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The map label for this gene is lip2 [H]

Identifier: 108797294

GI number: 108797294

Start: 351712

End: 352644

Strand: Reverse

Name: lip2 [H]

Synonym: Mmcs_0314

Alternate gene names: 108797294

Gene position: 352644-351712 (Counterclockwise)

Preceding gene: 108797295

Following gene: 108797293

Centisome position: 6.18

GC content: 70.31

Gene sequence:

>933_bases
ATGACCGGGGCGCTCGACCCGCAGATCGCCGACCTCATCGAGGGGCTGGACCGCGGCTTCCCACCGGTGCAGACCATGAC
CGGCGCGCAGGCACGGGCCACGATCCGCTCCCGGTTCATCGCCCCCGCCGAACCCGAGCCGGTCGCCGCGGTCGAGGACC
GCAGCGTGGGTGAGATCCCGATACGGATTTACCATCCCGCCGGTGCCGGACCCCTGCCCGTCCTGGTCTACGCCCACGGC
GGCGGTTTCGTGTTCTGCGACCTCGACAGCCACGACGGGCTGTGCCGCGACATCGCCAATCAGACTGCCGCCATTGTCGT
TTCGGTCGGCTACCGACTGGCTCCCGAGCATCCGTGGCCGGCCGCGGCCGAGGACGTGTACGCGGTCACGCGGTGGGTGG
CGGACAACTGCACCGCACTGGGCGCCGATCCCGGACGTATCGCGGTCGGCGGTGACAGCGCCGGAGGCAATCTGGCCGCG
GTCACCGCCCTGATCGCCCGGGACCGCGGCGGGCCTTCGCTGGTCGCCCAGTTGCTCGTCTACCCGATGGTCACCCCCGA
TTTCACCACCGAGTCGTACCGGTTGTTCGGGTCCGGGTACTACAACCCGGCCGAGGCGCTGCGGTGGTACTGGGATCAGT
ACGTGCCCAACGACTTCGACCGCACGCACCCCTATGTGTCGCCGCTGCACGCCGATCTGAGCGGGCTGCCGCCTGCTGTC
GTGGTGATCGCCGGCCACGATCCGCTCCGGGACGAGGGTGTGCGATTCGGTGAGGCGCTGTCCGCGGCCGGGGTGCCCAC
GGTGGTGCGCCGTTTCGACGGTGGCATCCACGGCTTCATGACCATGCCGAGCCTCGAACTCGCGCAGACCGCCCGCGCGC
AGCTGTGCCAGGATGCCGTCGCTCTGCTGACGGGAGTTCCCGCCGGTGGCTGA

Upstream 100 bases:

>100_bases
GCGGGCCGCAGCGCGTCGCGCCGACCCTGCAGCAGGTGCGGCCACTGCGCAGCGGCCCCACGCCGCGTCCGGCCCACGAG
TCGACCGCCCTGCAGCTCGC

Downstream 100 bases:

>100_bases
GGTTTTCGTGACCGACCGGGTGGTCACCCGGCCCGGACGCACCCGCGAGTTCGTCGACGCCTATCTCACCGGATACGCGC
CCGGGGCGCGGCAACGCGGG

Product: alpha/beta hydrolase fold-3

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MTGALDPQIADLIEGLDRGFPPVQTMTGAQARATIRSRFIAPAEPEPVAAVEDRSVGEIPIRIYHPAGAGPLPVLVYAHG
GGFVFCDLDSHDGLCRDIANQTAAIVVSVGYRLAPEHPWPAAAEDVYAVTRWVADNCTALGADPGRIAVGGDSAGGNLAA
VTALIARDRGGPSLVAQLLVYPMVTPDFTTESYRLFGSGYYNPAEALRWYWDQYVPNDFDRTHPYVSPLHADLSGLPPAV
VVIAGHDPLRDEGVRFGEALSAAGVPTVVRRFDGGIHGFMTMPSLELAQTARAQLCQDAVALLTGVPAGG

Sequences:

>Translated_310_residues
MTGALDPQIADLIEGLDRGFPPVQTMTGAQARATIRSRFIAPAEPEPVAAVEDRSVGEIPIRIYHPAGAGPLPVLVYAHG
GGFVFCDLDSHDGLCRDIANQTAAIVVSVGYRLAPEHPWPAAAEDVYAVTRWVADNCTALGADPGRIAVGGDSAGGNLAA
VTALIARDRGGPSLVAQLLVYPMVTPDFTTESYRLFGSGYYNPAEALRWYWDQYVPNDFDRTHPYVSPLHADLSGLPPAV
VVIAGHDPLRDEGVRFGEALSAAGVPTVVRRFDGGIHGFMTMPSLELAQTARAQLCQDAVALLTGVPAGG
>Mature_309_residues
TGALDPQIADLIEGLDRGFPPVQTMTGAQARATIRSRFIAPAEPEPVAAVEDRSVGEIPIRIYHPAGAGPLPVLVYAHGG
GFVFCDLDSHDGLCRDIANQTAAIVVSVGYRLAPEHPWPAAAEDVYAVTRWVADNCTALGADPGRIAVGGDSAGGNLAAV
TALIARDRGGPSLVAQLLVYPMVTPDFTTESYRLFGSGYYNPAEALRWYWDQYVPNDFDRTHPYVSPLHADLSGLPPAVV
VIAGHDPLRDEGVRFGEALSAAGVPTVVRRFDGGIHGFMTMPSLELAQTARAQLCQDAVALLTGVPAGG

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI206597554, Length=316, Percent_Identity=29.4303797468354, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI157041239, Length=301, Percent_Identity=27.2425249169435, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI68051721, Length=304, Percent_Identity=27.6315789473684, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI68299767, Length=324, Percent_Identity=28.7037037037037, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI61966717, Length=297, Percent_Identity=26.9360269360269, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI226423947, Length=313, Percent_Identity=26.8370607028754, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI157041237, Length=253, Percent_Identity=25.6916996047431, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI21328446, Length=93, Percent_Identity=40.8602150537634, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1786682, Length=267, Percent_Identity=29.2134831460674, Blast_Score=111, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17567059, Length=336, Percent_Identity=29.7619047619048, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17540028, Length=175, Percent_Identity=32.5714285714286, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI72001146, Length=144, Percent_Identity=34.0277777777778, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71996133, Length=144, Percent_Identity=32.6388888888889, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI115533410, Length=149, Percent_Identity=32.8859060402685, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI115533412, Length=91, Percent_Identity=38.4615384615385, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24656084, Length=119, Percent_Identity=37.8151260504202, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24656076, Length=119, Percent_Identity=37.8151260504202, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI20130169, Length=119, Percent_Identity=37.8151260504202, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 32707; Mature: 32576

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGALDPQIADLIEGLDRGFPPVQTMTGAQARATIRSRFIAPAEPEPVAAVEDRSVGEIP
CCCCCCHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHCCCCCCCCCCEEECCCCCCCCC
IRIYHPAGAGPLPVLVYAHGGGFVFCDLDSHDGLCRDIANQTAAIVVSVGYRLAPEHPWP
EEEECCCCCCCCEEEEEEECCCEEEEEECCCCCHHHHHHCCCEEEEEEECCEECCCCCCC
AAAEDVYAVTRWVADNCTALGADPGRIAVGGDSAGGNLAAVTALIARDRGGPSLVAQLLV
CCHHHHHHHHHHHHCCCEEECCCCCEEEECCCCCCCCHHHHHHHHHCCCCCHHHHHHHHH
YPMVTPDFTTESYRLFGSGYYNPAEALRWYWDQYVPNDFDRTHPYVSPLHADLSGLPPAV
HHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCEE
VVIAGHDPLRDEGVRFGEALSAAGVPTVVRRFDGGIHGFMTMPSLELAQTARAQLCQDAV
EEEECCCCCCHHCCHHHHHHHHCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHH
ALLTGVPAGG
HHHHCCCCCC
>Mature Secondary Structure 
TGALDPQIADLIEGLDRGFPPVQTMTGAQARATIRSRFIAPAEPEPVAAVEDRSVGEIP
CCCCCHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHCCCCCCCCCCEEECCCCCCCCC
IRIYHPAGAGPLPVLVYAHGGGFVFCDLDSHDGLCRDIANQTAAIVVSVGYRLAPEHPWP
EEEECCCCCCCCEEEEEEECCCEEEEEECCCCCHHHHHHCCCEEEEEEECCEECCCCCCC
AAAEDVYAVTRWVADNCTALGADPGRIAVGGDSAGGNLAAVTALIARDRGGPSLVAQLLV
CCHHHHHHHHHHHHCCCEEECCCCCEEEECCCCCCCCHHHHHHHHHCCCCCHHHHHHHHH
YPMVTPDFTTESYRLFGSGYYNPAEALRWYWDQYVPNDFDRTHPYVSPLHADLSGLPPAV
HHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCEE
VVIAGHDPLRDEGVRFGEALSAAGVPTVVRRFDGGIHGFMTMPSLELAQTARAQLCQDAV
EEEECCCCCCHHCCHHHHHHHHCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHH
ALLTGVPAGG
HHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]