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The map label for this gene is tdcB [H]

Identifier: 110632670

GI number: 110632670

Start: 342601

End: 343575

Strand: Direct

Name: tdcB [H]

Synonym: Meso_0309

Alternate gene names: 110632670

Gene position: 342601-343575 (Clockwise)

Preceding gene: 110632669

Following gene: 110632672

Centisome position: 7.76

GC content: 64.1

Gene sequence:

>975_bases
ATGACCGACATTGCCATGATCGAAGCCGCGCGGAGCCGCATTGCGGGCCATGTGCGCCGCACACCGCTCCTTTTCTCGCC
GTTTTTCGATGAAATCGCAGGCCGGCGTGTTCTTGTGAAGACCGAGTCCCTCCAGCTTACCGGCTCTTTCAAGTTCCGCG
GTGCCTGGTCGGCGATATCGGCGCTGGACCCGGACGTTCGGGCGAAAGGCGTGCTCGCCTTTTCCTCGGGCAATCATGCG
CAGGCCGTGGCGCTCGCCGCGCGAATGCACGGCATTTCTTCCACCATAGTCATGCCATCCGACGCGCCGAAGCTGAAGAT
CGAAAACACGCGGGCCTATGGCGCCGAAGTGGTGCTCTATGATCGCGCGAAAGAGGACCGTGATGCGATCGGTGTGAAGC
TCGCGGCTGAAAGGGGACTTACGCTGATCAAGCCCTTCGACGAGCCGCTGGTCATTGCCGGCCAGGGCACTACGGGCCTT
GAGCTCGCGGAGCAGGCCAAGGAAATAGGCGTGGAAAGGGCGGAAGTGCTTGTCCCCTGTGGAGGTGGCGGACTCACCTC
CGGCATAGCGCTAGCGCTTGAAGCGCGTGCACCCCGGCTCAAGGCGCGCCCCTGCGAGCCCGCGGGCTTCGACGATGTGA
CCCGCTCCCTCGCTTCCGGGAAGATCGAGCGCAATGCGGCGATGTCAGGTTCGATCTGCGACGCCATTGTCACGCCGTCG
CCCGGCACGATCACCTTTCCGATCCTGAGGCGGCTTTGCGGCGCGGGAATCGTCGTAACCGACGAGGAGGCGCTGCATGC
AATGGCGCTGGCCTTCACCCGGCTCAAGATCGTGGTAGAGCCGGGCGGCGCGGTGGCGCTCGCGGCAGCACTGTTCCATG
GCGAGGAGATGGCGGCTGACACGGTTATCGCGGTTGCCTCCGGCGGCAATGTGGATGCCGCCTTGTTTCGGCAGGCTCTG
GAACGGTTTGCTTAG

Upstream 100 bases:

>100_bases
CGGAGCACATAGACGAAGCATGACATTGCCGCGCATTCGCGTTAGGCATCTCCCGACTGGAACTCTCGTCCCTCGATTGC
TTAAGCCAGGAGCGCCGGCC

Downstream 100 bases:

>100_bases
ATCCTACTGGAAATCATAGACACTGAATCCAGTCACCATCTCATCCAGGCCAAGTGGTCGGGTGAGGGGCGGTTCGGCGC
GCGCAAGACAGCCTTGCCGC

Product: L-threonine ammonia-lyase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MTDIAMIEAARSRIAGHVRRTPLLFSPFFDEIAGRRVLVKTESLQLTGSFKFRGAWSAISALDPDVRAKGVLAFSSGNHA
QAVALAARMHGISSTIVMPSDAPKLKIENTRAYGAEVVLYDRAKEDRDAIGVKLAAERGLTLIKPFDEPLVIAGQGTTGL
ELAEQAKEIGVERAEVLVPCGGGGLTSGIALALEARAPRLKARPCEPAGFDDVTRSLASGKIERNAAMSGSICDAIVTPS
PGTITFPILRRLCGAGIVVTDEEALHAMALAFTRLKIVVEPGGAVALAAALFHGEEMAADTVIAVASGGNVDAALFRQAL
ERFA

Sequences:

>Translated_324_residues
MTDIAMIEAARSRIAGHVRRTPLLFSPFFDEIAGRRVLVKTESLQLTGSFKFRGAWSAISALDPDVRAKGVLAFSSGNHA
QAVALAARMHGISSTIVMPSDAPKLKIENTRAYGAEVVLYDRAKEDRDAIGVKLAAERGLTLIKPFDEPLVIAGQGTTGL
ELAEQAKEIGVERAEVLVPCGGGGLTSGIALALEARAPRLKARPCEPAGFDDVTRSLASGKIERNAAMSGSICDAIVTPS
PGTITFPILRRLCGAGIVVTDEEALHAMALAFTRLKIVVEPGGAVALAAALFHGEEMAADTVIAVASGGNVDAALFRQAL
ERFA
>Mature_323_residues
TDIAMIEAARSRIAGHVRRTPLLFSPFFDEIAGRRVLVKTESLQLTGSFKFRGAWSAISALDPDVRAKGVLAFSSGNHAQ
AVALAARMHGISSTIVMPSDAPKLKIENTRAYGAEVVLYDRAKEDRDAIGVKLAAERGLTLIKPFDEPLVIAGQGTTGLE
LAEQAKEIGVERAEVLVPCGGGGLTSGIALALEARAPRLKARPCEPAGFDDVTRSLASGKIERNAAMSGSICDAIVTPSP
GTITFPILRRLCGAGIVVTDEEALHAMALAFTRLKIVVEPGGAVALAAALFHGEEMAADTVIAVASGGNVDAALFRQALE
RFA

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=314, Percent_Identity=36.9426751592357, Blast_Score=192, Evalue=5e-49,
Organism=Escherichia coli, GI1789505, Length=311, Percent_Identity=36.0128617363344, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1790207, Length=293, Percent_Identity=33.1058020477816, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI1789235, Length=358, Percent_Identity=23.7430167597765, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17508781, Length=316, Percent_Identity=32.9113924050633, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71991565, Length=322, Percent_Identity=34.1614906832298, Blast_Score=130, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17537387, Length=328, Percent_Identity=30.4878048780488, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6322631, Length=307, Percent_Identity=42.671009771987, Blast_Score=213, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6320930, Length=300, Percent_Identity=36, Blast_Score=142, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6319788, Length=322, Percent_Identity=26.0869565217391, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21355833, Length=319, Percent_Identity=33.8557993730408, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24645328, Length=235, Percent_Identity=31.4893617021277, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 33968; Mature: 33836

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDIAMIEAARSRIAGHVRRTPLLFSPFFDEIAGRRVLVKTESLQLTGSFKFRGAWSAIS
CCCHHHHHHHHHHHHHHHHCCCEEECCHHHHHCCCEEEEEEEEEEEEEEEEECCHHHHHH
ALDPDVRAKGVLAFSSGNHAQAVALAARMHGISSTIVMPSDAPKLKIENTRAYGAEVVLY
HCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEECCCCCCEEEECCCCCCCEEEEE
DRAKEDRDAIGVKLAAERGLTLIKPFDEPLVIAGQGTTGLELAEQAKEIGVERAEVLVPC
ECCCCCCHHHCEEEEHHCCCEEEECCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEEEEC
GGGGLTSGIALALEARAPRLKARPCEPAGFDDVTRSLASGKIERNAAMSGSICDAIVTPS
CCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEECCC
PGTITFPILRRLCGAGIVVTDEEALHAMALAFTRLKIVVEPGGAVALAAALFHGEEMAAD
CCEEEHHHHHHHHCCCEEEECHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHCCCHHCCC
TVIAVASGGNVDAALFRQALERFA
EEEEEECCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TDIAMIEAARSRIAGHVRRTPLLFSPFFDEIAGRRVLVKTESLQLTGSFKFRGAWSAIS
CCHHHHHHHHHHHHHHHHCCCEEECCHHHHHCCCEEEEEEEEEEEEEEEEECCHHHHHH
ALDPDVRAKGVLAFSSGNHAQAVALAARMHGISSTIVMPSDAPKLKIENTRAYGAEVVLY
HCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEECCCCCCEEEECCCCCCCEEEEE
DRAKEDRDAIGVKLAAERGLTLIKPFDEPLVIAGQGTTGLELAEQAKEIGVERAEVLVPC
ECCCCCCHHHCEEEEHHCCCEEEECCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEEEEC
GGGGLTSGIALALEARAPRLKARPCEPAGFDDVTRSLASGKIERNAAMSGSICDAIVTPS
CCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEECCC
PGTITFPILRRLCGAGIVVTDEEALHAMALAFTRLKIVVEPGGAVALAAALFHGEEMAAD
CCEEEHHHHHHHHCCCEEEECHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHCCCHHCCC
TVIAVASGGNVDAALFRQALERFA
EEEEEECCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA