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The map label for this gene is hipA [C]

Identifier: 110632871

GI number: 110632871

Start: 564057

End: 565325

Strand: Direct

Name: hipA [C]

Synonym: Meso_0511

Alternate gene names: 110632871

Gene position: 564057-565325 (Clockwise)

Preceding gene: 110632870

Following gene: 110632892

Centisome position: 12.78

GC content: 64.14

Gene sequence:

>1269_bases
ATGACGCGCACCCTCGATATCTGGTGGGACGGGCGCCTGGTGGGTCAGCTGACGCAGGACAAGCATGGTGAACTCGGCTT
CGCCTATGCGCGGGCTTGGCTCGACGACGAGGCGGCGCAGCCCTTGTCAGCCTCACTGCCAAAGCGGACGAAGCCGTTCA
GTCGTCGCGAGTGCCGCCCATTTTTCGGCGGTCTCTTGCCGGAGGAAAGCCAGCGCGACGCCGCGGCTCAGGCACTCGGC
GTGTCGCGCGCCAATGATTTCGCCCTTCTTGATCGCCTCGGCGGCGATGTGGCGGGCGCGCTCCAGCTTCTGCCGCCCGG
CGAAGGTCCGACCGCTCCTGCCCCCGATCAACGGCCAATCCCGCTTGACGATGAGGGCCTGATCCGGGTGCTGGACGCGC
TGCCCGTCCGCCCATTGCTCGCGGGCGAGGAAGGCTTGCGGCTCTCTCTCGCTGGCGCCCAATCGAAGGTGCCGGTGGTT
CTGGTGGAAGGCGCAGTGGCGTTGCCTGCTCCGGGCCAGCCCACGACGCATATTCTCAAGCCCCCGATATCCCGCTTCGC
GGCCACGACCGAGAACGAGGCCTTCGTGATGCGCCTTGCTGCCGCCATCGGCCTCGATGTCGCGCCGGTAGAAGCCCGCA
TCGTTCAGGATCGAACGTTTCTGCTGGTCCAGCGCTATGACCGCCTCATTGGCGACGATGGCTTTGTGCGCCGCATCCAT
CAGGAGGATTTCTGCCAGGCGCTCGGCGTGCCACCGGAGACCAAATATGCGAGCGAAGGCGGGCCGACCTTCAAGGATTG
CTTCGCGCTGCTCCGCCGCGTCGCCGCAAGGCCCGCTGTCGATGTGCTGAAGCTTCTCGATGCGGTGATCTTCAATGTGA
TCGCCGGGAACGCCGACGCACACGGCAAGAATTTTTCGATCCTCTACGGCGACGAAGGCCCACGCCTAGCCCCGCTGTAT
GATTTGCTTGCGACAGTTGCCTATCCCGATCTCTCGCCGAAATTTGCCATGAAGATCGGGAAACGAGCGACGCTTGCCGA
ACTGGATGCGAAGGGGTGGGCAGCGTTCGCGGCGGACACAGGTCTCGGTCTGCCGCTGATACGACGACGGGTTGCGGAGA
TCAGCAAAGAGGTCCTCGAGAAAGCAGCCGCAGTCGCAGAGGAACTTTCGCGCCCTGAGTTGGACCGAACGGCTATCGAG
CAGTTTGCCAACATGATCCGTGACCGCGCCGATCGCTGTGCTTTGACGATCGCGGGAGCCATGCGATGA

Upstream 100 bases:

>100_bases
AGCCGACCGCGCAGATCGGCAAGACACTTCAGGTCCTAGCCGCGTTGGGCTGCTCGCTCGATATCACACCGCCGCCCGAT
CCCAAAGGAGCGCGGAAGGG

Downstream 100 bases:

>100_bases
CGCGGTCGATAAAGAGCCGCCCATCGTCGGTTAAACCCGGGAAGTAATACGCGCTGCGGTACGGATATCGGCGATCTGGA
TGCCAAGAGCCTGCAGATTT

Product: HipA-like

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 421

Protein sequence:

>422_residues
MTRTLDIWWDGRLVGQLTQDKHGELGFAYARAWLDDEAAQPLSASLPKRTKPFSRRECRPFFGGLLPEESQRDAAAQALG
VSRANDFALLDRLGGDVAGALQLLPPGEGPTAPAPDQRPIPLDDEGLIRVLDALPVRPLLAGEEGLRLSLAGAQSKVPVV
LVEGAVALPAPGQPTTHILKPPISRFAATTENEAFVMRLAAAIGLDVAPVEARIVQDRTFLLVQRYDRLIGDDGFVRRIH
QEDFCQALGVPPETKYASEGGPTFKDCFALLRRVAARPAVDVLKLLDAVIFNVIAGNADAHGKNFSILYGDEGPRLAPLY
DLLATVAYPDLSPKFAMKIGKRATLAELDAKGWAAFAADTGLGLPLIRRRVAEISKEVLEKAAAVAEELSRPELDRTAIE
QFANMIRDRADRCALTIAGAMR

Sequences:

>Translated_422_residues
MTRTLDIWWDGRLVGQLTQDKHGELGFAYARAWLDDEAAQPLSASLPKRTKPFSRRECRPFFGGLLPEESQRDAAAQALG
VSRANDFALLDRLGGDVAGALQLLPPGEGPTAPAPDQRPIPLDDEGLIRVLDALPVRPLLAGEEGLRLSLAGAQSKVPVV
LVEGAVALPAPGQPTTHILKPPISRFAATTENEAFVMRLAAAIGLDVAPVEARIVQDRTFLLVQRYDRLIGDDGFVRRIH
QEDFCQALGVPPETKYASEGGPTFKDCFALLRRVAARPAVDVLKLLDAVIFNVIAGNADAHGKNFSILYGDEGPRLAPLY
DLLATVAYPDLSPKFAMKIGKRATLAELDAKGWAAFAADTGLGLPLIRRRVAEISKEVLEKAAAVAEELSRPELDRTAIE
QFANMIRDRADRCALTIAGAMR
>Mature_421_residues
TRTLDIWWDGRLVGQLTQDKHGELGFAYARAWLDDEAAQPLSASLPKRTKPFSRRECRPFFGGLLPEESQRDAAAQALGV
SRANDFALLDRLGGDVAGALQLLPPGEGPTAPAPDQRPIPLDDEGLIRVLDALPVRPLLAGEEGLRLSLAGAQSKVPVVL
VEGAVALPAPGQPTTHILKPPISRFAATTENEAFVMRLAAAIGLDVAPVEARIVQDRTFLLVQRYDRLIGDDGFVRRIHQ
EDFCQALGVPPETKYASEGGPTFKDCFALLRRVAARPAVDVLKLLDAVIFNVIAGNADAHGKNFSILYGDEGPRLAPLYD
LLATVAYPDLSPKFAMKIGKRATLAELDAKGWAAFAADTGLGLPLIRRRVAEISKEVLEKAAAVAEELSRPELDRTAIEQ
FANMIRDRADRCALTIAGAMR

Specific function: Unbalanced Or Excessive Expression Of Hipa Is Toxic To The Cell. [C]

COG id: COG3550

COG function: function code R; Uncharacterized protein related to capsule biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli hipA, H.influenzae HI_0665 and y4dM [H]

Homologues:

Organism=Escherichia coli, GI1787785, Length=343, Percent_Identity=31.7784256559767, Blast_Score=142, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012893
- InterPro:   IPR012894
- InterPro:   IPR017508 [H]

Pfam domain/function: PF07804 HipA_C; PF07805 HipA_N [H]

EC number: NA

Molecular weight: Translated: 45628; Mature: 45497

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRTLDIWWDGRLVGQLTQDKHGELGFAYARAWLDDEAAQPLSASLPKRTKPFSRRECRP
CCCEEEEEECCEEEECCCCCCCCCHHHHHHHHHHCHHHCCCHHHCCCCCCCCCCHHCCCH
FFGGLLPEESQRDAAAQALGVSRANDFALLDRLGGDVAGALQLLPPGEGPTAPAPDQRPI
HHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHEECCCCCCCCCCCCCCCCC
PLDDEGLIRVLDALPVRPLLAGEEGLRLSLAGAQSKVPVVLVEGAVALPAPGQPTTHILK
CCCCHHHHHHHHHCCCCHHHCCCCCCEEEECCCCCCCCEEEECCCEECCCCCCCCCHHCC
PPISRFAATTENEAFVMRLAAAIGLDVAPVEARIVQDRTFLLVQRYDRLIGDDGFVRRIH
CCHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHCCCHHHHHHH
QEDFCQALGVPPETKYASEGGPTFKDCFALLRRVAARPAVDVLKLLDAVIFNVIAGNADA
HHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCC
HGKNFSILYGDEGPRLAPLYDLLATVAYPDLSPKFAMKIGKRATLAELDAKGWAAFAADT
CCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHCCCCCEEEECCC
GLGLPLIRRRVAEISKEVLEKAAAVAEELSRPELDRTAIEQFANMIRDRADRCALTIAGA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHEEEEECCC
MR
CC
>Mature Secondary Structure 
TRTLDIWWDGRLVGQLTQDKHGELGFAYARAWLDDEAAQPLSASLPKRTKPFSRRECRP
CCEEEEEECCEEEECCCCCCCCCHHHHHHHHHHCHHHCCCHHHCCCCCCCCCCHHCCCH
FFGGLLPEESQRDAAAQALGVSRANDFALLDRLGGDVAGALQLLPPGEGPTAPAPDQRPI
HHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHEECCCCCCCCCCCCCCCCC
PLDDEGLIRVLDALPVRPLLAGEEGLRLSLAGAQSKVPVVLVEGAVALPAPGQPTTHILK
CCCCHHHHHHHHHCCCCHHHCCCCCCEEEECCCCCCCCEEEECCCEECCCCCCCCCHHCC
PPISRFAATTENEAFVMRLAAAIGLDVAPVEARIVQDRTFLLVQRYDRLIGDDGFVRRIH
CCHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHCCCHHHHHHH
QEDFCQALGVPPETKYASEGGPTFKDCFALLRRVAARPAVDVLKLLDAVIFNVIAGNADA
HHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCC
HGKNFSILYGDEGPRLAPLYDLLATVAYPDLSPKFAMKIGKRATLAELDAKGWAAFAADT
CCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHCCCCCEEEECCC
GLGLPLIRRRVAEISKEVLEKAAAVAEELSRPELDRTAIEQFANMIRDRADRCALTIAGA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHEEEEECCC
MR
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]