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The map label for this gene is ilvD [H]

Identifier: 110636082

GI number: 110636082

Start: 4060185

End: 4061897

Strand: Reverse

Name: ilvD [H]

Synonym: Meso_3757

Alternate gene names: 110636082

Gene position: 4061897-4060185 (Counterclockwise)

Preceding gene: 110636089

Following gene: 110636081

Centisome position: 92.06

GC content: 62.35

Gene sequence:

>1713_bases
ATGGAGAATGGGCTTCGCAAGGGCTTGACCGACTATGGGGACAAGGAATTTTCCCTGTTCCTTCGCCGCGTATTCATCAA
GGCAATGGGCTATTCCGACGAAGCTCTCGATCGCCCGATCGTCGGGATCACGAACACCTTCAGCGACTACAATCCCTGCC
ATGGCAACGTTCCTGCCCTGATCGAAGGTGTGAAACGCGGGGTGATGCTTGCGGGCGCCCTGCCCATGGTTTTTCCGACC
ATCTCGATTCATGAGAGCTTTGCTCATCCGACATCGATGTTCCTTCGGAATCTGATGTCGATGGACACCGAGGAGATGAT
CCGCGCCCAACCAATGGATGCGGTCGTCCTGATCGGCGGGTGCGACAAGACCCTACCCGCACAGATGATGGCGGCGGTAA
GCGCCGGCATCCCCTCCATCGTACTTCCAGTCGGACCGATGGTGGTGGGGCACCACAAGGGAGAGGTTCTGGGCGCCTGC
ACAGACTGCCGGCGGTTGTGGAGCGGTCATCGGGCCGGCCGCATCAGCAAGTCCGAGATCGACGAGGTGAGCGGGCGACT
TGCCCCGTCGGTGGGGACGTGCATGGTCATGGGTACGGCCAGCACCATGGCCAGCATGTGCGAAGCGCTGGGATTTTCAC
TGCCGATGAGCGCAAGCATCCCGGCGACTCATGCCGAACGGATCCGATGCGCCGAAGCGACTGGGAAGCGAGCGGTTGAA
ATGGCCCGCAGCGGCGGGCCCCTGCCGCACGAGATCCTTACGCAGGATTCCCTTCACAACGCGCAGGTTTTGCTGCAGGC
CCTTGGGGGTTCGACCAACGGCCTAATCCACCTTGCCGCGATCGCTGGTCGCGCCGGCCTTTCGGTCGACCTGGAGGAGT
TCGATGCCTTGGGACGTTCAGTTCCGGTGCTGGTCGACCTGAAACCGTCCGGAATGCATTACATGGAGCATTTCCACCAT
GCGGGCGGCGTACCACGCTTGCTTGCCGAGTTATCGGACCTACTGCGCCTCGATGCCCGGACGGTCACCGGCGGGATTCT
CGCCGATATCGTCTCGCAGGCGGAAATCGTTCCCGGCCAAACGGTGATCCGGCCGAGATCGGCACCGATCAGTCCGGAGG
GCGGCATGGCGGTGCTGCGGGGCAACCTGGCTCCTGACGGGGCGATCATCAAACAGTCGGCGGCCTCCAGCGCCCTCGCC
CGTCATCGTGGCGTCGCCCTCGTGTTCGATTCCCTGCCCGACCTGATGGCTCGCATCGATGCGCCCGATCTTGATGTCTC
CCCCGGCACCGTGCTCGTGCTCAGAAACGCCGGCCCCAAGGGCGCGCCCGGTATGCCGGAGGCAGGCTATATACCTATCC
CCAAGAAGCTGGCCAGCAGCGGGGTCACAGACATGGTCCGCATTTCCGACGCACGCATGAGCGGCACCGCTTTTGGAACG
GTCGTCCTGCATGTGGCCCCTGAAGCCGCGGTCGGCGGACCATTGGGGCTTGTCAGAACCGGGGACGAGATCGAGCTTGA
CATACCCGGGCGCCGGCTTGAGCTTCTCGTCAGCGAGGAGGAATTAAGCAAGCGGACACCGTCAGCCCCACCGCAAGACC
TTCCGCAACGAGGATACGCGAGACTTTTTCAGGAGCAGATCCTTCAGGCGGACAGAGGCTGTGATTTCGAATTCCTCATC
CCTCCTCCGGATTCGCGACATGATGGCAGATAG

Upstream 100 bases:

>100_bases
ATCATTATTGACAATTTGCCCCGTCAAGCGATAACCCGAGCCTACCGAGCTGCAAAATCGAGCGCGTTTAGTGCCTGCAG
AGGGTGGAGGAGAAAAGTCG

Downstream 100 bases:

>100_bases
CGACCCTGTCCCACCCGGTGCTCCTCGCTGCCTGCCGCCTCGACGGCTGGAGCGCACACCGCACTTTCTTCCGCCCCCCG
GCAGCTGCGATGCGCATGTC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 570; Mature: 570

Protein sequence:

>570_residues
MENGLRKGLTDYGDKEFSLFLRRVFIKAMGYSDEALDRPIVGITNTFSDYNPCHGNVPALIEGVKRGVMLAGALPMVFPT
ISIHESFAHPTSMFLRNLMSMDTEEMIRAQPMDAVVLIGGCDKTLPAQMMAAVSAGIPSIVLPVGPMVVGHHKGEVLGAC
TDCRRLWSGHRAGRISKSEIDEVSGRLAPSVGTCMVMGTASTMASMCEALGFSLPMSASIPATHAERIRCAEATGKRAVE
MARSGGPLPHEILTQDSLHNAQVLLQALGGSTNGLIHLAAIAGRAGLSVDLEEFDALGRSVPVLVDLKPSGMHYMEHFHH
AGGVPRLLAELSDLLRLDARTVTGGILADIVSQAEIVPGQTVIRPRSAPISPEGGMAVLRGNLAPDGAIIKQSAASSALA
RHRGVALVFDSLPDLMARIDAPDLDVSPGTVLVLRNAGPKGAPGMPEAGYIPIPKKLASSGVTDMVRISDARMSGTAFGT
VVLHVAPEAAVGGPLGLVRTGDEIELDIPGRRLELLVSEEELSKRTPSAPPQDLPQRGYARLFQEQILQADRGCDFEFLI
PPPDSRHDGR

Sequences:

>Translated_570_residues
MENGLRKGLTDYGDKEFSLFLRRVFIKAMGYSDEALDRPIVGITNTFSDYNPCHGNVPALIEGVKRGVMLAGALPMVFPT
ISIHESFAHPTSMFLRNLMSMDTEEMIRAQPMDAVVLIGGCDKTLPAQMMAAVSAGIPSIVLPVGPMVVGHHKGEVLGAC
TDCRRLWSGHRAGRISKSEIDEVSGRLAPSVGTCMVMGTASTMASMCEALGFSLPMSASIPATHAERIRCAEATGKRAVE
MARSGGPLPHEILTQDSLHNAQVLLQALGGSTNGLIHLAAIAGRAGLSVDLEEFDALGRSVPVLVDLKPSGMHYMEHFHH
AGGVPRLLAELSDLLRLDARTVTGGILADIVSQAEIVPGQTVIRPRSAPISPEGGMAVLRGNLAPDGAIIKQSAASSALA
RHRGVALVFDSLPDLMARIDAPDLDVSPGTVLVLRNAGPKGAPGMPEAGYIPIPKKLASSGVTDMVRISDARMSGTAFGT
VVLHVAPEAAVGGPLGLVRTGDEIELDIPGRRLELLVSEEELSKRTPSAPPQDLPQRGYARLFQEQILQADRGCDFEFLI
PPPDSRHDGR
>Mature_570_residues
MENGLRKGLTDYGDKEFSLFLRRVFIKAMGYSDEALDRPIVGITNTFSDYNPCHGNVPALIEGVKRGVMLAGALPMVFPT
ISIHESFAHPTSMFLRNLMSMDTEEMIRAQPMDAVVLIGGCDKTLPAQMMAAVSAGIPSIVLPVGPMVVGHHKGEVLGAC
TDCRRLWSGHRAGRISKSEIDEVSGRLAPSVGTCMVMGTASTMASMCEALGFSLPMSASIPATHAERIRCAEATGKRAVE
MARSGGPLPHEILTQDSLHNAQVLLQALGGSTNGLIHLAAIAGRAGLSVDLEEFDALGRSVPVLVDLKPSGMHYMEHFHH
AGGVPRLLAELSDLLRLDARTVTGGILADIVSQAEIVPGQTVIRPRSAPISPEGGMAVLRGNLAPDGAIIKQSAASSALA
RHRGVALVFDSLPDLMARIDAPDLDVSPGTVLVLRNAGPKGAPGMPEAGYIPIPKKLASSGVTDMVRISDARMSGTAFGT
VVLHVAPEAAVGGPLGLVRTGDEIELDIPGRRLELLVSEEELSKRTPSAPPQDLPQRGYARLFQEQILQADRGCDFEFLI
PPPDSRHDGR

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=555, Percent_Identity=32.7927927927928, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI1788157, Length=523, Percent_Identity=31.9311663479924, Blast_Score=173, Evalue=3e-44,
Organism=Escherichia coli, GI2367371, Length=472, Percent_Identity=31.9915254237288, Blast_Score=165, Evalue=8e-42,
Organism=Escherichia coli, GI1786464, Length=454, Percent_Identity=33.2599118942731, Blast_Score=160, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6322476, Length=554, Percent_Identity=31.7689530685921, Blast_Score=263, Evalue=6e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 60403; Mature: 60403

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENGLRKGLTDYGDKEFSLFLRRVFIKAMGYSDEALDRPIVGITNTFSDYNPCHGNVPAL
CCCCHHHCHHHCCCHHHHHHHHHHHHHHCCCCHHHHCCCCEEEECCCCCCCCCCCCHHHH
IEGVKRGVMLAGALPMVFPTISIHESFAHPTSMFLRNLMSMDTEEMIRAQPMDAVVLIGG
HHHHHHCEEHHCCHHHHHCCHHHHHHHCCHHHHHHHHHHCCCHHHHHHCCCCCEEEEEEC
CDKTLPAQMMAAVSAGIPSIVLPVGPMVVGHHKGEVLGACTDCRRLWSGHRAGRISKSEI
CCCCHHHHHHHHHHCCCCEEEECCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHH
DEVSGRLAPSVGTCMVMGTASTMASMCEALGFSLPMSASIPATHAERIRCAEATGKRAVE
HHHHCCCCCCCCCEEEEECHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
MARSGGPLPHEILTQDSLHNAQVLLQALGGSTNGLIHLAAIAGRAGLSVDLEEFDALGRS
HHHCCCCCCHHHHCCCCHHHHHHHHHHHCCCCCCEEEEEEHHCCCCCEEEHHHHHHCCCC
VPVLVDLKPSGMHYMEHFHHAGGVPRLLAELSDLLRLDARTVTGGILADIVSQAEIVPGQ
CCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TVIRPRSAPISPEGGMAVLRGNLAPDGAIIKQSAASSALARHRGVALVFDSLPDLMARID
EEECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHCC
APDLDVSPGTVLVLRNAGPKGAPGMPEAGYIPIPKKLASSGVTDMVRISDARMSGTAFGT
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEECCCCCCCCEEEE
VVLHVAPEAAVGGPLGLVRTGDEIELDIPGRRLELLVSEEELSKRTPSAPPQDLPQRGYA
EEEEECCCCCCCCCEEEEECCCEEEEECCCCEEEEEECHHHHHHCCCCCCCHHCCHHHHH
RLFQEQILQADRGCDFEFLIPPPDSRHDGR
HHHHHHHHHHHCCCCEEEEECCCCCCCCCC
>Mature Secondary Structure
MENGLRKGLTDYGDKEFSLFLRRVFIKAMGYSDEALDRPIVGITNTFSDYNPCHGNVPAL
CCCCHHHCHHHCCCHHHHHHHHHHHHHHCCCCHHHHCCCCEEEECCCCCCCCCCCCHHHH
IEGVKRGVMLAGALPMVFPTISIHESFAHPTSMFLRNLMSMDTEEMIRAQPMDAVVLIGG
HHHHHHCEEHHCCHHHHHCCHHHHHHHCCHHHHHHHHHHCCCHHHHHHCCCCCEEEEEEC
CDKTLPAQMMAAVSAGIPSIVLPVGPMVVGHHKGEVLGACTDCRRLWSGHRAGRISKSEI
CCCCHHHHHHHHHHCCCCEEEECCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHH
DEVSGRLAPSVGTCMVMGTASTMASMCEALGFSLPMSASIPATHAERIRCAEATGKRAVE
HHHHCCCCCCCCCEEEEECHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
MARSGGPLPHEILTQDSLHNAQVLLQALGGSTNGLIHLAAIAGRAGLSVDLEEFDALGRS
HHHCCCCCCHHHHCCCCHHHHHHHHHHHCCCCCCEEEEEEHHCCCCCEEEHHHHHHCCCC
VPVLVDLKPSGMHYMEHFHHAGGVPRLLAELSDLLRLDARTVTGGILADIVSQAEIVPGQ
CCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TVIRPRSAPISPEGGMAVLRGNLAPDGAIIKQSAASSALARHRGVALVFDSLPDLMARID
EEECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHCC
APDLDVSPGTVLVLRNAGPKGAPGMPEAGYIPIPKKLASSGVTDMVRISDARMSGTAFGT
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEECCCCCCCCEEEE
VVLHVAPEAAVGGPLGLVRTGDEIELDIPGRRLELLVSEEELSKRTPSAPPQDLPQRGYA
EEEEECCCCCCCCCEEEEECCCEEEEECCCCEEEEEECHHHHHHCCCCCCCHHCCHHHHH
RLFQEQILQADRGCDFEFLIPPPDSRHDGR
HHHHHHHHHHHCCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA