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The map label for this gene is fabG [H]

Identifier: 110636037

GI number: 110636037

Start: 4006422

End: 4007186

Strand: Reverse

Name: fabG [H]

Synonym: Meso_3712

Alternate gene names: 110636037

Gene position: 4007186-4006422 (Counterclockwise)

Preceding gene: 110636038

Following gene: 110636036

Centisome position: 90.82

GC content: 65.49

Gene sequence:

>765_bases
TTGGAAAAGGCAGTCGTATTGATTACCGGGGCGGCCAGCGGAATCGGCGCCGCCGTAGCGCGCAAGCTCGCCGCAGACGG
ATTTCGCGTTGCGGCGTGCGACCTGAATTTGCCTGGCGCGGAGGCAACCGCGTCAGCGCTGGGGGATGGCCACAAAGCGT
GGCTGATGAATGTGACGGATGAGTCGAGCGTGGCCGCCAGCTTCGCCGGTGCCGTCGAGAGTATGGGGCCAATCTACGGC
GTCGTTTGTTGCGCGGGGGGCGTGAAGTCGTCCTATGACAAGATGCCCGCAACCGCAGATGTTTCGCTCGACGACTGGAT
TTGGACGGAGGCGTTAAACGCGCGCGGCGCGTTCTTGTGTATTCGCGAATTCCTGCGTCAGCATCGTGCAAACCGGTTGC
AGGGCGGCAGGATCGTGACCTTCGCGTCGCTGGCTGGCCAAACCGGCCGAAAGGCCGGGGTTTCCTACGGTGCGGCCAAG
GCAGCGGTGCTGGGCCTGACGCGCACTGTGGCGCTCGAGGTCGCGCCCCAGGGGATTACCTGCAACGCCGTGGCGCCGGG
AGTCATCGACACGCCCGCCTTCCGCGGCATCGTGGAGGCAGGTCCCCAAGACGAATTGCGGGGCCCCTACATCCAGGAGG
TTCCGCTGAAGCGCGTCGGCAAAGCCGAGGAAGTCGCCGCCGCGGTCTCCTATCTGATGTCACCGGGTGCCGGGTTCGTC
ACCGGCTCGACCCTCGACGTCAATGGCGGGCTCAGGATGGGCTGA

Upstream 100 bases:

>100_bases
GCAATTCGAGTGCCGCTGTTTCGGACGGTGAGAATTGCGTTGCGTTGACGTGATTTGGTATTTGGTATACTGTACACAGA
AACTAGGGAGCGAAACGATC

Downstream 100 bases:

>100_bases
CTGCGGCCGCTCGCATGCGACCGATGACGGCTCCATCAGTCGCCAGAATCGCGGTCGCGACGAGCGACCGCCAGCGGCAA
CACAACGGGAGGAGAACCGA

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MEKAVVLITGAASGIGAAVARKLAADGFRVAACDLNLPGAEATASALGDGHKAWLMNVTDESSVAASFAGAVESMGPIYG
VVCCAGGVKSSYDKMPATADVSLDDWIWTEALNARGAFLCIREFLRQHRANRLQGGRIVTFASLAGQTGRKAGVSYGAAK
AAVLGLTRTVALEVAPQGITCNAVAPGVIDTPAFRGIVEAGPQDELRGPYIQEVPLKRVGKAEEVAAAVSYLMSPGAGFV
TGSTLDVNGGLRMG

Sequences:

>Translated_254_residues
MEKAVVLITGAASGIGAAVARKLAADGFRVAACDLNLPGAEATASALGDGHKAWLMNVTDESSVAASFAGAVESMGPIYG
VVCCAGGVKSSYDKMPATADVSLDDWIWTEALNARGAFLCIREFLRQHRANRLQGGRIVTFASLAGQTGRKAGVSYGAAK
AAVLGLTRTVALEVAPQGITCNAVAPGVIDTPAFRGIVEAGPQDELRGPYIQEVPLKRVGKAEEVAAAVSYLMSPGAGFV
TGSTLDVNGGLRMG
>Mature_254_residues
MEKAVVLITGAASGIGAAVARKLAADGFRVAACDLNLPGAEATASALGDGHKAWLMNVTDESSVAASFAGAVESMGPIYG
VVCCAGGVKSSYDKMPATADVSLDDWIWTEALNARGAFLCIREFLRQHRANRLQGGRIVTFASLAGQTGRKAGVSYGAAK
AAVLGLTRTVALEVAPQGITCNAVAPGVIDTPAFRGIVEAGPQDELRGPYIQEVPLKRVGKAEEVAAAVSYLMSPGAGFV
TGSTLDVNGGLRMG

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=265, Percent_Identity=33.9622641509434, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI40254992, Length=254, Percent_Identity=32.2834645669291, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI66933014, Length=254, Percent_Identity=32.2834645669291, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI19923817, Length=262, Percent_Identity=29.3893129770992, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI5031737, Length=251, Percent_Identity=31.0756972111554, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI10190704, Length=259, Percent_Identity=31.6602316602317, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI32483357, Length=249, Percent_Identity=29.3172690763052, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4758504, Length=255, Percent_Identity=30.1960784313725, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI59889578, Length=236, Percent_Identity=29.2372881355932, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI83715985, Length=256, Percent_Identity=28.90625, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI33667109, Length=200, Percent_Identity=31.5, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI126723750, Length=255, Percent_Identity=27.0588235294118, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI7705925, Length=257, Percent_Identity=28.4046692607004, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1787335, Length=253, Percent_Identity=35.1778656126482, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1789057, Length=264, Percent_Identity=31.0606060606061, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI2367175, Length=253, Percent_Identity=35.5731225296443, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI1788459, Length=253, Percent_Identity=32.4110671936759, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI87082100, Length=251, Percent_Identity=31.8725099601594, Blast_Score=97, Evalue=7e-22,
Organism=Escherichia coli, GI1786812, Length=254, Percent_Identity=31.1023622047244, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1790717, Length=251, Percent_Identity=29.0836653386454, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1787905, Length=250, Percent_Identity=29.6, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI2367365, Length=251, Percent_Identity=31.0756972111554, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1789378, Length=256, Percent_Identity=29.6875, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789208, Length=252, Percent_Identity=27.3809523809524, Blast_Score=71, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17555706, Length=257, Percent_Identity=35.7976653696498, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI25147288, Length=252, Percent_Identity=33.7301587301587, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17538182, Length=258, Percent_Identity=31.0077519379845, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17560676, Length=254, Percent_Identity=25.1968503937008, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI115534694, Length=246, Percent_Identity=28.8617886178862, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17561402, Length=264, Percent_Identity=25.7575757575758, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17560332, Length=264, Percent_Identity=28.7878787878788, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71994604, Length=262, Percent_Identity=28.2442748091603, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17564282, Length=203, Percent_Identity=29.5566502463054, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71994600, Length=264, Percent_Identity=29.9242424242424, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=262, Percent_Identity=29.3893129770992, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6324126, Length=198, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24639444, Length=251, Percent_Identity=33.4661354581673, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI23397609, Length=255, Percent_Identity=32.9411764705882, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI21355319, Length=259, Percent_Identity=28.957528957529, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI17737361, Length=262, Percent_Identity=31.2977099236641, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21357041, Length=262, Percent_Identity=30.1526717557252, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI28571526, Length=258, Percent_Identity=30.2325581395349, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24644337, Length=120, Percent_Identity=42.5, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24644339, Length=255, Percent_Identity=30.1960784313725, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24649181, Length=194, Percent_Identity=30.4123711340206, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 25940; Mature: 25940

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKAVVLITGAASGIGAAVARKLAADGFRVAACDLNLPGAEATASALGDGHKAWLMNVTD
CCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCEEEEEECCC
ESSVAASFAGAVESMGPIYGVVCCAGGVKSSYDKMPATADVSLDDWIWTEALNARGAFLC
CHHHHHHHHHHHHHHCHHHHHHHCCCCCCCHHHCCCCCCCCCHHHHHHHHHHCCCCHHHH
IREFLRQHRANRLQGGRIVTFASLAGQTGRKAGVSYGAAKAAVLGLTRTVALEVAPQGIT
HHHHHHHHHHHHCCCCEEEEEEHHCCCCCCHHCCCCCHHHHHHHHHHHEEEEEECCCCEE
CNAVAPGVIDTPAFRGIVEAGPQDELRGPYIQEVPLKRVGKAEEVAAAVSYLMSPGAGFV
ECCCCCCCCCCHHHHHHHHCCCCHHHCCCCHHHCCHHHCCCHHHHHHHHHHHHCCCCCEE
TGSTLDVNGGLRMG
ECCEEECCCCCCCC
>Mature Secondary Structure
MEKAVVLITGAASGIGAAVARKLAADGFRVAACDLNLPGAEATASALGDGHKAWLMNVTD
CCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCEEEEEECCC
ESSVAASFAGAVESMGPIYGVVCCAGGVKSSYDKMPATADVSLDDWIWTEALNARGAFLC
CHHHHHHHHHHHHHHCHHHHHHHCCCCCCCHHHCCCCCCCCCHHHHHHHHHHCCCCHHHH
IREFLRQHRANRLQGGRIVTFASLAGQTGRKAGVSYGAAKAAVLGLTRTVALEVAPQGIT
HHHHHHHHHHHHCCCCEEEEEEHHCCCCCCHHCCCCCHHHHHHHHHHHEEEEEECCCCEE
CNAVAPGVIDTPAFRGIVEAGPQDELRGPYIQEVPLKRVGKAEEVAAAVSYLMSPGAGFV
ECCCCCCCCCCHHHHHHHHCCCCHHHCCCCHHHCCHHHCCCHHHHHHHHHHHHCCCCCEE
TGSTLDVNGGLRMG
ECCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]