Click here to switch to the map view.

The map label for this gene is ilvA [H]

Identifier: 110835466

GI number: 110835466

Start: 2948604

End: 2950121

Strand: Reverse

Name: ilvA [H]

Synonym: ABO_2605

Alternate gene names: 110835466

Gene position: 2950121-2948604 (Counterclockwise)

Preceding gene: 110835468

Following gene: 110835462

Centisome position: 94.55

GC content: 55.01

Gene sequence:

>1518_bases
ATGCTGGACAAATACGTTAAACGGATACTGCAATCCCGCGTCTATGACGTGGCGGTGGAAACTCCTATTCATGCAGCGCC
GTTAATTTCCAAACGTATTGGCAACCGGGTGCTTCTCAAGCGTGAAGACCTGCAGCCGGTGTTCTCTTTCAAACTGCGCG
GAGCCTACAACAAGCTGTGTCAGTTGAATCAAGAGCAGCTGGCCCGTGGGGTAATCTGTGCCTCAGCGGGTAACCATGCG
CAGGGATTGGCCTTGGCCGCTTCGTCTATGGGTGTGAAGGCGGCGATTGTGATGCCGCGCACCACGCCGGATATCAAGGT
GAGCTCCGTGCGGCGTCATGGCGGTAAGGTTGTGTTGCATGGTGACAGCTTTGATGAGGCCCTGGCTCACGCATTGAAAC
TTCAGGAGCGAGATAACCTGACCTTTGTCCACCCCTACGATGATCCGGATGTGATTGCCGGACAGGGCACTGTGGGCATG
GAAATTCTGCGTCAGCAAAGCCGTGATCTGGATGCTATTTTTATCCCAGTGGGTGGCGGTGGTTTAGCGGCCGGTGTGGC
CGCCTATGTGAAATATGTGCGCCCGGAGGTGAAAGTGATCGCCGTGGAGCCGGAAGATGCAGCTTGCCTGAAAGCGGCCT
TGGAGAAAAAGCGCCGGGTCACGCTGTCGGAAGTGGGGTTGTTTGCCGATGGTGTTGCGGTGAAGCAGATCGGCAAAGAA
ACCTACAAGGTACTGCGCGATCATGTGGATGAGGTGATCACTGCCACCACCGATGAAATTTGTGCTGCGATTAAGGATTC
CTTCGAAGATACCCGCGCCATCTGTGAGCCGGCGGGGGCATTGGCGTTGGCGGGTCTAAAGAACTGGGTGGCCAAGCATA
ATGTACGAGATCAGACCCTGGTCGCTATTCAGAGTGGCGCCAATGTGAACTTTGATCGTCTGCGCCATGTGTCTGAGCGG
GCTGAGCTGGGTGAGCAACGCGAAGCCATTTTGGCGGTCACCATTCCTGAGTCTCCGGGTGCGTTTCGGGCGTTTTGCCA
GGCCCTGGGTCGGCGCGGCATCACCGAATTCAATTACCGTTACAGTGATGATCGCGACGCAAATATCTTTGTGGGTATCC
AGCTGCGCCCTGATGGTGAAGCCTTGCAGGCGTTAATGAACGAGCTGCAGGAACGCGGTTATCCAGTGGTGGATATGAGC
GGCAACGAGATGGCCAAGCTACATATTCGTCATCTTGTGGGGGGGCACACTTCCCGGCAGGACCTTCAGGAGCGCTTATT
TCGAGTGGAATTTCCAGAGCGCCCCGGTGCGCTGATGAAGTTTCTCCAGTCTTTGGGTGAGAAATGGAATATCAGCCTGT
TCCACTATCGTAATCACGGAGCAGCTTACGGTCGCGTATTGGTGGGCTTCCAGGTAGAGGAAGGCAGGCAGTCTAAGCTG
CTAGCCGACCTTAAGAAGGTGCCTTACCCTATGGTGGAGGAAAGTGAAAATCCCGCCTACCGATTATTTTTGAACTAA

Upstream 100 bases:

>100_bases
TAGGTCAGCCGTGGCTGTGGCTCGACCCTAGCCTATCGCATTTGTGTCGGTCAGACCCTAGACTATTCCTTTCCCCCCAA
CAGAATGAGCCCGGACCCCC

Downstream 100 bases:

>100_bases
ACGTTTTTTAGTTGGTCGATTATTCGGCGTAGCCGATTTTACTTCTGTTTAGTTTGCAATCGGCCCTGCTCTCTCTAACG
TGCTGATTTTACAATCATCT

Product: threonine dehydratase, biosynthetic

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 505; Mature: 505

Protein sequence:

>505_residues
MLDKYVKRILQSRVYDVAVETPIHAAPLISKRIGNRVLLKREDLQPVFSFKLRGAYNKLCQLNQEQLARGVICASAGNHA
QGLALAASSMGVKAAIVMPRTTPDIKVSSVRRHGGKVVLHGDSFDEALAHALKLQERDNLTFVHPYDDPDVIAGQGTVGM
EILRQQSRDLDAIFIPVGGGGLAAGVAAYVKYVRPEVKVIAVEPEDAACLKAALEKKRRVTLSEVGLFADGVAVKQIGKE
TYKVLRDHVDEVITATTDEICAAIKDSFEDTRAICEPAGALALAGLKNWVAKHNVRDQTLVAIQSGANVNFDRLRHVSER
AELGEQREAILAVTIPESPGAFRAFCQALGRRGITEFNYRYSDDRDANIFVGIQLRPDGEALQALMNELQERGYPVVDMS
GNEMAKLHIRHLVGGHTSRQDLQERLFRVEFPERPGALMKFLQSLGEKWNISLFHYRNHGAAYGRVLVGFQVEEGRQSKL
LADLKKVPYPMVEESENPAYRLFLN

Sequences:

>Translated_505_residues
MLDKYVKRILQSRVYDVAVETPIHAAPLISKRIGNRVLLKREDLQPVFSFKLRGAYNKLCQLNQEQLARGVICASAGNHA
QGLALAASSMGVKAAIVMPRTTPDIKVSSVRRHGGKVVLHGDSFDEALAHALKLQERDNLTFVHPYDDPDVIAGQGTVGM
EILRQQSRDLDAIFIPVGGGGLAAGVAAYVKYVRPEVKVIAVEPEDAACLKAALEKKRRVTLSEVGLFADGVAVKQIGKE
TYKVLRDHVDEVITATTDEICAAIKDSFEDTRAICEPAGALALAGLKNWVAKHNVRDQTLVAIQSGANVNFDRLRHVSER
AELGEQREAILAVTIPESPGAFRAFCQALGRRGITEFNYRYSDDRDANIFVGIQLRPDGEALQALMNELQERGYPVVDMS
GNEMAKLHIRHLVGGHTSRQDLQERLFRVEFPERPGALMKFLQSLGEKWNISLFHYRNHGAAYGRVLVGFQVEEGRQSKL
LADLKKVPYPMVEESENPAYRLFLN
>Mature_505_residues
MLDKYVKRILQSRVYDVAVETPIHAAPLISKRIGNRVLLKREDLQPVFSFKLRGAYNKLCQLNQEQLARGVICASAGNHA
QGLALAASSMGVKAAIVMPRTTPDIKVSSVRRHGGKVVLHGDSFDEALAHALKLQERDNLTFVHPYDDPDVIAGQGTVGM
EILRQQSRDLDAIFIPVGGGGLAAGVAAYVKYVRPEVKVIAVEPEDAACLKAALEKKRRVTLSEVGLFADGVAVKQIGKE
TYKVLRDHVDEVITATTDEICAAIKDSFEDTRAICEPAGALALAGLKNWVAKHNVRDQTLVAIQSGANVNFDRLRHVSER
AELGEQREAILAVTIPESPGAFRAFCQALGRRGITEFNYRYSDDRDANIFVGIQLRPDGEALQALMNELQERGYPVVDMS
GNEMAKLHIRHLVGGHTSRQDLQERLFRVEFPERPGALMKFLQSLGEKWNISLFHYRNHGAAYGRVLVGFQVEEGRQSKL
LADLKKVPYPMVEESENPAYRLFLN

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=296, Percent_Identity=35.1351351351351, Blast_Score=166, Evalue=7e-41,
Organism=Homo sapiens, GI33469958, Length=314, Percent_Identity=31.8471337579618, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI19923959, Length=274, Percent_Identity=30.6569343065693, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1790207, Length=501, Percent_Identity=55.2894211576846, Blast_Score=534, Evalue=1e-153,
Organism=Escherichia coli, GI1789505, Length=312, Percent_Identity=35.5769230769231, Blast_Score=183, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI71991565, Length=334, Percent_Identity=33.8323353293413, Blast_Score=155, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI17537387, Length=338, Percent_Identity=34.0236686390533, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17508781, Length=287, Percent_Identity=33.4494773519164, Blast_Score=142, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6320930, Length=514, Percent_Identity=48.8326848249027, Blast_Score=460, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6322631, Length=302, Percent_Identity=31.7880794701987, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6319788, Length=269, Percent_Identity=26.0223048327138, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355833, Length=322, Percent_Identity=32.6086956521739, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24645328, Length=258, Percent_Identity=30.2325581395349, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 55894; Mature: 55894

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDKYVKRILQSRVYDVAVETPIHAAPLISKRIGNRVLLKREDLQPVFSFKLRGAYNKLC
CCHHHHHHHHHHHHHHEEECCCCCHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHH
QLNQEQLARGVICASAGNHAQGLALAASSMGVKAAIVMPRTTPDIKVSSVRRHGGKVVLH
CCCHHHHHCEEEEECCCCCCCCCEEEHHCCCCEEEEEECCCCCCCCHHHHHHCCCEEEEE
GDSFDEALAHALKLQERDNLTFVHPYDDPDVIAGQGTVGMEILRQQSRDLDAIFIPVGGG
CCCHHHHHHHHHHHHCCCCEEEECCCCCCCEEECCCCHHHHHHHHHCCCCCEEEEEECCC
GLAAGVAAYVKYVRPEVKVIAVEPEDAACLKAALEKKRRVTLSEVGLFADGVAVKQIGKE
HHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCHHHHCHHHCCHHHHHHHHH
TYKVLRDHVDEVITATTDEICAAIKDSFEDTRAICEPAGALALAGLKNWVAKHNVRDQTL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEE
VAIQSGANVNFDRLRHVSERAELGEQREAILAVTIPESPGAFRAFCQALGRRGITEFNYR
EEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCEECCCE
YSDDRDANIFVGIQLRPDGEALQALMNELQERGYPVVDMSGNEMAKLHIRHLVGGHTSRQ
ECCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCCCCHH
DLQERLFRVEFPERPGALMKFLQSLGEKWNISLFHYRNHGAAYGRVLVGFQVEEGRQSKL
HHHHHHHCCCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEEEEECCCCHHHH
LADLKKVPYPMVEESENPAYRLFLN
HHHHHHCCCCCCCCCCCCCEEEEEC
>Mature Secondary Structure
MLDKYVKRILQSRVYDVAVETPIHAAPLISKRIGNRVLLKREDLQPVFSFKLRGAYNKLC
CCHHHHHHHHHHHHHHEEECCCCCHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHH
QLNQEQLARGVICASAGNHAQGLALAASSMGVKAAIVMPRTTPDIKVSSVRRHGGKVVLH
CCCHHHHHCEEEEECCCCCCCCCEEEHHCCCCEEEEEECCCCCCCCHHHHHHCCCEEEEE
GDSFDEALAHALKLQERDNLTFVHPYDDPDVIAGQGTVGMEILRQQSRDLDAIFIPVGGG
CCCHHHHHHHHHHHHCCCCEEEECCCCCCCEEECCCCHHHHHHHHHCCCCCEEEEEECCC
GLAAGVAAYVKYVRPEVKVIAVEPEDAACLKAALEKKRRVTLSEVGLFADGVAVKQIGKE
HHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCHHHHCHHHCCHHHHHHHHH
TYKVLRDHVDEVITATTDEICAAIKDSFEDTRAICEPAGALALAGLKNWVAKHNVRDQTL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEE
VAIQSGANVNFDRLRHVSERAELGEQREAILAVTIPESPGAFRAFCQALGRRGITEFNYR
EEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCEECCCE
YSDDRDANIFVGIQLRPDGEALQALMNELQERGYPVVDMSGNEMAKLHIRHLVGGHTSRQ
ECCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCCCCHH
DLQERLFRVEFPERPGALMKFLQSLGEKWNISLFHYRNHGAAYGRVLVGFQVEEGRQSKL
HHHHHHHCCCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEEEEECCCCHHHH
LADLKKVPYPMVEESENPAYRLFLN
HHHHHHCCCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA