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The map label for this gene is ksdD [H]

Identifier: 108797273

GI number: 108797273

Start: 330421

End: 332127

Strand: Reverse

Name: ksdD [H]

Synonym: Mmcs_0293

Alternate gene names: 108797273

Gene position: 332127-330421 (Counterclockwise)

Preceding gene: 108797280

Following gene: 108797272

Centisome position: 5.82

GC content: 69.95

Gene sequence:

>1707_bases
GTGACGACTGCGCATACAGCGACGATTCCCGGTGGACTGCCGGTCCGCGACACCACCGTCGACCTCCTGGTGGTGGGCTC
CGGTACCGGGATGGGCGCCGCGCTGGCCGCCCGGGCCCGCGGCCTGTCGGTGCTGATCGTCGAGAAGTCGGAGTTCGTCG
GCGGCTCGACGGCGCGGTCCGGAGGTGCGCTGTGGCTGCCCGCCAGTCAGGTGATCGACGGTGACGGCGGCGGGGACACC
TCGCAGCGGGCCGCGACCTATCTCGACGCGGTGGTGGACGGCACGGCGCCCGCGTCGCGCTCCGCCGCATTCCTCGAACA
CGTCGACGCCACGATCGACCTGTTGCGCCGCACGACCCCGATGCGGCTGTTCTGGGCGCGGGAGTACTCGGACTACCACC
CGGAACAACCCGGCGGTTCCGCTGCGGGCCGCACGTGCGAGTGCCGCCCGCTGGACACCGCGGTCCTCGGGGAGTACTTG
CCGAGGTTGCGTCCGGGCGTGATGGAAGTCAAGATCCCGATGCCGACGACCGGCGCCGACTACCGCTGGCTGAACCTGAT
GTCGCGGGTGCCCCGCAAGGGAATCCCGTTGGTGGCCAAGCGACTCGGTCAGGGGATCGGTGGTCTGCTGCTCGGCCGGC
GGTACGCGGCGGGTGGGCAGGCGCTGGCGGCCGGCCTGTTCGCCGGTGTGTTGCGCGCCGGCATCCCGATCTGGACCGAG
ACCGCACTGCAGCGACTCGTCACCGACGACGGTGGCCGGGTCACCGGGGCCGTGGTCGACCACCGGGGTCAGGAGATCAC
CGTCACCGCGCGCCGGGGTGTCGTACTGGCTGCCGGGGGTTTCGACCATCACATGGACATGCGCTGGAAGTTCCAGTCCG
AGAGGCTGGGTGAGCATGCGAGCCTCGGCGCGGAGACCAACACCGGTGACGCCATCCGCGTCGCCCAGGATCTCGGCGCG
GCAATCGATCTCATGGATCAGTCGTGGTGGTTCCCCGCGGTGGCGGCGCTTCCGGACGGCGATCCGAAGGTGATGCTTGC
CGAACGGTCGCTTCCGGGATCACTCATCGTCGACCAGACGGGCAGCCGGTTCGTCAACGAGTCCTGCGACTACATGACCT
TCGGGCAGGCAGTGCTCGACCGGGAACGCGCAGGCGACCCGGTCGAGGCGATGTGGATCGTGTTCGACCAGCAGTACCGC
AACAGCTACGTGTTCGCCGCGGAGCTGTTCCCGCGGATGGCGGTCCCGAAAGCCTGGTACGACGCCGGCATCGCGCACCG
TTCGGAGAGCCTCGACGACCTCGGCCGCAAGATGGGGGTGCCGGACGCGCAGTTCGTGGCCACGGTGCGGCGGTTCAACG
AGATGGCCCATGCGGGGCAGGATTCCGACCTCGGGCGCGGTCGCAGCGCCTATGACCGGTACTACGGCGACCTCACGGTG
ACCCCGAACCCGAATCTGCGTGCGCTCGACCGCGGCCCCTTCTACGCCGTGAAGATGGTGCTCAGCGACCTCGGCACCTG
CGGTGGTCTGCGCGCCGACGACCGAGCCCGCGTCCTGCGGGAGGACGGCACCACGATCGACGGTCTGTACGCGATCGGGA
ACACGGCCGCCAACGCCTTCGGCGCCACCTATCCTGGCGCCGGGGCGACGATCGCCCAGGGCCTGGTGTACGGCTACATC
GCCGCACAGGATGCGGCACAGGCCTGA

Upstream 100 bases:

>100_bases
GAGGACGATCCAACACCGTGGGTCCCTGCCGCCGGCCAGGTGTTCCGCTGACCGGGCGAGCCGGTGCTGCCGGGAGGGGT
GACGCCCTAGCGTCACGGCC

Downstream 100 bases:

>100_bases
CTGAGAGGAGCTCACCGGAATGTCCCGTTACACCGATCGGCGCGTCCTCATCACCGGCGGCGGATCGGGCATCGGACAGG
CGTGCGTGCTGCGGATCCTC

Product: 3-ketosteroid-delta-1-dehydrogenase

Products: NA

Alternate protein names: 3-keto-Delta(4)-steroid Delta(1)-dehydrogenase; KSDD; 3-oxo-Delta(4)-steroid 1-dehydrogenase; KSTD [H]

Number of amino acids: Translated: 568; Mature: 567

Protein sequence:

>568_residues
MTTAHTATIPGGLPVRDTTVDLLVVGSGTGMGAALAARARGLSVLIVEKSEFVGGSTARSGGALWLPASQVIDGDGGGDT
SQRAATYLDAVVDGTAPASRSAAFLEHVDATIDLLRRTTPMRLFWAREYSDYHPEQPGGSAAGRTCECRPLDTAVLGEYL
PRLRPGVMEVKIPMPTTGADYRWLNLMSRVPRKGIPLVAKRLGQGIGGLLLGRRYAAGGQALAAGLFAGVLRAGIPIWTE
TALQRLVTDDGGRVTGAVVDHRGQEITVTARRGVVLAAGGFDHHMDMRWKFQSERLGEHASLGAETNTGDAIRVAQDLGA
AIDLMDQSWWFPAVAALPDGDPKVMLAERSLPGSLIVDQTGSRFVNESCDYMTFGQAVLDRERAGDPVEAMWIVFDQQYR
NSYVFAAELFPRMAVPKAWYDAGIAHRSESLDDLGRKMGVPDAQFVATVRRFNEMAHAGQDSDLGRGRSAYDRYYGDLTV
TPNPNLRALDRGPFYAVKMVLSDLGTCGGLRADDRARVLREDGTTIDGLYAIGNTAANAFGATYPGAGATIAQGLVYGYI
AAQDAAQA

Sequences:

>Translated_568_residues
MTTAHTATIPGGLPVRDTTVDLLVVGSGTGMGAALAARARGLSVLIVEKSEFVGGSTARSGGALWLPASQVIDGDGGGDT
SQRAATYLDAVVDGTAPASRSAAFLEHVDATIDLLRRTTPMRLFWAREYSDYHPEQPGGSAAGRTCECRPLDTAVLGEYL
PRLRPGVMEVKIPMPTTGADYRWLNLMSRVPRKGIPLVAKRLGQGIGGLLLGRRYAAGGQALAAGLFAGVLRAGIPIWTE
TALQRLVTDDGGRVTGAVVDHRGQEITVTARRGVVLAAGGFDHHMDMRWKFQSERLGEHASLGAETNTGDAIRVAQDLGA
AIDLMDQSWWFPAVAALPDGDPKVMLAERSLPGSLIVDQTGSRFVNESCDYMTFGQAVLDRERAGDPVEAMWIVFDQQYR
NSYVFAAELFPRMAVPKAWYDAGIAHRSESLDDLGRKMGVPDAQFVATVRRFNEMAHAGQDSDLGRGRSAYDRYYGDLTV
TPNPNLRALDRGPFYAVKMVLSDLGTCGGLRADDRARVLREDGTTIDGLYAIGNTAANAFGATYPGAGATIAQGLVYGYI
AAQDAAQA
>Mature_567_residues
TTAHTATIPGGLPVRDTTVDLLVVGSGTGMGAALAARARGLSVLIVEKSEFVGGSTARSGGALWLPASQVIDGDGGGDTS
QRAATYLDAVVDGTAPASRSAAFLEHVDATIDLLRRTTPMRLFWAREYSDYHPEQPGGSAAGRTCECRPLDTAVLGEYLP
RLRPGVMEVKIPMPTTGADYRWLNLMSRVPRKGIPLVAKRLGQGIGGLLLGRRYAAGGQALAAGLFAGVLRAGIPIWTET
ALQRLVTDDGGRVTGAVVDHRGQEITVTARRGVVLAAGGFDHHMDMRWKFQSERLGEHASLGAETNTGDAIRVAQDLGAA
IDLMDQSWWFPAVAALPDGDPKVMLAERSLPGSLIVDQTGSRFVNESCDYMTFGQAVLDRERAGDPVEAMWIVFDQQYRN
SYVFAAELFPRMAVPKAWYDAGIAHRSESLDDLGRKMGVPDAQFVATVRRFNEMAHAGQDSDLGRGRSAYDRYYGDLTVT
PNPNLRALDRGPFYAVKMVLSDLGTCGGLRADDRARVLREDGTTIDGLYAIGNTAANAFGATYPGAGATIAQGLVYGYIA
AQDAAQA

Specific function: Catalyzes the elimination of the C-1 and C-2 hydrogen atoms of the A-ring from the polycyclic ring structure of 3- ketosteroids. Is also involved in the formation of 1,4- androstadiene-3,17-dione (ADD) from 4-androstene-3,17-dione (AD) to [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. 3-oxosteroid dehydrogenase subfamily [H]

Homologues:

Organism=Caenorhabditis elegans, GI71986328, Length=349, Percent_Identity=23.7822349570201, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: =1.3.99.4 [H]

Molecular weight: Translated: 60595; Mature: 60464

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAHTATIPGGLPVRDTTVDLLVVGSGTGMGAALAARARGLSVLIVEKSEFVGGSTARS
CCCCCEEECCCCCCCCCCEEEEEEEECCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCC
GGALWLPASQVIDGDGGGDTSQRAATYLDAVVDGTAPASRSAAFLEHVDATIDLLRRTTP
CCEEEECHHHEECCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCC
MRLFWAREYSDYHPEQPGGSAAGRTCECRPLDTAVLGEYLPRLRPGVMEVKIPMPTTGAD
EEEEEECCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCC
YRWLNLMSRVPRKGIPLVAKRLGQGIGGLLLGRRYAAGGQALAAGLFAGVLRAGIPIWTE
HHHHHHHHHCCCCCCCHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHH
TALQRLVTDDGGRVTGAVVDHRGQEITVTARRGVVLAAGGFDHHMDMRWKFQSERLGEHA
HHHHHHHCCCCCEEEEEEEECCCCEEEEEEECCEEEEECCCCCCCCEEEEECHHHCCCHH
SLGAETNTGDAIRVAQDLGAAIDLMDQSWWFPAVAALPDGDPKVMLAERSLPGSLIVDQT
HCCCCCCCCCHHHHHHHHCHHHHHHCCCCCCCEEEECCCCCCCEEEEECCCCCCEEEECC
GSRFVNESCDYMTFGQAVLDRERAGDPVEAMWIVFDQQYRNSYVFAAELFPRMAVPKAWY
CCHHHHCCCCCEEHHHHHHHHHHCCCCCEEEEEEEEHHHCCCEEEHHHHHHHHCCCHHHH
DAGIAHRSESLDDLGRKMGVPDAQFVATVRRFNEMAHAGQDSDLGRGRSAYDRYYGDLTV
HHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCEEE
TPNPNLRALDRGPFYAVKMVLSDLGTCGGLRADDRARVLREDGTTIDGLYAIGNTAANAF
CCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCEEEEEEECCCHHHHHC
GATYPGAGATIAQGLVYGYIAAQDAAQA
CCCCCCCCHHHHHHHHHHHHCCHHHCCC
>Mature Secondary Structure 
TTAHTATIPGGLPVRDTTVDLLVVGSGTGMGAALAARARGLSVLIVEKSEFVGGSTARS
CCCCEEECCCCCCCCCCEEEEEEEECCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCC
GGALWLPASQVIDGDGGGDTSQRAATYLDAVVDGTAPASRSAAFLEHVDATIDLLRRTTP
CCEEEECHHHEECCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCC
MRLFWAREYSDYHPEQPGGSAAGRTCECRPLDTAVLGEYLPRLRPGVMEVKIPMPTTGAD
EEEEEECCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCC
YRWLNLMSRVPRKGIPLVAKRLGQGIGGLLLGRRYAAGGQALAAGLFAGVLRAGIPIWTE
HHHHHHHHHCCCCCCCHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHH
TALQRLVTDDGGRVTGAVVDHRGQEITVTARRGVVLAAGGFDHHMDMRWKFQSERLGEHA
HHHHHHHCCCCCEEEEEEEECCCCEEEEEEECCEEEEECCCCCCCCEEEEECHHHCCCHH
SLGAETNTGDAIRVAQDLGAAIDLMDQSWWFPAVAALPDGDPKVMLAERSLPGSLIVDQT
HCCCCCCCCCHHHHHHHHCHHHHHHCCCCCCCEEEECCCCCCCEEEEECCCCCCEEEECC
GSRFVNESCDYMTFGQAVLDRERAGDPVEAMWIVFDQQYRNSYVFAAELFPRMAVPKAWY
CCHHHHCCCCCEEHHHHHHHHHHCCCCCEEEEEEEEHHHCCCEEEHHHHHHHHCCCHHHH
DAGIAHRSESLDDLGRKMGVPDAQFVATVRRFNEMAHAGQDSDLGRGRSAYDRYYGDLTV
HHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCEEE
TPNPNLRALDRGPFYAVKMVLSDLGTCGGLRADDRARVLREDGTTIDGLYAIGNTAANAF
CCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCEEEEEEECCCHHHHHC
GATYPGAGATIAQGLVYGYIAAQDAAQA
CCCCCCCCHHHHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA