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The map label for this gene is ptxD [H]

Identifier: 113474249

GI number: 113474249

Start: 566682

End: 567677

Strand: Direct

Name: ptxD [H]

Synonym: Tery_0368

Alternate gene names: 113474249

Gene position: 566682-567677 (Clockwise)

Preceding gene: 113474248

Following gene: 113474257

Centisome position: 7.31

GC content: 35.04

Gene sequence:

>996_bases
ATGGATAAAAAACCATTAGTTGTTATTACCCATTGGATTCATTCTCAAGTTATTGATTATTTAAGTAAAACTTGTGAAGT
TATTCTCAATCAAACTCAATACACATTGTCTCGTGAAGAAATTATCAATCGAACAAAAGAAGCTGAAGGTCTAATGGTAT
TTATGCCTGACTTTATTGAATCAAGTTTCTTAGATGCTTGTCCTCAATTAAAAGTTATTGCAGGAGCTTTAAGAGGGTAT
GATAATTTTGATATAGATGCTTGTACAAAACGAGGTATTTGGTTCACAATTGTTCCCGACTTATTAGCAGCACCCACAGC
GGAATTAACTGTTGGATTATTATTGGGATTAGCTCGTCGAATGTTAGAAGGCGATCGCCTAATTCGTGATGGTCAATTTC
AAGGATGGAAACCAAAACTTTACAGTAGAGGATTATTACATCAAAATCTAGGAATTGTAGGGATGGGAAAATTAGGAAAA
GCTTTAGCCCAAAGATTGGTAGGTTTTAACATGAATTTATTCTACAGTGATTCTATTCCCTTATCTGTAGAACAAGAAAC
TGCTTGGAAAATTTCTAGAGTTTCTTTAGAAGAACTCTTAAAGATTAGTGATTATGTAGTTTTAATGGTACCATTAATTC
CTGATACCTATCATCTTATTAATCAAGATACCTTAGCCAAGATGAAACCAAAAAGTTTCCTGATCAATGCCTGTCGGGGA
TCAGTTGTAGATGAGAAAGCGATCGGGTCAGCAATTCAATCAGGACATTTAGCTGGATATGCTGCTGATGTCTTTGAGAT
GGAAGATAGGGCTATCCCTCATCGCCCTCAAGGGATTTACAATACATTAATAACTGAAAAAAATAAGACTTTTTTGACTC
CTCATCTGGGTTCTGCTGTTGATGAAATTCGCCATGATATTTCTTTTGAAGCAGCCAAAAATATTGTGCAAGTTTTATCA
GGAGAAATTCCTCAAGGAGCTGTTAACAAGCTATAA

Upstream 100 bases:

>100_bases
AAGTATCTAGTTTTTTCTACTGGGGAGAAGGAAATATAATTTATTTCAATATATTCCCTACTTCCCACTATCTACTCCCT
TAATTTCTCAGGTATTCAAT

Downstream 100 bases:

>100_bases
ATTAAAGAAGATAGTAGTCCTAAAATAAAATAGTAAACAGAAAGGAGATTATAACTATTAACTAACTCCGGTACTTTCTA
TTTATTGTTCTCTGTGTTCT

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NAD-dependent phosphite dehydrogenase [H]

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MDKKPLVVITHWIHSQVIDYLSKTCEVILNQTQYTLSREEIINRTKEAEGLMVFMPDFIESSFLDACPQLKVIAGALRGY
DNFDIDACTKRGIWFTIVPDLLAAPTAELTVGLLLGLARRMLEGDRLIRDGQFQGWKPKLYSRGLLHQNLGIVGMGKLGK
ALAQRLVGFNMNLFYSDSIPLSVEQETAWKISRVSLEELLKISDYVVLMVPLIPDTYHLINQDTLAKMKPKSFLINACRG
SVVDEKAIGSAIQSGHLAGYAADVFEMEDRAIPHRPQGIYNTLITEKNKTFLTPHLGSAVDEIRHDISFEAAKNIVQVLS
GEIPQGAVNKL

Sequences:

>Translated_331_residues
MDKKPLVVITHWIHSQVIDYLSKTCEVILNQTQYTLSREEIINRTKEAEGLMVFMPDFIESSFLDACPQLKVIAGALRGY
DNFDIDACTKRGIWFTIVPDLLAAPTAELTVGLLLGLARRMLEGDRLIRDGQFQGWKPKLYSRGLLHQNLGIVGMGKLGK
ALAQRLVGFNMNLFYSDSIPLSVEQETAWKISRVSLEELLKISDYVVLMVPLIPDTYHLINQDTLAKMKPKSFLINACRG
SVVDEKAIGSAIQSGHLAGYAADVFEMEDRAIPHRPQGIYNTLITEKNKTFLTPHLGSAVDEIRHDISFEAAKNIVQVLS
GEIPQGAVNKL
>Mature_331_residues
MDKKPLVVITHWIHSQVIDYLSKTCEVILNQTQYTLSREEIINRTKEAEGLMVFMPDFIESSFLDACPQLKVIAGALRGY
DNFDIDACTKRGIWFTIVPDLLAAPTAELTVGLLLGLARRMLEGDRLIRDGQFQGWKPKLYSRGLLHQNLGIVGMGKLGK
ALAQRLVGFNMNLFYSDSIPLSVEQETAWKISRVSLEELLKISDYVVLMVPLIPDTYHLINQDTLAKMKPKSFLINACRG
SVVDEKAIGSAIQSGHLAGYAADVFEMEDRAIPHRPQGIYNTLITEKNKTFLTPHLGSAVDEIRHDISFEAAKNIVQVLS
GEIPQGAVNKL

Specific function: Catalyzes phosphite (phosphonate) oxidation [H]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=319, Percent_Identity=30.7210031347962, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI6912396, Length=300, Percent_Identity=34.3333333333333, Blast_Score=154, Evalue=7e-38,
Organism=Homo sapiens, GI61743967, Length=301, Percent_Identity=30.5647840531561, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4557497, Length=301, Percent_Identity=30.5647840531561, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI145580578, Length=300, Percent_Identity=30.3333333333333, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI4557499, Length=300, Percent_Identity=30.3333333333333, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI145580575, Length=300, Percent_Identity=30.3333333333333, Blast_Score=108, Evalue=5e-24,
Organism=Escherichia coli, GI87082289, Length=330, Percent_Identity=33.3333333333333, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1789279, Length=326, Percent_Identity=27.9141104294479, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1787645, Length=246, Percent_Identity=27.6422764227642, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1788660, Length=231, Percent_Identity=29.4372294372294, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=317, Percent_Identity=29.9684542586751, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI25147481, Length=296, Percent_Identity=27.027027027027, Blast_Score=87, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6324055, Length=306, Percent_Identity=32.0261437908497, Blast_Score=125, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6320925, Length=310, Percent_Identity=29.0322580645161, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6322116, Length=310, Percent_Identity=27.741935483871, Blast_Score=106, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6324964, Length=229, Percent_Identity=28.82096069869, Blast_Score=89, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6321253, Length=175, Percent_Identity=30.2857142857143, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324980, Length=133, Percent_Identity=32.3308270676692, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28571528, Length=307, Percent_Identity=32.8990228013029, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI28574286, Length=327, Percent_Identity=30.2752293577982, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI24585514, Length=320, Percent_Identity=30, Blast_Score=141, Evalue=7e-34,
Organism=Drosophila melanogaster, GI28574282, Length=320, Percent_Identity=30, Blast_Score=141, Evalue=7e-34,
Organism=Drosophila melanogaster, GI45551003, Length=320, Percent_Identity=30, Blast_Score=141, Evalue=7e-34,
Organism=Drosophila melanogaster, GI28574284, Length=320, Percent_Identity=30, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI45552429, Length=320, Percent_Identity=30, Blast_Score=140, Evalue=8e-34,
Organism=Drosophila melanogaster, GI19921140, Length=328, Percent_Identity=29.8780487804878, Blast_Score=137, Evalue=7e-33,
Organism=Drosophila melanogaster, GI24646446, Length=302, Percent_Identity=29.1390728476821, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24646448, Length=302, Percent_Identity=29.1390728476821, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24646452, Length=302, Percent_Identity=29.1390728476821, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24646450, Length=302, Percent_Identity=29.1390728476821, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI62472511, Length=302, Percent_Identity=29.1390728476821, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24585516, Length=307, Percent_Identity=25.0814332247557, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.20.1.1 [H]

Molecular weight: Translated: 36923; Mature: 36923

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3 ; PS50208 CASPASE_P20

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKKPLVVITHWIHSQVIDYLSKTCEVILNQTQYTLSREEIINRTKEAEGLMVFMPDFIE
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEECHHHHH
SSFLDACPQLKVIAGALRGYDNFDIDACTKRGIWFTIVPDLLAAPTAELTVGLLLGLARR
HHHHHHCCHHHHHHHHHCCCCCCCHHHHCCCCEEEEECCHHHHCCHHHHHHHHHHHHHHH
MLEGDRLIRDGQFQGWKPKLYSRGLLHQNLGIVGMGKLGKALAQRLVGFNMNLFYSDSIP
HHCCCCEEECCCCCCCCCHHHHCCHHHHCCCEEECHHHHHHHHHHHHCCCCEEEECCCCC
LSVEQETAWKISRVSLEELLKISDYVVLMVPLIPDTYHLINQDTLAKMKPKSFLINACRG
CEECHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHCCHHHHHCCHHHHHHHHHCC
SVVDEKAIGSAIQSGHLAGYAADVFEMEDRAIPHRPQGIYNTLITEKNKTFLTPHLGSAV
CCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCEEECCCHHHHH
DEIRHDISFEAAKNIVQVLSGEIPQGAVNKL
HHHHHHCCHHHHHHHHHHHCCCCCCCHHCCC
>Mature Secondary Structure
MDKKPLVVITHWIHSQVIDYLSKTCEVILNQTQYTLSREEIINRTKEAEGLMVFMPDFIE
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEECHHHHH
SSFLDACPQLKVIAGALRGYDNFDIDACTKRGIWFTIVPDLLAAPTAELTVGLLLGLARR
HHHHHHCCHHHHHHHHHCCCCCCCHHHHCCCCEEEEECCHHHHCCHHHHHHHHHHHHHHH
MLEGDRLIRDGQFQGWKPKLYSRGLLHQNLGIVGMGKLGKALAQRLVGFNMNLFYSDSIP
HHCCCCEEECCCCCCCCCHHHHCCHHHHCCCEEECHHHHHHHHHHHHCCCCEEEECCCCC
LSVEQETAWKISRVSLEELLKISDYVVLMVPLIPDTYHLINQDTLAKMKPKSFLINACRG
CEECHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHCCHHHHHCCHHHHHHHHHCC
SVVDEKAIGSAIQSGHLAGYAADVFEMEDRAIPHRPQGIYNTLITEKNKTFLTPHLGSAV
CCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCEEECCCHHHHH
DEIRHDISFEAAKNIVQVLSGEIPQGAVNKL
HHHHHHCCHHHHHHHHHHHCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9791102; 11278981 [H]