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The map label for this gene is grxC [C]

Identifier: 110835493

GI number: 110835493

Start: 2980695

End: 2981432

Strand: Reverse

Name: grxC [C]

Synonym: ABO_2632

Alternate gene names: 110835493

Gene position: 2981432-2980695 (Counterclockwise)

Preceding gene: 110835494

Following gene: 110835492

Centisome position: 95.55

GC content: 53.52

Gene sequence:

>738_bases
ATGTTTGAGAATCGCGAAGGTCAGCCTGTTCCAGCGGTAACGTTTCGAACCCGGGAAGGCAACGAATGGAAAGATGTCAC
CACCGATGACGTGTTCAAGGGAAAAACTGTGGTGGTGTTTGCCTTGCCTGGAGCGTTTACCCCCACCTGTTCTTCGACCC
ATCTGCCACGCTATAACGAGCTGGCGCCTGTACTCAAGGCTAACGGTGTAGATGATATTGTCTGCCTGTCGGTGAACGAT
GGTTTTGTTATGAATGCTTGGGCTGGTGATCAGGCTGCTGGCAATATTCACTTTATCCCAGATGGTAACGGTGAGTTCAC
CGACAAGATGGGTATGCTCGTGAATAAACAGGACTTGGGCTTTGGCCCGCGAAGCTGGCGCTACTCCATGCTGGTGAAAG
ACGGCGTCATCGATCGCATGTTCATTGAGCCGGATAAGCCCGGGGATCCGTTTGAAGTGTCTGATGCGGATACCATGCTA
AAGTATATTAACGGCGAAGCGGTTTTGCCTAAGCGAGTGACCGTGTTCACCAAGCCGGGCTGCCCGCACTGCACGCGTGC
GAAACAGGCGCTGACCGATTACGGTTATGCCTTTGAAGAAATTGAGTTGGGTAGCCGAGGGTTGAGTTACAGCTCTTTGG
CTGCGGTCACCGGCGCGGGGACCACGCCACAGATATACATTGAAGGTGAGCGTATAGGCGGCGCTGATGAGTTGGAGGCC
TGGTTGCAACAGGGCTAA

Upstream 100 bases:

>100_bases
TCGTCTTTATTGATTTTTCTAGGGTGGCTATTCTCGATCTTGTGCTTGAGAAAGCCGCCCTTTCAGTAAGCGGCTTCGAT
TCTATCCAGGGAGTCAATAT

Downstream 100 bases:

>100_bases
CTCGCAACGCGTGAATGCGAACTTTCTTCCTTCTTTGGGGCCCGGCGGGGCCCTTTTTTGTGCCGCTGTGCCGTTCACGT
CGCACACTGCATGCTATTCG

Product: peroxiredoxin family protein/glutaredoxin

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MFENREGQPVPAVTFRTREGNEWKDVTTDDVFKGKTVVVFALPGAFTPTCSSTHLPRYNELAPVLKANGVDDIVCLSVND
GFVMNAWAGDQAAGNIHFIPDGNGEFTDKMGMLVNKQDLGFGPRSWRYSMLVKDGVIDRMFIEPDKPGDPFEVSDADTML
KYINGEAVLPKRVTVFTKPGCPHCTRAKQALTDYGYAFEEIELGSRGLSYSSLAAVTGAGTTPQIYIEGERIGGADELEA
WLQQG

Sequences:

>Translated_245_residues
MFENREGQPVPAVTFRTREGNEWKDVTTDDVFKGKTVVVFALPGAFTPTCSSTHLPRYNELAPVLKANGVDDIVCLSVND
GFVMNAWAGDQAAGNIHFIPDGNGEFTDKMGMLVNKQDLGFGPRSWRYSMLVKDGVIDRMFIEPDKPGDPFEVSDADTML
KYINGEAVLPKRVTVFTKPGCPHCTRAKQALTDYGYAFEEIELGSRGLSYSSLAAVTGAGTTPQIYIEGERIGGADELEA
WLQQG
>Mature_245_residues
MFENREGQPVPAVTFRTREGNEWKDVTTDDVFKGKTVVVFALPGAFTPTCSSTHLPRYNELAPVLKANGVDDIVCLSVND
GFVMNAWAGDQAAGNIHFIPDGNGEFTDKMGMLVNKQDLGFGPRSWRYSMLVKDGVIDRMFIEPDKPGDPFEVSDADTML
KYINGEAVLPKRVTVFTKPGCPHCTRAKQALTDYGYAFEEIELGSRGLSYSSLAAVTGAGTTPQIYIEGERIGGADELEA
WLQQG

Specific function: The Disulfide Bond Functions As An Electron Carrier In The Glutathione-Dependent Synthesis Of Deoxyribonucleotides By The Enzyme Ribonucleotide Reductase. In Addition, It Is Also Involved In Reducing Some Disulfides In A Coupled System With Glutathione R

COG id: COG0678

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI6912238, Length=147, Percent_Identity=40.8163265306122, Blast_Score=107, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6323138, Length=146, Percent_Identity=28.7671232876712, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI78706776, Length=146, Percent_Identity=42.4657534246575, Blast_Score=110, Evalue=7e-25,
Organism=Drosophila melanogaster, GI78709078, Length=146, Percent_Identity=42.4657534246575, Blast_Score=110, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011767
- InterPro:   IPR002109
- InterPro:   IPR011906
- InterPro:   IPR014025
- InterPro:   IPR013740
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin; PF08534 Redoxin [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 26797; Mature: 26797

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS00195 GLUTAREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFENREGQPVPAVTFRTREGNEWKDVTTDDVFKGKTVVVFALPGAFTPTCSSTHLPRYNE
CCCCCCCCCCCEEEEEECCCCCCCCCCCCHHCCCCEEEEEEECCCCCCCCCCCCCCCHHH
LAPVLKANGVDDIVCLSVNDGFVMNAWAGDQAAGNIHFIPDGNGEFTDKMGMLVNKQDLG
HCHHHHCCCCCCEEEEEECCCEEEEECCCCCCCCEEEEEECCCCCCCHHHCEEEEHHHCC
FGPRSWRYSMLVKDGVIDRMFIEPDKPGDPFEVSDADTMLKYINGEAVLPKRVTVFTKPG
CCCCCEEEEEEEECCCEEEEEECCCCCCCCEEECCHHHHHHHHCCCEECCCEEEEEECCC
CPHCTRAKQALTDYGYAFEEIELGSRGLSYSSLAAVTGAGTTPQIYIEGERIGGADELEA
CCCHHHHHHHHHHHCCEEEEEECCCCCCCHHHHEEEECCCCCCEEEEECCCCCCHHHHHH
WLQQG
HHHCC
>Mature Secondary Structure
MFENREGQPVPAVTFRTREGNEWKDVTTDDVFKGKTVVVFALPGAFTPTCSSTHLPRYNE
CCCCCCCCCCCEEEEEECCCCCCCCCCCCHHCCCCEEEEEEECCCCCCCCCCCCCCCHHH
LAPVLKANGVDDIVCLSVNDGFVMNAWAGDQAAGNIHFIPDGNGEFTDKMGMLVNKQDLG
HCHHHHCCCCCCEEEEEECCCEEEEECCCCCCCCEEEEEECCCCCCCHHHCEEEEHHHCC
FGPRSWRYSMLVKDGVIDRMFIEPDKPGDPFEVSDADTMLKYINGEAVLPKRVTVFTKPG
CCCCCEEEEEEEECCCEEEEEECCCCCCCCEEECCHHHHHHHHCCCEECCCEEEEEECCC
CPHCTRAKQALTDYGYAFEEIELGSRGLSYSSLAAVTGAGTTPQIYIEGERIGGADELEA
CCCHHHHHHHHHHHCCEEEEEECCCCCCCHHHHEEEECCCCCCEEEEECCCCCCHHHHHH
WLQQG
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]