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The map label for this gene is iciA [C]

Identifier: 108797334

GI number: 108797334

Start: 395740

End: 396654

Strand: Direct

Name: iciA [C]

Synonym: Mmcs_0354

Alternate gene names: 108797334

Gene position: 395740-396654 (Clockwise)

Preceding gene: 108797332

Following gene: 108797336

Centisome position: 6.94

GC content: 71.8

Gene sequence:

>915_bases
GTGGCCACAGCCCATTCGCGGACGCGTGACGAGGTCCGCCTCGGCGCCGACCAACTGGCCGCCCTCGCGGCGGTGATCGA
ATTCGGCAGCTTCGACGCGGCCGCCGAGCACCTGCATGTGACCCCGTCCGCGGTGAGCCAACGCATCAAGGCGCTCGAAC
AGCGGGTCGGACAGGTTCTGGTGGTGCGCGAAAAGCCCTGTCGGGCAACAGCATCGGGCATACCACTGCTGCGCCTCGCG
GCGCAGACCGCGCTGCTCGAGGCCGAAGCGCTCGGGGAGCTCGGCGGTCCGGGCGCCGCCCTGGTGCCGCGGGTGGCGGT
GGCCGTCAACGCGGACTCCATGGCCACGTGGTTCACCGCCGTGCTGGGCGACGTCTCGGAGGTGTTGTTCGACATCCGGA
TCGAGGATCAGGATCACTCCGCCCGGCTGCTGCGCGAAGGCGTGGTGATGGGGGCGGTCACCACCGAGCGCAGCCCGGTG
CCCGGCTGCCGGGTGCAGTCCCTCGGGGTGATGCGGTACCTGCCCGTGGCGAGCGCGGGGTACGTCGAGCGGTATCTGCC
CGACGGTTTCACCGCGGTCGCCGCGGCGCACGCGCCGTCGCTGGCCTGGAATCGCGATGATGCGTTACAGGACATGCTGA
TCCGCCGGGCATTTCGCCGCGCGATCACCCGGCCGGTGCACTACGTGCCCACCGCGGAGGGGTTCGGCGCGGCGGTGCGC
GCCGGGCTGGGCTGGGGGATGTACCCGGAGCAACTGGCCGTCCCCGAACTGGCCGGTGGTTCGCTCGTCCGGGTCGCCGA
CGTGCATCTCGACGTGCCGTTGTACTGGCAGTGCTGGAAACTCGACAGCCCGCTGGTGGCGCGACTGACCGGCGCGGTCC
GATCCGCGGCGGCCGGTCTGGCGCGGCGGCGATGA

Upstream 100 bases:

>100_bases
TCGAAGAAGCGATCGAGGCGATTCATGGGACGAACCCTAAGGTGAACCACCGTCGACGGCGAATTACCACGGCGGGCGCC
AGGAATCCTAGATTGGTTCG

Downstream 100 bases:

>100_bases
CGATTTATACGCGCCCTCTGAGGATGAGGTTCCAGTAGGTGCGCGGCAGCACGTAGCGGTCGAACGCCCACGCCGTGCGG
CGAGATTCGAGTGGGTCGAC

Product: chromosome replication initiation inhibitor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MATAHSRTRDEVRLGADQLAALAAVIEFGSFDAAAEHLHVTPSAVSQRIKALEQRVGQVLVVREKPCRATASGIPLLRLA
AQTALLEAEALGELGGPGAALVPRVAVAVNADSMATWFTAVLGDVSEVLFDIRIEDQDHSARLLREGVVMGAVTTERSPV
PGCRVQSLGVMRYLPVASAGYVERYLPDGFTAVAAAHAPSLAWNRDDALQDMLIRRAFRRAITRPVHYVPTAEGFGAAVR
AGLGWGMYPEQLAVPELAGGSLVRVADVHLDVPLYWQCWKLDSPLVARLTGAVRSAAAGLARRR

Sequences:

>Translated_304_residues
MATAHSRTRDEVRLGADQLAALAAVIEFGSFDAAAEHLHVTPSAVSQRIKALEQRVGQVLVVREKPCRATASGIPLLRLA
AQTALLEAEALGELGGPGAALVPRVAVAVNADSMATWFTAVLGDVSEVLFDIRIEDQDHSARLLREGVVMGAVTTERSPV
PGCRVQSLGVMRYLPVASAGYVERYLPDGFTAVAAAHAPSLAWNRDDALQDMLIRRAFRRAITRPVHYVPTAEGFGAAVR
AGLGWGMYPEQLAVPELAGGSLVRVADVHLDVPLYWQCWKLDSPLVARLTGAVRSAAAGLARRR
>Mature_303_residues
ATAHSRTRDEVRLGADQLAALAAVIEFGSFDAAAEHLHVTPSAVSQRIKALEQRVGQVLVVREKPCRATASGIPLLRLAA
QTALLEAEALGELGGPGAALVPRVAVAVNADSMATWFTAVLGDVSEVLFDIRIEDQDHSARLLREGVVMGAVTTERSPVP
GCRVQSLGVMRYLPVASAGYVERYLPDGFTAVAAAHAPSLAWNRDDALQDMLIRRAFRRAITRPVHYVPTAEGFGAAVRA
GLGWGMYPEQLAVPELAGGSLVRVADVHLDVPLYWQCWKLDSPLVARLTGAVRSAAAGLARRR

Specific function: Specific Inhibitor Of Chromosomal Initiation Of Replication In VItro. Binds The Three 13-Mers In The Origin (Oric) To Block Initiation Of Replication. [C]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789283, Length=280, Percent_Identity=36.4285714285714, Blast_Score=153, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR017685
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32481; Mature: 32350

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATAHSRTRDEVRLGADQLAALAAVIEFGSFDAAAEHLHVTPSAVSQRIKALEQRVGQVL
CCCCCCCCHHHHHHCHHHHHHHHHHHHHCCCHHHHHHEECCHHHHHHHHHHHHHHHCCEE
VVREKPCRATASGIPLLRLAAQTALLEAEALGELGGPGAALVPRVAVAVNADSMATWFTA
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHEEEEECCCHHHHHHHH
VLGDVSEVLFDIRIEDQDHSARLLREGVVMGAVTTERSPVPGCRVQSLGVMRYLPVASAG
HHHHHHHHHEEEEECCCCHHHHHHHCCHHEEEEECCCCCCCCCCHHHCCHHHHCCCCCCH
YVERYLPDGFTAVAAAHAPSLAWNRDDALQDMLIRRAFRRAITRPVHYVPTAEGFGAAVR
HHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHH
AGLGWGMYPEQLAVPELAGGSLVRVADVHLDVPLYWQCWKLDSPLVARLTGAVRSAAAGL
HCCCCCCCHHHHCCCCCCCCCEEEEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHH
ARRR
HCCC
>Mature Secondary Structure 
ATAHSRTRDEVRLGADQLAALAAVIEFGSFDAAAEHLHVTPSAVSQRIKALEQRVGQVL
CCCCCCCHHHHHHCHHHHHHHHHHHHHCCCHHHHHHEECCHHHHHHHHHHHHHHHCCEE
VVREKPCRATASGIPLLRLAAQTALLEAEALGELGGPGAALVPRVAVAVNADSMATWFTA
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHEEEEECCCHHHHHHHH
VLGDVSEVLFDIRIEDQDHSARLLREGVVMGAVTTERSPVPGCRVQSLGVMRYLPVASAG
HHHHHHHHHEEEEECCCCHHHHHHHCCHHEEEEECCCCCCCCCCHHHCCHHHHCCCCCCH
YVERYLPDGFTAVAAAHAPSLAWNRDDALQDMLIRRAFRRAITRPVHYVPTAEGFGAAVR
HHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHH
AGLGWGMYPEQLAVPELAGGSLVRVADVHLDVPLYWQCWKLDSPLVARLTGAVRSAAAGL
HCCCCCCCHHHHCCCCCCCCCEEEEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHH
ARRR
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]