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The map label for this gene is dxs

Identifier: 110835027

GI number: 110835027

Start: 2475019

End: 2476956

Strand: Direct

Name: dxs

Synonym: ABO_2166

Alternate gene names: 110835027

Gene position: 2475019-2476956 (Clockwise)

Preceding gene: 110835026

Following gene: 110835038

Centisome position: 79.32

GC content: 57.12

Gene sequence:

>1938_bases
ATGCCCAAGACGTTTACTCAAATTCCGCTGACGCGACCTAACACCCCTCTGCTGGACACACTGGCCAGCCCTGCGGATCT
GCGGAAGCTACCAACGCCACAACTAGAACGCGTGGTCGATGAGTTACGTGAATATCTGCTCTACGCAGTGGGCCAGTGTG
GCGGGCATTTCGGCGCAGGGCTTGGGGTGGTGGAGCTCACCGTCGCCCTGCATTACCTGTATCACACCCCCGACGACAAG
TTGGTCTGGGATGTGGGCCACCAGTGCTACCCGCACAAGATCCTTACTGGGCGCCGCGAATCACTGACCAGCATTCGTCA
AGCCGGCGGCCTGTCCGGTTTTCCCAAACGAAGCGAATCCGAATACGACACCTTCGGGGTCGGCCACTCATCAACCTCTA
TCAGTGCCGCACTGGGTATGGCGCTGGGAGCAGAAATGGCCGGCAGCGACCGCCGGGCAGTCGCCATTATCGGTGACGGC
GCCATGACAGCAGGGCAAGCCTTTGAAGCCATGAGCCACGCGGCGCACACTCGCTCCAATTTGCTGGTCATCCTCAACGA
CAACAACATGTCGATTTCCCACAACGTAGGCGGGCTATCCAATTATTTTGCCCGCATCTGGGCCAGCAAGAGCTACATCG
CCCTACGTGAAGGCGGCAAAAAGGTACTGTCAACTATGCCGGCAGCTTGGGACTTTATTCGTCGTACAGAAGAAAGCATG
AAGAACATGGTCAGCCCCGACATGCTGTTCGAGGCGATCGGCTTCAATTACATTGGCCCTATTGATGGCCACAATGTGAA
CGAACTGGTCAGTACCCTGAGGAATTTGCGCGACCTAGAAGGCCCACAGCTGCTGCACGTGTACACCACAAAAGGCAAAG
GTTTTGCACCAGCGGAAGCCGACCCGGTAGGCTACCATGCCATCAACAAGATCGAGCCCAAGCCAAAGGTTCAGGTCGCG
GTCCCAAGCAAACCTTCTGCGGCAAAACAAAAGCTACCCAAGTATCAGGATATCTTTGGGCAATGGCTTTGTGACATGGC
GGAGCAAGACCCAAGACTAGTGGGCATCACCCCGGCCATGTGCGAAGGCTCTGGCATGGTGGAATTCAGCCGCCGTTTCC
CGGGCCGCTATCATGATGTAGCCATCTGTGAACAACACGCTGTAACCTTGGCGGGAGGCCTGGCCTGCGAGAATCAAAAA
CCAGTGGTGGCAATCTACTCCACTTTCCTGCAGCGCGGTTATGACCAACTGATTCACGATGTGGCTTTGCAGGAGCTAGA
TGTGACCTTTGGCCTAGACCGGGCCGGGCTGGTGGGCGAAGACGGTGCCACCCATGGCGGCGTATTTGATCTGGCTTATT
TGCGCACTGTACCGAACATGATCATTGCAGCCCCTTCCGATGAGAATGAGTGCCGCCAACTGTTATACTCCGCCTACCAG
CACGAAGGGCCAGCAGCAGTGCGCTACCCCCGCGGCACTGGCCCCGGCGCCACCATAGAACAGACCATGACGGCCCTACC
TATCGGCCAATCTCGCACTCTACGCGAGGGTCTGCAGGTGGCCATCCTGGCTTTTGGCGCCATGGTTCCTGCAGCACTAG
AAGCGGCTATCCCCCTCAACGCCACCGTGATAGACATGCGCTGGGTGAAACCTCTTGACCGTGACGCCATCCTCCGCGCC
GCCGCACAGCACACACTGTTAGTCACCGTAGAAGATCACCAACAAATGGGAGGCGCCGGTTCTGCCGTAAATGAGCTGCT
GCATGAAGAAGCGGTCGTACTGGATGTGCTAAACCTTGCCCTGCCCGATCATTTCATCCATCACGGTAAACGGGATGTAT
TACTCGCCCAAGCAGGACTGGATGCCGCCGGTATTGAACGCCAAATCCGTGAAAGGCTAAACCGGCAGCAAAGGCTACGA
GAAGCCCACCAGCGTTAA

Upstream 100 bases:

>100_bases
CAGTTATACTAGCGGTTCGAGCGAGACCCTGGACGCTTTTGTTATACAGCGTTTCGCTGACTCATTACTCTGCCTTGCAC
TCATCAGGCTGCATGACCCT

Downstream 100 bases:

>100_bases
TAATCAACAGCAAAGAAAAGCTCGAACGGGGGGAGATTATCGCTCCCTTCGCCGCTTTGGCGCTCCGTAGCTAGAGCTGC
CCCGCGGCCGGCGGTGCTTC

Product: deoxyxylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 645; Mature: 644

Protein sequence:

>645_residues
MPKTFTQIPLTRPNTPLLDTLASPADLRKLPTPQLERVVDELREYLLYAVGQCGGHFGAGLGVVELTVALHYLYHTPDDK
LVWDVGHQCYPHKILTGRRESLTSIRQAGGLSGFPKRSESEYDTFGVGHSSTSISAALGMALGAEMAGSDRRAVAIIGDG
AMTAGQAFEAMSHAAHTRSNLLVILNDNNMSISHNVGGLSNYFARIWASKSYIALREGGKKVLSTMPAAWDFIRRTEESM
KNMVSPDMLFEAIGFNYIGPIDGHNVNELVSTLRNLRDLEGPQLLHVYTTKGKGFAPAEADPVGYHAINKIEPKPKVQVA
VPSKPSAAKQKLPKYQDIFGQWLCDMAEQDPRLVGITPAMCEGSGMVEFSRRFPGRYHDVAICEQHAVTLAGGLACENQK
PVVAIYSTFLQRGYDQLIHDVALQELDVTFGLDRAGLVGEDGATHGGVFDLAYLRTVPNMIIAAPSDENECRQLLYSAYQ
HEGPAAVRYPRGTGPGATIEQTMTALPIGQSRTLREGLQVAILAFGAMVPAALEAAIPLNATVIDMRWVKPLDRDAILRA
AAQHTLLVTVEDHQQMGGAGSAVNELLHEEAVVLDVLNLALPDHFIHHGKRDVLLAQAGLDAAGIERQIRERLNRQQRLR
EAHQR

Sequences:

>Translated_645_residues
MPKTFTQIPLTRPNTPLLDTLASPADLRKLPTPQLERVVDELREYLLYAVGQCGGHFGAGLGVVELTVALHYLYHTPDDK
LVWDVGHQCYPHKILTGRRESLTSIRQAGGLSGFPKRSESEYDTFGVGHSSTSISAALGMALGAEMAGSDRRAVAIIGDG
AMTAGQAFEAMSHAAHTRSNLLVILNDNNMSISHNVGGLSNYFARIWASKSYIALREGGKKVLSTMPAAWDFIRRTEESM
KNMVSPDMLFEAIGFNYIGPIDGHNVNELVSTLRNLRDLEGPQLLHVYTTKGKGFAPAEADPVGYHAINKIEPKPKVQVA
VPSKPSAAKQKLPKYQDIFGQWLCDMAEQDPRLVGITPAMCEGSGMVEFSRRFPGRYHDVAICEQHAVTLAGGLACENQK
PVVAIYSTFLQRGYDQLIHDVALQELDVTFGLDRAGLVGEDGATHGGVFDLAYLRTVPNMIIAAPSDENECRQLLYSAYQ
HEGPAAVRYPRGTGPGATIEQTMTALPIGQSRTLREGLQVAILAFGAMVPAALEAAIPLNATVIDMRWVKPLDRDAILRA
AAQHTLLVTVEDHQQMGGAGSAVNELLHEEAVVLDVLNLALPDHFIHHGKRDVLLAQAGLDAAGIERQIRERLNRQQRLR
EAHQR
>Mature_644_residues
PKTFTQIPLTRPNTPLLDTLASPADLRKLPTPQLERVVDELREYLLYAVGQCGGHFGAGLGVVELTVALHYLYHTPDDKL
VWDVGHQCYPHKILTGRRESLTSIRQAGGLSGFPKRSESEYDTFGVGHSSTSISAALGMALGAEMAGSDRRAVAIIGDGA
MTAGQAFEAMSHAAHTRSNLLVILNDNNMSISHNVGGLSNYFARIWASKSYIALREGGKKVLSTMPAAWDFIRRTEESMK
NMVSPDMLFEAIGFNYIGPIDGHNVNELVSTLRNLRDLEGPQLLHVYTTKGKGFAPAEADPVGYHAINKIEPKPKVQVAV
PSKPSAAKQKLPKYQDIFGQWLCDMAEQDPRLVGITPAMCEGSGMVEFSRRFPGRYHDVAICEQHAVTLAGGLACENQKP
VVAIYSTFLQRGYDQLIHDVALQELDVTFGLDRAGLVGEDGATHGGVFDLAYLRTVPNMIIAAPSDENECRQLLYSAYQH
EGPAAVRYPRGTGPGATIEQTMTALPIGQSRTLREGLQVAILAFGAMVPAALEAAIPLNATVIDMRWVKPLDRDAILRAA
AQHTLLVTVEDHQQMGGAGSAVNELLHEEAVVLDVLNLALPDHFIHHGKRDVLLAQAGLDAAGIERQIRERLNRQQRLRE
AHQR

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=558, Percent_Identity=24.5519713261649, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI4507521, Length=558, Percent_Identity=24.5519713261649, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI133778974, Length=504, Percent_Identity=23.2142857142857, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI225637463, Length=544, Percent_Identity=25.3676470588235, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI225637459, Length=547, Percent_Identity=25.4113345521024, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI225637461, Length=547, Percent_Identity=25.4113345521024, Blast_Score=87, Evalue=5e-17,
Organism=Escherichia coli, GI1786622, Length=619, Percent_Identity=56.8659127625202, Blast_Score=719, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=566, Percent_Identity=24.5583038869258, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24666278, Length=531, Percent_Identity=26.7419962335217, Blast_Score=115, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24645119, Length=552, Percent_Identity=25.5434782608696, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI45551847, Length=552, Percent_Identity=25.5434782608696, Blast_Score=106, Evalue=5e-23,
Organism=Drosophila melanogaster, GI45550715, Length=552, Percent_Identity=25.5434782608696, Blast_Score=106, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_ALCBS (Q0VMI4)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_693886.1
- ProteinModelPortal:   Q0VMI4
- SMR:   Q0VMI4
- STRING:   Q0VMI4
- GeneID:   4213338
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_2166
- NMPDR:   fig|393595.12.peg.2166
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- PhylomeDB:   Q0VMI4
- BioCyc:   ABOR393595:ABO_2166-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 70354; Mature: 70223

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKTFTQIPLTRPNTPLLDTLASPADLRKLPTPQLERVVDELREYLLYAVGQCGGHFGAG
CCCCCCCCCCCCCCCCHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
LGVVELTVALHYLYHTPDDKLVWDVGHQCYPHKILTGRRESLTSIRQAGGLSGFPKRSES
HHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCC
EYDTFGVGHSSTSISAALGMALGAEMAGSDRRAVAIIGDGAMTAGQAFEAMSHAAHTRSN
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCC
LLVILNDNNMSISHNVGGLSNYFARIWASKSYIALREGGKKVLSTMPAAWDFIRRTEESM
EEEEECCCCEEEECCCCCHHHHHHHHHCCCCEEEEHHCCHHHHHHCHHHHHHHHHHHHHH
KNMVSPDMLFEAIGFNYIGPIDGHNVNELVSTLRNLRDLEGPQLLHVYTTKGKGFAPAEA
HHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCC
DPVGYHAINKIEPKPKVQVAVPSKPSAAKQKLPKYQDIFGQWLCDMAEQDPRLVGITPAM
CCCCHHHHCCCCCCCCEEEECCCCCCHHHHHCCHHHHHHHHHHHHHHCCCCCEEECCHHH
CEGSGMVEFSRRFPGRYHDVAICEQHAVTLAGGLACENQKPVVAIYSTFLQRGYDQLIHD
CCCCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHH
VALQELDVTFGLDRAGLVGEDGATHGGVFDLAYLRTVPNMIIAAPSDENECRQLLYSAYQ
HHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHH
HEGPAAVRYPRGTGPGATIEQTMTALPIGQSRTLREGLQVAILAFGAMVPAALEAAIPLN
CCCCCEEECCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ATVIDMRWVKPLDRDAILRAAAQHTLLVTVEDHQQMGGAGSAVNELLHEEAVVLDVLNLA
EEEEEEHHCCCCCHHHHHHHHHCCEEEEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHH
LPDHFIHHGKRDVLLAQAGLDAAGIERQIRERLNRQQRLREAHQR
CCHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PKTFTQIPLTRPNTPLLDTLASPADLRKLPTPQLERVVDELREYLLYAVGQCGGHFGAG
CCCCCCCCCCCCCCCHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
LGVVELTVALHYLYHTPDDKLVWDVGHQCYPHKILTGRRESLTSIRQAGGLSGFPKRSES
HHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCC
EYDTFGVGHSSTSISAALGMALGAEMAGSDRRAVAIIGDGAMTAGQAFEAMSHAAHTRSN
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCC
LLVILNDNNMSISHNVGGLSNYFARIWASKSYIALREGGKKVLSTMPAAWDFIRRTEESM
EEEEECCCCEEEECCCCCHHHHHHHHHCCCCEEEEHHCCHHHHHHCHHHHHHHHHHHHHH
KNMVSPDMLFEAIGFNYIGPIDGHNVNELVSTLRNLRDLEGPQLLHVYTTKGKGFAPAEA
HHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCC
DPVGYHAINKIEPKPKVQVAVPSKPSAAKQKLPKYQDIFGQWLCDMAEQDPRLVGITPAM
CCCCHHHHCCCCCCCCEEEECCCCCCHHHHHCCHHHHHHHHHHHHHHCCCCCEEECCHHH
CEGSGMVEFSRRFPGRYHDVAICEQHAVTLAGGLACENQKPVVAIYSTFLQRGYDQLIHD
CCCCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHH
VALQELDVTFGLDRAGLVGEDGATHGGVFDLAYLRTVPNMIIAAPSDENECRQLLYSAYQ
HHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHH
HEGPAAVRYPRGTGPGATIEQTMTALPIGQSRTLREGLQVAILAFGAMVPAALEAAIPLN
CCCCCEEECCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ATVIDMRWVKPLDRDAILRAAAQHTLLVTVEDHQQMGGAGSAVNELLHEEAVVLDVLNLA
EEEEEEHHCCCCCHHHHHHHHHCCEEEEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHH
LPDHFIHHGKRDVLLAQAGLDAAGIERQIRERLNRQQRLREAHQR
CCHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA