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The map label for this gene is guaA [H]

Identifier: 110632855

GI number: 110632855

Start: 549263

End: 550822

Strand: Direct

Name: guaA [H]

Synonym: Meso_0495

Alternate gene names: 110632855

Gene position: 549263-550822 (Clockwise)

Preceding gene: 110632854

Following gene: 110632856

Centisome position: 12.45

GC content: 62.05

Gene sequence:

>1560_bases
ATGACCATTACCCATCCCGACACTGTTCTGATCATCGATTTCGGCAGCCAGGTCACGCAGCTGATCGCCCGGCGCGTCCG
CGAGGCCGGCGTCTATTCCGAAATTGCTCCCTTTCAGTCAGCCGAAGAGGCTTATCTGCGGCTCAAGCCGAAGGCGGTCA
TCCTTTCCGGCAGCCCGGCCTCGACCGTCGAGATCGACAGTCCTCGTGCGCCCGATGTGATTTTCCAGTCAGGCGTGCCG
GTTCTCGGTATCTGCTATGGCGAGCAGACCATGTGCGCCCAGCTCGGCGGCAAGGTCGAATCCAGTGATCATCGCGAGTT
CGGCCGCGCCTTCCTCGAGATCGAGGAGGATTGCGGGCTGTTCGCCGGCATCTGGGCGCCCGGCACGCGCCATCAGGTCT
GGATGAGCCATGGCGACCGCGTGACGGCGCTTCCGCCCGGCTTTAAGGTTGTCGGAACTTCAGCGGGCGCGCCTTTTGCG
GCCATCGCCGACGATAAGCGCAAATATTACGGTGTGCAGTTCCATCCGGAAGTGGTCCACACACCCGATGGCGCAAAGCT
GCTTGCCAACTTCGTTCACAGGATCGCGGGCCTTAAGGGCGATTGGACCATGGCCGCTTATCGCGAACAGGCGGTGGATG
CGATCCGCGCCCAGGTTGGTTCCGGCAAGGTGATCTGTGCGCTCTCCGGCGGCGTCGATTCCTCCGTCGCCGCGCTTCTC
ACCCATGAGGCGGTGGGAGAGCAGCTCACCTGCATCCTTGTCGACCATGGCCTGATGCGCAAGAACGAGGCGGCGGAAGT
GGTCTCCATGTTCCGCGAGCACTATAATGTGCCGCTCGTGCTGGTCGATGCTTCCGACCGTTTCCTAAGCGCGCTCGAGG
GTGAAACCGATCCCGAGAAGAAGCGCAAAACGATCGGCCGTCTCTTCATTGAGGTGTTCGAGGACGAGGCAAAAAAGCTG
GGTGGCGCTGATTTTTTGGTGCAGGGCACGCTCTATCCGGACGTGATCGAGAGTGTCTCCTTCACGGGCGGCCCCTCGGT
CACCATCAAATCGCACCACAATGTGGGCGGCCTGCCCGAGCGCATGAACATGAAGCTGGTCGAGCCGCTGCGCGAGCTCT
TCAAGGACGAGGTGCGGGTGCTCGGCAGGAAGCTCGGCCTGCCCGACCATTTCATCGGCCGTCATCCCTTCCCGGGCCCC
GGCCTTGCCATCCGCTGTCCCGGCGGGATCACGCGCGAGAAGCTCGAAATCCTGCGCGCGGCCGACGCCATTTACCTCGA
CGAGATCCGCAAGTCGGGCCTTTACGACGCGATCTGGCAAGCCTTCGCCGTGCTTTTGCCGGTACAGACCGTCGGGGTGA
TGGGAGACGGCCGCACCTATGAATATGTCTGCGCGCTTCGCGCGGTGACGTCAGTCGATGGCATGACGGCTGATTTCTAT
CACTTCGACATGGAGTTCCTTGGCCGCGCCGCCACCCGCATCATCAACGAAGTGCGCGGGATCAATCGCGTGGTCTACGA
TGTGACGTCCAAGCCACCTGGGACTATCGAGTGGGAGTAA

Upstream 100 bases:

>100_bases
CTGATCGGGTGGCGGAAAACGCATGGTGCTGAACGGATTGCGGCAAAAAACCCCTATCGAACCCGTTGCGCGGGATCGCT
TCCTTCTTTAAAGCCTCGCC

Downstream 100 bases:

>100_bases
TTTTTGCCCATCCGAGGCTATCCGAAACTACGCCAGAATACGACGTAACCACCTGAAAAACAAAAATATTTCAGCCGAGA
CCTATCGAGAGCTATCGGTG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 519; Mature: 518

Protein sequence:

>519_residues
MTITHPDTVLIIDFGSQVTQLIARRVREAGVYSEIAPFQSAEEAYLRLKPKAVILSGSPASTVEIDSPRAPDVIFQSGVP
VLGICYGEQTMCAQLGGKVESSDHREFGRAFLEIEEDCGLFAGIWAPGTRHQVWMSHGDRVTALPPGFKVVGTSAGAPFA
AIADDKRKYYGVQFHPEVVHTPDGAKLLANFVHRIAGLKGDWTMAAYREQAVDAIRAQVGSGKVICALSGGVDSSVAALL
THEAVGEQLTCILVDHGLMRKNEAAEVVSMFREHYNVPLVLVDASDRFLSALEGETDPEKKRKTIGRLFIEVFEDEAKKL
GGADFLVQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMNMKLVEPLRELFKDEVRVLGRKLGLPDHFIGRHPFPGP
GLAIRCPGGITREKLEILRAADAIYLDEIRKSGLYDAIWQAFAVLLPVQTVGVMGDGRTYEYVCALRAVTSVDGMTADFY
HFDMEFLGRAATRIINEVRGINRVVYDVTSKPPGTIEWE

Sequences:

>Translated_519_residues
MTITHPDTVLIIDFGSQVTQLIARRVREAGVYSEIAPFQSAEEAYLRLKPKAVILSGSPASTVEIDSPRAPDVIFQSGVP
VLGICYGEQTMCAQLGGKVESSDHREFGRAFLEIEEDCGLFAGIWAPGTRHQVWMSHGDRVTALPPGFKVVGTSAGAPFA
AIADDKRKYYGVQFHPEVVHTPDGAKLLANFVHRIAGLKGDWTMAAYREQAVDAIRAQVGSGKVICALSGGVDSSVAALL
THEAVGEQLTCILVDHGLMRKNEAAEVVSMFREHYNVPLVLVDASDRFLSALEGETDPEKKRKTIGRLFIEVFEDEAKKL
GGADFLVQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMNMKLVEPLRELFKDEVRVLGRKLGLPDHFIGRHPFPGP
GLAIRCPGGITREKLEILRAADAIYLDEIRKSGLYDAIWQAFAVLLPVQTVGVMGDGRTYEYVCALRAVTSVDGMTADFY
HFDMEFLGRAATRIINEVRGINRVVYDVTSKPPGTIEWE
>Mature_518_residues
TITHPDTVLIIDFGSQVTQLIARRVREAGVYSEIAPFQSAEEAYLRLKPKAVILSGSPASTVEIDSPRAPDVIFQSGVPV
LGICYGEQTMCAQLGGKVESSDHREFGRAFLEIEEDCGLFAGIWAPGTRHQVWMSHGDRVTALPPGFKVVGTSAGAPFAA
IADDKRKYYGVQFHPEVVHTPDGAKLLANFVHRIAGLKGDWTMAAYREQAVDAIRAQVGSGKVICALSGGVDSSVAALLT
HEAVGEQLTCILVDHGLMRKNEAAEVVSMFREHYNVPLVLVDASDRFLSALEGETDPEKKRKTIGRLFIEVFEDEAKKLG
GADFLVQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMNMKLVEPLRELFKDEVRVLGRKLGLPDHFIGRHPFPGPG
LAIRCPGGITREKLEILRAADAIYLDEIRKSGLYDAIWQAFAVLLPVQTVGVMGDGRTYEYVCALRAVTSVDGMTADFYH
FDMEFLGRAATRIINEVRGINRVVYDVTSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=549, Percent_Identity=36.0655737704918, Blast_Score=294, Evalue=1e-79,
Organism=Escherichia coli, GI1788854, Length=520, Percent_Identity=55.3846153846154, Blast_Score=588, Evalue=1e-169,
Organism=Escherichia coli, GI1789760, Length=151, Percent_Identity=32.4503311258278, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71992717, Length=571, Percent_Identity=35.9019264448336, Blast_Score=284, Evalue=7e-77,
Organism=Caenorhabditis elegans, GI71992710, Length=571, Percent_Identity=35.9019264448336, Blast_Score=284, Evalue=8e-77,
Organism=Caenorhabditis elegans, GI133901714, Length=569, Percent_Identity=35.8523725834798, Blast_Score=283, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6323873, Length=520, Percent_Identity=52.3076923076923, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI281365319, Length=550, Percent_Identity=34.9090909090909, Blast_Score=275, Evalue=6e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 56748; Mature: 56616

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITHPDTVLIIDFGSQVTQLIARRVREAGVYSEIAPFQSAEEAYLRLKPKAVILSGSPA
CCCCCCCEEEEEECCHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHEEECCCEEEEECCCC
STVEIDSPRAPDVIFQSGVPVLGICYGEQTMCAQLGGKVESSDHREFGRAFLEIEEDCGL
CEEEECCCCCCCCEECCCCCEEEEEECCHHHHHHHCCCCCCCHHHHHHHHHEEECCCCCE
FAGIWAPGTRHQVWMSHGDRVTALPPGFKVVGTSAGAPFAAIADDKRKYYGVQFHPEVVH
EEEECCCCCCCEEEECCCCEEEECCCCCEEEECCCCCCEEEEECCCHHEECEEECCCEEE
TPDGAKLLANFVHRIAGLKGDWTMAAYREQAVDAIRAQVGSGKVICALSGGVDSSVAALL
CCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHH
THEAVGEQLTCILVDHGLMRKNEAAEVVSMFREHYNVPLVLVDASDRFLSALEGETDPEK
HHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCCHHH
KRKTIGRLFIEVFEDEAKKLGGADFLVQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPE
HHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHCCCCCCCEEEEECCCCCCCCCH
RMNMKLVEPLRELFKDEVRVLGRKLGLPDHFIGRHPFPGPGLAIRCPGGITREKLEILRA
HCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCEEEECCCCCCHHHHHHHHH
ADAIYLDEIRKSGLYDAIWQAFAVLLPVQTVGVMGDGRTYEYVCALRAVTSVDGMTADFY
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHCCCCEEHHH
HFDMEFLGRAATRIINEVRGINRVVYDVTSKPPGTIEWE
HHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
TITHPDTVLIIDFGSQVTQLIARRVREAGVYSEIAPFQSAEEAYLRLKPKAVILSGSPA
CCCCCCEEEEEECCHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHEEECCCEEEEECCCC
STVEIDSPRAPDVIFQSGVPVLGICYGEQTMCAQLGGKVESSDHREFGRAFLEIEEDCGL
CEEEECCCCCCCCEECCCCCEEEEEECCHHHHHHHCCCCCCCHHHHHHHHHEEECCCCCE
FAGIWAPGTRHQVWMSHGDRVTALPPGFKVVGTSAGAPFAAIADDKRKYYGVQFHPEVVH
EEEECCCCCCCEEEECCCCEEEECCCCCEEEECCCCCCEEEEECCCHHEECEEECCCEEE
TPDGAKLLANFVHRIAGLKGDWTMAAYREQAVDAIRAQVGSGKVICALSGGVDSSVAALL
CCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHH
THEAVGEQLTCILVDHGLMRKNEAAEVVSMFREHYNVPLVLVDASDRFLSALEGETDPEK
HHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCCHHH
KRKTIGRLFIEVFEDEAKKLGGADFLVQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPE
HHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHCCCCCCCEEEEECCCCCCCCCH
RMNMKLVEPLRELFKDEVRVLGRKLGLPDHFIGRHPFPGPGLAIRCPGGITREKLEILRA
HCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCEEEECCCCCCHHHHHHHHH
ADAIYLDEIRKSGLYDAIWQAFAVLLPVQTVGVMGDGRTYEYVCALRAVTSVDGMTADFY
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHCCCCEEHHH
HFDMEFLGRAATRIINEVRGINRVVYDVTSKPPGTIEWE
HHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA