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The map label for this gene is ppx [H]

Identifier: 109947129

GI number: 109947129

Start: 460271

End: 461725

Strand: Direct

Name: ppx [H]

Synonym: Hac_0536

Alternate gene names: 109947129

Gene position: 460271-461725 (Clockwise)

Preceding gene: 109947128

Following gene: 109947130

Centisome position: 29.62

GC content: 39.86

Gene sequence:

>1455_bases
ATGGCTAAAATCACAGCCGTGATTGATATTGGCTCCAATTCGGTGTGTTTGGCAGTCTTTAAAAAGACAAGCCAATTTGG
GTTTTACTTGCTTTTTGAGACAAAATCTAGGGTTAGGATTTCTGAGGGTTGTTACGCTTCTAAAGGGGTTTTGCAAGAAG
TCCCTATGCAAAGAGCCATCAAAGCCTTGAGTGAGTTTAAAGAAATCGCCCTCAAATACAAAAGCAAAAAAATCTTATGC
GTGGCGACCTCAGCGGTGCGCGATGCCCCTAACAGATTGGAATTTGTATCAAGGGTGAAAAAGGCTTGCGGTTTGCAAAT
CAAAGTGATTGATGGGCAAAAAGAAGCGCTCTATGGTGGGATTGCGTGCGCGAATTTGTTGCATAAAAATTCAGGGATCA
CGATAGATATTGGAGGGGGTAGTACCGAATGTGCGTTGATTGAAAAAGGCAAGATTAAGGATCTCATCTCGCTTGATATT
GGCACGATCCGTATTAAAGAAATGTTTTTGGATAAAGCCTTGAATATCAAATCGGCTAAAGCCTTTATCCAACAAGAAAT
TTCTAAACTCCCCTTTAAGCATAAAAACGCCTTTGGGGTGGGGGGGACGATTAGGGCGTTGAGTAAAGCATTGATGAAAC
GCTTTGATTATCCCATTGATTCTTTGCATGGTTATGAAGTAGATGTGCATAAAAATTTAGCGTTCATTGAAAAAATCATC
ACGCTTAAAGAAGACAAACTGCGGCTTTTAGGGGTGAATGAAGAGCGTTTAGATAGCATCAGGGGTGGGGCGTTGATTTT
ATTAGTTGTGCTGGAGCATTTAAAAACTTCCTTGATGATCACTAGTGGCGTAGGGGTGAGAGAAGGCGTGTTTTTGAGCG
ATTTGTTGCGTCACCATTACCATAAATTCCCCCCCAATATCAACCCTTCTTTAACCTCTTTAAAAGATCGCTTTTTACCC
CATGAAAAGCACAGCCAAAAGGTCAAAAAAGAATGCGTGAAATTGTTTGAAGCCTTATCGCCTTTGCATAAAATAGATGA
AAAATACCTTTTCCATTTAAAGATTGCTGGGGAATTAGCGAGCATGGGTAAGATTTTAAATATTTATTTAGCCCACAAGC
ACAGCGCATATTTTATTTTAAACGCTTTGAGTTATGGCTTTAGCCACCAAGATAGGGCGATCATTTGCTTATTAGCGCAA
TTTAGCCATAAAAAAATCCCTAAAGACAACGCTATCGCTCATATCAGCGCGATGATGCCAAGCCTTTTGACCTTGCAATG
GCTGAGTTTTATCCTTTCTTTAGCCGAAAATTTGTGCATGACAGACAGCCACGATTTAAAATACAAATTAGAAAAAAACA
AGCTTGTGATCCACTCTAATGATGCACTTTATTTGGCTAAAGAAATGCTGCCTAAACTCATTAAGCCCATTCCTTTGATG
ATAGAGTTTGCTTGA

Upstream 100 bases:

>100_bases
CCTGTGGATGCGATTTTACCGGATCCTAACAATACAGAAAGCATAGAGGAATTGAAATACAAATACGAAAGCTTGCAAGA
GCAAGGTTAAAGGCTTACTG

Downstream 100 bases:

>100_bases
AAATAGCGATTGTAAGGCTTTCAGCGCTTGGGGATATTATCGTGAGCGCGGTGTTTTTAGCGATGATTAAAGAGTGTTTT
ACTAACGCTCAAATAGAATG

Product: hypothetical protein

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MAKITAVIDIGSNSVCLAVFKKTSQFGFYLLFETKSRVRISEGCYASKGVLQEVPMQRAIKALSEFKEIALKYKSKKILC
VATSAVRDAPNRLEFVSRVKKACGLQIKVIDGQKEALYGGIACANLLHKNSGITIDIGGGSTECALIEKGKIKDLISLDI
GTIRIKEMFLDKALNIKSAKAFIQQEISKLPFKHKNAFGVGGTIRALSKALMKRFDYPIDSLHGYEVDVHKNLAFIEKII
TLKEDKLRLLGVNEERLDSIRGGALILLVVLEHLKTSLMITSGVGVREGVFLSDLLRHHYHKFPPNINPSLTSLKDRFLP
HEKHSQKVKKECVKLFEALSPLHKIDEKYLFHLKIAGELASMGKILNIYLAHKHSAYFILNALSYGFSHQDRAIICLLAQ
FSHKKIPKDNAIAHISAMMPSLLTLQWLSFILSLAENLCMTDSHDLKYKLEKNKLVIHSNDALYLAKEMLPKLIKPIPLM
IEFA

Sequences:

>Translated_484_residues
MAKITAVIDIGSNSVCLAVFKKTSQFGFYLLFETKSRVRISEGCYASKGVLQEVPMQRAIKALSEFKEIALKYKSKKILC
VATSAVRDAPNRLEFVSRVKKACGLQIKVIDGQKEALYGGIACANLLHKNSGITIDIGGGSTECALIEKGKIKDLISLDI
GTIRIKEMFLDKALNIKSAKAFIQQEISKLPFKHKNAFGVGGTIRALSKALMKRFDYPIDSLHGYEVDVHKNLAFIEKII
TLKEDKLRLLGVNEERLDSIRGGALILLVVLEHLKTSLMITSGVGVREGVFLSDLLRHHYHKFPPNINPSLTSLKDRFLP
HEKHSQKVKKECVKLFEALSPLHKIDEKYLFHLKIAGELASMGKILNIYLAHKHSAYFILNALSYGFSHQDRAIICLLAQ
FSHKKIPKDNAIAHISAMMPSLLTLQWLSFILSLAENLCMTDSHDLKYKLEKNKLVIHSNDALYLAKEMLPKLIKPIPLM
IEFA
>Mature_483_residues
AKITAVIDIGSNSVCLAVFKKTSQFGFYLLFETKSRVRISEGCYASKGVLQEVPMQRAIKALSEFKEIALKYKSKKILCV
ATSAVRDAPNRLEFVSRVKKACGLQIKVIDGQKEALYGGIACANLLHKNSGITIDIGGGSTECALIEKGKIKDLISLDIG
TIRIKEMFLDKALNIKSAKAFIQQEISKLPFKHKNAFGVGGTIRALSKALMKRFDYPIDSLHGYEVDVHKNLAFIEKIIT
LKEDKLRLLGVNEERLDSIRGGALILLVVLEHLKTSLMITSGVGVREGVFLSDLLRHHYHKFPPNINPSLTSLKDRFLPH
EKHSQKVKKECVKLFEALSPLHKIDEKYLFHLKIAGELASMGKILNIYLAHKHSAYFILNALSYGFSHQDRAIICLLAQF
SHKKIPKDNAIAHISAMMPSLLTLQWLSFILSLAENLCMTDSHDLKYKLEKNKLVIHSNDALYLAKEMLPKLIKPIPLMI
EFA

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=435, Percent_Identity=24.1379310344828, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI48994966, Length=462, Percent_Identity=24.025974025974, Blast_Score=96, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 54218; Mature: 54087

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKITAVIDIGSNSVCLAVFKKTSQFGFYLLFETKSRVRISEGCYASKGVLQEVPMQRAI
CCEEEEEEEECCCCEEEEEEECCCCCEEEEEEECCCCEEECCCCCCCCCHHHHCCHHHHH
KALSEFKEIALKYKSKKILCVATSAVRDAPNRLEFVSRVKKACGLQIKVIDGQKEALYGG
HHHHHHHHHHHHHCCCEEEEEEEHHHHCCCHHHHHHHHHHHHHCCEEEEECCCHHHHHHH
IACANLLHKNSGITIDIGGGSTECALIEKGKIKDLISLDIGTIRIKEMFLDKALNIKSAK
HHHHHHHHCCCCEEEEECCCCCEEEEEECCCCHHHHHCCCCHHHHHHHHHHHHCCHHHHH
AFIQQEISKLPFKHKNAFGVGGTIRALSKALMKRFDYPIDSLHGYEVDVHKNLAFIEKII
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHCCCCEEEHHCCHHHHHHHH
TLKEDKLRLLGVNEERLDSIRGGALILLVVLEHLKTSLMITSGVGVREGVFLSDLLRHHY
HHCCCCEEEECCCHHHHHHHCCCHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHH
HKFPPNINPSLTSLKDRFLPHEKHSQKVKKECVKLFEALSPLHKIDEKYLFHLKIAGELA
HCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEHHHHH
SMGKILNIYLAHKHSAYFILNALSYGFSHQDRAIICLLAQFSHKKIPKDNAIAHISAMMP
HHHHHHEEEEEECCCCEEEEEHHHHCCCCCCCEEEEEEEHHHCCCCCCCCHHHHHHHHHH
SLLTLQWLSFILSLAENLCMTDSHDLKYKLEKNKLVIHSNDALYLAKEMLPKLIKPIPLM
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCEEEEECCCHHHHHHHHHHHHHCCCCEE
IEFA
EEEC
>Mature Secondary Structure 
AKITAVIDIGSNSVCLAVFKKTSQFGFYLLFETKSRVRISEGCYASKGVLQEVPMQRAI
CEEEEEEEECCCCEEEEEEECCCCCEEEEEEECCCCEEECCCCCCCCCHHHHCCHHHHH
KALSEFKEIALKYKSKKILCVATSAVRDAPNRLEFVSRVKKACGLQIKVIDGQKEALYGG
HHHHHHHHHHHHHCCCEEEEEEEHHHHCCCHHHHHHHHHHHHHCCEEEEECCCHHHHHHH
IACANLLHKNSGITIDIGGGSTECALIEKGKIKDLISLDIGTIRIKEMFLDKALNIKSAK
HHHHHHHHCCCCEEEEECCCCCEEEEEECCCCHHHHHCCCCHHHHHHHHHHHHCCHHHHH
AFIQQEISKLPFKHKNAFGVGGTIRALSKALMKRFDYPIDSLHGYEVDVHKNLAFIEKII
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHCCCCEEEHHCCHHHHHHHH
TLKEDKLRLLGVNEERLDSIRGGALILLVVLEHLKTSLMITSGVGVREGVFLSDLLRHHY
HHCCCCEEEECCCHHHHHHHCCCHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHH
HKFPPNINPSLTSLKDRFLPHEKHSQKVKKECVKLFEALSPLHKIDEKYLFHLKIAGELA
HCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEHHHHH
SMGKILNIYLAHKHSAYFILNALSYGFSHQDRAIICLLAQFSHKKIPKDNAIAHISAMMP
HHHHHHEEEEEECCCCEEEEEHHHHCCCCCCCEEEEEEEHHHCCCCCCCCHHHHHHHHHH
SLLTLQWLSFILSLAENLCMTDSHDLKYKLEKNKLVIHSNDALYLAKEMLPKLIKPIPLM
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCEEEEECCCHHHHHHHHHHHHHCCCCEE
IEFA
EEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]