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The map label for this gene is hepT [H]

Identifier: 108797750

GI number: 108797750

Start: 825754

End: 826761

Strand: Direct

Name: hepT [H]

Synonym: Mmcs_0771

Alternate gene names: 108797750

Gene position: 825754-826761 (Clockwise)

Preceding gene: 108797743

Following gene: 108797751

Centisome position: 14.47

GC content: 70.04

Gene sequence:

>1008_bases
GTGAGGACACCGGCGACTGTGGTGGCGGGCGTGGACTTCGGCGACGCGGCCTTCGCGGCCGACGTCCGCGCCGGAGTCGC
CCGCATCGAGGATCTGATGTCCACCGAGCTGGGCAAGGCGGACGAGCTGATGGCCGAGGCCGTTCAGCATCTCTTCCAGG
CCGGCGGTAAGCGGTTCCGCCCGCTGTTCACTGTGCTGTCGGCGCGGCTCGGGCCCGAACCCGACGCCTGGCAGGTGACG
GTGGCGGGTGCGGTGATCGAACTGGTGCACCTGGCGACGCTGTACCACGACGACGTCATGGACGAGGCCCAGGTCCGGCG
CGGGGCGCCGAGCGCCAACGCCCGCTGGGGCAACAACATCGCCATCCTCGCGGGCGACTACCTGTTCGCCACCGCGTCGC
GGCTGGTGTCGCGGTTGGGGCCGGAGGCCGTGCGGATCATCGCCGACACGTTCGCCCAACTGGTGACCGGTCAGATGCGG
GAGACCCGCGGTGCGGTCGAGGGCGTCGACGAGATCGAGCACTACCTCAAGGTCGTCTACGAGAAGACGGCCTGCCTGAT
CGCGGCGTCGGGGCGGTTCGGGGCGACGTTCTCCGGCGCCGACGAGACCCAGATCGAGCGGTTGGCGCGCCTGGGCGGAA
TCGTCGGCACGGCGTTCCAGATCTCCGACGACATCATCGACATCGACAGCGATCCCGACGAATCCGGCAAGGTTCCGGGC
ACCGATCTACGTGAGGGTGTTCACACTCTGCCGGTGCTCTACGCGCTGCGGGAGTCCGGTCCCGACACCGACCGCCTGCG
CGAACTGCTCGCCCGGCCCGTCGACAACGACGACGATCTCGCCGAGGCCCTGCGGCTGCTACGCCGCTCACCAGGCATGG
AGCAGGCCAAGGCGACCGTCGCCCGCTACGCGCAGCAGGCCCGCGACGAACTGGCCGCCCTGCCCGACATGCCGGGAAGG
CAGGCGCTGGCCTCACTGGTCGACTACACGATCACCCGCCACGGCTGA

Upstream 100 bases:

>100_bases
CCGGCGCGGGCCGCCCAGGCCGCGGCAGCCGAACCCGCAGGTCCGGCGCCGACAACGACCACATCCGCCCGGGTCTTCAT
TGTCACAGTATGTTGGCAGG

Downstream 100 bases:

>100_bases
ACATCGCCGGAACCCAGACGGCTGTATGCAGCGTTGGATCAGCGAAGACTCACGAGGAGGTAGCTGATGACGTGGAATCC
GCACGCGAACAGGTTCAAGA

Product: trans-hexaprenyltranstransferase

Products: NA

Alternate protein names: HEPPP synthase subunit 2; Spore germination protein C3 [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MRTPATVVAGVDFGDAAFAADVRAGVARIEDLMSTELGKADELMAEAVQHLFQAGGKRFRPLFTVLSARLGPEPDAWQVT
VAGAVIELVHLATLYHDDVMDEAQVRRGAPSANARWGNNIAILAGDYLFATASRLVSRLGPEAVRIIADTFAQLVTGQMR
ETRGAVEGVDEIEHYLKVVYEKTACLIAASGRFGATFSGADETQIERLARLGGIVGTAFQISDDIIDIDSDPDESGKVPG
TDLREGVHTLPVLYALRESGPDTDRLRELLARPVDNDDDLAEALRLLRRSPGMEQAKATVARYAQQARDELAALPDMPGR
QALASLVDYTITRHG

Sequences:

>Translated_335_residues
MRTPATVVAGVDFGDAAFAADVRAGVARIEDLMSTELGKADELMAEAVQHLFQAGGKRFRPLFTVLSARLGPEPDAWQVT
VAGAVIELVHLATLYHDDVMDEAQVRRGAPSANARWGNNIAILAGDYLFATASRLVSRLGPEAVRIIADTFAQLVTGQMR
ETRGAVEGVDEIEHYLKVVYEKTACLIAASGRFGATFSGADETQIERLARLGGIVGTAFQISDDIIDIDSDPDESGKVPG
TDLREGVHTLPVLYALRESGPDTDRLRELLARPVDNDDDLAEALRLLRRSPGMEQAKATVARYAQQARDELAALPDMPGR
QALASLVDYTITRHG
>Mature_335_residues
MRTPATVVAGVDFGDAAFAADVRAGVARIEDLMSTELGKADELMAEAVQHLFQAGGKRFRPLFTVLSARLGPEPDAWQVT
VAGAVIELVHLATLYHDDVMDEAQVRRGAPSANARWGNNIAILAGDYLFATASRLVSRLGPEAVRIIADTFAQLVTGQMR
ETRGAVEGVDEIEHYLKVVYEKTACLIAASGRFGATFSGADETQIERLARLGGIVGTAFQISDDIIDIDSDPDESGKVPG
TDLREGVHTLPVLYALRESGPDTDRLRELLARPVDNDDDLAEALRLLRRSPGMEQAKATVARYAQQARDELAALPDMPGR
QALASLVDYTITRHG

Specific function: Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7) [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=313, Percent_Identity=32.5878594249201, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI4758430, Length=275, Percent_Identity=25.4545454545455, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI83700220, Length=275, Percent_Identity=25.4545454545455, Blast_Score=75, Evalue=8e-14,
Organism=Escherichia coli, GI1789578, Length=294, Percent_Identity=31.9727891156463, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1786623, Length=233, Percent_Identity=28.3261802575107, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17505681, Length=301, Percent_Identity=31.2292358803987, Blast_Score=153, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6319475, Length=295, Percent_Identity=30.8474576271186, Blast_Score=129, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6325188, Length=311, Percent_Identity=23.7942122186495, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24651612, Length=293, Percent_Identity=32.4232081911263, Blast_Score=141, Evalue=5e-34,
Organism=Drosophila melanogaster, GI281365769, Length=287, Percent_Identity=26.1324041811847, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24660002, Length=287, Percent_Identity=26.1324041811847, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014119
- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.30 [H]

Molecular weight: Translated: 36135; Mature: 36135

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTPATVVAGVDFGDAAFAADVRAGVARIEDLMSTELGKADELMAEAVQHLFQAGGKRFR
CCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHH
PLFTVLSARLGPEPDAWQVTVAGAVIELVHLATLYHDDVMDEAQVRRGAPSANARWGNNI
HHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
AILAGDYLFATASRLVSRLGPEAVRIIADTFAQLVTGQMRETRGAVEGVDEIEHYLKVVY
EEEECHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
EKTACLIAASGRFGATFSGADETQIERLARLGGIVGTAFQISDDIIDIDSDPDESGKVPG
HHHHHEEEECCCCCCEECCCCHHHHHHHHHHHHHHHHHHEECCCEEECCCCCCCCCCCCC
TDLREGVHTLPVLYALRESGPDTDRLRELLARPVDNDDDLAEALRLLRRSPGMEQAKATV
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHH
ARYAQQARDELAALPDMPGRQALASLVDYTITRHG
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRTPATVVAGVDFGDAAFAADVRAGVARIEDLMSTELGKADELMAEAVQHLFQAGGKRFR
CCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHH
PLFTVLSARLGPEPDAWQVTVAGAVIELVHLATLYHDDVMDEAQVRRGAPSANARWGNNI
HHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
AILAGDYLFATASRLVSRLGPEAVRIIADTFAQLVTGQMRETRGAVEGVDEIEHYLKVVY
EEEECHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
EKTACLIAASGRFGATFSGADETQIERLARLGGIVGTAFQISDDIIDIDSDPDESGKVPG
HHHHHEEEECCCCCCEECCCCHHHHHHHHHHHHHHHHHHEECCCEEECCCCCCCCCCCCC
TDLREGVHTLPVLYALRESGPDTDRLRELLARPVDNDDDLAEALRLLRRSPGMEQAKATV
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHH
ARYAQQARDELAALPDMPGRQALASLVDYTITRHG
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 2121900; 9720033 [H]