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The map label for this gene is edd [H]

Identifier: 108812290

GI number: 108812290

Start: 2403996

End: 2405867

Strand: Reverse

Name: edd [H]

Synonym: YPN_2128

Alternate gene names: 108812290

Gene position: 2405867-2403996 (Counterclockwise)

Preceding gene: 108812291

Following gene: 108812287

Centisome position: 53.06

GC content: 53.26

Gene sequence:

>1872_bases
ATGAACCCCATTATCACCCGTGTCACGCAGCGTATCATTGCGCGCTCAGCGGCCACACGCACGGCATATCTGCAACGTAT
CAGTGCAGCAAAAGAGCATACCGTTCACCGTTCACAACTGGCTTGCGGTAATCTGGCGCACGGCTTTGCGGCTTGTCAGC
CAGAGGATAAAGCGGCCCTAAAAAATAGGGTGCGTAGCGATATCGCCATCATTACGTCCTATAACGATATGCTGTCTGCT
CATCAACCTTATGAACATTACCCACAACAACTGAAAGACGCATTGCATGAGGTTGGGGCCATTGGGCAGGTTGCCGGTGG
GGTTCCTGCCATGTGTGATGGGGTGACGCAAGGGCAGGATGGGATGGAGTTGTCGCTAATGAGCCGCGATGTGATTGCTA
TGTCAGCGGCTATTGGCCTGTCACACAATATGTTTGATGGTGCTCTCTACCTCGGTGTGTGCGATAAAATCGTTCCCGGT
TTGTTAATGGCAGCGCTGTCATTTGGCCATTTACCGGCTATTTTTGTCCCCGCCGGGCCTATGGCCAGCGGTTTGCCTAA
CAAAGAGAAAGTCCGGATCCGCCAACTTTACGCCGAGGGGAAAGTGGATAGGCAAGCCTTGTTGGAGGCTGAAGCCGCTT
CGTATCACAGTGCCGGGACCTGTACTTTTTACGGTACTGCCAATTCTAATCAGATGGTGATGGAAGTGATGGGGCTGCAT
TTGCCGGGAGCCTCTTTTATCCAACCGAATACACCACTGCGTGATGCGCTGACTGCAGCGGCGGCACGTCAAATCACCCG
TCTGACCGAAACCGGCATTAATTGTATTGATGGCAATCATATTGATGTTAACCATATCAACAGTAGCCATATCAACAGCA
GCTATTTGCCTGTTGGCCAATTGGTGGATGAAAAAGTGGTCGTCAATGGGATTGTCGCGCTGCTGGCAACCGGCGGTTCG
ACTAATCACACCTTACATTTGGTCGCGATGGCGCGGGCGGCGGGCATCATCATTAATTGGGATGATTTCTCTGAACTGTC
GGAAGCGGTGCCGCAGCTATGCCGTATTTACCCTAATGGCCCAGCGGACATCAACTATTTTCAGGCATCGGGTGGTGTGG
CACTGCTGGTTAATATGCTATTGCAAGGCGGTTTACTGCACGAAGAGGTGCATACCGTCGCTGGATTTGGTTTGCAGCGT
TATACGCAAGAGCCTTATCTGGCGGCGGGTAAATTGCAATGGCGTCCTGGGCCGCAACAGTCACTGGATGCGACGGTGAT
CGCCAGTCTGGAACAGCCTTTTTCTGCTCAGGGGGGGACGAAAGTATTAAACGGCAATCTGGGGCGGGCGGTAATGAAAA
CCTCGGCAGTGCCACGGGAGCATCAGGTTATTGAAGGGCCAGCGCGGGTATTTGAGAGTCAGCATGATGTGGAAGCCGCC
TTTGAATCCGGTGATTTGGATCGCGATTGTGTGGTGGTGGTGCGTTATCAGGGGCCGCAGGCCATTGGTATGCCGGAGTT
ACATAAGCTGATGCCGCCGCTAGGAGTATTACTTGATCGTGGCTTTAAGGTAGCGTTGGTGACGGATGGCCGATTATCCG
GCGCATCAGGCAAGGTGCCGTCTGCCATTCACGTGACGCCAGAAGCCTATTGCGGTGGTTTACTGGCCAACGTCCGCAAT
GGTGACCGGATTCGGGTTGATGGGGTCAGTGGCGAGCTGTCATTACTGGTGGATGAGGCTGAATTGGCCACTCGCGATAG
TCCGTTACCGGCTATCTCTGCTTTCCATGTGGGATGTGGCCGTGAGTTGTTTGGGGCATTACGTGAACAGCTTTCTGGTG
CAGAGCAGGGGGCGTGTTGTATTCGTTTCTAA

Upstream 100 bases:

>100_bases
CAATTTACTGTTACAGGTACTGGCCGACTTTGTCGGCCTGCCCACTGGCAGCATTGAACTTTTGACCCCATTAACCCCAT
TGAGCGCATAAGGAATGGAG

Downstream 100 bases:

>100_bases
ATGCTATTTAGGTAGTTTTATTCAGAGCACTGTGCGCCATTTCCGCGCAGGATTTCAATATATGAATGAGTTTCAAGTCA
ATAAATAAAAACGCAGATTT

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 623; Mature: 623

Protein sequence:

>623_residues
MNPIITRVTQRIIARSAATRTAYLQRISAAKEHTVHRSQLACGNLAHGFAACQPEDKAALKNRVRSDIAIITSYNDMLSA
HQPYEHYPQQLKDALHEVGAIGQVAGGVPAMCDGVTQGQDGMELSLMSRDVIAMSAAIGLSHNMFDGALYLGVCDKIVPG
LLMAALSFGHLPAIFVPAGPMASGLPNKEKVRIRQLYAEGKVDRQALLEAEAASYHSAGTCTFYGTANSNQMVMEVMGLH
LPGASFIQPNTPLRDALTAAAARQITRLTETGINCIDGNHIDVNHINSSHINSSYLPVGQLVDEKVVVNGIVALLATGGS
TNHTLHLVAMARAAGIIINWDDFSELSEAVPQLCRIYPNGPADINYFQASGGVALLVNMLLQGGLLHEEVHTVAGFGLQR
YTQEPYLAAGKLQWRPGPQQSLDATVIASLEQPFSAQGGTKVLNGNLGRAVMKTSAVPREHQVIEGPARVFESQHDVEAA
FESGDLDRDCVVVVRYQGPQAIGMPELHKLMPPLGVLLDRGFKVALVTDGRLSGASGKVPSAIHVTPEAYCGGLLANVRN
GDRIRVDGVSGELSLLVDEAELATRDSPLPAISAFHVGCGRELFGALREQLSGAEQGACCIRF

Sequences:

>Translated_623_residues
MNPIITRVTQRIIARSAATRTAYLQRISAAKEHTVHRSQLACGNLAHGFAACQPEDKAALKNRVRSDIAIITSYNDMLSA
HQPYEHYPQQLKDALHEVGAIGQVAGGVPAMCDGVTQGQDGMELSLMSRDVIAMSAAIGLSHNMFDGALYLGVCDKIVPG
LLMAALSFGHLPAIFVPAGPMASGLPNKEKVRIRQLYAEGKVDRQALLEAEAASYHSAGTCTFYGTANSNQMVMEVMGLH
LPGASFIQPNTPLRDALTAAAARQITRLTETGINCIDGNHIDVNHINSSHINSSYLPVGQLVDEKVVVNGIVALLATGGS
TNHTLHLVAMARAAGIIINWDDFSELSEAVPQLCRIYPNGPADINYFQASGGVALLVNMLLQGGLLHEEVHTVAGFGLQR
YTQEPYLAAGKLQWRPGPQQSLDATVIASLEQPFSAQGGTKVLNGNLGRAVMKTSAVPREHQVIEGPARVFESQHDVEAA
FESGDLDRDCVVVVRYQGPQAIGMPELHKLMPPLGVLLDRGFKVALVTDGRLSGASGKVPSAIHVTPEAYCGGLLANVRN
GDRIRVDGVSGELSLLVDEAELATRDSPLPAISAFHVGCGRELFGALREQLSGAEQGACCIRF
>Mature_623_residues
MNPIITRVTQRIIARSAATRTAYLQRISAAKEHTVHRSQLACGNLAHGFAACQPEDKAALKNRVRSDIAIITSYNDMLSA
HQPYEHYPQQLKDALHEVGAIGQVAGGVPAMCDGVTQGQDGMELSLMSRDVIAMSAAIGLSHNMFDGALYLGVCDKIVPG
LLMAALSFGHLPAIFVPAGPMASGLPNKEKVRIRQLYAEGKVDRQALLEAEAASYHSAGTCTFYGTANSNQMVMEVMGLH
LPGASFIQPNTPLRDALTAAAARQITRLTETGINCIDGNHIDVNHINSSHINSSYLPVGQLVDEKVVVNGIVALLATGGS
TNHTLHLVAMARAAGIIINWDDFSELSEAVPQLCRIYPNGPADINYFQASGGVALLVNMLLQGGLLHEEVHTVAGFGLQR
YTQEPYLAAGKLQWRPGPQQSLDATVIASLEQPFSAQGGTKVLNGNLGRAVMKTSAVPREHQVIEGPARVFESQHDVEAA
FESGDLDRDCVVVVRYQGPQAIGMPELHKLMPPLGVLLDRGFKVALVTDGRLSGASGKVPSAIHVTPEAYCGGLLANVRN
GDRIRVDGVSGELSLLVDEAELATRDSPLPAISAFHVGCGRELFGALREQLSGAEQGACCIRF

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=623, Percent_Identity=75.7624398073836, Blast_Score=972, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=555, Percent_Identity=30.990990990991, Blast_Score=199, Evalue=5e-52,
Organism=Escherichia coli, GI2367371, Length=478, Percent_Identity=29.0794979079498, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1786464, Length=538, Percent_Identity=26.5799256505576, Blast_Score=124, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6322476, Length=495, Percent_Identity=31.7171717171717, Blast_Score=182, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 66398; Mature: 66398

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPIITRVTQRIIARSAATRTAYLQRISAAKEHTVHRSQLACGNLAHGFAACQPEDKAAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHCCCCCHHHHH
KNRVRSDIAIITSYNDMLSAHQPYEHYPQQLKDALHEVGAIGQVAGGVPAMCDGVTQGQD
HHHHHCCEEEEEECHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCHHHCCCCCCCC
GMELSLMSRDVIAMSAAIGLSHNMFDGALYLGVCDKIVPGLLMAALSFGHLPAIFVPAGP
CCEEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
MASGLPNKEKVRIRQLYAEGKVDRQALLEAEAASYHSAGTCTFYGTANSNQMVMEVMGLH
HHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHCC
LPGASFIQPNTPLRDALTAAAARQITRLTETGINCIDGNHIDVNHINSSHINSSYLPVGQ
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEECCCEEEEECCCCCCCCCCCCCHHH
LVDEKVVVNGIVALLATGGSTNHTLHLVAMARAAGIIINWDDFSELSEAVPQLCRIYPNG
HHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHCCEEEECCCHHHHHHHHHHHHHCCCCC
PADINYFQASGGVALLVNMLLQGGLLHEEVHTVAGFGLQRYTQEPYLAAGKLQWRPGPQQ
CCCCEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHCCCCCEECCEEECCCCCCC
SLDATVIASLEQPFSAQGGTKVLNGNLGRAVMKTSAVPREHQVIEGPARVFESQHDVEAA
CCCHHHHHHHCCCCCCCCCCEEECCCCCHHHHHHCCCCCHHHHHCCHHHHHCCCHHHHHH
FESGDLDRDCVVVVRYQGPQAIGMPELHKLMPPLGVLLDRGFKVALVTDGRLSGASGKVP
HHCCCCCCCEEEEEEECCCCCCCCHHHHHHCCHHHHHHCCCCEEEEEECCCCCCCCCCCC
SAIHVTPEAYCGGLLANVRNGDRIRVDGVSGELSLLVDEAELATRDSPLPAISAFHVGCG
CEEEECHHHHHCHHHHHCCCCCEEEEECCCCCEEEEEECHHHHCCCCCCCCHHHHCCCCC
RELFGALREQLSGAEQGACCIRF
HHHHHHHHHHHCCCCCCCEEECC
>Mature Secondary Structure
MNPIITRVTQRIIARSAATRTAYLQRISAAKEHTVHRSQLACGNLAHGFAACQPEDKAAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHCCCCCHHHHH
KNRVRSDIAIITSYNDMLSAHQPYEHYPQQLKDALHEVGAIGQVAGGVPAMCDGVTQGQD
HHHHHCCEEEEEECHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCHHHCCCCCCCC
GMELSLMSRDVIAMSAAIGLSHNMFDGALYLGVCDKIVPGLLMAALSFGHLPAIFVPAGP
CCEEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
MASGLPNKEKVRIRQLYAEGKVDRQALLEAEAASYHSAGTCTFYGTANSNQMVMEVMGLH
HHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHCC
LPGASFIQPNTPLRDALTAAAARQITRLTETGINCIDGNHIDVNHINSSHINSSYLPVGQ
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEECCCEEEEECCCCCCCCCCCCCHHH
LVDEKVVVNGIVALLATGGSTNHTLHLVAMARAAGIIINWDDFSELSEAVPQLCRIYPNG
HHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHCCEEEECCCHHHHHHHHHHHHHCCCCC
PADINYFQASGGVALLVNMLLQGGLLHEEVHTVAGFGLQRYTQEPYLAAGKLQWRPGPQQ
CCCCEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHCCCCCEECCEEECCCCCCC
SLDATVIASLEQPFSAQGGTKVLNGNLGRAVMKTSAVPREHQVIEGPARVFESQHDVEAA
CCCHHHHHHHCCCCCCCCCCEEECCCCCHHHHHHCCCCCHHHHHCCHHHHHCCCHHHHHH
FESGDLDRDCVVVVRYQGPQAIGMPELHKLMPPLGVLLDRGFKVALVTDGRLSGASGKVP
HHCCCCCCCEEEEEEECCCCCCCCHHHHHHCCHHHHHHCCCCEEEEEECCCCCCCCCCCC
SAIHVTPEAYCGGLLANVRNGDRIRVDGVSGELSLLVDEAELATRDSPLPAISAFHVGCG
CEEEECHHHHHCHHHHHCCCCCEEEEECCCCCEEEEEECHHHHCCCCCCCCHHHHCCCCC
RELFGALREQLSGAEQGACCIRF
HHHHHHHHHHHCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]