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The map label for this gene is clpB [H]

Identifier: 109947115

GI number: 109947115

Start: 447538

End: 450108

Strand: Direct

Name: clpB [H]

Synonym: Hac_0522

Alternate gene names: 109947115

Gene position: 447538-450108 (Clockwise)

Preceding gene: 109947114

Following gene: 109947116

Centisome position: 28.8

GC content: 38.51

Gene sequence:

>2571_bases
ATGAATTTATTTGAAAAAATGACCAACCAATTGCATGAGACTTTAGACAGTGCACTCGCTCTAGCCTTACACCACAAAAA
CGCTGAAGTAACGCCCTTGCACATGCTTTTTGCGATGCTTAATAATTCCCAAGGCATTCTCATTCAAGCCTTACAAAAAA
TGTCTGTGGATATTCAAGCTTTAAGGCTTAGCGTTCAAAGCGAGTTAGGCAAGTTTGCTAAAGTTTCACAAATCAACAAA
CAAAATATCCAATTAAACCAAGCTCTAATAGAAAGTTTTGAAAACGCTCAAGGCTTGAGCGCTAAAATGGGCGATTCTTT
CATCGCCGTAGATGTGTATCTTTTGGTCAATATGAGTCTTTTTGAAAGCGTTTTAAAGCCCTATTTAGACACTAAAGAAT
TGCAAAAAACTTTAGAGTTTTTAAGAAAAGGTGCGACTATCCAGGATAAAAATGATGATTCTAATTTAGAAAGTTTAGAA
AAATTTGGCATTGATTTAACGCAAAAAGCTTTAGAAAATAAGCTTGATCCGGTGATCGGAAGAGATGAAGAAATCATTCG
CATGATGCAAATTTTAATAAGAAAAACAAAAAATAACCCTATTTTATTGGGTGAGCCTGGAGTGGGGAAAACGGCTGTTG
TGGAAGGTTTAGCCCAACGCATTGTCAACAAAGAAGTGCCTACAACGCTTTTAAACAAACGAGTCATCGCTTTAGATTTA
AGCTTATTAGTAGCTGGAGCGAAATACAGAGGCGAGTTTGAAGAGCGTTTGAAAAAGGTGATTGAAGAAGTTAAAAAAAG
CGCGAATGTGATTTTATTCATTGATGAAATCCACACGATTGTGGGGGCTGGGGCTAGTGAAGGGGGCATGGATGCGGCTA
ATATTTTAAAACCGGCTCTAGCTAGGGGAGAATTGCACACGATTGGAGCGACCACTTTGAAAGAATACCGCAAGTATTTT
GAAAAAGATATGGCGTTACAAAGGCGTTTCCAACCTATTTTACTCAATGAACCTAGCATCAATGAAGCTTTACAGATTTT
AAGGGGGTTAAAAGAAACTTTAGAAACGCACCATAATATCACTATCAATGACTCTGCTCTCATAGCGAGCACTAAACTCT
CTAGCCGTTATATTACCGATAGGTTTTTACCTGATAAAGCGATTGATTTGATTGATGAAGGGGCGGCTCAATTAAAAATG
CAAATGGAATCAGAGCCGGCCAAACTCTCTAGCATCAAGCGCTCCATTCAAAGATTAGAAATGGAAAAACAAGCCCTTGA
AATGGAAAAAAAAGAGAGCAATAACAAACGCATGCAAGAAATCCTTAAAGAATTGAGCGATTTGAAAGAAGAAAAAATCA
AATTAGAAGTGCAATTTGAAAATGAAAAAGAAGTGTTTAAAGAAATTTCACGCTTGAAAATGGAAATGGAAAATTTGAAA
AAAGAGGCTGAGAGGTTTAAACGCAATGGGGATTACCAGCAAGCGGCTGAAATTGAATACTCTAAAATCCCTGAAAATGA
AAAGAAAGAAAAAGAATTGCAACACAAATGGGAAGCGATGCAACAAAGTGGTGCACTCTTGCAAAACGCTTTAACCGAAA
ACAACATCGCTGAAATTGTGAGTCAATGGACGCACATCCCAGTTCAAAAAATGCTCCAAAGCGAAAAGAATAGGGTTTTA
AACATTGAAAGAGAATTGCAAAAAAGAGTGGTGGGGCAAGAAAAAGCGCTCAAAGCGATCGCTAAAGCGATTAAAAGGAA
TAAGGCTGGGCTTAGCGATAGCAATAAACCCATAGGGAGTTTTCTCTTTTTAGGACCCACAGGGGTGGGTAAAACCGAGA
GCGCTAAAGCTTTGGCACAATTCTTGTTTGATAGCGATAAAAATCTTATAAGAATTGACATGAGCGAATACATGGAAAAG
CATGCCATAAGCCGTCTTATTGGGGCTGCTCCTGGGTATGTGGGCTATGAAGAAGGCGGGCAATTGACAGAAGCGGTGCG
CAGAAAACCTTATAGCGTGGTGCTGTTAGATGAAGTGGAAAAAGCCCATCCGGATGTGTTTAACCTCTTGTTGCAGGTTT
TAGATGAAGGGCATTTAACCGATAGTAAGGGCGTGAGAGTGGATTTCAAAAACACGATTTTGATTTTAACTAGTAATGTC
GCTAGCGGTGCGCTTTTAGAAGAAAGTTTGAGTGAAGATGATAAACAAAAAGCCATTAAAGAGAGCTTGAAACAATTCTT
CAAGCCAGAATTTTTGAACCGCTTAGATGAAATCGTTTCTTTTAACGCGCTAGATAGCCATGCCATTATTAATATCGTGG
GGATACTCTTTGAAAACATTCAAAAAAAAGCGCTTGAAAGGGGTATTAACATCGCTTTAGATGAAAAGGCAAAGGAATTG
ATCGCAGAAGTGGGGTTTGACAGATTCTATGGCGCTAGACCACTAAAACGCGCGTTATACGAAATGGTAGAAGACAAGCT
CGCTGAACTCATTTTAGAGGATAAAATCAAAGAAAATGATAGCGTGGCATTTGTGGTAGAAAATAACGAAATTGTGCCTA
AAATTAAGTGA

Upstream 100 bases:

>100_bases
ATTTTAGAGAGTTTGTCACTAGTGTGAGCCTCTTAAAAACCTTTGAGAGCGAAAATAGTGTAAAATAGTAAAAATTTTTA
AAACTCAAAAAGGATTGATA

Downstream 100 bases:

>100_bases
GGTTTTATTATCCTAAAAAATATAAGAAATAATTATTTTTAAAAAGGATTAAAAACTATGTTTGATAATACGCTCATCAA
TTTATTTGAGACAGCGCCTC

Product: ATP-dependent Clp protease, ATP-binding subunit ClpB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 856; Mature: 856

Protein sequence:

>856_residues
MNLFEKMTNQLHETLDSALALALHHKNAEVTPLHMLFAMLNNSQGILIQALQKMSVDIQALRLSVQSELGKFAKVSQINK
QNIQLNQALIESFENAQGLSAKMGDSFIAVDVYLLVNMSLFESVLKPYLDTKELQKTLEFLRKGATIQDKNDDSNLESLE
KFGIDLTQKALENKLDPVIGRDEEIIRMMQILIRKTKNNPILLGEPGVGKTAVVEGLAQRIVNKEVPTTLLNKRVIALDL
SLLVAGAKYRGEFEERLKKVIEEVKKSANVILFIDEIHTIVGAGASEGGMDAANILKPALARGELHTIGATTLKEYRKYF
EKDMALQRRFQPILLNEPSINEALQILRGLKETLETHHNITINDSALIASTKLSSRYITDRFLPDKAIDLIDEGAAQLKM
QMESEPAKLSSIKRSIQRLEMEKQALEMEKKESNNKRMQEILKELSDLKEEKIKLEVQFENEKEVFKEISRLKMEMENLK
KEAERFKRNGDYQQAAEIEYSKIPENEKKEKELQHKWEAMQQSGALLQNALTENNIAEIVSQWTHIPVQKMLQSEKNRVL
NIERELQKRVVGQEKALKAIAKAIKRNKAGLSDSNKPIGSFLFLGPTGVGKTESAKALAQFLFDSDKNLIRIDMSEYMEK
HAISRLIGAAPGYVGYEEGGQLTEAVRRKPYSVVLLDEVEKAHPDVFNLLLQVLDEGHLTDSKGVRVDFKNTILILTSNV
ASGALLEESLSEDDKQKAIKESLKQFFKPEFLNRLDEIVSFNALDSHAIINIVGILFENIQKKALERGINIALDEKAKEL
IAEVGFDRFYGARPLKRALYEMVEDKLAELILEDKIKENDSVAFVVENNEIVPKIK

Sequences:

>Translated_856_residues
MNLFEKMTNQLHETLDSALALALHHKNAEVTPLHMLFAMLNNSQGILIQALQKMSVDIQALRLSVQSELGKFAKVSQINK
QNIQLNQALIESFENAQGLSAKMGDSFIAVDVYLLVNMSLFESVLKPYLDTKELQKTLEFLRKGATIQDKNDDSNLESLE
KFGIDLTQKALENKLDPVIGRDEEIIRMMQILIRKTKNNPILLGEPGVGKTAVVEGLAQRIVNKEVPTTLLNKRVIALDL
SLLVAGAKYRGEFEERLKKVIEEVKKSANVILFIDEIHTIVGAGASEGGMDAANILKPALARGELHTIGATTLKEYRKYF
EKDMALQRRFQPILLNEPSINEALQILRGLKETLETHHNITINDSALIASTKLSSRYITDRFLPDKAIDLIDEGAAQLKM
QMESEPAKLSSIKRSIQRLEMEKQALEMEKKESNNKRMQEILKELSDLKEEKIKLEVQFENEKEVFKEISRLKMEMENLK
KEAERFKRNGDYQQAAEIEYSKIPENEKKEKELQHKWEAMQQSGALLQNALTENNIAEIVSQWTHIPVQKMLQSEKNRVL
NIERELQKRVVGQEKALKAIAKAIKRNKAGLSDSNKPIGSFLFLGPTGVGKTESAKALAQFLFDSDKNLIRIDMSEYMEK
HAISRLIGAAPGYVGYEEGGQLTEAVRRKPYSVVLLDEVEKAHPDVFNLLLQVLDEGHLTDSKGVRVDFKNTILILTSNV
ASGALLEESLSEDDKQKAIKESLKQFFKPEFLNRLDEIVSFNALDSHAIINIVGILFENIQKKALERGINIALDEKAKEL
IAEVGFDRFYGARPLKRALYEMVEDKLAELILEDKIKENDSVAFVVENNEIVPKIK
>Mature_856_residues
MNLFEKMTNQLHETLDSALALALHHKNAEVTPLHMLFAMLNNSQGILIQALQKMSVDIQALRLSVQSELGKFAKVSQINK
QNIQLNQALIESFENAQGLSAKMGDSFIAVDVYLLVNMSLFESVLKPYLDTKELQKTLEFLRKGATIQDKNDDSNLESLE
KFGIDLTQKALENKLDPVIGRDEEIIRMMQILIRKTKNNPILLGEPGVGKTAVVEGLAQRIVNKEVPTTLLNKRVIALDL
SLLVAGAKYRGEFEERLKKVIEEVKKSANVILFIDEIHTIVGAGASEGGMDAANILKPALARGELHTIGATTLKEYRKYF
EKDMALQRRFQPILLNEPSINEALQILRGLKETLETHHNITINDSALIASTKLSSRYITDRFLPDKAIDLIDEGAAQLKM
QMESEPAKLSSIKRSIQRLEMEKQALEMEKKESNNKRMQEILKELSDLKEEKIKLEVQFENEKEVFKEISRLKMEMENLK
KEAERFKRNGDYQQAAEIEYSKIPENEKKEKELQHKWEAMQQSGALLQNALTENNIAEIVSQWTHIPVQKMLQSEKNRVL
NIERELQKRVVGQEKALKAIAKAIKRNKAGLSDSNKPIGSFLFLGPTGVGKTESAKALAQFLFDSDKNLIRIDMSEYMEK
HAISRLIGAAPGYVGYEEGGQLTEAVRRKPYSVVLLDEVEKAHPDVFNLLLQVLDEGHLTDSKGVRVDFKNTILILTSNV
ASGALLEESLSEDDKQKAIKESLKQFFKPEFLNRLDEIVSFNALDSHAIINIVGILFENIQKKALERGINIALDEKAKEL
IAEVGFDRFYGARPLKRALYEMVEDKLAELILEDKIKENDSVAFVVENNEIVPKIK

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=321, Percent_Identity=36.1370716510903, Blast_Score=204, Evalue=3e-52,
Organism=Escherichia coli, GI1788943, Length=858, Percent_Identity=48.2517482517483, Blast_Score=820, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=413, Percent_Identity=38.498789346247, Blast_Score=268, Evalue=8e-73,
Organism=Saccharomyces cerevisiae, GI6320464, Length=712, Percent_Identity=49.5786516853933, Blast_Score=692, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=870, Percent_Identity=38.8505747126437, Blast_Score=578, Evalue=1e-165,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 96759; Mature: 96759

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLFEKMTNQLHETLDSALALALHHKNAEVTPLHMLFAMLNNSQGILIQALQKMSVDIQA
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
LRLSVQSELGKFAKVSQINKQNIQLNQALIESFENAQGLSAKMGDSFIAVDVYLLVNMSL
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCHHCCCCHHHHHHHHHHHHHH
FESVLKPYLDTKELQKTLEFLRKGATIQDKNDDSNLESLEKFGIDLTQKALENKLDPVIG
HHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCC
RDEEIIRMMQILIRKTKNNPILLGEPGVGKTAVVEGLAQRIVNKEVPTTLLNKRVIALDL
CCHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHH
SLLVAGAKYRGEFEERLKKVIEEVKKSANVILFIDEIHTIVGAGASEGGMDAANILKPAL
HHHHHCHHHCCHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCCCHHHHHHHHH
ARGELHTIGATTLKEYRKYFEKDMALQRRFQPILLNEPSINEALQILRGLKETLETHHNI
HCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCE
TINDSALIASTKLSSRYITDRFLPDKAIDLIDEGAAQLKMQMESEPAKLSSIKRSIQRLE
EECCCCEEEHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHH
MEKQALEMEKKESNNKRMQEILKELSDLKEEKIKLEVQFENEKEVFKEISRLKMEMENLK
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHHHHHHHHHHHH
KEAERFKRNGDYQQAAEIEYSKIPENEKKEKELQHKWEAMQQSGALLQNALTENNIAEIV
HHHHHHHHCCCHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
SQWTHIPVQKMLQSEKNRVLNIERELQKRVVGQEKALKAIAKAIKRNKAGLSDSNKPIGS
HHHHCCCHHHHHHHHHHHEEHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCCC
FLFLGPTGVGKTESAKALAQFLFDSDKNLIRIDMSEYMEKHAISRLIGAAPGYVGYEEGG
EEEECCCCCCCCHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCC
QLTEAVRRKPYSVVLLDEVEKAHPDVFNLLLQVLDEGHLTDSKGVRVDFKNTILILTSNV
HHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEECCC
ASGALLEESLSEDDKQKAIKESLKQFFKPEFLNRLDEIVSFNALDSHAIINIVGILFENI
CCCHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
QKKALERGINIALDEKAKELIAEVGFDRFYGARPLKRALYEMVEDKLAELILEDKIKEND
HHHHHHCCCCEEEHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
SVAFVVENNEIVPKIK
CEEEEEECCCCCCCCC
>Mature Secondary Structure
MNLFEKMTNQLHETLDSALALALHHKNAEVTPLHMLFAMLNNSQGILIQALQKMSVDIQA
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
LRLSVQSELGKFAKVSQINKQNIQLNQALIESFENAQGLSAKMGDSFIAVDVYLLVNMSL
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCHHCCCCHHHHHHHHHHHHHH
FESVLKPYLDTKELQKTLEFLRKGATIQDKNDDSNLESLEKFGIDLTQKALENKLDPVIG
HHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCC
RDEEIIRMMQILIRKTKNNPILLGEPGVGKTAVVEGLAQRIVNKEVPTTLLNKRVIALDL
CCHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHH
SLLVAGAKYRGEFEERLKKVIEEVKKSANVILFIDEIHTIVGAGASEGGMDAANILKPAL
HHHHHCHHHCCHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCCCHHHHHHHHH
ARGELHTIGATTLKEYRKYFEKDMALQRRFQPILLNEPSINEALQILRGLKETLETHHNI
HCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCE
TINDSALIASTKLSSRYITDRFLPDKAIDLIDEGAAQLKMQMESEPAKLSSIKRSIQRLE
EECCCCEEEHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHH
MEKQALEMEKKESNNKRMQEILKELSDLKEEKIKLEVQFENEKEVFKEISRLKMEMENLK
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHHHHHHHHHHHH
KEAERFKRNGDYQQAAEIEYSKIPENEKKEKELQHKWEAMQQSGALLQNALTENNIAEIV
HHHHHHHHCCCHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
SQWTHIPVQKMLQSEKNRVLNIERELQKRVVGQEKALKAIAKAIKRNKAGLSDSNKPIGS
HHHHCCCHHHHHHHHHHHEEHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCCC
FLFLGPTGVGKTESAKALAQFLFDSDKNLIRIDMSEYMEKHAISRLIGAAPGYVGYEEGG
EEEECCCCCCCCHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCC
QLTEAVRRKPYSVVLLDEVEKAHPDVFNLLLQVLDEGHLTDSKGVRVDFKNTILILTSNV
HHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEECCC
ASGALLEESLSEDDKQKAIKESLKQFFKPEFLNRLDEIVSFNALDSHAIINIVGILFENI
CCCHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
QKKALERGINIALDEKAKELIAEVGFDRFYGARPLKRALYEMVEDKLAELILEDKIKEND
HHHHHHCCCCEEEHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
SVAFVVENNEIVPKIK
CEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]