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The map label for this gene is lpxC [H]

Identifier: 109947693

GI number: 109947693

Start: 1009248

End: 1010135

Strand: Reverse

Name: lpxC [H]

Synonym: Hac_1163

Alternate gene names: 109947693

Gene position: 1010135-1009248 (Counterclockwise)

Preceding gene: 109947694

Following gene: 109947692

Centisome position: 65.01

GC content: 39.41

Gene sequence:

>888_bases
ATGAAACAAACGACCATTAACCACTCCGTAGAATTAGTAGGAATAGGCTTGCACAAGGGCGTTCCTGTGAAGCTTGTTTT
AGAGCCTTTGGAAGAAAATCAAGGCATTGTTTTTTACCGCTCTGACTTGGGCGTGAAACTCCCCTTAAGACCTGAAAACA
TCGTGGATACCAAAATGGCAACCGTGTTGGGTAAGGATAATGCGAGGATTTCTACGATTGAACATTTGCTTTCAGTTATC
CATGCTTATGGCATTGACAATATTAAAATCTCTGTGGATAATGAAGAAATCCCTATCATGGATGGGAGTGCTTTGGCTTA
TTGCATGCTTTTAGATGAAGTGGGGATTAAAGAATTAGACGCTCCTAAAAAAGTGATGGAAATCAAGCAAGCCATTGAGG
TGAGAGAAGGCGATAAGTTTGTCAAAATTGAGCCAGATAACCAGCTTTCTTTGAATTTTACGATTGATTTTAACCATCCG
GTTATTTCTAAACAAAACCACCATTTTGTTTTTAGTAAAAGTGCTTACAAAGAGCAAGTCGCTAAAGCTCGTACCTTTGG
GTTTTTGCAGGAAGTGAATTATTTGCGCTCCATTGGTTTGGCTAAAGGGGGGAGCTTGAATAATTGTATCGTGTTGGATG
AAAACAGCATTTTGAATAAAGAGGGTTTGAGGTGCGAAAAGGAATTTGTGCACCACAAAATTTTAGACGCCATGGGGGAT
TTAATGGTCTTAGGCATGTCTGTAATGGGCAAATACACTTCTTTTTCAGGGAGCCATAAACTCAATTCCATGTTAGTTAA
AGCCGTTTTAGCAGACGCTAAAAATTATGAAGTTTTAGTGGCCCTAGATCCAGTTAAAGAACTTGCGTTGCAAAAGGCTT
TCGCTTAA

Upstream 100 bases:

>100_bases
ATAAAATTTTATCTTTAAAAGAGATTGAACGGCTTTTAGTTAATAAAAATATTAAAATAATCACTAAAAATGACGATATA
ATGGAGATAAAGGAAATACT

Downstream 100 bases:

>100_bases
TTTTAAACTAGGGTTTATTTTTTGGAATTGGATTTAGTGCTTATCTCTTTAGGCGAGGGGGTTTTGCTTGGGGTGTATCA
AGAGAATTTTTTACAAACTT

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MKQTTINHSVELVGIGLHKGVPVKLVLEPLEENQGIVFYRSDLGVKLPLRPENIVDTKMATVLGKDNARISTIEHLLSVI
HAYGIDNIKISVDNEEIPIMDGSALAYCMLLDEVGIKELDAPKKVMEIKQAIEVREGDKFVKIEPDNQLSLNFTIDFNHP
VISKQNHHFVFSKSAYKEQVAKARTFGFLQEVNYLRSIGLAKGGSLNNCIVLDENSILNKEGLRCEKEFVHHKILDAMGD
LMVLGMSVMGKYTSFSGSHKLNSMLVKAVLADAKNYEVLVALDPVKELALQKAFA

Sequences:

>Translated_295_residues
MKQTTINHSVELVGIGLHKGVPVKLVLEPLEENQGIVFYRSDLGVKLPLRPENIVDTKMATVLGKDNARISTIEHLLSVI
HAYGIDNIKISVDNEEIPIMDGSALAYCMLLDEVGIKELDAPKKVMEIKQAIEVREGDKFVKIEPDNQLSLNFTIDFNHP
VISKQNHHFVFSKSAYKEQVAKARTFGFLQEVNYLRSIGLAKGGSLNNCIVLDENSILNKEGLRCEKEFVHHKILDAMGD
LMVLGMSVMGKYTSFSGSHKLNSMLVKAVLADAKNYEVLVALDPVKELALQKAFA
>Mature_295_residues
MKQTTINHSVELVGIGLHKGVPVKLVLEPLEENQGIVFYRSDLGVKLPLRPENIVDTKMATVLGKDNARISTIEHLLSVI
HAYGIDNIKISVDNEEIPIMDGSALAYCMLLDEVGIKELDAPKKVMEIKQAIEVREGDKFVKIEPDNQLSLNFTIDFNHP
VISKQNHHFVFSKSAYKEQVAKARTFGFLQEVNYLRSIGLAKGGSLNNCIVLDENSILNKEGLRCEKEFVHHKILDAMGD
LMVLGMSVMGKYTSFSGSHKLNSMLVKAVLADAKNYEVLVALDPVKELALQKAFA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=288, Percent_Identity=43.75, Blast_Score=257, Evalue=6e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 32771; Mature: 32771

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQTTINHSVELVGIGLHKGVPVKLVLEPLEENQGIVFYRSDLGVKLPLRPENIVDTKMA
CCCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCEEEEECCCCEECCCCCCCHHHHHHH
TVLGKDNARISTIEHLLSVIHAYGIDNIKISVDNEEIPIMDGSALAYCMLLDEVGIKELD
HHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEECCCHHHHHHHHHHCCCCCCC
APKKVMEIKQAIEVREGDKFVKIEPDNQLSLNFTIDFNHPVISKQNHHFVFSKSAYKEQV
CCHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEEEEECCCCCCCCCCEEEEECHHHHHHH
AKARTFGFLQEVNYLRSIGLAKGGSLNNCIVLDENSILNKEGLRCEKEFVHHKILDAMGD
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHH
LMVLGMSVMGKYTSFSGSHKLNSMLVKAVLADAKNYEVLVALDPVKELALQKAFA
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCC
>Mature Secondary Structure
MKQTTINHSVELVGIGLHKGVPVKLVLEPLEENQGIVFYRSDLGVKLPLRPENIVDTKMA
CCCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCEEEEECCCCEECCCCCCCHHHHHHH
TVLGKDNARISTIEHLLSVIHAYGIDNIKISVDNEEIPIMDGSALAYCMLLDEVGIKELD
HHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEECCCHHHHHHHHHHCCCCCCC
APKKVMEIKQAIEVREGDKFVKIEPDNQLSLNFTIDFNHPVISKQNHHFVFSKSAYKEQV
CCHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEEEEECCCCCCCCCCEEEEECHHHHHHH
AKARTFGFLQEVNYLRSIGLAKGGSLNNCIVLDENSILNKEGLRCEKEFVHHKILDAMGD
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHH
LMVLGMSVMGKYTSFSGSHKLNSMLVKAVLADAKNYEVLVALDPVKELALQKAFA
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA