVSDFNGNIDIDGDGDNDFTSNGDRNGLVVKFSDDTNSPPTDIALSNNTIDEN
VAANTPIGNLSSTDPDTGDTFTYSLVSGAGDTDNGTFNISGDELTIKSSPDYENKPSYSIRVETTDAAGETYQKELTINV
NDLFDGNSGNDILRGTAAADSIYGLEGRDKLYGKGGNDIISGGADSDIVKGDSGDDQLNGDDGRDRLYGGTGNDIISGGE
DKDIVKGDSGDDQLNGDAGPDRLYGGTGNDILLGGDGNDLLYGQGGDDELNGGPGMDRLYGSDGIDTFVLGEGQERDSIY
NFAVGTDKIKLEGSLSFGQLQIFPRGSSSLIEVTATGEELAIVLGVNAADINDGSVFI

Specific function: One of the virulence factors of A.actinomycetemcomitans might be a cytotoxin, possibly the membrane-bound hemolysin [H]

COG id: COG2931

COG function: function code Q; RTX toxins and related Ca2+-binding proteins

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein. Secreted (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: NA

Molecular weight: Translated: 98347; Mature: 98347

Theoretical pI: Translated: 3.84; Mature: 3.84

Prosite motif: PS50268 CADHERIN_2 ; PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLNTKSIVIIDASVENYQQLLNGVIPGVKPFLLGGDTDGIQQIGDILQKHPETDTLHII
CCCCCEEEEEEECCHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEE
SHGSPGCLYLGNSQLSLDTLKGYEPQLQQWQLDNLLLYGCNVAAGDGGEEFIDKLHRLTG
ECCCCCEEEECCCEEEEHHHCCCCCHHHHEECCCEEEEECEEEECCCHHHHHHHHHHHCC
AEIAASKSLTGAAVKGGNWELEVRTGQTKPSLALQVEAMASYSDTLELQFEWAKHIGGQG
CCEEECCCCCCEEEECCCEEEEEEECCCCCCEEEEEEEECCCCCEEEEEEEHHHHCCCCC
LTYVYRITTDSIGNVLVAGVFDDNIDIDGDGNNDFTSNKDSSTRDAYVAKFDSNGNWIWA
EEEEEEEECCCCCCEEEEEEECCCEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEE
KQIGGRGSEDIKTITTDSSGNVLVAGGFGGNIDIDGDGNNDFSSNNDSSNNDAFAAKLDS
EECCCCCCCCCEEEEECCCCCEEEECCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEECC
NGNLVWAKQIGGSVTTGNYISGIITDSSGNALVAGTFKGNIDIDGDGNNDFTSNNDGSND
CCCEEEEHHCCCCEEECCEEEEEEECCCCCEEEEEEEECEEEECCCCCCCCCCCCCCCCC
SYVAKFDSNGNLVWAKRIGGSNGNSSGAITIDSSDNVLVAGGFKGNIDIDDDGNNNFTSN
CEEEEECCCCCEEEEEECCCCCCCCCEEEEECCCCCEEEECCCCCCEEECCCCCCCCCCC
GEADSYVAKFDSNGNFVWAKQFGSIRADYINSITTDSNGNVLVGGLFNSYIDIDGDGNND
CCCCCEEEEECCCCCEEEEECCCCEEHHHHCCEEECCCCCEEEEEECCCEEEEECCCCCC
FTSISDIDGYVAKLDSNGNLVWAKQFGSSLGGVVRSLTTDSSGNVLVVGNFSGDVDIDGD
CCEECCCCCEEEEECCCCCEEEHHHHCCHHHHHHHHHCCCCCCCEEEEECCCCCEEECCC
GNNDFTSNGNGNHTFTAKYDSNGNLVWVKHNLHNAYTITTDSSGNVLMVSDFNGNIDIDG
CCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCEEEEEECCCCCEEEEEECCCEEEECC
DGDNDFTSNGDRNGLVVKFSDDTNSPPTDIALSNNTIDENVAANTPIGNLSSTDPDTGDT
CCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCE
FTYSLVSGAGDTDNGTFNISGDELTIKSSPDYENKPSYSIRVETTDAAGETYQKELTINV
EEEEEEECCCCCCCCEEEECCCEEEEECCCCCCCCCCEEEEEEECCCCCCCEEEEEEEEE
NDLFDGNSGNDILRGTAAADSIYGLEGRDKLYGKGGNDIISGGADSDIVKGDSGDDQLNG
HEECCCCCCCCEEEEECCCCCEECCCCCCEECCCCCCCEECCCCCCCEEECCCCCCCCCC
DDGRDRLYGGTGNDIISGGEDKDIVKGDSGDDQLNGDAGPDRLYGGTGNDILLGGDGNDL
CCCCCEEECCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEE
LYGQGGDDELNGGPGMDRLYGSDGIDTFVLGEGQERDSIYNFAVGTDKIKLEGSLSFGQL
EEECCCCCCCCCCCCCHHHCCCCCCCEEEECCCCCCCCEEEEEECCCEEEEEECCCCCEE
QIFPRGSSSLIEVTATGEELAIVLGVNAADINDGSVFI
EEEECCCCCEEEEEECCCEEEEEEECCCCCCCCCCEEC
>Mature Secondary Structure
MKLNTKSIVIIDASVENYQQLLNGVIPGVKPFLLGGDTDGIQQIGDILQKHPETDTLHII
CCCCCEEEEEEECCHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEE
SHGSPGCLYLGNSQLSLDTLKGYEPQLQQWQLDNLLLYGCNVAAGDGGEEFIDKLHRLTG
ECCCCCEEEECCCEEEEHHHCCCCCHHHHEECCCEEEEECEEEECCCHHHHHHHHHHHCC
AEIAASKSLTGAAVKGGNWELEVRTGQTKPSLALQVEAMASYSDTLELQFEWAKHIGGQG
CCEEECCCCCCEEEECCCEEEEEEECCCCCCEEEEEEEECCCCCEEEEEEEHHHHCCCCC
LTYVYRITTDSIGNVLVAGVFDDNIDIDGDGNNDFTSNKDSSTRDAYVAKFDSNGNWIWA
EEEEEEEECCCCCCEEEEEEECCCEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEE
KQIGGRGSEDIKTITTDSSGNVLVAGGFGGNIDIDGDGNNDFSSNNDSSNNDAFAAKLDS
EECCCCCCCCCEEEEECCCCCEEEECCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEECC
NGNLVWAKQIGGSVTTGNYISGIITDSSGNALVAGTFKGNIDIDGDGNNDFTSNNDGSND
CCCEEEEHHCCCCEEECCEEEEEEECCCCCEEEEEEEECEEEECCCCCCCCCCCCCCCCC
SYVAKFDSNGNLVWAKRIGGSNGNSSGAITIDSSDNVLVAGGFKGNIDIDDDGNNNFTSN
CEEEEECCCCCEEEEEECCCCCCCCCEEEEECCCCCEEEECCCCCCEEECCCCCCCCCCC
GEADSYVAKFDSNGNFVWAKQFGSIRADYINSITTDSNGNVLVGGLFNSYIDIDGDGNND
CCCCCEEEEECCCCCEEEEECCCCEEHHHHCCEEECCCCCEEEEEECCCEEEEECCCCCC
FTSISDIDGYVAKLDSNGNLVWAKQFGSSLGGVVRSLTTDSSGNVLVVGNFSGDVDIDGD
CCEECCCCCEEEEECCCCCEEEHHHHCCHHHHHHHHHCCCCCCCEEEEECCCCCEEECCC
GNNDFTSNGNGNHTFTAKYDSNGNLVWVKHNLHNAYTITTDSSGNVLMVSDFNGNIDIDG
CCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCEEEEEECCCCCEEEEEECCCEEEECC
DGDNDFTSNGDRNGLVVKFSDDTNSPPTDIALSNNTIDENVAANTPIGNLSSTDPDTGDT
CCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCE
FTYSLVSGAGDTDNGTFNISGDELTIKSSPDYENKPSYSIRVETTDAAGETYQKELTINV
EEEEEEECCCCCCCCEEEECCCEEEEECCCCCCCCCCEEEEEEECCCCCCCEEEEEEEEE
NDLFDGNSGNDILRGTAAADSIYGLEGRDKLYGKGGNDIISGGADSDIVKGDSGDDQLNG
HEECCCCCCCCEEEEECCCCCEECCCCCCEECCCCCCCEECCCCCCCEEECCCCCCCCCC
DDGRDRLYGGTGNDIISGGEDKDIVKGDSGDDQLNGDAGPDRLYGGTGNDILLGGDGNDL
CCCCCEEECCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEE
LYGQGGDDELNGGPGMDRLYGSDGIDTFVLGEGQERDSIYNFAVGTDKIKLEGSLSFGQL
EEECCCCCCCCCCCCCHHHCCCCCCCEEEECCCCCCCCEEEEEECCCEEEEEECCCCCEE
QIFPRGSSSLIEVTATGEELAIVLGVNAADINDGSVFI
EEEECCCCCEEEEEECCCEEEEEEECCCCCCCCCCEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2670940 [H]