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The map label for this gene is htpX

Identifier: 108797751

GI number: 108797751

Start: 826828

End: 827703

Strand: Direct

Name: htpX

Synonym: Mmcs_0772

Alternate gene names: 108797751

Gene position: 826828-827703 (Clockwise)

Preceding gene: 108797750

Following gene: 108797752

Centisome position: 14.49

GC content: 67.12

Gene sequence:

>876_bases
ATGACGTGGAATCCGCACGCGAACAGGTTCAAGACGTTCCTGTTGCTGGTGGGGATGTCTGCGCTGATCGTGTTCGTCGG
TTCGCTGTTCGGCCGGTCGATCATGGCGTTGGCCGTGCTGTTCGCCGTCGGCATGAACGTCTACGTGTACTTCAACAGCG
ACAAGCTGGCCCTCAAGGCGATGCATGCGCAGCCGGTCAGCGAGTTGCAGGCGCCGGTGATGTACCGCATCGTGCGCGAG
CTGTCCAACGCCGCACACCAGCCGATGCCGCGGCTGTACATCTCCGATACCGCGAACCCGAACGCGTTCGCGACCGGACG
TAATCCGCGTAACTCGGCGGTGTGCTGCACGACCGGGATCCTGCAGATCCTCAACGAGCGGGAACTGCGCGCGGTGCTGG
GCCACGAACTGTCCCACGTCTACAACCGCGACATCCTCATCTCGTGTGTGGCGGGCGCGATGGCGTCGGTGATCACCGCG
CTGGCCAACATCGCGTTGTTCGCCGGCATGTTCGGCGGTAACCGCGAGGGCACCAACCCGTTTGCGCTGCTGCTGGTTTC
GTTCCTCGGGCCGATCGCGGCGACGGTGGTCCGGCTGGCGGTGTCGCGGTCGCGCGAGTATCAGGCCGACCAGTCGGGCG
CCGAACTCACCGGGGACCCGCTGGCGCTGGCGTCGGCGCTGCGCAAGATCTCCGGCGGGGTGGAGGCCGCGCCGCTGCCC
CCGCAGCCGCAGCTGGCCGATCAGGCGCACCTGATGATCGCCAGCCCGTTCCGGTCGGGGGAGAAGATCGGCAAGCTGTT
CTCGACGCATCCGCCGATGGCCGACCGGATCCGCCGCCTCGAAGAGATGGCCGGCCGCGGTCCGGGCCTCTACTGA

Upstream 100 bases:

>100_bases
ACTGGTCGACTACACGATCACCCGCCACGGCTGAACATCGCCGGAACCCAGACGGCTGTATGCAGCGTTGGATCAGCGAA
GACTCACGAGGAGGTAGCTG

Downstream 100 bases:

>100_bases
CCGCTCTGCGGCGCCGAACGTGCGCTCACTGCGAAAAACCGCTCCCGAATTCGCACTGGCCGCACGTTCGGCGCGTCAAA
GCCGCGAAACGAAATCCATC

Product: heat shock protein HtpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MTWNPHANRFKTFLLLVGMSALIVFVGSLFGRSIMALAVLFAVGMNVYVYFNSDKLALKAMHAQPVSELQAPVMYRIVRE
LSNAAHQPMPRLYISDTANPNAFATGRNPRNSAVCCTTGILQILNERELRAVLGHELSHVYNRDILISCVAGAMASVITA
LANIALFAGMFGGNREGTNPFALLLVSFLGPIAATVVRLAVSRSREYQADQSGAELTGDPLALASALRKISGGVEAAPLP
PQPQLADQAHLMIASPFRSGEKIGKLFSTHPPMADRIRRLEEMAGRGPGLY

Sequences:

>Translated_291_residues
MTWNPHANRFKTFLLLVGMSALIVFVGSLFGRSIMALAVLFAVGMNVYVYFNSDKLALKAMHAQPVSELQAPVMYRIVRE
LSNAAHQPMPRLYISDTANPNAFATGRNPRNSAVCCTTGILQILNERELRAVLGHELSHVYNRDILISCVAGAMASVITA
LANIALFAGMFGGNREGTNPFALLLVSFLGPIAATVVRLAVSRSREYQADQSGAELTGDPLALASALRKISGGVEAAPLP
PQPQLADQAHLMIASPFRSGEKIGKLFSTHPPMADRIRRLEEMAGRGPGLY
>Mature_290_residues
TWNPHANRFKTFLLLVGMSALIVFVGSLFGRSIMALAVLFAVGMNVYVYFNSDKLALKAMHAQPVSELQAPVMYRIVREL
SNAAHQPMPRLYISDTANPNAFATGRNPRNSAVCCTTGILQILNERELRAVLGHELSHVYNRDILISCVAGAMASVITAL
ANIALFAGMFGGNREGTNPFALLLVSFLGPIAATVVRLAVSRSREYQADQSGAELTGDPLALASALRKISGGVEAAPLPP
QPQLADQAHLMIASPFRSGEKIGKLFSTHPPMADRIRRLEEMAGRGPGLY

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=292, Percent_Identity=30.4794520547945, Blast_Score=96, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_MYCSJ (A3PUK0)

Other databases:

- EMBL:   CP000580
- RefSeq:   YP_001069068.1
- ProteinModelPortal:   A3PUK0
- STRING:   A3PUK0
- MEROPS:   M48.004
- EnsemblBacteria:   EBMYCT00000048871
- GeneID:   4876510
- GenomeReviews:   CP000580_GR
- KEGG:   mjl:Mjls_0767
- eggNOG:   COG0501
- GeneTree:   EBGT00050000016372
- HOGENOM:   HBG739460
- OMA:   RRGAEIC
- PhylomeDB:   A3PUK0
- ProtClustDB:   PRK03072
- BioCyc:   MSP164757:MJLS_0767-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.-

Molecular weight: Translated: 31372; Mature: 31241

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 136-136

Signals:

None

Transmembrane regions:

HASH(0x11df0cac)-; HASH(0x1396b520)-; HASH(0x1396b340)-; HASH(0x135d89c8)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWNPHANRFKTFLLLVGMSALIVFVGSLFGRSIMALAVLFAVGMNVYVYFNSDKLALKA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHH
MHAQPVSELQAPVMYRIVRELSNAAHQPMPRLYISDTANPNAFATGRNPRNSAVCCTTGI
HHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCEECCCCCCCCCHHHHHHH
LQILNERELRAVLGHELSHVYNRDILISCVAGAMASVITALANIALFAGMFGGNREGTNP
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
FALLLVSFLGPIAATVVRLAVSRSREYQADQSGAELTGDPLALASALRKISGGVEAAPLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
PQPQLADQAHLMIASPFRSGEKIGKLFSTHPPMADRIRRLEEMAGRGPGLY
CCCCCCCCHHEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCH
>Mature Secondary Structure 
TWNPHANRFKTFLLLVGMSALIVFVGSLFGRSIMALAVLFAVGMNVYVYFNSDKLALKA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHH
MHAQPVSELQAPVMYRIVRELSNAAHQPMPRLYISDTANPNAFATGRNPRNSAVCCTTGI
HHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCEECCCCCCCCCHHHHHHH
LQILNERELRAVLGHELSHVYNRDILISCVAGAMASVITALANIALFAGMFGGNREGTNP
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
FALLLVSFLGPIAATVVRLAVSRSREYQADQSGAELTGDPLALASALRKISGGVEAAPLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
PQPQLADQAHLMIASPFRSGEKIGKLFSTHPPMADRIRRLEEMAGRGPGLY
CCCCCCCCHHEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA