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The map label for this gene is fabG [C]

Identifier: 108797274

GI number: 108797274

Start: 332228

End: 333022

Strand: Direct

Name: fabG [C]

Synonym: Mmcs_0294

Alternate gene names: 108797274

Gene position: 332228-333022 (Clockwise)

Preceding gene: 108797271

Following gene: 108797275

Centisome position: 5.82

GC content: 67.67

Gene sequence:

>795_bases
ATGACAGACCTCGACAGGTACGGGCCGTGGGCCGTCATCGCCGGTGGATCCGAAGGAGTCGGAGCGGAGTTCGCGCGGTC
ACTCGCCGGAGATGGTTTCAACCTCGTGCTGATCGCCCGCAAACCCGGGCCGCTGGACGAGACCGCCGAGTCCTGCCGCG
AACTCGGCGCCGACGTGCGCACGCTGTCCCTCGATCTGCTCGACCCCGAGGCCACCTCGCGCATCGCCGAAGCCACCGCC
GACATCGAGGTGGGTCTGCTGATCTACAACGCAGGCGCCAGTACGTGCAACGATCCCTTCCTCGACGCCGATCTGGCCGA
GTGGCGCAAGATCATCGACCTCAACATGTCCAGGATGCTCGAGCTGACGCAGCATTTCGGCAGGCGCATGGTCGCGCAGT
CGCGCGGCGGCATCATTCTGGTCGGATCGCTGTCGGGGTACATGGGCTCGGTGCGGCATGCGGTGTACTCCGGGGTGAAG
GCGTTCGGCCGGATGTTCGCCGAGAGCCTCTGGCTGGAACTGCGTGAGCAGGGTGTGGATGTTCTCGAACTGGTCCTCGG
GGTGACCCGGACACCGGCGATGGAGCGCGCCGGCCTGCGATTCGACATCCCGGGGTTCATCGTCAACGACCCCGCCGACG
TCGCCCGCGAGGGGCTGGAGCATCTCGGTGACGGGCCGGTACACGTCGCCGGCGGCAACGCCGAGCAGGCGGCGCGCAAC
AGCGGTCCGGACCGCGCCAGGATCGTGCTCGAATCCCACCTGGCCATCCAACGACTCATCGGGGCGCAGCCGTGA

Upstream 100 bases:

>100_bases
GGCCGTGACGCTAGGGCGTCACCCCTCCCGGCAGCACCGGCTCGCCCGGTCAGCGGAACACCTGGCCGGCGGCAGGGACC
CACGGTGTTGGATCGTCCTC

Downstream 100 bases:

>100_bases
GCTCGGACCGGCTGGCGGCCCTCGAGGCGCGGTTGCAGCGGCTCGAGGACGAACGCGACATCCAGCGGCTCATCGCGAGC
TACGGCCCGTACGTGGACGC

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MTDLDRYGPWAVIAGGSEGVGAEFARSLAGDGFNLVLIARKPGPLDETAESCRELGADVRTLSLDLLDPEATSRIAEATA
DIEVGLLIYNAGASTCNDPFLDADLAEWRKIIDLNMSRMLELTQHFGRRMVAQSRGGIILVGSLSGYMGSVRHAVYSGVK
AFGRMFAESLWLELREQGVDVLELVLGVTRTPAMERAGLRFDIPGFIVNDPADVAREGLEHLGDGPVHVAGGNAEQAARN
SGPDRARIVLESHLAIQRLIGAQP

Sequences:

>Translated_264_residues
MTDLDRYGPWAVIAGGSEGVGAEFARSLAGDGFNLVLIARKPGPLDETAESCRELGADVRTLSLDLLDPEATSRIAEATA
DIEVGLLIYNAGASTCNDPFLDADLAEWRKIIDLNMSRMLELTQHFGRRMVAQSRGGIILVGSLSGYMGSVRHAVYSGVK
AFGRMFAESLWLELREQGVDVLELVLGVTRTPAMERAGLRFDIPGFIVNDPADVAREGLEHLGDGPVHVAGGNAEQAARN
SGPDRARIVLESHLAIQRLIGAQP
>Mature_263_residues
TDLDRYGPWAVIAGGSEGVGAEFARSLAGDGFNLVLIARKPGPLDETAESCRELGADVRTLSLDLLDPEATSRIAEATAD
IEVGLLIYNAGASTCNDPFLDADLAEWRKIIDLNMSRMLELTQHFGRRMVAQSRGGIILVGSLSGYMGSVRHAVYSGVKA
FGRMFAESLWLELREQGVDVLELVLGVTRTPAMERAGLRFDIPGFIVNDPADVAREGLEHLGDGPVHVAGGNAEQAARNS
GPDRARIVLESHLAIQRLIGAQP

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG0300

COG function: function code R; Short-chain dehydrogenases of various substrate specificities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI7705855, Length=200, Percent_Identity=30.5, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI4557649, Length=225, Percent_Identity=27.1111111111111, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI226371731, Length=229, Percent_Identity=26.2008733624454, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1787335, Length=240, Percent_Identity=28.3333333333333, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082160, Length=178, Percent_Identity=29.2134831460674, Blast_Score=68, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI25152911, Length=224, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17560176, Length=186, Percent_Identity=28.494623655914, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI212646214, Length=224, Percent_Identity=24.5535714285714, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=183, Percent_Identity=23.4972677595628, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17559552, Length=222, Percent_Identity=24.3243243243243, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319635, Length=238, Percent_Identity=28.9915966386555, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6322067, Length=184, Percent_Identity=26.6304347826087, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24640442, Length=183, Percent_Identity=34.9726775956284, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24584752, Length=227, Percent_Identity=29.5154185022026, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24584744, Length=190, Percent_Identity=32.1052631578947, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28574402, Length=185, Percent_Identity=31.8918918918919, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24584748, Length=225, Percent_Identity=27.5555555555556, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI161076933, Length=225, Percent_Identity=27.5555555555556, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 28306; Mature: 28174

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLDRYGPWAVIAGGSEGVGAEFARSLAGDGFNLVLIARKPGPLDETAESCRELGADVR
CCCCCCCCCEEEEECCCCCCCHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCE
TLSLDLLDPEATSRIAEATADIEVGLLIYNAGASTCNDPFLDADLAEWRKIIDLNMSRML
EEEEEEECCHHHHHHHHHHCCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCHHHHH
ELTQHFGRRMVAQSRGGIILVGSLSGYMGSVRHAVYSGVKAFGRMFAESLWLELREQGVD
HHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
VLELVLGVTRTPAMERAGLRFDIPGFIVNDPADVAREGLEHLGDGPVHVAGGNAEQAARN
HHHHHHHCCCCCHHHHCCCEECCCCEEECCHHHHHHHHHHHHCCCCEEEECCCHHHHHHC
SGPDRARIVLESHLAIQRLIGAQP
CCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TDLDRYGPWAVIAGGSEGVGAEFARSLAGDGFNLVLIARKPGPLDETAESCRELGADVR
CCCCCCCCEEEEECCCCCCCHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCE
TLSLDLLDPEATSRIAEATADIEVGLLIYNAGASTCNDPFLDADLAEWRKIIDLNMSRML
EEEEEEECCHHHHHHHHHHCCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCHHHHH
ELTQHFGRRMVAQSRGGIILVGSLSGYMGSVRHAVYSGVKAFGRMFAESLWLELREQGVD
HHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
VLELVLGVTRTPAMERAGLRFDIPGFIVNDPADVAREGLEHLGDGPVHVAGGNAEQAARN
HHHHHHHCCCCCHHHHCCCEECCCCEEECCHHHHHHHHHHHHCCCCEEEECCCHHHHHHC
SGPDRARIVLESHLAIQRLIGAQP
CCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12950922 [H]