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The map label for this gene is groEL

Identifier: 110632718

GI number: 110632718

Start: 399629

End: 401263

Strand: Reverse

Name: groEL

Synonym: Meso_0357

Alternate gene names: 110632718

Gene position: 401263-399629 (Counterclockwise)

Preceding gene: 110632719

Following gene: 110632717

Centisome position: 9.09

GC content: 63.43

Gene sequence:

>1635_bases
ATGGCTGCAAAAGACGTAAAATTTTCCCGTGATGCCCGCGAGCGTATGCTTCGCGGCGTCAACATCCTTGCCGACGCGGT
GAAGGTGACGCTCGGCCCGAAGGGCCGCAACGTCGTGCTCGACAAGTCCTTCGGCGCCCCGCGCATCACGAAGGACGGCG
TGACCGTCGCCAAGGAAATCGAGCTTGAGGACAAGTTCGAGAATATGGGCGCCCAGATGGTGCGCGAAGTGGCGTCGAAG
ACCAACGACATCGCCGGCGACGGCACCACGACGGCCACCGTTCTCGCCCAGGCGATCGTACAGGAAGGCGCAAAGGCCGT
TGCCGCCGGCATGAACCCGATGGACCTGAAGCGCGGCGTTGATCTGGCCGTTGCCGAAGTCGTCGATTACCTGGCCAAGG
CGGCCAAGAAGATCAAGACCTCCGAAGAGGTTGCCCAGGTCGGCACGATTTCCGCCAATGGCGAGAAGGAAATCGGCCAG
ATGATTGCCGAGGCCATGCAGAAGGTCGGCAATGAGGGCGTGATTACTGTCGAGGAAGCCAAGACCGCCGAGACCGAGCT
TGAAGTGGTCGAGGGCATGCAGTTCGACCGCGGCTATCTCTCTCCGTACTTCATCACCAACCCGGAGAAGATGGTGGCGG
AGCTCGAGGACGTTTACATCCTCCTGCACGAGAAGAAGCTCTCCAACCTCCAGGCCATGCTGCCTGTGCTCGAAGCTGTG
GTGCAGTCGGGCAGGCCGCTGCTTATCATCGCCGAGGACGTCGAGGGCGAGGCTCTCGCCACGCTGGTGGTCAACAAGCT
GCGTGGCGGCCTGAAGATCGCAGCCGTGAAGGCACCGGGCTTCGGCGACCGCCGCAAAGCCATGCTCGAAGACATCGCGG
TCCTCACGGGCGGCCAGGTGATCTCCGAAGATCTCGGCATCAAGCTCGAGAACGTCACGCTCGACATGCTGGGCCGTGCC
AAGCGCGTTTCCATCGCCAAGGAGACGACCACCATCGTTGACGGTGCCGGCCAGAAAAGCGAGATCGAAGGCCGCGTTGC
CCAGATCAAGTCGCAGATCGAGGAGACCACCTCCGATTACGACCGCGAGAAGCTGCAGGAGCGCCTGGCCAAGCTCGCCG
GCGGCGTCGCGGTGATCCGCGTCGGCGGTGCGACCGAGGTAGAGGTGAAGGAGAAGAAGGACCGCGTGGACGATGCGCTA
AACGCCACCCGCGCGGCCGTCGAGGAAGGCATTGTTCCGGGCGGCGGCACCGCACTTCTGCGCGCCTCCAGCGAAATCAA
GGCCAAGGGCGAGAATGCCGACCAGGAGGCCGGCGTGAACATCGTTCGCCGCGCAATCCAGGCTCCTGCCCGCCAGATCG
CTTCGAATGCGGGCGCCGAGGCTTCGATCGTCGTCGGCAAGATTCTCGACAACAACGCCGTCACGTTCGGTTACAATGCC
CAGACGGGCGAATATGGCGACATGATCGGCATGGGCATCGTGGACCCGATGAAAGTGGTCCGCACCGCTCTTCAGGACGC
GGCTTCGGTCGCCGGCCTGCTGATCACCACCGAGGCCATGATCGCCGAGCTGCCGAAGAAGGACTCGCCGGCCCCGGCGA
TGCCAGGCGGCGGCATGGGCGGCATGGATTTCTAA

Upstream 100 bases:

>100_bases
TGATCATGAAGGAGTCCGACATCATGGGCATCATCGGCTGAGCAAAGCCGCTATTTGCTGAACCTAACCAGGGCTTCGCC
CGAAGCCAGGAGTGACCAAT

Downstream 100 bases:

>100_bases
GAGGTCGAGACCTCGGATTTCCGAAAGGGCGGCAGAAATGCCGCCCTTTTTTATTTCGCGGGTGCACCCTGCGATCCTTA
TATTCCCGAGGGCGGGTCTT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MAAKDVKFSRDARERMLRGVNILADAVKVTLGPKGRNVVLDKSFGAPRITKDGVTVAKEIELEDKFENMGAQMVREVASK
TNDIAGDGTTTATVLAQAIVQEGAKAVAAGMNPMDLKRGVDLAVAEVVDYLAKAAKKIKTSEEVAQVGTISANGEKEIGQ
MIAEAMQKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFITNPEKMVAELEDVYILLHEKKLSNLQAMLPVLEAV
VQSGRPLLIIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAVLTGGQVISEDLGIKLENVTLDMLGRA
KRVSIAKETTTIVDGAGQKSEIEGRVAQIKSQIEETTSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVDDAL
NATRAAVEEGIVPGGGTALLRASSEIKAKGENADQEAGVNIVRRAIQAPARQIASNAGAEASIVVGKILDNNAVTFGYNA
QTGEYGDMIGMGIVDPMKVVRTALQDAASVAGLLITTEAMIAELPKKDSPAPAMPGGGMGGMDF

Sequences:

>Translated_544_residues
MAAKDVKFSRDARERMLRGVNILADAVKVTLGPKGRNVVLDKSFGAPRITKDGVTVAKEIELEDKFENMGAQMVREVASK
TNDIAGDGTTTATVLAQAIVQEGAKAVAAGMNPMDLKRGVDLAVAEVVDYLAKAAKKIKTSEEVAQVGTISANGEKEIGQ
MIAEAMQKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFITNPEKMVAELEDVYILLHEKKLSNLQAMLPVLEAV
VQSGRPLLIIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAVLTGGQVISEDLGIKLENVTLDMLGRA
KRVSIAKETTTIVDGAGQKSEIEGRVAQIKSQIEETTSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVDDAL
NATRAAVEEGIVPGGGTALLRASSEIKAKGENADQEAGVNIVRRAIQAPARQIASNAGAEASIVVGKILDNNAVTFGYNA
QTGEYGDMIGMGIVDPMKVVRTALQDAASVAGLLITTEAMIAELPKKDSPAPAMPGGGMGGMDF
>Mature_543_residues
AAKDVKFSRDARERMLRGVNILADAVKVTLGPKGRNVVLDKSFGAPRITKDGVTVAKEIELEDKFENMGAQMVREVASKT
NDIAGDGTTTATVLAQAIVQEGAKAVAAGMNPMDLKRGVDLAVAEVVDYLAKAAKKIKTSEEVAQVGTISANGEKEIGQM
IAEAMQKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFITNPEKMVAELEDVYILLHEKKLSNLQAMLPVLEAVV
QSGRPLLIIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAVLTGGQVISEDLGIKLENVTLDMLGRAK
RVSIAKETTTIVDGAGQKSEIEGRVAQIKSQIEETTSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVDDALN
ATRAAVEEGIVPGGGTALLRASSEIKAKGENADQEAGVNIVRRAIQAPARQIASNAGAEASIVVGKILDNNAVTFGYNAQ
TGEYGDMIGMGIVDPMKVVRTALQDAASVAGLLITTEAMIAELPKKDSPAPAMPGGGMGGMDF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=54.3560606060606, Blast_Score=568, Evalue=1e-162,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=54.3560606060606, Blast_Score=568, Evalue=1e-162,
Organism=Homo sapiens, GI5453607, Length=546, Percent_Identity=21.7948717948718, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1790586, Length=530, Percent_Identity=69.0566037735849, Blast_Score=718, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=54.2533081285444, Blast_Score=570, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=54.0284360189574, Blast_Score=227, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17564182, Length=559, Percent_Identity=23.4347048300537, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=58.5551330798479, Blast_Score=608, Evalue=1e-175,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=57.0075757575758, Blast_Score=595, Evalue=1e-170,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=57.0075757575758, Blast_Score=595, Evalue=1e-170,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=54.6489563567362, Blast_Score=569, Evalue=1e-162,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=54.6489563567362, Blast_Score=569, Evalue=1e-162,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=54.6489563567362, Blast_Score=569, Evalue=1e-162,
Organism=Drosophila melanogaster, GI17864606, Length=546, Percent_Identity=46.5201465201465, Blast_Score=480, Evalue=1e-135,
Organism=Drosophila melanogaster, GI24584129, Length=537, Percent_Identity=36.1266294227188, Blast_Score=341, Evalue=6e-94,
Organism=Drosophila melanogaster, GI19921262, Length=537, Percent_Identity=36.1266294227188, Blast_Score=341, Evalue=6e-94,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH601_MESSB (Q11LG4)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_672926.1
- ProteinModelPortal:   Q11LG4
- SMR:   Q11LG4
- STRING:   Q11LG4
- GeneID:   4181956
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_0357
- NMPDR:   fig|266779.1.peg.4157
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   NSDTSIG
- PhylomeDB:   Q11LG4
- BioCyc:   MSP266779:MESO_0357-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57493; Mature: 57362

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVKFSRDARERMLRGVNILADAVKVTLGPKGRNVVLDKSFGAPRITKDGVTVAKEI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCCCCCCCCHHHC
ELEDKFENMGAQMVREVASKTNDIAGDGTTTATVLAQAIVQEGAKAVAAGMNPMDLKRGV
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCHHHHHCCCCHHHHHCCC
DLAVAEVVDYLAKAAKKIKTSEEVAQVGTISANGEKEIGQMIAEAMQKVGNEGVITVEEA
HHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECC
KTAETELEVVEGMQFDRGYLSPYFITNPEKMVAELEDVYILLHEKKLSNLQAMLPVLEAV
CCHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHH
VQSGRPLLIIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAVLTGGQV
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHH
ISEDLGIKLENVTLDMLGRAKRVSIAKETTTIVDGAGQKSEIEGRVAQIKSQIEETTSDY
HHHHHCEEEEEEEHHHHCCHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHH
DREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVDDALNATRAAVEEGIVPGGGTALL
HHHHHHHHHHHHHCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
RASSEIKAKGENADQEAGVNIVRRAIQAPARQIASNAGAEASIVVGKILDNNAVTFGYNA
ECCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCEEECCCC
QTGEYGDMIGMGIVDPMKVVRTALQDAASVAGLLITTEAMIAELPKKDSPAPAMPGGGMG
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GMDF
CCCC
>Mature Secondary Structure 
AAKDVKFSRDARERMLRGVNILADAVKVTLGPKGRNVVLDKSFGAPRITKDGVTVAKEI
CCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCCCCCCCCHHHC
ELEDKFENMGAQMVREVASKTNDIAGDGTTTATVLAQAIVQEGAKAVAAGMNPMDLKRGV
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCHHHHHCCCCHHHHHCCC
DLAVAEVVDYLAKAAKKIKTSEEVAQVGTISANGEKEIGQMIAEAMQKVGNEGVITVEEA
HHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECC
KTAETELEVVEGMQFDRGYLSPYFITNPEKMVAELEDVYILLHEKKLSNLQAMLPVLEAV
CCHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHH
VQSGRPLLIIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAVLTGGQV
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHH
ISEDLGIKLENVTLDMLGRAKRVSIAKETTTIVDGAGQKSEIEGRVAQIKSQIEETTSDY
HHHHHCEEEEEEEHHHHCCHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHH
DREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVDDALNATRAAVEEGIVPGGGTALL
HHHHHHHHHHHHHCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
RASSEIKAKGENADQEAGVNIVRRAIQAPARQIASNAGAEASIVVGKILDNNAVTFGYNA
ECCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCEEECCCC
QTGEYGDMIGMGIVDPMKVVRTALQDAASVAGLLITTEAMIAELPKKDSPAPAMPGGGMG
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GMDF
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA