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The map label for this gene is lpxL1 [H]

Identifier: 110835153

GI number: 110835153

Start: 2613897

End: 2614811

Strand: Direct

Name: lpxL1 [H]

Synonym: ABO_2292

Alternate gene names: 110835153

Gene position: 2613897-2614811 (Clockwise)

Preceding gene: 110835152

Following gene: 110835165

Centisome position: 83.77

GC content: 54.32

Gene sequence:

>915_bases
ATGGGAAAACGCATCAACCGACCTTCACGCCTCTCCGATCCGCGCCTATACCCTAGCTGGCTAGGCGTCGGGCTATTCTG
GCTAGTCGGCCAGCTACCGTGGACTGTTTTATTGGCCGCGGGTCGTGGACTGGGCCACCTTGCCTGGCATCTGACAAAAA
AACGCCGCCATGTTGTTCAGACCAACATTCGGTTTTGCTTCCCAGAATTAAGTGCCGAAGAGCAAGAAACCTTAGCCAGG
CGCTGCATGGTCAGCACCGGCGAAGCCATTCTGGAAATGGCCGGAAGCTTCAGCAACCACCGCATCAACCTTAATAACCG
CCTGACTATCAATGGCTTAGAGCATGTCCGCAATGCCCAAGCCGCAGGGCAAGGGGTGTTGTTACTGGGCATGCATTTCA
ACAGCATAGATGTGGGGTCGCGGTTACTGAGTTGCGCATTTGATATGAATGCAGTCTATCGCCCCAACGATAACCTGGTG
ATTGATCGCTTGATCAATAAGGGACGCCTGAACTACATGAAAGGCATCGTTAAGCGCACAGATATTCGACATATCGTTCG
CTTGCTCAGAAAGGGAGACATAGTGTGGTATGCCCCGGATCAGGATTACGGCACCGCCCACGCGGTATTTGTGCCTTTTT
TTGGCGTGCCCGCAGCGACCATTACCGCCACCAGCCGCATCGCCCGCATGGGCAAGGCCGCCGTCATTCCCTGCGCGCAC
TACCGCCTACCCGGCGGCCGCTACGAAATCGAATTCGGCCCGGCGCTTGAAGATTTTCCCAGTGGCGACGATAAAGCGGA
TACAGCTCGGGTTAATAGCACAATTGAGCACTATGTGCGCAAGCATCCCGAGCAGTATCTCTGGGTTCACAAGCGGTTTA
AACACCAAAAGAACGGACAATCGCCCTATAAGTAA

Upstream 100 bases:

>100_bases
TTCCATGCCAGCTGGCTTAGCCTTTGGCTCCCTTTAGCGCTTCTGCTGGCCCGACTCAGCGAGCGCCCAAGCATCCATCC
CAACAGTCGTTGAGATTACC

Downstream 100 bases:

>100_bases
ACCTACTTTCTGACCAGCACCACCACCACGCTATTTCCCGAACTATCGAATACTTTCTCCAAGGAAAAGCGCGGTTCTTG
CAACGCAAGAAGTCGATCTT

Product: lipid A biosynthesis lauroyl acyltransferase

Products: NA

Alternate protein names: Heat shock protein B [H]

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MGKRINRPSRLSDPRLYPSWLGVGLFWLVGQLPWTVLLAAGRGLGHLAWHLTKKRRHVVQTNIRFCFPELSAEEQETLAR
RCMVSTGEAILEMAGSFSNHRINLNNRLTINGLEHVRNAQAAGQGVLLLGMHFNSIDVGSRLLSCAFDMNAVYRPNDNLV
IDRLINKGRLNYMKGIVKRTDIRHIVRLLRKGDIVWYAPDQDYGTAHAVFVPFFGVPAATITATSRIARMGKAAVIPCAH
YRLPGGRYEIEFGPALEDFPSGDDKADTARVNSTIEHYVRKHPEQYLWVHKRFKHQKNGQSPYK

Sequences:

>Translated_304_residues
MGKRINRPSRLSDPRLYPSWLGVGLFWLVGQLPWTVLLAAGRGLGHLAWHLTKKRRHVVQTNIRFCFPELSAEEQETLAR
RCMVSTGEAILEMAGSFSNHRINLNNRLTINGLEHVRNAQAAGQGVLLLGMHFNSIDVGSRLLSCAFDMNAVYRPNDNLV
IDRLINKGRLNYMKGIVKRTDIRHIVRLLRKGDIVWYAPDQDYGTAHAVFVPFFGVPAATITATSRIARMGKAAVIPCAH
YRLPGGRYEIEFGPALEDFPSGDDKADTARVNSTIEHYVRKHPEQYLWVHKRFKHQKNGQSPYK
>Mature_303_residues
GKRINRPSRLSDPRLYPSWLGVGLFWLVGQLPWTVLLAAGRGLGHLAWHLTKKRRHVVQTNIRFCFPELSAEEQETLARR
CMVSTGEAILEMAGSFSNHRINLNNRLTINGLEHVRNAQAAGQGVLLLGMHFNSIDVGSRLLSCAFDMNAVYRPNDNLVI
DRLINKGRLNYMKGIVKRTDIRHIVRLLRKGDIVWYAPDQDYGTAHAVFVPFFGVPAATITATSRIARMGKAAVIPCAHY
RLPGGRYEIEFGPALEDFPSGDDKADTARVNSTIEHYVRKHPEQYLWVHKRFKHQKNGQSPYK

Specific function: Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA. Has 10 fold selectivity for lauroyl- ACP over myristoyl-ACP [H]

COG id: COG1560

COG function: function code M; Lauroyl/myristoyl acyltransferase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the htrB/msbB family [H]

Homologues:

Organism=Escherichia coli, GI1787292, Length=296, Percent_Identity=39.527027027027, Blast_Score=221, Evalue=6e-59,
Organism=Escherichia coli, GI87082094, Length=292, Percent_Identity=35.2739726027397, Blast_Score=198, Evalue=4e-52,
Organism=Escherichia coli, GI1788161, Length=295, Percent_Identity=29.4915254237288, Blast_Score=125, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004960
- InterPro:   IPR011920 [H]

Pfam domain/function: PF03279 Lip_A_acyltrans [H]

EC number: 2.3.1.-

Molecular weight: Translated: 34433; Mature: 34302

Theoretical pI: Translated: 10.50; Mature: 10.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKRINRPSRLSDPRLYPSWLGVGLFWLVGQLPWTVLLAAGRGLGHLAWHLTKKRRHVVQ
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
TNIRFCFPELSAEEQETLARRCMVSTGEAILEMAGSFSNHRINLNNRLTINGLEHVRNAQ
HCCEEECCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCCCCEEECCCEEEECHHHHHHHHH
AAGQGVLLLGMHFNSIDVGSRLLSCAFDMNAVYRPNDNLVIDRLINKGRLNYMKGIVKRT
HCCCCEEEEEEECCCHHHHHHHHHHHHCCCCEECCCCCEEHHHHHCCCHHHHHHHHHHHH
DIRHIVRLLRKGDIVWYAPDQDYGTAHAVFVPFFGVPAATITATSRIARMGKAAVIPCAH
HHHHHHHHHHHCCEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEHHH
YRLPGGRYEIEFGPALEDFPSGDDKADTARVNSTIEHYVRKHPEQYLWVHKRFKHQKNGQ
EECCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
SPYK
CCCC
>Mature Secondary Structure 
GKRINRPSRLSDPRLYPSWLGVGLFWLVGQLPWTVLLAAGRGLGHLAWHLTKKRRHVVQ
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
TNIRFCFPELSAEEQETLARRCMVSTGEAILEMAGSFSNHRINLNNRLTINGLEHVRNAQ
HCCEEECCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCCCCEEECCCEEEECHHHHHHHHH
AAGQGVLLLGMHFNSIDVGSRLLSCAFDMNAVYRPNDNLVIDRLINKGRLNYMKGIVKRT
HCCCCEEEEEEECCCHHHHHHHHHHHHCCCCEECCCCCEEHHHHHCCCHHHHHHHHHHHH
DIRHIVRLLRKGDIVWYAPDQDYGTAHAVFVPFFGVPAATITATSRIARMGKAAVIPCAH
HHHHHHHHHHHCCEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEHHH
YRLPGGRYEIEFGPALEDFPSGDDKADTARVNSTIEHYVRKHPEQYLWVHKRFKHQKNGQ
EECCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
SPYK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]