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The map label for this gene is fabD [H]

Identifier: 108812193

GI number: 108812193

Start: 2293606

End: 2294535

Strand: Reverse

Name: fabD [H]

Synonym: YPN_2031

Alternate gene names: 108812193

Gene position: 2294535-2293606 (Counterclockwise)

Preceding gene: 108812194

Following gene: 108812192

Centisome position: 50.6

GC content: 51.51

Gene sequence:

>930_bases
ATGTCGAAATTTGCAATGGTATTTCCAGGTCAGGGTTCTCAGTCCCTCGGCATGCTGGCCGATTTGGCCGCACAATTTCC
GATAGTTGAAGCGACCTTCAGTGAAGCGTCGTCTGTCCTGGGCTATGATCTCTGGCAATTAGTACAACAAGGCCCTGCAG
AAGAGCTGAATAAAACGTGGCAAACACAGCCCGCATTGCTGACCGCATCTGTGGCAATTTGGCGTATCTGGCAGCATCAG
GGGGGCAAATTGCCATCACTGATGGCGGGTCATAGTTTGGGTGAATATTCAGCGTTGGTTTGTGCTGGTGTTCTGGATTT
TAAACAGGCCGTTAGCTTGGTTGAACTGCGTGGGAAACTCATGCAGGAGGCGGTACCTGAAGGTACCGGTGCCATGTATG
CCATTATTGGTTTGGATAATGAATCCATTGCCAAAGCGTGTGAAGAATCAGCCCAGGGCCAGGTCGTGTCACCGGTAAAC
TTTAATTCACCCGGTCAGGTGGTTATTGCTGGCAACAAAGACGCTGTCGAACGTGCTGGCGCAGCATGTAAAGCCGCTGG
CGCAAAGCGGGCTTTGCCATTGCCTGTCAGTGTGCCTTCCCATTGTGCGCTAATGAAACCTGCGGCCGACAAGCTGGCAG
TCGCACTTGAGAAGATTGATTTTCAGGAGCCGCTCTTCCCAGTGGTGAACAACGTCGATGTGAAAGCTGAGGTGTCCCCA
GTCGCTATCCGTAGCGCATTGGTCCGTCAGCTGTATAATCCGGTACGTTGGACTGAAAGTGTTGAATTTATTGCAGCTGA
AGGTGTTGAACTGCTGTTAGAGATTGGGCCAGGTAAAGTATTGACCGGCCTGACCAAGCGTATCGTTGATTCATTGGCTG
CCGCGGCAGTCAACGATGTTGTCACGCTGAACAGTGCGCTTGAACACTAA

Upstream 100 bases:

>100_bases
TTGGTATTGCTTGAGGCGTTTGGCGGTGGATTTACCTGGGGTTCTGCACTGGTTCGTTTTTGATTTAACCGGCCGTTTTT
TGATGTAACAGGAATGCAAA

Downstream 100 bases:

>100_bases
GAAAGAGGGTAACATGAGCTTCGAAGGAAAAATTGCACTGGTCACTGGCGCGAGCCGTGGTATTGGTCGCGCTATTGCAG
AATTATTGGTTGAACGCGGT

Product: malonyl CoA-acyl carrier protein transacylase

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MSKFAMVFPGQGSQSLGMLADLAAQFPIVEATFSEASSVLGYDLWQLVQQGPAEELNKTWQTQPALLTASVAIWRIWQHQ
GGKLPSLMAGHSLGEYSALVCAGVLDFKQAVSLVELRGKLMQEAVPEGTGAMYAIIGLDNESIAKACEESAQGQVVSPVN
FNSPGQVVIAGNKDAVERAGAACKAAGAKRALPLPVSVPSHCALMKPAADKLAVALEKIDFQEPLFPVVNNVDVKAEVSP
VAIRSALVRQLYNPVRWTESVEFIAAEGVELLLEIGPGKVLTGLTKRIVDSLAAAAVNDVVTLNSALEH

Sequences:

>Translated_309_residues
MSKFAMVFPGQGSQSLGMLADLAAQFPIVEATFSEASSVLGYDLWQLVQQGPAEELNKTWQTQPALLTASVAIWRIWQHQ
GGKLPSLMAGHSLGEYSALVCAGVLDFKQAVSLVELRGKLMQEAVPEGTGAMYAIIGLDNESIAKACEESAQGQVVSPVN
FNSPGQVVIAGNKDAVERAGAACKAAGAKRALPLPVSVPSHCALMKPAADKLAVALEKIDFQEPLFPVVNNVDVKAEVSP
VAIRSALVRQLYNPVRWTESVEFIAAEGVELLLEIGPGKVLTGLTKRIVDSLAAAAVNDVVTLNSALEH
>Mature_308_residues
SKFAMVFPGQGSQSLGMLADLAAQFPIVEATFSEASSVLGYDLWQLVQQGPAEELNKTWQTQPALLTASVAIWRIWQHQG
GKLPSLMAGHSLGEYSALVCAGVLDFKQAVSLVELRGKLMQEAVPEGTGAMYAIIGLDNESIAKACEESAQGQVVSPVNF
NSPGQVVIAGNKDAVERAGAACKAAGAKRALPLPVSVPSHCALMKPAADKLAVALEKIDFQEPLFPVVNNVDVKAEVSPV
AIRSALVRQLYNPVRWTESVEFIAAEGVELLLEIGPGKVLTGLTKRIVDSLAAAAVNDVVTLNSALEH

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=322, Percent_Identity=32.2981366459627, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI27477045, Length=114, Percent_Identity=39.4736842105263, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI1787334, Length=308, Percent_Identity=78.5714285714286, Blast_Score=471, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI71984332, Length=295, Percent_Identity=28.8135593220339, Blast_Score=107, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17550940, Length=296, Percent_Identity=29.0540540540541, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24665753, Length=308, Percent_Identity=32.7922077922078, Blast_Score=142, Evalue=3e-34,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR004410
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 32652; Mature: 32521

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKFAMVFPGQGSQSLGMLADLAAQFPIVEATFSEASSVLGYDLWQLVQQGPAEELNKTW
CCCEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
QTQPALLTASVAIWRIWQHQGGKLPSLMAGHSLGEYSALVCAGVLDFKQAVSLVELRGKL
CCCCHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MQEAVPEGTGAMYAIIGLDNESIAKACEESAQGQVVSPVNFNSPGQVVIAGNKDAVERAG
HHHHCCCCCCCEEEEEECCCHHHHHHHHHHCCCCEECCCCCCCCCCEEEECCHHHHHHHC
AACKAAGAKRALPLPVSVPSHCALMKPAADKLAVALEKIDFQEPLFPVVNNVDVKAEVSP
CHHHHCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHHCCCCCCHHHHCCCCCEECCCH
VAIRSALVRQLYNPVRWTESVEFIAAEGVELLLEIGPGKVLTGLTKRIVDSLAAAAVNDV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
VTLNSALEH
HHHHHHHCC
>Mature Secondary Structure 
SKFAMVFPGQGSQSLGMLADLAAQFPIVEATFSEASSVLGYDLWQLVQQGPAEELNKTW
CCEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
QTQPALLTASVAIWRIWQHQGGKLPSLMAGHSLGEYSALVCAGVLDFKQAVSLVELRGKL
CCCCHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MQEAVPEGTGAMYAIIGLDNESIAKACEESAQGQVVSPVNFNSPGQVVIAGNKDAVERAG
HHHHCCCCCCCEEEEEECCCHHHHHHHHHHCCCCEECCCCCCCCCCEEEECCHHHHHHHC
AACKAAGAKRALPLPVSVPSHCALMKPAADKLAVALEKIDFQEPLFPVVNNVDVKAEVSP
CHHHHCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHHCCCCCCHHHHCCCCCEECCCH
VAIRSALVRQLYNPVRWTESVEFIAAEGVELLLEIGPGKVLTGLTKRIVDSLAAAAVNDV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
VTLNSALEH
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]