BacMap

Definition	Alcanivorax borkumensis SK2 chromosome, complete genome.
Accession	NC_008260
Length	3,120,143

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The map label for this gene is AKR1A1 [C]

Identifier: 110835275

GI number: 110835275

Start: 2733269

End: 2734222

Strand: Direct

Name: AKR1A1 [C]

Synonym: ABO_2414

Alternate gene names: 110835275

Gene position: 2733269-2734222 (Clockwise)

Preceding gene: 110835273

Following gene: 110835276

Centisome position: 87.6

GC content: 54.19

Gene sequence:

>954_bases
ATGAAAACGCTGACTTTCGAAAATGGTGACACCCTACCCATGCTGGGCCTGGGCACCTGGAAATCCGCTCCCGGCGAGGT
GTACAACGCCGTCAGAAGCGCCATTGAGATGGGTTATCGGCATATCGACTGTGCCCATATTTATGGCAACGAGGACGAAA
TCGGCAGAGCCCTAAGCGATGTATTGTCCGCCGGCACAGTAACCCGCGAACAATTGTGGATTACCTCAAAACTGTGGAAC
AGTGACCATGCCCCCGAGGATGTTCAGCCCGCACTGGAAACCACCTTACGTAACCTGCAGCTGGATTATCTCGACCTTTA
TCTCATGCACTGGCCGGTCGCTCTGAAGCCGGGCGTATCCTTTCCTGAATCTGCCGACGACATGGTGTCACTGAACGATT
TACCGGTGGAAACCACCTGGGCGGCCATGGAAGCGCTGGTGGACAACAATCTGACTCGGCAGATCGGCGTGTCGAATTTC
AGCGTAAAAAAACTGCAGGATTTAATAGGCAAGGCACAACGCAAACCCGCCATGAACCAAGTAGAGCTACATCCTTATTT
GCAACAACAGAGCATGCTGGATTTCTGCCAACAACAAGGCATCCATCTCACGGCCTATGCTCCACTGGGCTCATCCGATC
GCCCCGCTGGCTTAAAAGCTGAGGGCGAACCGGCACTGCTGGAAGACCCGATTATCCATGAGATTGCTGACCGTCATCGT
GCCAGCCCGGCTCAAGTGTTGATCAGCTGGGCTCTACATCGCAACACAGCGGTAATCCCCAAATCGGTTAACCCGGAGCG
CCTAAAACAAAACCTGGCTGCCGAGGAACTGACCCTCAGCGACGAGGACATGGATGCCATTCGCTCACTGGACAAGCATC
GCCGTTACGTGGACGGTGGTTTCTGGGCACAACCGGGCAGCGATTACACTGTCGCTAATCTTTGGGATGATTGA

Upstream 100 bases:

>100_bases
CTGCCGGGAATCAAACCAGGATTCATCAGGAACCCAACCGCCACTGGCAAAGTCCCACTATCAGAAACGCAAATACACAC
AGGCTTAACAGGAGCAGACC

Downstream 100 bases:

>100_bases
CGCTAGCAAAAAAATCGAGGGGTTTTTGTAACGCCGTGGCCGGCACCTGCATCTACTGGCATTGATTTCCCACACTCCAT
TATCAGGGAGCCACTGAAAA

Product: aldehyde reductase

Products: aldehyde; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MKTLTFENGDTLPMLGLGTWKSAPGEVYNAVRSAIEMGYRHIDCAHIYGNEDEIGRALSDVLSAGTVTREQLWITSKLWN
SDHAPEDVQPALETTLRNLQLDYLDLYLMHWPVALKPGVSFPESADDMVSLNDLPVETTWAAMEALVDNNLTRQIGVSNF
SVKKLQDLIGKAQRKPAMNQVELHPYLQQQSMLDFCQQQGIHLTAYAPLGSSDRPAGLKAEGEPALLEDPIIHEIADRHR
ASPAQVLISWALHRNTAVIPKSVNPERLKQNLAAEELTLSDEDMDAIRSLDKHRRYVDGGFWAQPGSDYTVANLWDD

Sequences:

>Translated_317_residues
MKTLTFENGDTLPMLGLGTWKSAPGEVYNAVRSAIEMGYRHIDCAHIYGNEDEIGRALSDVLSAGTVTREQLWITSKLWN
SDHAPEDVQPALETTLRNLQLDYLDLYLMHWPVALKPGVSFPESADDMVSLNDLPVETTWAAMEALVDNNLTRQIGVSNF
SVKKLQDLIGKAQRKPAMNQVELHPYLQQQSMLDFCQQQGIHLTAYAPLGSSDRPAGLKAEGEPALLEDPIIHEIADRHR
ASPAQVLISWALHRNTAVIPKSVNPERLKQNLAAEELTLSDEDMDAIRSLDKHRRYVDGGFWAQPGSDYTVANLWDD
>Mature_317_residues
MKTLTFENGDTLPMLGLGTWKSAPGEVYNAVRSAIEMGYRHIDCAHIYGNEDEIGRALSDVLSAGTVTREQLWITSKLWN
SDHAPEDVQPALETTLRNLQLDYLDLYLMHWPVALKPGVSFPESADDMVSLNDLPVETTWAAMEALVDNNLTRQIGVSNF
SVKKLQDLIGKAQRKPAMNQVELHPYLQQQSMLDFCQQQGIHLTAYAPLGSSDRPAGLKAEGEPALLEDPIIHEIADRHR
ASPAQVLISWALHRNTAVIPKSVNPERLKQNLAAEELTLSDEDMDAIRSLDKHRRYVDGGFWAQPGSDYTVANLWDD

Specific function: Reduction [C]

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase family [H]

Homologues:

Organism=Homo sapiens, GI24497577, Length=297, Percent_Identity=47.4747474747475, Blast_Score=297, Evalue=1e-80,
Organism=Homo sapiens, GI5174391, Length=297, Percent_Identity=47.4747474747475, Blast_Score=297, Evalue=1e-80,
Organism=Homo sapiens, GI4502049, Length=295, Percent_Identity=48.8135593220339, Blast_Score=261, Evalue=6e-70,
Organism=Homo sapiens, GI223468663, Length=287, Percent_Identity=46.3414634146341, Blast_Score=259, Evalue=2e-69,
Organism=Homo sapiens, GI310109920, Length=312, Percent_Identity=41.025641025641, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI45446745, Length=312, Percent_Identity=41.025641025641, Blast_Score=253, Evalue=1e-67,
Organism=Homo sapiens, GI4503285, Length=312, Percent_Identity=41.025641025641, Blast_Score=253, Evalue=1e-67,
Organism=Homo sapiens, GI5453543, Length=312, Percent_Identity=40.7051282051282, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI5174695, Length=306, Percent_Identity=40.5228758169935, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI24497583, Length=318, Percent_Identity=40.251572327044, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI24497585, Length=302, Percent_Identity=40.0662251655629, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI93277124, Length=309, Percent_Identity=40.7766990291262, Blast_Score=238, Evalue=8e-63,
Organism=Homo sapiens, GI310109922, Length=311, Percent_Identity=39.5498392282958, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI291291012, Length=278, Percent_Identity=43.8848920863309, Blast_Score=232, Evalue=3e-61,
Organism=Homo sapiens, GI300116273, Length=276, Percent_Identity=41.6666666666667, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI300116271, Length=304, Percent_Identity=35.1973684210526, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI310109926, Length=123, Percent_Identity=47.1544715447154, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI207028673, Length=120, Percent_Identity=48.3333333333333, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI310109924, Length=165, Percent_Identity=38.7878787878788, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI87082198, Length=293, Percent_Identity=36.518771331058, Blast_Score=194, Evalue=4e-51,
Organism=Escherichia coli, GI1786400, Length=290, Percent_Identity=36.2068965517241, Blast_Score=178, Evalue=4e-46,
Organism=Escherichia coli, GI1788081, Length=295, Percent_Identity=31.1864406779661, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1788070, Length=335, Percent_Identity=21.7910447761194, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787674, Length=321, Percent_Identity=22.7414330218069, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17537077, Length=299, Percent_Identity=39.4648829431438, Blast_Score=244, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI17537075, Length=299, Percent_Identity=39.1304347826087, Blast_Score=242, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17564128, Length=306, Percent_Identity=39.2156862745098, Blast_Score=224, Evalue=6e-59,
Organism=Caenorhabditis elegans, GI17550248, Length=300, Percent_Identity=36.6666666666667, Blast_Score=209, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17566692, Length=308, Percent_Identity=33.1168831168831, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17552492, Length=282, Percent_Identity=34.3971631205674, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17537079, Length=302, Percent_Identity=31.1258278145695, Blast_Score=174, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI17561298, Length=296, Percent_Identity=30.7432432432432, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71998625, Length=298, Percent_Identity=35.2348993288591, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17538386, Length=301, Percent_Identity=30.2325581395349, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17561300, Length=302, Percent_Identity=31.1258278145695, Blast_Score=158, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17562292, Length=296, Percent_Identity=29.0540540540541, Blast_Score=147, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI17550246, Length=77, Percent_Identity=45.4545454545455, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324694, Length=304, Percent_Identity=41.7763157894737, Blast_Score=237, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6320576, Length=310, Percent_Identity=39.0322580645161, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6321896, Length=316, Percent_Identity=38.2911392405063, Blast_Score=215, Evalue=8e-57,
Organism=Saccharomyces cerevisiae, GI6319625, Length=320, Percent_Identity=33.4375, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6322556, Length=297, Percent_Identity=30.6397306397306, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6320079, Length=303, Percent_Identity=29.3729372937294, Blast_Score=126, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24662789, Length=303, Percent_Identity=43.5643564356436, Blast_Score=254, Evalue=6e-68,
Organism=Drosophila melanogaster, GI24644950, Length=312, Percent_Identity=42.6282051282051, Blast_Score=250, Evalue=8e-67,
Organism=Drosophila melanogaster, GI221378297, Length=329, Percent_Identity=40.7294832826748, Blast_Score=245, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24662781, Length=295, Percent_Identity=44.0677966101695, Blast_Score=230, Evalue=8e-61,
Organism=Drosophila melanogaster, GI24657054, Length=279, Percent_Identity=41.2186379928315, Blast_Score=228, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24662785, Length=291, Percent_Identity=43.6426116838488, Blast_Score=224, Evalue=6e-59,
Organism=Drosophila melanogaster, GI21356425, Length=293, Percent_Identity=38.9078498293515, Blast_Score=214, Evalue=5e-56,
Organism=Drosophila melanogaster, GI24663317, Length=298, Percent_Identity=37.248322147651, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI20129731, Length=311, Percent_Identity=35.048231511254, Blast_Score=199, Evalue=1e-51,
Organism=Drosophila melanogaster, GI45553081, Length=299, Percent_Identity=34.7826086956522, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI281366140, Length=265, Percent_Identity=34.3396226415094, Blast_Score=159, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.1.1.2

Molecular weight: Translated: 35394; Mature: 35394

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLTFENGDTLPMLGLGTWKSAPGEVYNAVRSAIEMGYRHIDCAHIYGNEDEIGRALSD
CCEEECCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHH
VLSAGTVTREQLWITSKLWNSDHAPEDVQPALETTLRNLQLDYLDLYLMHWPVALKPGVS
HHHCCCCCHHHHEEHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCEEECCCCC
FPESADDMVSLNDLPVETTWAAMEALVDNNLTRQIGVSNFSVKKLQDLIGKAQRKPAMNQ
CCCCCCCEEECCCCCCHHHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCC
VELHPYLQQQSMLDFCQQQGIHLTAYAPLGSSDRPAGLKAEGEPALLEDPIIHEIADRHR
EECCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
ASPAQVLISWALHRNTAVIPKSVNPERLKQNLAAEELTLSDEDMDAIRSLDKHRRYVDGG
CCHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
FWAQPGSDYTVANLWDD
CCCCCCCCEEEECCCCC
>Mature Secondary Structure
MKTLTFENGDTLPMLGLGTWKSAPGEVYNAVRSAIEMGYRHIDCAHIYGNEDEIGRALSD
CCEEECCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHH
VLSAGTVTREQLWITSKLWNSDHAPEDVQPALETTLRNLQLDYLDLYLMHWPVALKPGVS
HHHCCCCCHHHHEEHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCEEECCCCC
FPESADDMVSLNDLPVETTWAAMEALVDNNLTRQIGVSNFSVKKLQDLIGKAQRKPAMNQ
CCCCCCCEEECCCCCCHHHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCC
VELHPYLQQQSMLDFCQQQGIHLTAYAPLGSSDRPAGLKAEGEPALLEDPIIHEIADRHR
EECCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
ASPAQVLISWALHRNTAVIPKSVNPERLKQNLAAEELTLSDEDMDAIRSLDKHRRYVDGG
CCHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
FWAQPGSDYTVANLWDD
CCCCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NADP+

Specific reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA