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The map label for this gene is pdxB [H]

Identifier: 108812345

GI number: 108812345

Start: 2467181

End: 2468368

Strand: Reverse

Name: pdxB [H]

Synonym: YPN_2183

Alternate gene names: 108812345

Gene position: 2468368-2467181 (Counterclockwise)

Preceding gene: 108812346

Following gene: 108812344

Centisome position: 54.43

GC content: 53.7

Gene sequence:

>1188_bases
GTGGCTTATACTAAGCCCCCTGTTTTTCATCTGTATGGCAGTTCGCTGTCGGAGAGTAAAGTGAAAATTCTGGTTGATGA
AAATATGCCGTACGCTGAGGAGCTGTTCCGGCGTTTAGGTGATGTACAGGCTGTGCCAGGGCGTCCCATTCCTCGTGACG
CGTTGGTTGATGCCGATGCTCTGATGGTACGTTCGGTCACCAAAGTGAACGAGGCGCTGCTACACGGTACCTCAATTGGT
TTTGTTGGCACGGCGACGGCGGGTACCGACCATGTCGATGACACTTGGCTGCGTCAGCAGGGGATCGGTTTCTCTGCGGC
CCCCGGTTGTAACGCCATCGCCGTGGTTGAATATGTTTTCTCTGCGTTGATGATGATGGCTGAACGGGATGGCTTCCAGT
TGCGCGATAAAACCGTGGGCATTATCGGCGTCGGAAATGTGGGTTCACGGCTGAATGCTCGTTTGCAAGCCTTAGGTGTT
CGGACCTTGTTGTGCGACCCCCCGCGTGCTGATCGTGGTGATAACGAAGCCTTCTGGCCGCTGGAAAAACTGGTACGTGA
GGCTGACGTTCTGACCTTCCATACTCCGCTGAATAAAACCGGAGCCTACCAAAGTCTGCATATGGCCGATGATGAACTGC
TGGCCGCCTTACCGGATGGCCGTATTCTGATCAACGCCTGCCGGGGTGCGGTGGTGGATAACGCAGCACTATTACGGGCG
CTGGAAAAAGGGAAAAAACTCAGCGTGGTATTGGACGTCTGGGAGCCAGAACCGGATCTCTCTTTACCGCTGTTGGCCCG
TGTCGATATTGGCACACCGCATATTGCCGGATATACGCTAGAAGGCAAAGCACGGGGTACCACACAGGTTTTTGAGGCGT
TCAGTCAGCATTTGGGGCAACCACAGTCGGTCGAACTGGCCTCTTTATTGCCAGTGCCAGAGTTTAGCCATTTACGTCTA
AATGGTGAGTTGGATGAAGGCAAATTAAAACGATTGATGCACTTAGTGTATGATGTGCGCCGCGATGACGCGCCATTGCG
CCATGTCGCTGGCCTGCCAGGGGAGTTTGACCGCCTGCGCAAGCATTATCAGGAGCGGCGTGAATGGTCATCACTGTGTG
TACAGTGCGATGATGCTACCAGTGCTGGACTCTTGCAGCAGCTAGGTTTTACTACTCAATTGCTGTGA

Upstream 100 bases:

>100_bases
AGTGTGGCATTAGATGTCGGTTATAGCTCCGCCTCTGCTTTTATCGCCATGTTTCAGCAAATATCGGGTACCACGCCTGA
GCGTTTCCGGCGGGGCAATA

Downstream 100 bases:

>100_bases
CGATAGGGTAGTACGAATATCACGCGTAAAAATTAATAACAGGGCGGTGTGTTACCGCCCTTGCTGTTCAATAACGTCAT
GTTATTCAATAATTTAATCA

Product: erythronate-4-phosphate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MAYTKPPVFHLYGSSLSESKVKILVDENMPYAEELFRRLGDVQAVPGRPIPRDALVDADALMVRSVTKVNEALLHGTSIG
FVGTATAGTDHVDDTWLRQQGIGFSAAPGCNAIAVVEYVFSALMMMAERDGFQLRDKTVGIIGVGNVGSRLNARLQALGV
RTLLCDPPRADRGDNEAFWPLEKLVREADVLTFHTPLNKTGAYQSLHMADDELLAALPDGRILINACRGAVVDNAALLRA
LEKGKKLSVVLDVWEPEPDLSLPLLARVDIGTPHIAGYTLEGKARGTTQVFEAFSQHLGQPQSVELASLLPVPEFSHLRL
NGELDEGKLKRLMHLVYDVRRDDAPLRHVAGLPGEFDRLRKHYQERREWSSLCVQCDDATSAGLLQQLGFTTQLL

Sequences:

>Translated_395_residues
MAYTKPPVFHLYGSSLSESKVKILVDENMPYAEELFRRLGDVQAVPGRPIPRDALVDADALMVRSVTKVNEALLHGTSIG
FVGTATAGTDHVDDTWLRQQGIGFSAAPGCNAIAVVEYVFSALMMMAERDGFQLRDKTVGIIGVGNVGSRLNARLQALGV
RTLLCDPPRADRGDNEAFWPLEKLVREADVLTFHTPLNKTGAYQSLHMADDELLAALPDGRILINACRGAVVDNAALLRA
LEKGKKLSVVLDVWEPEPDLSLPLLARVDIGTPHIAGYTLEGKARGTTQVFEAFSQHLGQPQSVELASLLPVPEFSHLRL
NGELDEGKLKRLMHLVYDVRRDDAPLRHVAGLPGEFDRLRKHYQERREWSSLCVQCDDATSAGLLQQLGFTTQLL
>Mature_394_residues
AYTKPPVFHLYGSSLSESKVKILVDENMPYAEELFRRLGDVQAVPGRPIPRDALVDADALMVRSVTKVNEALLHGTSIGF
VGTATAGTDHVDDTWLRQQGIGFSAAPGCNAIAVVEYVFSALMMMAERDGFQLRDKTVGIIGVGNVGSRLNARLQALGVR
TLLCDPPRADRGDNEAFWPLEKLVREADVLTFHTPLNKTGAYQSLHMADDELLAALPDGRILINACRGAVVDNAALLRAL
EKGKKLSVVLDVWEPEPDLSLPLLARVDIGTPHIAGYTLEGKARGTTQVFEAFSQHLGQPQSVELASLLPVPEFSHLRLN
GELDEGKLKRLMHLVYDVRRDDAPLRHVAGLPGEFDRLRKHYQERREWSSLCVQCDDATSAGLLQQLGFTTQLL

Specific function: Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=303, Percent_Identity=28.3828382838284, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI145580578, Length=273, Percent_Identity=24.1758241758242, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI4557499, Length=273, Percent_Identity=24.1758241758242, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI61743967, Length=155, Percent_Identity=33.5483870967742, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4557497, Length=155, Percent_Identity=33.5483870967742, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI145580575, Length=175, Percent_Identity=30.2857142857143, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1788660, Length=371, Percent_Identity=72.2371967654987, Blast_Score=525, Evalue=1e-150,
Organism=Escherichia coli, GI1787645, Length=206, Percent_Identity=27.1844660194175, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1789279, Length=310, Percent_Identity=26.7741935483871, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082289, Length=159, Percent_Identity=32.7044025157233, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=263, Percent_Identity=26.615969581749, Blast_Score=94, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6322116, Length=332, Percent_Identity=27.710843373494, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320925, Length=332, Percent_Identity=27.4096385542169, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324055, Length=293, Percent_Identity=24.9146757679181, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324964, Length=271, Percent_Identity=25.4612546125461, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19921140, Length=295, Percent_Identity=28.4745762711864, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28574286, Length=231, Percent_Identity=26.8398268398268, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24646446, Length=228, Percent_Identity=24.1228070175439, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24646448, Length=228, Percent_Identity=24.1228070175439, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24646452, Length=228, Percent_Identity=24.1228070175439, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24646450, Length=228, Percent_Identity=24.1228070175439, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI62472511, Length=228, Percent_Identity=24.1228070175439, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR020921
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.290 [H]

Molecular weight: Translated: 43360; Mature: 43229

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYTKPPVFHLYGSSLSESKVKILVDENMPYAEELFRRLGDVQAVPGRPIPRDALVDADA
CCCCCCCEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCHHHHCCHHH
LMVRSVTKVNEALLHGTSIGFVGTATAGTDHVDDTWLRQQGIGFSAAPGCNAIAVVEYVF
HHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHH
SALMMMAERDGFQLRDKTVGIIGVGNVGSRLNARLQALGVRTLLCDPPRADRGDNEAFWP
HHHHHHHHCCCCEECCCEEEEEEECCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCH
LEKLVREADVLTFHTPLNKTGAYQSLHMADDELLAALPDGRILINACRGAVVDNAALLRA
HHHHHHHCCEEEEECCCCCCCCCCCHHCCCHHHHHCCCCCCEEEEECCCCHHHHHHHHHH
LEKGKKLSVVLDVWEPEPDLSLPLLARVDIGTPHIAGYTLEGKARGTTQVFEAFSQHLGQ
HHCCCEEEEEEEEECCCCCCCCCEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHCCC
PQSVELASLLPVPEFSHLRLNGELDEGKLKRLMHLVYDVRRDDAPLRHVAGLPGEFDRLR
CCCCCHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHH
KHYQERREWSSLCVQCDDATSAGLLQQLGFTTQLL
HHHHHHHHHHHHEEECCCCCHHHHHHHHCCHHHCC
>Mature Secondary Structure 
AYTKPPVFHLYGSSLSESKVKILVDENMPYAEELFRRLGDVQAVPGRPIPRDALVDADA
CCCCCCEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCHHHHCCHHH
LMVRSVTKVNEALLHGTSIGFVGTATAGTDHVDDTWLRQQGIGFSAAPGCNAIAVVEYVF
HHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHH
SALMMMAERDGFQLRDKTVGIIGVGNVGSRLNARLQALGVRTLLCDPPRADRGDNEAFWP
HHHHHHHHCCCCEECCCEEEEEEECCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCH
LEKLVREADVLTFHTPLNKTGAYQSLHMADDELLAALPDGRILINACRGAVVDNAALLRA
HHHHHHHCCEEEEECCCCCCCCCCCHHCCCHHHHHCCCCCCEEEEECCCCHHHHHHHHHH
LEKGKKLSVVLDVWEPEPDLSLPLLARVDIGTPHIAGYTLEGKARGTTQVFEAFSQHLGQ
HHCCCEEEEEEEEECCCCCCCCCEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHCCC
PQSVELASLLPVPEFSHLRLNGELDEGKLKRLMHLVYDVRRDDAPLRHVAGLPGEFDRLR
CCCCCHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHH
KHYQERREWSSLCVQCDDATSAGLLQQLGFTTQLL
HHHHHHHHHHHHEEECCCCCHHHHHHHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA