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The map label for this gene is mutY [H]

Identifier: 110835146

GI number: 110835146

Start: 2605587

End: 2606663

Strand: Direct

Name: mutY [H]

Synonym: ABO_2285

Alternate gene names: 110835146

Gene position: 2605587-2606663 (Clockwise)

Preceding gene: 110835145

Following gene: 110835147

Centisome position: 83.51

GC content: 60.82

Gene sequence:

>1077_bases
ATGCCTAAATACTCATTGAGTCCCGAGCATTTCAGCCAGGCGCTGCTCGACTGGTACGACCAGCATGGCCGCCAAGACCT
TCCTTGGCAGCACCCTCGCACGCCTTATCAGGTGTGGATATCGGAAATCATGCTGCAACAAACCCAAGTGAACACGGTGA
TTCCCTACTTCCAGCGGTTCATGGAGCACTTTCCGGATGTCAAAACGCTGGCGCTGGCCAAACAGGATGAAGTCCTACAC
CTGTGGACCGGCCTCGGCTACTACGCCCGCGCCCGCAACCTCCACAAATGTGCGCAGCAATTACTGGAGAACTACGCAGG
TGATTTCCCCAACACCGTAGAAGAAGTGGCCACACTCCCCGGCATCGGCCCCTCCACGGCTGGGGCTATCCTTGCCCAGA
GCCGCGGCATTCGCGCTCCCATCCTCGACGGCAACGTTAAACGGGTGCTGGCCCGACTGCATGCCGTACCTGGCTGGCCC
GGCAAGAAACCTGTGGAAAGCCGGCTATGGGAGCTGGCCGAGCACTACACACCCGACCACCGACTGGCAGACTACACCCA
GGCGATCATGGACCTGGGAGCGACCCTGTGTCGACGCAGCACCCCCGACTGCACCGCCTGCCCAGTGAAAACCGGGTGCC
AAGCCCATGCCAACGGCAACCCCCAGGACTACCCCGGCAAAAAGCCGAAAAAAACCCTGCCGGTGCGCACCACCGTCATG
CTTATCTTGCGTGACAGGGAGGGTCAGGTCTGGCTGGAACAGCGCCCCCAGCAAGGCATCTGGGGCGGCCTGTGGTGCTT
CCCGCAAACCTGTGCCATGGAACAGGTACACCATGCCCTTCAAACCCGCGCTTTTGATGCCCGTGGCGACACCCAACAGC
TGCCCCCCTTTCGGCACACTTTCAGCCACTACCACCTGGATATCGAGCCGCTGGAAGTGGCCGTGGACACAGCCGGCCCC
TGTGACAATAATGGCCGCTGGGTAAACCCACAAAACCCCGGGAAATTGGGGCTGGCAGCCCCTGTGAAAAAGCTGCTAGC
CAGCTTGTCCGCACCACGGCAAGCCCGCATGTTATAG

Upstream 100 bases:

>100_bases
ACCGCGGTGTATTTCACACGCACGCGGCCGCTAAACCGAACCGCAATCGTAGGGCGAAAGCAAACCAACGTCAGCTTTCG
CCCTACCCACCCGGAAGTCC

Downstream 100 bases:

>100_bases
TCGCCCCAAACCTCCATTCAGACCAAGCATTCCCACGGAGACGTTATGAGCCGCACGGTTTTCTGCCGCAAATACCAAAG
CGACATGGAAGGTCTGCCCC

Product: A/G specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MPKYSLSPEHFSQALLDWYDQHGRQDLPWQHPRTPYQVWISEIMLQQTQVNTVIPYFQRFMEHFPDVKTLALAKQDEVLH
LWTGLGYYARARNLHKCAQQLLENYAGDFPNTVEEVATLPGIGPSTAGAILAQSRGIRAPILDGNVKRVLARLHAVPGWP
GKKPVESRLWELAEHYTPDHRLADYTQAIMDLGATLCRRSTPDCTACPVKTGCQAHANGNPQDYPGKKPKKTLPVRTTVM
LILRDREGQVWLEQRPQQGIWGGLWCFPQTCAMEQVHHALQTRAFDARGDTQQLPPFRHTFSHYHLDIEPLEVAVDTAGP
CDNNGRWVNPQNPGKLGLAAPVKKLLASLSAPRQARML

Sequences:

>Translated_358_residues
MPKYSLSPEHFSQALLDWYDQHGRQDLPWQHPRTPYQVWISEIMLQQTQVNTVIPYFQRFMEHFPDVKTLALAKQDEVLH
LWTGLGYYARARNLHKCAQQLLENYAGDFPNTVEEVATLPGIGPSTAGAILAQSRGIRAPILDGNVKRVLARLHAVPGWP
GKKPVESRLWELAEHYTPDHRLADYTQAIMDLGATLCRRSTPDCTACPVKTGCQAHANGNPQDYPGKKPKKTLPVRTTVM
LILRDREGQVWLEQRPQQGIWGGLWCFPQTCAMEQVHHALQTRAFDARGDTQQLPPFRHTFSHYHLDIEPLEVAVDTAGP
CDNNGRWVNPQNPGKLGLAAPVKKLLASLSAPRQARML
>Mature_357_residues
PKYSLSPEHFSQALLDWYDQHGRQDLPWQHPRTPYQVWISEIMLQQTQVNTVIPYFQRFMEHFPDVKTLALAKQDEVLHL
WTGLGYYARARNLHKCAQQLLENYAGDFPNTVEEVATLPGIGPSTAGAILAQSRGIRAPILDGNVKRVLARLHAVPGWPG
KKPVESRLWELAEHYTPDHRLADYTQAIMDLGATLCRRSTPDCTACPVKTGCQAHANGNPQDYPGKKPKKTLPVRTTVML
ILRDREGQVWLEQRPQQGIWGGLWCFPQTCAMEQVHHALQTRAFDARGDTQQLPPFRHTFSHYHLDIEPLEVAVDTAGPC
DNNGRWVNPQNPGKLGLAAPVKKLLASLSAPRQARML

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI6912520, Length=400, Percent_Identity=31.5, Blast_Score=184, Evalue=9e-47,
Organism=Homo sapiens, GI115298648, Length=400, Percent_Identity=31.5, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI115298650, Length=400, Percent_Identity=31.5, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI115298654, Length=400, Percent_Identity=31.5, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI115298652, Length=400, Percent_Identity=31.5, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI190358497, Length=402, Percent_Identity=31.592039800995, Blast_Score=184, Evalue=1e-46,
Organism=Escherichia coli, GI1789331, Length=346, Percent_Identity=57.2254335260116, Blast_Score=390, Evalue=1e-110,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 40403; Mature: 40271

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKYSLSPEHFSQALLDWYDQHGRQDLPWQHPRTPYQVWISEIMLQQTQVNTVIPYFQRF
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MEHFPDVKTLALAKQDEVLHLWTGLGYYARARNLHKCAQQLLENYAGDFPNTVEEVATLP
HHHCCCHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
GIGPSTAGAILAQSRGIRAPILDGNVKRVLARLHAVPGWPGKKPVESRLWELAEHYTPDH
CCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCH
RLADYTQAIMDLGATLCRRSTPDCTACPVKTGCQAHANGNPQDYPGKKPKKTLPVRTTVM
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEE
LILRDREGQVWLEQRPQQGIWGGLWCFPQTCAMEQVHHALQTRAFDARGDTQQLPPFRHT
EEEECCCCCCHHHCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
FSHYHLDIEPLEVAVDTAGPCDNNGRWVNPQNPGKLGLAAPVKKLLASLSAPRQARML
HHHHCCCCCHHEEEEECCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHCCCHHHCCC
>Mature Secondary Structure 
PKYSLSPEHFSQALLDWYDQHGRQDLPWQHPRTPYQVWISEIMLQQTQVNTVIPYFQRF
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MEHFPDVKTLALAKQDEVLHLWTGLGYYARARNLHKCAQQLLENYAGDFPNTVEEVATLP
HHHCCCHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
GIGPSTAGAILAQSRGIRAPILDGNVKRVLARLHAVPGWPGKKPVESRLWELAEHYTPDH
CCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCH
RLADYTQAIMDLGATLCRRSTPDCTACPVKTGCQAHANGNPQDYPGKKPKKTLPVRTTVM
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEE
LILRDREGQVWLEQRPQQGIWGGLWCFPQTCAMEQVHHALQTRAFDARGDTQQLPPFRHT
EEEECCCCCCHHHCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
FSHYHLDIEPLEVAVDTAGPCDNNGRWVNPQNPGKLGLAAPVKKLLASLSAPRQARML
HHHHCCCCCHHEEEEECCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]