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The map label for this gene is norA [H]

Identifier: 113474167

GI number: 113474167

Start: 422371

End: 423588

Strand: Direct

Name: norA [H]

Synonym: Tery_0273

Alternate gene names: 113474167

Gene position: 422371-423588 (Clockwise)

Preceding gene: 113474166

Following gene: 113474168

Centisome position: 5.45

GC content: 31.77

Gene sequence:

>1218_bases
ATGAGTAAAAAAACAGTATCTCAAAACATAAAAAACTCCATCAAAATTTATCAAGATTCTAATTTTCAGATTATTATTGG
AATCATTTCAATGGCAATTTTAGGTGGTCCTGGTATAAGCCCTCTTTTACCTTCAATAGCTAAAAATTGGAACATTTCTC
CCGAACATATTGGTTGGGTAATCTCAGCATTTTTTATTCCTATTACTATAGGTACTCCAATCTCTGGAATATTAGCAGAT
CGTTATGGCAGAAAACAAATTTTGATACCTGCCTTAATCTTATTTGCAATTAGTGGAACCCTTTGTTCATTAGCTCCCAA
TTTTCAGACCTTAATAGGGCTTCGTTTTGTACAAGGAATTGGCGCAGCACCACTAGAGTCATTAACTTTAACATTAATTA
GTGACTTTTATAGCGGTAAGTTGCTAACAACAGCCATGGCTTTTAAGACCATGAGTGTTGGTCTTAGTTTAGTGATTTAT
CCTTTAATTAGTAGTGGATTAACTACCTGGGGATGGCGGTATCCTTTCTTATTATATTTAATAGCTATTCCCTTAAGTAT
TTGGATTTTATTTTCTTTAAAAAATCCAGCTATACCTAAGCAAAAATCATTTAACTTAAAAAAATATTTGAGAAATATTT
GGCAAAGTTTTAATAATTATCAAGTTAGGAGTTTATTAATAGTAATTATTGTAAACTTTATATTTTCATTGGGTCCTTGC
TTAACTTATATACCTCTATTTGCCGATCGCCAGTTAGGAGCTTCTTATATTGTCATCGGAATTATTTTAGCCAGCAGAGG
TATTTTTTTAGCATTTGCTTCATCTCAATTAGGGATATTTGCCAAGTACCTATCTGAACTGACCCTGATAAAAATTTCAT
TTATTATTTATTGTATTGCTTTTATAATGATTCCCACAATAAATAATATTTGGCTGTTATTTATTCCTGGCATTTTATTA
GGTTTAGCTCATGGTATGTTAGTTCCCTCAACCCAATCTTTATTAGGGCAATTATCTCCCGAAAATTATCGAGCAGGTTT
TATGGCAGTTACTTCATCAGCTTTATCTTTCGGGCGAACTTTAGGTCCAATTCTAGCAGGAAGTATGTTTTATATTGGGG
GAATGGCAGGAGTATTTTATAGCAGTTCAATTGTGAGTTTAGTTATTTTTGTTTTTATCAGTTATCTAGTTATAAATACC
CAATCCATAAAAAGTTAA

Upstream 100 bases:

>100_bases
AAAAACCATAATTATTTCTTAAGAGCAATAAAAGAAAAAATAATAACCATAAAAATTGAGAGAACTATCAAAACTAAACT
TAATATGAGATAGTTTAATT

Downstream 100 bases:

>100_bases
AAGCAGTCAAAACAGAGCAGCTAAAAAATATTTAGGTAAGACTTATCTATAACTAAAATATATAGTACAATAATGCCAAA
ATAACACTAAAGCTGTTATA

Product: major facilitator transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MSKKTVSQNIKNSIKIYQDSNFQIIIGIISMAILGGPGISPLLPSIAKNWNISPEHIGWVISAFFIPITIGTPISGILAD
RYGRKQILIPALILFAISGTLCSLAPNFQTLIGLRFVQGIGAAPLESLTLTLISDFYSGKLLTTAMAFKTMSVGLSLVIY
PLISSGLTTWGWRYPFLLYLIAIPLSIWILFSLKNPAIPKQKSFNLKKYLRNIWQSFNNYQVRSLLIVIIVNFIFSLGPC
LTYIPLFADRQLGASYIVIGIILASRGIFLAFASSQLGIFAKYLSELTLIKISFIIYCIAFIMIPTINNIWLLFIPGILL
GLAHGMLVPSTQSLLGQLSPENYRAGFMAVTSSALSFGRTLGPILAGSMFYIGGMAGVFYSSSIVSLVIFVFISYLVINT
QSIKS

Sequences:

>Translated_405_residues
MSKKTVSQNIKNSIKIYQDSNFQIIIGIISMAILGGPGISPLLPSIAKNWNISPEHIGWVISAFFIPITIGTPISGILAD
RYGRKQILIPALILFAISGTLCSLAPNFQTLIGLRFVQGIGAAPLESLTLTLISDFYSGKLLTTAMAFKTMSVGLSLVIY
PLISSGLTTWGWRYPFLLYLIAIPLSIWILFSLKNPAIPKQKSFNLKKYLRNIWQSFNNYQVRSLLIVIIVNFIFSLGPC
LTYIPLFADRQLGASYIVIGIILASRGIFLAFASSQLGIFAKYLSELTLIKISFIIYCIAFIMIPTINNIWLLFIPGILL
GLAHGMLVPSTQSLLGQLSPENYRAGFMAVTSSALSFGRTLGPILAGSMFYIGGMAGVFYSSSIVSLVIFVFISYLVINT
QSIKS
>Mature_404_residues
SKKTVSQNIKNSIKIYQDSNFQIIIGIISMAILGGPGISPLLPSIAKNWNISPEHIGWVISAFFIPITIGTPISGILADR
YGRKQILIPALILFAISGTLCSLAPNFQTLIGLRFVQGIGAAPLESLTLTLISDFYSGKLLTTAMAFKTMSVGLSLVIYP
LISSGLTTWGWRYPFLLYLIAIPLSIWILFSLKNPAIPKQKSFNLKKYLRNIWQSFNNYQVRSLLIVIIVNFIFSLGPCL
TYIPLFADRQLGASYIVIGIILASRGIFLAFASSQLGIFAKYLSELTLIKISFIIYCIAFIMIPTINNIWLLFIPGILLG
LAHGMLVPSTQSLLGQLSPENYRAGFMAVTSSALSFGRTLGPILAGSMFYIGGMAGVFYSSSIVSLVIFVFISYLVINTQ
SIKS

Specific function: Involved in quinolone resistance. May constitute a membrane-associated active efflux pump of hydrophilic quinolones [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI87081983, Length=197, Percent_Identity=30.4568527918782, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1790195, Length=232, Percent_Identity=25.8620689655172, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1789042, Length=148, Percent_Identity=29.0540540540541, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87081723, Length=358, Percent_Identity=24.0223463687151, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44372; Mature: 44241

Theoretical pI: Translated: 10.32; Mature: 10.32

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKTVSQNIKNSIKIYQDSNFQIIIGIISMAILGGPGISPLLPSIAKNWNISPEHIGWV
CCCHHHHHHHHHCEEEEECCCCEEHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHH
ISAFFIPITIGTPISGILADRYGRKQILIPALILFAISGTLCSLAPNFQTLIGLRFVQGI
HHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
GAAPLESLTLTLISDFYSGKLLTTAMAFKTMSVGLSLVIYPLISSGLTTWGWRYPFLLYL
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
IAIPLSIWILFSLKNPAIPKQKSFNLKKYLRNIWQSFNNYQVRSLLIVIIVNFIFSLGPC
HHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
LTYIPLFADRQLGASYIVIGIILASRGIFLAFASSQLGIFAKYLSELTLIKISFIIYCIA
HHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
FIMIPTINNIWLLFIPGILLGLAHGMLVPSTQSLLGQLSPENYRAGFMAVTSSALSFGRT
HHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
LGPILAGSMFYIGGMAGVFYSSSIVSLVIFVFISYLVINTQSIKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKKTVSQNIKNSIKIYQDSNFQIIIGIISMAILGGPGISPLLPSIAKNWNISPEHIGWV
CCHHHHHHHHHCEEEEECCCCEEHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHH
ISAFFIPITIGTPISGILADRYGRKQILIPALILFAISGTLCSLAPNFQTLIGLRFVQGI
HHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
GAAPLESLTLTLISDFYSGKLLTTAMAFKTMSVGLSLVIYPLISSGLTTWGWRYPFLLYL
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
IAIPLSIWILFSLKNPAIPKQKSFNLKKYLRNIWQSFNNYQVRSLLIVIIVNFIFSLGPC
HHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
LTYIPLFADRQLGASYIVIGIILASRGIFLAFASSQLGIFAKYLSELTLIKISFIIYCIA
HHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
FIMIPTINNIWLLFIPGILLGLAHGMLVPSTQSLLGQLSPENYRAGFMAVTSSALSFGRT
HHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
LGPILAGSMFYIGGMAGVFYSSSIVSLVIFVFISYLVINTQSIKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA