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The map label for this gene is ppx [H]

Identifier: 110835322

GI number: 110835322

Start: 2786919

End: 2788409

Strand: Reverse

Name: ppx [H]

Synonym: ABO_2461

Alternate gene names: 110835322

Gene position: 2788409-2786919 (Counterclockwise)

Preceding gene: 110835329

Following gene: 110835319

Centisome position: 89.37

GC content: 56.2

Gene sequence:

>1491_bases
ATGGAGCATGGCGAACATCTGGCTGCCATTGATTTGGGGTCGAACAGTTTTCATATGGTGGTAGCCCGACAAGCGCAGGG
AGAAATCCAGATTCTCGACGGGTTGTCGGAGAAGGTGCAATTGGGGGCCGGCCTAGACCGGGAAAATCGCTTGGATGAGG
AAACAGTGGAGAGGGCGCTGGAGTGCCTTGGCCGGTTTGCCCAACGGATTGCCGGAATTCCACGCGGTAGCGTGCGGGTG
GTGGGGACCAATACCCTGCGCCAAGCCCGTAATGCCCGGGATTTTATCCGCCGCGCGGAAGCCGTGTTGGGCCACGATAT
TGAGGTGGTAGCCGGACGAGAGGAAGCGCGGCTGATTTACCTGGGGGTGGCCCACACCTTGGCTGATGACGCTGGGCAGC
GGCTGGTGGTGGATATTGGCGGTGGTTCCACTGAGCTGATCATTGGTGAGCGGTTTGAATCCACGGAAACCGAGTCGTTG
CATATGGGCTGTGTTAGCTTTGCCCAGCGTTTTTTCCCCAATGGCGAGATCACGGAAAAAGCCTTTGATCGGGCGGTGAC
GGCGGCACGCCAGGAAGTGTTATCAATCCATGCCAATTATCAGCGCCTTGGCTGGCAGCAGGTGGTGGGGGCCTCGGGCA
CGATCAAGGCAATCAGCCTTGTGTGTGTGGAGAACGGTTGGTCGGAATTCGGCATTAGCATGGAAGGGATGAAAAAAGCC
CGTAAACGGGTGATTAAAGCTGGTGCCGCAGACAAGCTGGGATTGAAGGGGTTACGTGAGGATCGACAGCCTATTTTTGC
TTCTGGTCTGGCCATTTTGTACGGCATTTTCGAGCAGTTAGGCATTGAACAAATGGATGTTTCCAGTGGCGCTTTACGTG
AAGGGTTACTGTACGACTTACTGGGGCGCTTTGGTCACGAGGATGTGCGTGATCGCAGTATTCAAGCGCTGATGAATCGC
CATCATGTGGAAAGCAGCCAAGCAGAGCGAGTGTGTGCCACAGCCCAGACGTTATACCAGCAGGTAGCCAGTGATTGGCA
GATCGAGGGAGACGAGGCCGCGGATACGCTCCGTTGGGGCTGTTTGCTCCATGAGGTGGGATTGGCGGTGTCTCATAGCC
AGTTTCACAAACACGGTGCTTATCTGGTGACTAACTCGGATCTGCCCGGTTTTTCTCGTCAGGAGCAGCAAATGGTGGCG
TTGATGGTGCGCGGTCATCGTCGCAAGGTGCCCTTGGCTGCGCTGGCGGAATTGCCGGAGGATGAACAAACCTGCTTGCT
GCGACTATGTTTGGTACTGCGTTTAGCGGTGCGGTTGCACCATGCCCGTAGTGATGAAAAGGTGCCTGAAATTCACGTGC
AGGCAACGGGTAATCGTCTTGCCATTACCTTTCCGGTTGGCTGGTTGGAGCAGCACCCGCTTACCCAAGCGGACCTGGAG
CAGGAACTCGATTACTTTCAGGCGGCAGGGTACCAGCTGGTGTTGGCGTGA

Upstream 100 bases:

>100_bases
AGAATTTCAAGCGAGGTCGTTAATTATCGCTGTAGTCGCTGCCTATGACATCGTAACGCCATGATTTTTGGATAGAATTG
GCCCAAAAGAAGGAGTGACT

Downstream 100 bases:

>100_bases
AAGGAATCGCTGCGAGCCGCTAGCGATGAGGAAAATAGCCTTAAAATGGGGGGGCGCGCTTTAGCCGGCGCAACCCCTTT
AAAGTTAGAAGCTGTTCATC

Product: hypothetical protein

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MEHGEHLAAIDLGSNSFHMVVARQAQGEIQILDGLSEKVQLGAGLDRENRLDEETVERALECLGRFAQRIAGIPRGSVRV
VGTNTLRQARNARDFIRRAEAVLGHDIEVVAGREEARLIYLGVAHTLADDAGQRLVVDIGGGSTELIIGERFESTETESL
HMGCVSFAQRFFPNGEITEKAFDRAVTAARQEVLSIHANYQRLGWQQVVGASGTIKAISLVCVENGWSEFGISMEGMKKA
RKRVIKAGAADKLGLKGLREDRQPIFASGLAILYGIFEQLGIEQMDVSSGALREGLLYDLLGRFGHEDVRDRSIQALMNR
HHVESSQAERVCATAQTLYQQVASDWQIEGDEAADTLRWGCLLHEVGLAVSHSQFHKHGAYLVTNSDLPGFSRQEQQMVA
LMVRGHRRKVPLAALAELPEDEQTCLLRLCLVLRLAVRLHHARSDEKVPEIHVQATGNRLAITFPVGWLEQHPLTQADLE
QELDYFQAAGYQLVLA

Sequences:

>Translated_496_residues
MEHGEHLAAIDLGSNSFHMVVARQAQGEIQILDGLSEKVQLGAGLDRENRLDEETVERALECLGRFAQRIAGIPRGSVRV
VGTNTLRQARNARDFIRRAEAVLGHDIEVVAGREEARLIYLGVAHTLADDAGQRLVVDIGGGSTELIIGERFESTETESL
HMGCVSFAQRFFPNGEITEKAFDRAVTAARQEVLSIHANYQRLGWQQVVGASGTIKAISLVCVENGWSEFGISMEGMKKA
RKRVIKAGAADKLGLKGLREDRQPIFASGLAILYGIFEQLGIEQMDVSSGALREGLLYDLLGRFGHEDVRDRSIQALMNR
HHVESSQAERVCATAQTLYQQVASDWQIEGDEAADTLRWGCLLHEVGLAVSHSQFHKHGAYLVTNSDLPGFSRQEQQMVA
LMVRGHRRKVPLAALAELPEDEQTCLLRLCLVLRLAVRLHHARSDEKVPEIHVQATGNRLAITFPVGWLEQHPLTQADLE
QELDYFQAAGYQLVLA
>Mature_496_residues
MEHGEHLAAIDLGSNSFHMVVARQAQGEIQILDGLSEKVQLGAGLDRENRLDEETVERALECLGRFAQRIAGIPRGSVRV
VGTNTLRQARNARDFIRRAEAVLGHDIEVVAGREEARLIYLGVAHTLADDAGQRLVVDIGGGSTELIIGERFESTETESL
HMGCVSFAQRFFPNGEITEKAFDRAVTAARQEVLSIHANYQRLGWQQVVGASGTIKAISLVCVENGWSEFGISMEGMKKA
RKRVIKAGAADKLGLKGLREDRQPIFASGLAILYGIFEQLGIEQMDVSSGALREGLLYDLLGRFGHEDVRDRSIQALMNR
HHVESSQAERVCATAQTLYQQVASDWQIEGDEAADTLRWGCLLHEVGLAVSHSQFHKHGAYLVTNSDLPGFSRQEQQMVA
LMVRGHRRKVPLAALAELPEDEQTCLLRLCLVLRLAVRLHHARSDEKVPEIHVQATGNRLAITFPVGWLEQHPLTQADLE
QELDYFQAAGYQLVLA

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=496, Percent_Identity=44.1532258064516, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI48994966, Length=478, Percent_Identity=42.0502092050209, Blast_Score=369, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 54867; Mature: 54867

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHGEHLAAIDLGSNSFHMVVARQAQGEIQILDGLSEKVQLGAGLDRENRLDEETVERAL
CCCCCEEEEEEECCCCEEEEEEECCCCCEEEECCCHHHHHHCCCCCCCCCCCHHHHHHHH
ECLGRFAQRIAGIPRGSVRVVGTNTLRQARNARDFIRRAEAVLGHDIEVVAGREEARLIY
HHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEE
LGVAHTLADDAGQRLVVDIGGGSTELIIGERFESTETESLHMGCVSFAQRFFPNGEITEK
EEHHHHHHCCCCCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCHHHH
AFDRAVTAARQEVLSIHANYQRLGWQQVVGASGTIKAISLVCVENGWSEFGISMEGMKKA
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCEEEEEEEEEECCHHHHCCCHHHHHHH
RKRVIKAGAADKLGLKGLREDRQPIFASGLAILYGIFEQLGIEQMDVSSGALREGLLYDL
HHHHHHCCCCCHHCCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
LGRFGHEDVRDRSIQALMNRHHVESSQAERVCATAQTLYQQVASDWQIEGDEAADTLRWG
HHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
CLLHEVGLAVSHSQFHKHGAYLVTNSDLPGFSRQEQQMVALMVRGHRRKVPLAALAELPE
HHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCC
DEQTCLLRLCLVLRLAVRLHHARSDEKVPEIHVQATGNRLAITFPVGWLEQHPLTQADLE
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEECCCHHCCCCCCHHHHH
QELDYFQAAGYQLVLA
HHHHHHHHCCEEEEEC
>Mature Secondary Structure
MEHGEHLAAIDLGSNSFHMVVARQAQGEIQILDGLSEKVQLGAGLDRENRLDEETVERAL
CCCCCEEEEEEECCCCEEEEEEECCCCCEEEECCCHHHHHHCCCCCCCCCCCHHHHHHHH
ECLGRFAQRIAGIPRGSVRVVGTNTLRQARNARDFIRRAEAVLGHDIEVVAGREEARLIY
HHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEE
LGVAHTLADDAGQRLVVDIGGGSTELIIGERFESTETESLHMGCVSFAQRFFPNGEITEK
EEHHHHHHCCCCCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCHHHH
AFDRAVTAARQEVLSIHANYQRLGWQQVVGASGTIKAISLVCVENGWSEFGISMEGMKKA
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCEEEEEEEEEECCHHHHCCCHHHHHHH
RKRVIKAGAADKLGLKGLREDRQPIFASGLAILYGIFEQLGIEQMDVSSGALREGLLYDL
HHHHHHCCCCCHHCCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
LGRFGHEDVRDRSIQALMNRHHVESSQAERVCATAQTLYQQVASDWQIEGDEAADTLRWG
HHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
CLLHEVGLAVSHSQFHKHGAYLVTNSDLPGFSRQEQQMVALMVRGHRRKVPLAALAELPE
HHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCC
DEQTCLLRLCLVLRLAVRLHHARSDEKVPEIHVQATGNRLAITFPVGWLEQHPLTQADLE
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEECCCHHCCCCCCHHHHH
QELDYFQAAGYQLVLA
HHHHHHHHCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]