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The map label for this gene is garD [H]

Identifier: 110636294

GI number: 110636294

Start: 4274101

End: 4275630

Strand: Reverse

Name: garD [H]

Synonym: Meso_3970

Alternate gene names: 110636294

Gene position: 4275630-4274101 (Counterclockwise)

Preceding gene: 110636312

Following gene: 110636293

Centisome position: 96.9

GC content: 57.45

Gene sequence:

>1530_bases
ATGACCAGTCCCAAACTGCATCGCGCGGCCATTCGCCTACACGAGGCCGATAATGTCATTGTGGCCACCCGCCGCCTAGA
GAGCGGGACTGATCTCGGGGAGACGGTCACGCTCGAGCCGATTCCGAACGGGCACAAGGTCGCGACATCCGAAATCAAGC
CGGGTGATCATGTAATTAAGTACGGTCACGTTATCGGTGTCGCGAGCAAGCCGATAAGGCCAGGTCAGCATGTGCACTTG
TCGAACCTCGCCATGCTGGAAAGCAAAACGGCACACGAGTTCGCAGTCGATGGCGGTCCGACCCCTCTCTTACCAGTCGA
GGAGCGCAGAACCTTCGAAGGTTACGTCCGCGAGAACGGGCTCGTCGGGACGCGCAATTACATCGGCATCATCACGTCGG
TGAATTGCTCTGCTACCGTCTCGCGAGCAATCGCCGATCATTATAAGACTAGAGGGTTCGGGGATTACCCAAATATCGAC
GGGGTTGTCGCGCTGACCCATGGGACCGGGTGCGCGATCCCGACCAACACGGAAGGCTATGTCTATCTTCGTCGCGTCCT
GAACGGCTATGCCCGCAACCCCAACTTCGCCGCGATCCTGATCATTGGCCTGGGTTGCGAGACAAACCAGATCAGCCACC
TCGTTGACGCATTCGAACTCCGGGATATCCCGCGGCTCCATACCATGACAATCCAGCAGGTGGGGGGCACACGCAAGACG
ATCGAGGAGGGCATTCGTGTTATCGATGGAATGCTTGAGGAGATAAACGCGACCAAGCGCCAGACCGTGCCGCTATCGGG
GCTTAAAGTGGCTCTGCAGTGCGGTGGGTCCGATGCATACTCCGGAATCACGGCGAATCCTGCCCTTGGCTACGCATCTG
ATCTCGTCGTTAAGCATGGAGGGACGGCCGTCCTTAGCGAAACCCCCGAAATCTATGGCGCGGAGCATCTTCTTACCCGT
CGCGCTGTCACATCCGAGATCGCCGAAAGGCTGATGGCGCGGATAGAGTGGTGGCGCAACTACACGTCCCTGAACGGCGC
CGAGCTGAACAACAACCCTTCTCACGGCAACAAGGAAGGTGGTCTGACGACCATACTGGAAAAATCCTTGGGAGCGGTGG
CCAAGGGCGGCTCCATGCCGCTGCAGGCTGTCTATGAGTATGCCGAGATCATCGACACCCCTGGTTTTGTCTTCATGGAT
ACGCCTGGCTACGATCCCGTCGCAGTGACGGGTCAAGTTGCAGGCGGATGCAATCTCATCGTATTCACGACCGGACGCGG
ATCCGTTTCGGGCTTCAAGCCCGCGCCTTGCATTAAAGTTGCCACCAATACCGCCATGTACGAAAGGATGAGGGAGGACA
TGGATATCAATTGCGGTGGCATTATTGATGGCAGCGACACTATTGCGGACGCCGGGCAGCGGATTTTTGAGCGAATCATC
GCGGTAGCATCCGGCGAGAAAAGCTTGAGCGAAACATTCGGCTATGGTGATAACGAGTTCGTTCCCTGGCAAATCGGGGC
TGTCACTTAG

Upstream 100 bases:

>100_bases
AAATTCCTCCGCAAAACTCAGCAAACCAAAAGGATGTCCTTGACTTCTTGATCGCTATCATAAATGACTTTTGCGCACAA
TAAGCAATATGGATTGCTAC

Downstream 100 bases:

>100_bases
AATGAGTAGGGGGCTATGTCGCATCGAACGCTAGCCAAAGAGGCAATAGCGGAGACTTTGAGAACTGCCCTCATCGAGAA
GACGCTTCCTGAAGGCGCTG

Product: D-galactarate dehydratase/Altronate hydrolase-like

Products: NA

Alternate protein names: GalcD [H]

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MTSPKLHRAAIRLHEADNVIVATRRLESGTDLGETVTLEPIPNGHKVATSEIKPGDHVIKYGHVIGVASKPIRPGQHVHL
SNLAMLESKTAHEFAVDGGPTPLLPVEERRTFEGYVRENGLVGTRNYIGIITSVNCSATVSRAIADHYKTRGFGDYPNID
GVVALTHGTGCAIPTNTEGYVYLRRVLNGYARNPNFAAILIIGLGCETNQISHLVDAFELRDIPRLHTMTIQQVGGTRKT
IEEGIRVIDGMLEEINATKRQTVPLSGLKVALQCGGSDAYSGITANPALGYASDLVVKHGGTAVLSETPEIYGAEHLLTR
RAVTSEIAERLMARIEWWRNYTSLNGAELNNNPSHGNKEGGLTTILEKSLGAVAKGGSMPLQAVYEYAEIIDTPGFVFMD
TPGYDPVAVTGQVAGGCNLIVFTTGRGSVSGFKPAPCIKVATNTAMYERMREDMDINCGGIIDGSDTIADAGQRIFERII
AVASGEKSLSETFGYGDNEFVPWQIGAVT

Sequences:

>Translated_509_residues
MTSPKLHRAAIRLHEADNVIVATRRLESGTDLGETVTLEPIPNGHKVATSEIKPGDHVIKYGHVIGVASKPIRPGQHVHL
SNLAMLESKTAHEFAVDGGPTPLLPVEERRTFEGYVRENGLVGTRNYIGIITSVNCSATVSRAIADHYKTRGFGDYPNID
GVVALTHGTGCAIPTNTEGYVYLRRVLNGYARNPNFAAILIIGLGCETNQISHLVDAFELRDIPRLHTMTIQQVGGTRKT
IEEGIRVIDGMLEEINATKRQTVPLSGLKVALQCGGSDAYSGITANPALGYASDLVVKHGGTAVLSETPEIYGAEHLLTR
RAVTSEIAERLMARIEWWRNYTSLNGAELNNNPSHGNKEGGLTTILEKSLGAVAKGGSMPLQAVYEYAEIIDTPGFVFMD
TPGYDPVAVTGQVAGGCNLIVFTTGRGSVSGFKPAPCIKVATNTAMYERMREDMDINCGGIIDGSDTIADAGQRIFERII
AVASGEKSLSETFGYGDNEFVPWQIGAVT
>Mature_508_residues
TSPKLHRAAIRLHEADNVIVATRRLESGTDLGETVTLEPIPNGHKVATSEIKPGDHVIKYGHVIGVASKPIRPGQHVHLS
NLAMLESKTAHEFAVDGGPTPLLPVEERRTFEGYVRENGLVGTRNYIGIITSVNCSATVSRAIADHYKTRGFGDYPNIDG
VVALTHGTGCAIPTNTEGYVYLRRVLNGYARNPNFAAILIIGLGCETNQISHLVDAFELRDIPRLHTMTIQQVGGTRKTI
EEGIRVIDGMLEEINATKRQTVPLSGLKVALQCGGSDAYSGITANPALGYASDLVVKHGGTAVLSETPEIYGAEHLLTRR
AVTSEIAERLMARIEWWRNYTSLNGAELNNNPSHGNKEGGLTTILEKSLGAVAKGGSMPLQAVYEYAEIIDTPGFVFMDT
PGYDPVAVTGQVAGGCNLIVFTTGRGSVSGFKPAPCIKVATNTAMYERMREDMDINCGGIIDGSDTIADAGQRIFERIIA
VASGEKSLSETFGYGDNEFVPWQIGAVT

Specific function: D-galactarate metabolism; first step. [C]

COG id: COG2721

COG function: function code G; Altronate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uxaA family [H]

Homologues:

Organism=Escherichia coli, GI1789516, Length=495, Percent_Identity=39.3939393939394, Blast_Score=331, Evalue=7e-92,
Organism=Escherichia coli, GI1789475, Length=487, Percent_Identity=35.3182751540041, Blast_Score=275, Evalue=6e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007392
- InterPro:   IPR017654
- InterPro:   IPR013974 [H]

Pfam domain/function: PF04295 GD_AH_C; PF08666 SAF [H]

EC number: =4.2.1.42 [H]

Molecular weight: Translated: 54673; Mature: 54542

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPKLHRAAIRLHEADNVIVATRRLESGTDLGETVTLEPIPNGHKVATSEIKPGDHVIK
CCCCHHHHHHEEEECCCCEEEEEEECCCCCCCCCEEEEEECCCCCEEEECCCCCCCCEEE
YGHVIGVASKPIRPGQHVHLSNLAMLESKTAHEFAVDGGPTPLLPVEERRTFEGYVRENG
ECEEEEECCCCCCCCCEEEHHHHHHHHCCCCCEEEECCCCCCCCCCHHCCCHHHHHHCCC
LVGTRNYIGIITSVNCSATVSRAIADHYKTRGFGDYPNIDGVVALTHGTGCAIPTNTEGY
CEECCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCH
VYLRRVLNGYARNPNFAAILIIGLGCETNQISHLVDAFELRDIPRLHTMTIQQVGGTRKT
HHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHH
IEEGIRVIDGMLEEINATKRQTVPLSGLKVALQCGGSDAYSGITANPALGYASDLVVKHG
HHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCEECCCCCCCHHHEEEECC
GTAVLSETPEIYGAEHLLTRRAVTSEIAERLMARIEWWRNYTSLNGAELNNNPSHGNKEG
CEEEECCCCCHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
GLTTILEKSLGAVAKGGSMPLQAVYEYAEIIDTPGFVFMDTPGYDPVAVTGQVAGGCNLI
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCCEEE
VFTTGRGSVSGFKPAPCIKVATNTAMYERMREDMDINCGGIIDGSDTIADAGQRIFERII
EEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHH
AVASGEKSLSETFGYGDNEFVPWQIGAVT
HHHCCCHHHHHHCCCCCCCEECEEECCCC
>Mature Secondary Structure 
TSPKLHRAAIRLHEADNVIVATRRLESGTDLGETVTLEPIPNGHKVATSEIKPGDHVIK
CCCHHHHHHEEEECCCCEEEEEEECCCCCCCCCEEEEEECCCCCEEEECCCCCCCCEEE
YGHVIGVASKPIRPGQHVHLSNLAMLESKTAHEFAVDGGPTPLLPVEERRTFEGYVRENG
ECEEEEECCCCCCCCCEEEHHHHHHHHCCCCCEEEECCCCCCCCCCHHCCCHHHHHHCCC
LVGTRNYIGIITSVNCSATVSRAIADHYKTRGFGDYPNIDGVVALTHGTGCAIPTNTEGY
CEECCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCH
VYLRRVLNGYARNPNFAAILIIGLGCETNQISHLVDAFELRDIPRLHTMTIQQVGGTRKT
HHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHH
IEEGIRVIDGMLEEINATKRQTVPLSGLKVALQCGGSDAYSGITANPALGYASDLVVKHG
HHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCEECCCCCCCHHHEEEECC
GTAVLSETPEIYGAEHLLTRRAVTSEIAERLMARIEWWRNYTSLNGAELNNNPSHGNKEG
CEEEECCCCCHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
GLTTILEKSLGAVAKGGSMPLQAVYEYAEIIDTPGFVFMDTPGYDPVAVTGQVAGGCNLI
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCCEEE
VFTTGRGSVSGFKPAPCIKVATNTAMYERMREDMDINCGGIIDGSDTIADAGQRIFERII
EEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHH
AVASGEKSLSETFGYGDNEFVPWQIGAVT
HHHCCCHHHHHHCCCCCCCEECEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 2407727; 9772162; 10762278 [H]