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The map label for this gene is yqjI [H]

Identifier: 110636270

GI number: 110636270

Start: 4251731

End: 4253149

Strand: Reverse

Name: yqjI [H]

Synonym: Meso_3946

Alternate gene names: 110636270

Gene position: 4253149-4251731 (Counterclockwise)

Preceding gene: 110636271

Following gene: 110636269

Centisome position: 96.39

GC content: 63.99

Gene sequence:

>1419_bases
ATGGAAAAAGCTGACATCGGTCTTATCGGTCTTGGGACCATGGGAGCCAATCTGGCCCTCAACATTGCCGAGAAGGGCTT
CCGCATTGCCGTGTTCAACCGCACGACGGAGCGGACGCATGAATTTGCTCAGGAGGCGGGCTCCCTCGCCGGGAATATTG
TGCCCTGCGACACGCTCCAGGCGCTTGTGGAGGGCATAAAACCGCCCCGGCCGATTATCCTGATGGTGCCGGCCGGCTCA
GTGGTGGACGAGCAGATCGCGGCTCTCGACCCGCTGGTCGCACGCGACGATATCATCATCGATGCGGGCAACGCCAATTT
TCGCGATACGCGCCGGCGCATGTTGGAACTCGCGAAAACCGGGCCCCGCTTCATCGGCATGGGCGTCTCTGGAGGCGAGG
ACGGCGCCCGCCACGGCCCATCGATCATGGTTGGCGGGCCGGACGAATCCTATCGGCGCATAGAACCGGTCCTGGAGGCG
ATCGCCGCGCGCTATGAGGGCGAGGCTTGCCAGGCCTGGCTTGGACCAGACGGCGCCGGCCATTTCGTAAAAACCATTCA
TAACGGCATCGAATACGCCGATATGCAAATGATCGCCGAGATCTACGGCATCCTGCGCGACGGCCACGGGCTTCAGGCCG
GCGAGATCGCTCCGATTTTCGCGCAGTGGAACGACGGGCGGCTCAATTCCTATCTGATCGAGATCACAGCCAAGGTCCTC
GAGGCGAGTGATCCCGATACGGGAAAGCCCATCGTGGATGTCATCCTGGACCGCGCCGGACAAAAGGGCACCGGCCGCTG
GTCTGCCATTGAGGCGCAATCGCTGGGCATCCCCGCAACGGCGATCGAGGCCGCCGTTGCCGCGCGCAGCCTCTCCGCCT
TGAAAGCTGAGCGCGAGACAGCCGAAAAGCGCTACGGCAGCCTCGCCGCCGCCATGGCGGGATCACCGGGCGCGGACGAG
CTGGCGACCCTGGAGGCGGCGCTCTTCGCAGGCAAGATAGTCGCCTATGCCCAGGGTTTCTCCGTCATGGCCGCCGCATC
GCGGGAGTTCGGCTGGAATCTGCCGCTCGGCACCATCGCGCGGATTTGGCGGGCAGGCTGCATCATCCGCTCGCAGTTCC
TCGGTGCAATTGCCGAGGCTTTCGACGGCGCACCGGAGACGGACAACCTGCTGATGACGGAGGCGTTCTCTCAACATATG
GAAGCCGCTCATCCGCGTCTGCGGCGCGTTGTCGCCAAAAGTGCGGAGGCGGGACTTCCCGTACCGTCGCTTTCGGCGGC
TCTCGCCCATTTCGATACGTTCCGCCGCGGGCGGGGCACAGCGAATCTCATCCAGGCGCAACGCGATTTCTTCGGCGCTC
ACGGTTTCGAGCGCGTGGACAGCGAAGGCAGTCATCACGCATCCTGGAAGCGGGACTAG

Upstream 100 bases:

>100_bases
TAGGCTGGAGCTTTACGGCAGGAAGCGGCGACGCCGCTAGGCTACCGAAAAGCATGGGTTACTCTGCACGCCAGCGCACA
CAAGATGGGTCTGTCTTCAT

Downstream 100 bases:

>100_bases
GCGGCAAAAAAGTGCCGCCGTGGTGGAGGGGAACCACGGCGGCCTTATATTATGTGCGGCAGCCCGGAGAGGGGGATAAG
GCTGCCGCTTTTATGTCCGG

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: GNTZII [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MEKADIGLIGLGTMGANLALNIAEKGFRIAVFNRTTERTHEFAQEAGSLAGNIVPCDTLQALVEGIKPPRPIILMVPAGS
VVDEQIAALDPLVARDDIIIDAGNANFRDTRRRMLELAKTGPRFIGMGVSGGEDGARHGPSIMVGGPDESYRRIEPVLEA
IAARYEGEACQAWLGPDGAGHFVKTIHNGIEYADMQMIAEIYGILRDGHGLQAGEIAPIFAQWNDGRLNSYLIEITAKVL
EASDPDTGKPIVDVILDRAGQKGTGRWSAIEAQSLGIPATAIEAAVAARSLSALKAERETAEKRYGSLAAAMAGSPGADE
LATLEAALFAGKIVAYAQGFSVMAAASREFGWNLPLGTIARIWRAGCIIRSQFLGAIAEAFDGAPETDNLLMTEAFSQHM
EAAHPRLRRVVAKSAEAGLPVPSLSAALAHFDTFRRGRGTANLIQAQRDFFGAHGFERVDSEGSHHASWKRD

Sequences:

>Translated_472_residues
MEKADIGLIGLGTMGANLALNIAEKGFRIAVFNRTTERTHEFAQEAGSLAGNIVPCDTLQALVEGIKPPRPIILMVPAGS
VVDEQIAALDPLVARDDIIIDAGNANFRDTRRRMLELAKTGPRFIGMGVSGGEDGARHGPSIMVGGPDESYRRIEPVLEA
IAARYEGEACQAWLGPDGAGHFVKTIHNGIEYADMQMIAEIYGILRDGHGLQAGEIAPIFAQWNDGRLNSYLIEITAKVL
EASDPDTGKPIVDVILDRAGQKGTGRWSAIEAQSLGIPATAIEAAVAARSLSALKAERETAEKRYGSLAAAMAGSPGADE
LATLEAALFAGKIVAYAQGFSVMAAASREFGWNLPLGTIARIWRAGCIIRSQFLGAIAEAFDGAPETDNLLMTEAFSQHM
EAAHPRLRRVVAKSAEAGLPVPSLSAALAHFDTFRRGRGTANLIQAQRDFFGAHGFERVDSEGSHHASWKRD
>Mature_472_residues
MEKADIGLIGLGTMGANLALNIAEKGFRIAVFNRTTERTHEFAQEAGSLAGNIVPCDTLQALVEGIKPPRPIILMVPAGS
VVDEQIAALDPLVARDDIIIDAGNANFRDTRRRMLELAKTGPRFIGMGVSGGEDGARHGPSIMVGGPDESYRRIEPVLEA
IAARYEGEACQAWLGPDGAGHFVKTIHNGIEYADMQMIAEIYGILRDGHGLQAGEIAPIFAQWNDGRLNSYLIEITAKVL
EASDPDTGKPIVDVILDRAGQKGTGRWSAIEAQSLGIPATAIEAAVAARSLSALKAERETAEKRYGSLAAAMAGSPGADE
LATLEAALFAGKIVAYAQGFSVMAAASREFGWNLPLGTIARIWRAGCIIRSQFLGAIAEAFDGAPETDNLLMTEAFSQHM
EAAHPRLRRVVAKSAEAGLPVPSLSAALAHFDTFRRGRGTANLIQAQRDFFGAHGFERVDSEGSHHASWKRD

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=472, Percent_Identity=46.6101694915254, Blast_Score=400, Evalue=1e-111,
Organism=Escherichia coli, GI1788341, Length=470, Percent_Identity=48.0851063829787, Blast_Score=440, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17542558, Length=473, Percent_Identity=43.7632135306554, Blast_Score=395, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6321695, Length=476, Percent_Identity=46.6386554621849, Blast_Score=414, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6321977, Length=455, Percent_Identity=46.5934065934066, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24639279, Length=470, Percent_Identity=47.4468085106383, Blast_Score=404, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 50329; Mature: 50329

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKADIGLIGLGTMGANLALNIAEKGFRIAVFNRTTERTHEFAQEAGSLAGNIVPCDTLQ
CCCCCCCEEEECCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHH
ALVEGIKPPRPIILMVPAGSVVDEQIAALDPLVARDDIIIDAGNANFRDTRRRMLELAKT
HHHHCCCCCCCEEEEECCCCHHHHHHHHHCCCEECCCEEEECCCCCHHHHHHHHHHHHHC
GPRFIGMGVSGGEDGARHGPSIMVGGPDESYRRIEPVLEAIAARYEGEACQAWLGPDGAG
CCCEEEECCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCHHEEECCCCCCH
HFVKTIHNGIEYADMQMIAEIYGILRDGHGLQAGEIAPIFAQWNDGRLNSYLIEITAKVL
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHH
EASDPDTGKPIVDVILDRAGQKGTGRWSAIEAQSLGIPATAIEAAVAARSLSALKAERET
HCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
AEKRYGSLAAAMAGSPGADELATLEAALFAGKIVAYAQGFSVMAAASREFGWNLPLGTIA
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHH
RIWRAGCIIRSQFLGAIAEAFDGAPETDNLLMTEAFSQHMEAAHPRLRRVVAKSAEAGLP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VPSLSAALAHFDTFRRGRGTANLIQAQRDFFGAHGFERVDSEGSHHASWKRD
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MEKADIGLIGLGTMGANLALNIAEKGFRIAVFNRTTERTHEFAQEAGSLAGNIVPCDTLQ
CCCCCCCEEEECCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHH
ALVEGIKPPRPIILMVPAGSVVDEQIAALDPLVARDDIIIDAGNANFRDTRRRMLELAKT
HHHHCCCCCCCEEEEECCCCHHHHHHHHHCCCEECCCEEEECCCCCHHHHHHHHHHHHHC
GPRFIGMGVSGGEDGARHGPSIMVGGPDESYRRIEPVLEAIAARYEGEACQAWLGPDGAG
CCCEEEECCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCHHEEECCCCCCH
HFVKTIHNGIEYADMQMIAEIYGILRDGHGLQAGEIAPIFAQWNDGRLNSYLIEITAKVL
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHH
EASDPDTGKPIVDVILDRAGQKGTGRWSAIEAQSLGIPATAIEAAVAARSLSALKAERET
HCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
AEKRYGSLAAAMAGSPGADELATLEAALFAGKIVAYAQGFSVMAAASREFGWNLPLGTIA
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHH
RIWRAGCIIRSQFLGAIAEAFDGAPETDNLLMTEAFSQHMEAAHPRLRRVVAKSAEAGLP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VPSLSAALAHFDTFRRGRGTANLIQAQRDFFGAHGFERVDSEGSHHASWKRD
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10568751; 9298659 [H]