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The map label for this gene is acdA [C]

Identifier: 110835084

GI number: 110835084

Start: 2536393

End: 2537637

Strand: Direct

Name: acdA [C]

Synonym: ABO_2223

Alternate gene names: 110835084

Gene position: 2536393-2537637 (Clockwise)

Preceding gene: 110835083

Following gene: 110835085

Centisome position: 81.29

GC content: 53.98

Gene sequence:

>1245_bases
ATGATCCAGTGGTCCGAACAACAGCAAATGATCCAGAAAATGGTGCGCGACTTTGTAGAAAAAGAAATTGTGCCGCAGCT
GGACGATATCGAATACAACGGCGTTCCCCCTTACGACATCCTGCGCAAAATGATCAAAACCTTCGGCATGGATGTGATGG
CCAAGCAATCGTTCGACAAACAGATTGCCCGCGAGAAAGCCATCGCCGCCGGTAACGCCGGGGAAGAAAAAAAGAAAAAA
GAAGGCCCTTCCGCCATGGCCGGCGAAGAAGCCGCCATGCGCATGATCCCCATTATTGAACTGTGCAAGCATGCCCAAGG
CTTGGTCACCGCCATGGGGGTTTCCATGGGGTTAGGTGGTGGCGCCATCATGAGCAAGGGCACCACTGAGCAAAAAGAGC
GCTGGGCTCTGCCTCTGCTCACATTGGAAAAGGTCGGTGCCTGGGCCATTTCAGAGCCCAATGCCGGCTCCGATGCCTTT
GGGCAAATGAAAACCTTGGCTAAACGCGACGGTAACGGCGGCTACATCATTAACGGTAGCAAAACGTGGATTACCAACGG
CCCCTATGCGGACACCATCATCCTGATCTGCAAACTGGATGAAGAAGGGGTCCCTGCTGACCAACGTAAGATCGTATCTT
TTATTCTCGATAGCGGCATGGAAGGTCTGACCCAATCCAAGCCCTTCAAGAAAATGGGCATCGGCTCCTCCCCCACAGGC
GAACTATTCCTTACCGATGTAAAAGCTGGACCGGAACGCCTGCTGGGCGGCAATGAAGACAGTTATGGCCGCAGCGGCGC
CAAAGGCACCTTCATGCAAGAGAGGGCTGGCGTCGCGGCCATGGCCTTAGGCATGGTGGAACGTGCCCTTGAGCTAAGCA
CCCAATATGCCAGCGACCGAGTTCAATTCGGCCGAGCCATCGGGCAGAACCAACTTATTCAGTTGAAATTGGCCAAGATG
GAAGTGGCACGCACCAACCTGCAAAACATGATTTTCCGCTATATTGAAATGACCGCCGAAGGTGCGCAGATGACATTGGC
CGAAGCCTCTGCCATGAAACTCTACGCTGCCCAGGCCGCCATGGAAGTGGCCACCGAAGCGGTACAGATCCATGGCGGCT
ACGGCTACATGCGCGAATCTCGAGTAGAACAATTAATGCGTGATGCCAAAATTCTACAGATCTATGCCGGCACCGATGAG
ATGCAAATTATCGCCATCGCTCGGGACTTGCTCGGCCGCGTATAA

Upstream 100 bases:

>100_bases
CCCTGACATCCAGCGTCAATCATTCCGTTCTTTTGATCAATGCATCACCGTCATCGGGCTTGTTACAGTTGATTGAATTT
CCACTCAACAGGACAGCCCG

Downstream 100 bases:

>100_bases
ACCGCGCTCGCTCCATCCATGTGAACGATTCCCCATCGCGCTAGGTGCGAGGGGGAATCGCCCACATCCCATACCTCCGC
CCCGAACCACACGCCTCCCT

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: Butyryl-CoA dehydrogenase; BCAD; SCAD [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MIQWSEQQQMIQKMVRDFVEKEIVPQLDDIEYNGVPPYDILRKMIKTFGMDVMAKQSFDKQIAREKAIAAGNAGEEKKKK
EGPSAMAGEEAAMRMIPIIELCKHAQGLVTAMGVSMGLGGGAIMSKGTTEQKERWALPLLTLEKVGAWAISEPNAGSDAF
GQMKTLAKRDGNGGYIINGSKTWITNGPYADTIILICKLDEEGVPADQRKIVSFILDSGMEGLTQSKPFKKMGIGSSPTG
ELFLTDVKAGPERLLGGNEDSYGRSGAKGTFMQERAGVAAMALGMVERALELSTQYASDRVQFGRAIGQNQLIQLKLAKM
EVARTNLQNMIFRYIEMTAEGAQMTLAEASAMKLYAAQAAMEVATEAVQIHGGYGYMRESRVEQLMRDAKILQIYAGTDE
MQIIAIARDLLGRV

Sequences:

>Translated_414_residues
MIQWSEQQQMIQKMVRDFVEKEIVPQLDDIEYNGVPPYDILRKMIKTFGMDVMAKQSFDKQIAREKAIAAGNAGEEKKKK
EGPSAMAGEEAAMRMIPIIELCKHAQGLVTAMGVSMGLGGGAIMSKGTTEQKERWALPLLTLEKVGAWAISEPNAGSDAF
GQMKTLAKRDGNGGYIINGSKTWITNGPYADTIILICKLDEEGVPADQRKIVSFILDSGMEGLTQSKPFKKMGIGSSPTG
ELFLTDVKAGPERLLGGNEDSYGRSGAKGTFMQERAGVAAMALGMVERALELSTQYASDRVQFGRAIGQNQLIQLKLAKM
EVARTNLQNMIFRYIEMTAEGAQMTLAEASAMKLYAAQAAMEVATEAVQIHGGYGYMRESRVEQLMRDAKILQIYAGTDE
MQIIAIARDLLGRV
>Mature_414_residues
MIQWSEQQQMIQKMVRDFVEKEIVPQLDDIEYNGVPPYDILRKMIKTFGMDVMAKQSFDKQIAREKAIAAGNAGEEKKKK
EGPSAMAGEEAAMRMIPIIELCKHAQGLVTAMGVSMGLGGGAIMSKGTTEQKERWALPLLTLEKVGAWAISEPNAGSDAF
GQMKTLAKRDGNGGYIINGSKTWITNGPYADTIILICKLDEEGVPADQRKIVSFILDSGMEGLTQSKPFKKMGIGSSPTG
ELFLTDVKAGPERLLGGNEDSYGRSGAKGTFMQERAGVAAMALGMVERALELSTQYASDRVQFGRAIGQNQLIQLKLAKM
EVARTNLQNMIFRYIEMTAEGAQMTLAEASAMKLYAAQAAMEVATEAVQIHGGYGYMRESRVEQLMRDAKILQIYAGTDE
MQIIAIARDLLGRV

Specific function: Has an optimum specificity for 4-carbon length fatty acyl-CoAs [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=415, Percent_Identity=31.3253012048193, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI226958412, Length=405, Percent_Identity=30.8641975308642, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI226958414, Length=302, Percent_Identity=36.0927152317881, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI4557235, Length=317, Percent_Identity=33.1230283911672, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI76496475, Length=317, Percent_Identity=33.1230283911672, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI4557231, Length=420, Percent_Identity=29.7619047619048, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI187960098, Length=420, Percent_Identity=29.7619047619048, Blast_Score=158, Evalue=8e-39,
Organism=Homo sapiens, GI4501857, Length=390, Percent_Identity=30, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI7656849, Length=409, Percent_Identity=25.9168704156479, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI21361497, Length=304, Percent_Identity=31.5789473684211, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI4501859, Length=292, Percent_Identity=33.2191780821918, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI4503943, Length=317, Percent_Identity=31.2302839116719, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI7669494, Length=315, Percent_Identity=32.0634920634921, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI48976061, Length=292, Percent_Identity=24.6575342465753, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI211971008, Length=292, Percent_Identity=24.6575342465753, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI38505218, Length=295, Percent_Identity=23.728813559322, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI87081958, Length=290, Percent_Identity=35.1724137931034, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1786223, Length=293, Percent_Identity=31.740614334471, Blast_Score=138, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI17569725, Length=409, Percent_Identity=32.7628361858191, Blast_Score=167, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI17538396, Length=420, Percent_Identity=30, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17534899, Length=416, Percent_Identity=31.7307692307692, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17570075, Length=420, Percent_Identity=30, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17534353, Length=307, Percent_Identity=33.2247557003257, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71985184, Length=303, Percent_Identity=30.03300330033, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17508101, Length=316, Percent_Identity=31.3291139240506, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17506239, Length=318, Percent_Identity=32.0754716981132, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17533517, Length=398, Percent_Identity=25.8793969849246, Blast_Score=134, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI17505929, Length=409, Percent_Identity=27.6283618581907, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17551932, Length=285, Percent_Identity=31.5789473684211, Blast_Score=131, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI71990804, Length=236, Percent_Identity=32.6271186440678, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71985192, Length=216, Percent_Identity=31.0185185185185, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI32563615, Length=220, Percent_Identity=32.7272727272727, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI86563381, Length=284, Percent_Identity=27.112676056338, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI86563383, Length=284, Percent_Identity=27.112676056338, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71982178, Length=205, Percent_Identity=30.2439024390244, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17531909, Length=247, Percent_Identity=25.9109311740891, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562446, Length=293, Percent_Identity=25.5972696245734, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21355753, Length=311, Percent_Identity=34.4051446945338, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI281363737, Length=305, Percent_Identity=34.4262295081967, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24660351, Length=408, Percent_Identity=30.3921568627451, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24646207, Length=408, Percent_Identity=30.6372549019608, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI21356377, Length=407, Percent_Identity=30.958230958231, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24666513, Length=315, Percent_Identity=32.6984126984127, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI19920834, Length=308, Percent_Identity=32.7922077922078, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: =1.3.99.2 [H]

Molecular weight: Translated: 45246; Mature: 45246

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00072 ACYL_COA_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
6.5 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
6.5 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQWSEQQQMIQKMVRDFVEKEIVPQLDDIEYNGVPPYDILRKMIKTFGMDVMAKQSFDK
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHH
QIAREKAIAAGNAGEEKKKKEGPSAMAGEEAAMRMIPIIELCKHAQGLVTAMGVSMGLGG
HHHHHHHHHCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GAIMSKGTTEQKERWALPLLTLEKVGAWAISEPNAGSDAFGQMKTLAKRDGNGGYIINGS
CHHCCCCCCHHHHHHCCCHHHHHHCCCEEECCCCCCCHHHHHHHHHHHCCCCCCEEECCC
KTWITNGPYADTIILICKLDEEGVPADQRKIVSFILDSGMEGLTQSKPFKKMGIGSSPTG
EEEECCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCHHHHHCCCCHHHHCCCCCCCC
ELFLTDVKAGPERLLGGNEDSYGRSGAKGTFMQERAGVAAMALGMVERALELSTQYASDR
CEEEEECCCCHHHHCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
VQFGRAIGQNQLIQLKLAKMEVARTNLQNMIFRYIEMTAEGAQMTLAEASAMKLYAAQAA
HHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
MEVATEAVQIHGGYGYMRESRVEQLMRDAKILQIYAGTDEMQIIAIARDLLGRV
HHHHHHHHEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MIQWSEQQQMIQKMVRDFVEKEIVPQLDDIEYNGVPPYDILRKMIKTFGMDVMAKQSFDK
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHH
QIAREKAIAAGNAGEEKKKKEGPSAMAGEEAAMRMIPIIELCKHAQGLVTAMGVSMGLGG
HHHHHHHHHCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GAIMSKGTTEQKERWALPLLTLEKVGAWAISEPNAGSDAFGQMKTLAKRDGNGGYIINGS
CHHCCCCCCHHHHHHCCCHHHHHHCCCEEECCCCCCCHHHHHHHHHHHCCCCCCEEECCC
KTWITNGPYADTIILICKLDEEGVPADQRKIVSFILDSGMEGLTQSKPFKKMGIGSSPTG
EEEECCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCHHHHHCCCCHHHHCCCCCCCC
ELFLTDVKAGPERLLGGNEDSYGRSGAKGTFMQERAGVAAMALGMVERALELSTQYASDR
CEEEEECCCCHHHHCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
VQFGRAIGQNQLIQLKLAKMEVARTNLQNMIFRYIEMTAEGAQMTLAEASAMKLYAAQAA
HHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
MEVATEAVQIHGGYGYMRESRVEQLMRDAKILQIYAGTDEMQIIAIARDLLGRV
HHHHHHHHEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8399220; 7857927 [H]