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The map label for this gene is hyuA [H]

Identifier: 109947497

GI number: 109947497

Start: 831823

End: 833964

Strand: Reverse

Name: hyuA [H]

Synonym: Hac_0951

Alternate gene names: 109947497

Gene position: 833964-831823 (Counterclockwise)

Preceding gene: 109947498

Following gene: 109947496

Centisome position: 53.67

GC content: 43.84

Gene sequence:

>2142_bases
ATGAAAGTCTCAAAAGTTCAGGTGATGGGTATTGATGCCGGTGGCACCATGACGGACACGTTTTTTGTTAAAGAAAATGG
TAGTTTCGTAGTTGGTAAAGCCCAAAGCAACCCAGAGGATGAGAGTTTGGCTATTTACAACAGCTCGCAAGACGCTTTGA
TGCATTGGAAGTCAGATGTAAATCAGGTCTATCCAGAACTAGTCACTTGTGTGTATTCAGGCACTGCAATGCTAAATAGG
GTCGTGCAAAGACGAGGTATGGAAGTGGGGCTAATTTGCAATAAAGGGTTTGAGCAGATGCACTCTATGGGTAGGGCGTT
GCAATCCTACCTTGGGTATGCACTAGAAGAAAGGCTTCATATCAACACGCACAAATATGACGATCCATTAGTCCCTTTAA
AAAGGATTAGAGGCATTACAGAAAGAACCGATGTTAAAGGGCAAGTGGTTATCCCAGTGCGTCAAGAAGAGGTGAAAACG
GCTGTTAAGGAGCTTGTAGAAGCGGGTGCAGAAGCTGTTGTCATTTGCTTGTTACAATCTCATAAAAACGCTGAAAGCGA
GCGGATCGTTAGAGATATTGTGCTCAAAGAACTTGAAAAATTAGGTAAAAATATCCCTATATTCGCTTCTGTGGATTACT
ACCCTCAAAGAAAAGAAAGCCACAGGATGAACACCACCATTTTAGAAGCTTATGCGGCTGAGCCAAGCAGACAGACTCTC
TCTAAAGTCAGCAACCACTTCAAAGAGCATGGTGCTAAATTTGACTTGCGTGTGATGGCAACGCATGGAGGCACCATTAG
TTGGAAAGCTAAAGAGCTCGCTAGGACGATTGTGAGCGGTCCCATTGGAGGGGTGATTGGATCTAAATTGCTTGGCGAAA
CGCTTGGTTATGAAAATATTGCATGCAGTGATATTGGTGGCACGAGCTTTGATATGGCGCTTATCGTTAAGAGCAATTTC
AATATCGCTTCTGACCCTGATATGGCACGCCTTGTTCTCTCTCTGCCTCTTGTTGCTATGGATTCTGTTGGTGCTGGTGC
AGGGAGTTTTGTGCGCATTGATCCGCATAGCCGATCGGTCAAACTAGGGCCTGATAGTGCAGGGTATAGGGTTGGCACTT
GTTGGAAAGATAGCGGTTTAGACACGGTTTCAGTGACGGATTGCCATATTGTTTTAGGCTATTTAAATCCGGATAATTTT
TTAGGCGGTTTGATCAAATTGGATGTGGAAAGGGCTAAGAAACACATTAAAGAGCAAGTCGCTGATCCGCTAGGCATTAG
CGTAGAAGATGCGGCTGCAGGTGTGATTGAGTTGCTTGATTTGGAGCTTAAAGAATACTTGCGATCCAATATTAGCGCTA
AAGGGTATAGTCCGTCTGATTTTGTGTGCTTTTCATATGGTGGTGCGGGGCCTGTGCATGCCTATGGCTATACAGAAGGT
TTAGGGTTTAAGGATGTGGTGGTGCCTGCGTGGGCGGCTGGGTTTAGTGCTTTTGGTTGTGCTTGTGCTGATTTTGAATA
CAGATACGACAAGAGCGTTGATATAGCCATTCCGCAGTATTCTTCAGACGAGTCCAAAATAGAAGCATGCAAGATCATCC
AGGATGCATGGGATGAATTGACTTTAAAAGTGATTGAAGAATTTAAGATCAATGGATTTTCTCAAAAAGATGTGATTTTA
AGACCTGGATACAGGATGCAGTATATGGGGCAGTTGAATGATTTAGAAATAACCTCTCCTATATCAAAGGCTGAAAGCGT
GGCTGATTGGGAAGAGATTGTCAAAGAATACGAAAAAACTTACGCTCGGGTTTATTCTGAATCCGCTTGTTCTCCAGAGC
TTGGTTTTAGCGTGACTGGGGTGATTATGCGTGGTGTTGTGGCTACACAAAAACCCGTAATTCCGGTTGAAAAAGAGCAT
GGTGCTACGCCTTCAAAAGAAGCCAAAATAGGCGTTAGGAAGTTCTATCGCCATAAGCAATGGGTGGATGCAGATGTGTG
GCGAATGGAAAAATTACTGCCCGGAAATGAAGTGATAGGACCTGCGATCATAGAATCAGATGCGACCACATTCGTGGTGC
CTAAAGGCTTTGCGACAAAGTTAGACAAACACAGATTGTTCCACTTGAAAGAAGTTAAATAA

Upstream 100 bases:

>100_bases
TCATTGACTATTCTTGAAATAAACGATCTTTATTTAGAAATCCACTCTATACTTTGAATAGGTTGCTTTTAGCAACACAT
TAAATACTAAGGAGGAAAAG

Downstream 100 bases:

>100_bases
TAGTAAAGGAGTTCTAAATGGCAAATTTATTGAAAAACGGCAAAACTTTAAAACAAGCTAGAGATGAAATCCTAGCTAGG
ACAGAAAAAACAGGTTATTA

Product: N-methylhydantoinase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 713; Mature: 713

Protein sequence:

>713_residues
MKVSKVQVMGIDAGGTMTDTFFVKENGSFVVGKAQSNPEDESLAIYNSSQDALMHWKSDVNQVYPELVTCVYSGTAMLNR
VVQRRGMEVGLICNKGFEQMHSMGRALQSYLGYALEERLHINTHKYDDPLVPLKRIRGITERTDVKGQVVIPVRQEEVKT
AVKELVEAGAEAVVICLLQSHKNAESERIVRDIVLKELEKLGKNIPIFASVDYYPQRKESHRMNTTILEAYAAEPSRQTL
SKVSNHFKEHGAKFDLRVMATHGGTISWKAKELARTIVSGPIGGVIGSKLLGETLGYENIACSDIGGTSFDMALIVKSNF
NIASDPDMARLVLSLPLVAMDSVGAGAGSFVRIDPHSRSVKLGPDSAGYRVGTCWKDSGLDTVSVTDCHIVLGYLNPDNF
LGGLIKLDVERAKKHIKEQVADPLGISVEDAAAGVIELLDLELKEYLRSNISAKGYSPSDFVCFSYGGAGPVHAYGYTEG
LGFKDVVVPAWAAGFSAFGCACADFEYRYDKSVDIAIPQYSSDESKIEACKIIQDAWDELTLKVIEEFKINGFSQKDVIL
RPGYRMQYMGQLNDLEITSPISKAESVADWEEIVKEYEKTYARVYSESACSPELGFSVTGVIMRGVVATQKPVIPVEKEH
GATPSKEAKIGVRKFYRHKQWVDADVWRMEKLLPGNEVIGPAIIESDATTFVVPKGFATKLDKHRLFHLKEVK

Sequences:

>Translated_713_residues
MKVSKVQVMGIDAGGTMTDTFFVKENGSFVVGKAQSNPEDESLAIYNSSQDALMHWKSDVNQVYPELVTCVYSGTAMLNR
VVQRRGMEVGLICNKGFEQMHSMGRALQSYLGYALEERLHINTHKYDDPLVPLKRIRGITERTDVKGQVVIPVRQEEVKT
AVKELVEAGAEAVVICLLQSHKNAESERIVRDIVLKELEKLGKNIPIFASVDYYPQRKESHRMNTTILEAYAAEPSRQTL
SKVSNHFKEHGAKFDLRVMATHGGTISWKAKELARTIVSGPIGGVIGSKLLGETLGYENIACSDIGGTSFDMALIVKSNF
NIASDPDMARLVLSLPLVAMDSVGAGAGSFVRIDPHSRSVKLGPDSAGYRVGTCWKDSGLDTVSVTDCHIVLGYLNPDNF
LGGLIKLDVERAKKHIKEQVADPLGISVEDAAAGVIELLDLELKEYLRSNISAKGYSPSDFVCFSYGGAGPVHAYGYTEG
LGFKDVVVPAWAAGFSAFGCACADFEYRYDKSVDIAIPQYSSDESKIEACKIIQDAWDELTLKVIEEFKINGFSQKDVIL
RPGYRMQYMGQLNDLEITSPISKAESVADWEEIVKEYEKTYARVYSESACSPELGFSVTGVIMRGVVATQKPVIPVEKEH
GATPSKEAKIGVRKFYRHKQWVDADVWRMEKLLPGNEVIGPAIIESDATTFVVPKGFATKLDKHRLFHLKEVK
>Mature_713_residues
MKVSKVQVMGIDAGGTMTDTFFVKENGSFVVGKAQSNPEDESLAIYNSSQDALMHWKSDVNQVYPELVTCVYSGTAMLNR
VVQRRGMEVGLICNKGFEQMHSMGRALQSYLGYALEERLHINTHKYDDPLVPLKRIRGITERTDVKGQVVIPVRQEEVKT
AVKELVEAGAEAVVICLLQSHKNAESERIVRDIVLKELEKLGKNIPIFASVDYYPQRKESHRMNTTILEAYAAEPSRQTL
SKVSNHFKEHGAKFDLRVMATHGGTISWKAKELARTIVSGPIGGVIGSKLLGETLGYENIACSDIGGTSFDMALIVKSNF
NIASDPDMARLVLSLPLVAMDSVGAGAGSFVRIDPHSRSVKLGPDSAGYRVGTCWKDSGLDTVSVTDCHIVLGYLNPDNF
LGGLIKLDVERAKKHIKEQVADPLGISVEDAAAGVIELLDLELKEYLRSNISAKGYSPSDFVCFSYGGAGPVHAYGYTEG
LGFKDVVVPAWAAGFSAFGCACADFEYRYDKSVDIAIPQYSSDESKIEACKIIQDAWDELTLKVIEEFKINGFSQKDVIL
RPGYRMQYMGQLNDLEITSPISKAESVADWEEIVKEYEKTYARVYSESACSPELGFSVTGVIMRGVVATQKPVIPVEKEH
GATPSKEAKIGVRKFYRHKQWVDADVWRMEKLLPGNEVIGPAIIESDATTFVVPKGFATKLDKHRLFHLKEVK

Specific function: Catalyzes the carboxylation of acetone to form acetoacetate. Has a reduced activity on butanone, and no activity on 2-pentatone, 3-pentatone, 2-hexanone, chloroacetone, pyruvate, phosphoenolpyruvate, acetaldehyde, propionaldehyde and propylene oxide [H]

COG id: COG0145

COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=511, Percent_Identity=25.8317025440313, Blast_Score=102, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI133901900, Length=722, Percent_Identity=22.7146814404432, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322634, Length=582, Percent_Identity=23.7113402061856, Blast_Score=121, Evalue=4e-28,
Organism=Drosophila melanogaster, GI45550492, Length=724, Percent_Identity=25.414364640884, Blast_Score=134, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008040
- InterPro:   IPR002821 [H]

Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A [H]

EC number: =6.4.1.6 [H]

Molecular weight: Translated: 78622; Mature: 78622

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVSKVQVMGIDAGGTMTDTFFVKENGSFVVGKAQSNPEDESLAIYNSSQDALMHWKSDV
CCCCEEEEEEECCCCCEEEEEEEECCCCEEEEECCCCCCCCEEEEEECCCHHHHHHHHHH
NQVYPELVTCVYSGTAMLNRVVQRRGMEVGLICNKGFEQMHSMGRALQSYLGYALEERLH
HHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHEE
INTHKYDDPLVPLKRIRGITERTDVKGQVVIPVRQEEVKTAVKELVEAGAEAVVICLLQS
ECCCCCCCCCCHHHHHCCCCHHCCCCCEEEEECCHHHHHHHHHHHHHCCCCEEEEEEHHC
HKNAESERIVRDIVLKELEKLGKNIPIFASVDYYPQRKESHRMNTTILEAYAAEPSRQTL
CCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHCCCCHHHHHHHHCCCHHHHH
SKVSNHFKEHGAKFDLRVMATHGGTISWKAKELARTIVSGPIGGVIGSKLLGETLGYENI
HHHHHHHHHCCCCEEEEEEEECCCEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCE
ACSDIGGTSFDMALIVKSNFNIASDPDMARLVLSLPLVAMDSVGAGAGSFVRIDPHSRSV
EECCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCHHHHHCCCCCCCCEEEECCCCCEE
KLGPDSAGYRVGTCWKDSGLDTVSVTDCHIVLGYLNPDNFLGGLIKLDVERAKKHIKEQV
EECCCCCCCEEEEEECCCCCCEEEEEEEEEEEEEECCHHHHCHHHEEEHHHHHHHHHHHH
ADPLGISVEDAAAGVIELLDLELKEYLRSNISAKGYSPSDFVCFSYGGAGPVHAYGYTEG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCEEECCCCCC
LGFKDVVVPAWAAGFSAFGCACADFEYRYDKSVDIAIPQYSSDESKIEACKIIQDAWDEL
CCCCHHHHHHHHHHHHHHCCEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHH
TLKVIEEFKINGFSQKDVILRPGYRMQYMGQLNDLEITSPISKAESVADWEEIVKEYEKT
HHHHHHHHHCCCCCCCCEEECCCCCEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHH
YARVYSESACSPELGFSVTGVIMRGVVATQKPVIPVEKEHGATPSKEAKIGVRKFYRHKQ
HHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
WVDADVWRMEKLLPGNEVIGPAIIESDATTFVVPKGFATKLDKHRLFHLKEVK
CCCHHHHHHHHHCCCCCCCCCCEECCCCCEEEECCCHHHHHHHHHCCEEECCC
>Mature Secondary Structure
MKVSKVQVMGIDAGGTMTDTFFVKENGSFVVGKAQSNPEDESLAIYNSSQDALMHWKSDV
CCCCEEEEEEECCCCCEEEEEEEECCCCEEEEECCCCCCCCEEEEEECCCHHHHHHHHHH
NQVYPELVTCVYSGTAMLNRVVQRRGMEVGLICNKGFEQMHSMGRALQSYLGYALEERLH
HHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHEE
INTHKYDDPLVPLKRIRGITERTDVKGQVVIPVRQEEVKTAVKELVEAGAEAVVICLLQS
ECCCCCCCCCCHHHHHCCCCHHCCCCCEEEEECCHHHHHHHHHHHHHCCCCEEEEEEHHC
HKNAESERIVRDIVLKELEKLGKNIPIFASVDYYPQRKESHRMNTTILEAYAAEPSRQTL
CCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHCCCCHHHHHHHHCCCHHHHH
SKVSNHFKEHGAKFDLRVMATHGGTISWKAKELARTIVSGPIGGVIGSKLLGETLGYENI
HHHHHHHHHCCCCEEEEEEEECCCEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCE
ACSDIGGTSFDMALIVKSNFNIASDPDMARLVLSLPLVAMDSVGAGAGSFVRIDPHSRSV
EECCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCHHHHHCCCCCCCCEEEECCCCCEE
KLGPDSAGYRVGTCWKDSGLDTVSVTDCHIVLGYLNPDNFLGGLIKLDVERAKKHIKEQV
EECCCCCCCEEEEEECCCCCCEEEEEEEEEEEEEECCHHHHCHHHEEEHHHHHHHHHHHH
ADPLGISVEDAAAGVIELLDLELKEYLRSNISAKGYSPSDFVCFSYGGAGPVHAYGYTEG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCEEECCCCCC
LGFKDVVVPAWAAGFSAFGCACADFEYRYDKSVDIAIPQYSSDESKIEACKIIQDAWDEL
CCCCHHHHHHHHHHHHHHCCEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHH
TLKVIEEFKINGFSQKDVILRPGYRMQYMGQLNDLEITSPISKAESVADWEEIVKEYEKT
HHHHHHHHHCCCCCCCCEEECCCCCEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHH
YARVYSESACSPELGFSVTGVIMRGVVATQKPVIPVEKEHGATPSKEAKIGVRKFYRHKQ
HHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
WVDADVWRMEKLLPGNEVIGPAIIESDATTFVVPKGFATKLDKHRLFHLKEVK
CCCHHHHHHHHHCCCCCCCCCCEECCCCCEEEECCCHHHHHHHHHCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12003937 [H]