Click here to switch to the map view.

The map label for this gene is aceA [H]

Identifier: 108797167

GI number: 108797167

Start: 207093

End: 209390

Strand: Reverse

Name: aceA [H]

Synonym: Mmcs_0187

Alternate gene names: 108797167

Gene position: 209390-207093 (Counterclockwise)

Preceding gene: 108797169

Following gene: 108797166

Centisome position: 3.67

GC content: 67.06

Gene sequence:

>2298_bases
GTGACCACCCACGCGGAATCCAAGACCGGCACGTCATTCGACCAAGAGGTCGCCGAGACGCAGCGCTATCTCGACAGCCC
CCGGTTCGAGGGCATCACCCGCCTCTACACGGCCCGACAGGTCGTCGAACAGCGCGGGACGATCCCCGTCGACCACACCG
TGGCCCGCGAGGCGGCGACGGCGTTCTACCCGCGCCTTCGCGAACTGTTCTCCCAGGGCAAGAGCATCACGACATTCGGC
CCCTACTCCCCCGGGCAGGCCGTGACCATGAAACGAGCCGGCATCGAGGGCATCTACCTGGGCGGCTGGGCCACCTCCGC
CAAGGGGTCCACCGACGAGGACCCCGGTCCCGATCTGGCCAGCTATCCGCTCAGCCAGGTGCCCGACGAAGCCGCCGGTC
TGGTGCGCGCACTGCTCACCGCCGACCGCAACCAGCACTACCTCCGGCTGCGGATGAGCGAGGAGCAACGGGCGGCAGCG
CCGCCTCCCGTCGACTTCCGGCCTTTCATCATCGCCGACGCCGACACCGGTCACGGTGGTGATCCCCACGTGCGCAACCT
GATTCGACGGTTCGTCGAGGCCGGCGTACCCGGGTACCACATCGAGGACCAGCGCCCCGGCACCAAGAAGTGCGGACATC
AGGGCGGCAAGGTCCTGGTGCCGTCGGACGAGCAGATCAAACGCCTCAACACCGCGCGGTTCCAACTCGACATCATGGGC
GTACCGGGCATCATCGTCGCCCGCACCGACGCCGAGGCCGCCAACCTGATCGACAGCCGCGCCGACGAACGCGATCAACC
CTTCCTGCTCGGCGCGACGAATCTGTCCATTCCGTCGTACAAGTCGTGCTTCCTGGCGATGATGCGCAGCTTCCACGACG
CGGGCGTCACCGCACTCAACGGCCACCTGCTCTACTGGCTGCCCGACGGCGAGTACGAGACCGCGCGCGCCTGGCTGGAA
CGCCACGGTATCGCCGACGTCATCGCCAAGGCCGTCGAGCAGTGGCGTTCCGACGGCGACCCGAGCAACGATGCGCTCTA
CGACGACGTCGAATCGCAGTTCATCGCGGCCTGGGAGGAGGACGCCGGGCTGAAGACCTACGCCGAGACGGTGGCCGCCC
GCCTCGAGTTCGCCGAGGGTGACGGCGAGGCGTACGCGATGGGCGTCGACGAGTGGACGCAGTTCGCCAAGCGGGCATCG
CTGTACACCGCCGGCAAGAAGGCCAGGGAGTTGGGCGTCGACGTCGACTGGGACTGCGAGCTGGCGAAGACCCCGGAGGG
GTATTACCAACTGCGCGGCGGCATTCCGTACGCGATCGCCAAACAACTGGCCGCCGCACCGTTCGCCGACATCCTGTGGA
TGGAGACCAAGACCGCCGACCTCGCCGACGCCAGGGAGTTCGCCGAGGCCATCCACGCCGAGTACCCCGACAAGATGCTC
GCCTACAACTTGTCGCCGTCGTTCAACTGGGACACCACCGGTATGACCGATGACGAGATGCGGGCGTTCCCTGAGGAACT
CGGCAAGATGGGCTTCGTCTTCAACTTCATCACCTACGGCGGACACCAGGTCGACGGGGTGGCCTCCGAGGAGTTCGCCA
CCGCCCTGCGGCAGGACGGCATGCTCGCGCTGGCCCGTCTGCAGCGCAAGATGCGGCTCGTCGAATCGCCCTACCGCACA
CCGCAGACGCTCGTCGGCGGGCCGCGCAGCGACGCCGCCCTGCTCGCCTCGTCCGGCCGCACCGCCACCACCAAGGCGAT
GGGCAAGGGCTCCACACAGCATCAGCACCTGGTGCAGACCGAGGTGCCCAAGAAGCTGCTCGAGGACTGGCTCGCGATGT
GGAGCGAGCACTATCAGCTGGGCGAGAAGTTGCGGGTGCAGTTGCGGCCCCGGCGCGCGGGCGGTGAAGTGCTCGAACTC
GGCATCTACGGCGAGCGCGACGGCGGCGAGGAGAAACTCGCCGACGTGCTGGTCGACCCGATCAAGGACCGGTACGGCCG
CAGCATCCTGACGGTGCGCGACCAGAACACCTATGCCGAGAAGTTGCGCAAGAAGCGGCTGATGACGCTGGTCCACCTGT
GGCTGGTGCACCGATTCAAGGCCGACGCGGTGTACTACGTGACACCGACCGACGACAACGTCTACCAGACCGAGAAGATG
AAGTCGCACGGCATTTTCAGCGATGTGCACAAGGACGTCGGGGAGATCATCGTTGCCGAGGTCAACCGCGCGCGCATCGA
GGAGCTGCTGGCCCCCGACCGGGAGGCGCTCGGCCGGCTGATCCGCAAGGAAGACTGA

Upstream 100 bases:

>100_bases
CCAACGTAACCACCGGAGCGCACCGACCGTCGTATCGTCGGGCAGATGAAGGTTTCCGGCTCGCGAGCCGGAACGGAACT
GCTCGATGAGGAGCGCCACG

Downstream 100 bases:

>100_bases
CCTCGCGCGCGGCCTCGGCGCATCCGCCGACGCGGTGCGCGTCGGCGTGGGCTTTGATGGACGGGATAGCGACGCGGACA
CCGGCCCCGCCGTAGAGGAG

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 765; Mature: 764

Protein sequence:

>765_residues
MTTHAESKTGTSFDQEVAETQRYLDSPRFEGITRLYTARQVVEQRGTIPVDHTVAREAATAFYPRLRELFSQGKSITTFG
PYSPGQAVTMKRAGIEGIYLGGWATSAKGSTDEDPGPDLASYPLSQVPDEAAGLVRALLTADRNQHYLRLRMSEEQRAAA
PPPVDFRPFIIADADTGHGGDPHVRNLIRRFVEAGVPGYHIEDQRPGTKKCGHQGGKVLVPSDEQIKRLNTARFQLDIMG
VPGIIVARTDAEAANLIDSRADERDQPFLLGATNLSIPSYKSCFLAMMRSFHDAGVTALNGHLLYWLPDGEYETARAWLE
RHGIADVIAKAVEQWRSDGDPSNDALYDDVESQFIAAWEEDAGLKTYAETVAARLEFAEGDGEAYAMGVDEWTQFAKRAS
LYTAGKKARELGVDVDWDCELAKTPEGYYQLRGGIPYAIAKQLAAAPFADILWMETKTADLADAREFAEAIHAEYPDKML
AYNLSPSFNWDTTGMTDDEMRAFPEELGKMGFVFNFITYGGHQVDGVASEEFATALRQDGMLALARLQRKMRLVESPYRT
PQTLVGGPRSDAALLASSGRTATTKAMGKGSTQHQHLVQTEVPKKLLEDWLAMWSEHYQLGEKLRVQLRPRRAGGEVLEL
GIYGERDGGEEKLADVLVDPIKDRYGRSILTVRDQNTYAEKLRKKRLMTLVHLWLVHRFKADAVYYVTPTDDNVYQTEKM
KSHGIFSDVHKDVGEIIVAEVNRARIEELLAPDREALGRLIRKED

Sequences:

>Translated_765_residues
MTTHAESKTGTSFDQEVAETQRYLDSPRFEGITRLYTARQVVEQRGTIPVDHTVAREAATAFYPRLRELFSQGKSITTFG
PYSPGQAVTMKRAGIEGIYLGGWATSAKGSTDEDPGPDLASYPLSQVPDEAAGLVRALLTADRNQHYLRLRMSEEQRAAA
PPPVDFRPFIIADADTGHGGDPHVRNLIRRFVEAGVPGYHIEDQRPGTKKCGHQGGKVLVPSDEQIKRLNTARFQLDIMG
VPGIIVARTDAEAANLIDSRADERDQPFLLGATNLSIPSYKSCFLAMMRSFHDAGVTALNGHLLYWLPDGEYETARAWLE
RHGIADVIAKAVEQWRSDGDPSNDALYDDVESQFIAAWEEDAGLKTYAETVAARLEFAEGDGEAYAMGVDEWTQFAKRAS
LYTAGKKARELGVDVDWDCELAKTPEGYYQLRGGIPYAIAKQLAAAPFADILWMETKTADLADAREFAEAIHAEYPDKML
AYNLSPSFNWDTTGMTDDEMRAFPEELGKMGFVFNFITYGGHQVDGVASEEFATALRQDGMLALARLQRKMRLVESPYRT
PQTLVGGPRSDAALLASSGRTATTKAMGKGSTQHQHLVQTEVPKKLLEDWLAMWSEHYQLGEKLRVQLRPRRAGGEVLEL
GIYGERDGGEEKLADVLVDPIKDRYGRSILTVRDQNTYAEKLRKKRLMTLVHLWLVHRFKADAVYYVTPTDDNVYQTEKM
KSHGIFSDVHKDVGEIIVAEVNRARIEELLAPDREALGRLIRKED
>Mature_764_residues
TTHAESKTGTSFDQEVAETQRYLDSPRFEGITRLYTARQVVEQRGTIPVDHTVAREAATAFYPRLRELFSQGKSITTFGP
YSPGQAVTMKRAGIEGIYLGGWATSAKGSTDEDPGPDLASYPLSQVPDEAAGLVRALLTADRNQHYLRLRMSEEQRAAAP
PPVDFRPFIIADADTGHGGDPHVRNLIRRFVEAGVPGYHIEDQRPGTKKCGHQGGKVLVPSDEQIKRLNTARFQLDIMGV
PGIIVARTDAEAANLIDSRADERDQPFLLGATNLSIPSYKSCFLAMMRSFHDAGVTALNGHLLYWLPDGEYETARAWLER
HGIADVIAKAVEQWRSDGDPSNDALYDDVESQFIAAWEEDAGLKTYAETVAARLEFAEGDGEAYAMGVDEWTQFAKRASL
YTAGKKARELGVDVDWDCELAKTPEGYYQLRGGIPYAIAKQLAAAPFADILWMETKTADLADAREFAEAIHAEYPDKMLA
YNLSPSFNWDTTGMTDDEMRAFPEELGKMGFVFNFITYGGHQVDGVASEEFATALRQDGMLALARLQRKMRLVESPYRTP
QTLVGGPRSDAALLASSGRTATTKAMGKGSTQHQHLVQTEVPKKLLEDWLAMWSEHYQLGEKLRVQLRPRRAGGEVLELG
IYGERDGGEEKLADVLVDPIKDRYGRSILTVRDQNTYAEKLRKKRLMTLVHLWLVHRFKADAVYYVTPTDDNVYQTEKMK
SHGIFSDVHKDVGEIIVAEVNRARIEELLAPDREALGRLIRKED

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=257, Percent_Identity=38.5214007782101, Blast_Score=172, Evalue=7e-44,
Organism=Escherichia coli, GI1786525, Length=231, Percent_Identity=30.3030303030303, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17561814, Length=242, Percent_Identity=39.2561983471074, Blast_Score=170, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI71982926, Length=247, Percent_Identity=38.8663967611336, Blast_Score=169, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6320908, Length=592, Percent_Identity=33.6148648648649, Blast_Score=300, Evalue=6e-82,
Organism=Saccharomyces cerevisiae, GI6325263, Length=597, Percent_Identity=30.4857621440536, Blast_Score=251, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 85257; Mature: 85126

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTHAESKTGTSFDQEVAETQRYLDSPRFEGITRLYTARQVVEQRGTIPVDHTVAREAAT
CCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
AFYPRLRELFSQGKSITTFGPYSPGQAVTMKRAGIEGIYLGGWATSAKGSTDEDPGPDLA
HHHHHHHHHHHCCCCEEECCCCCCCCEEEEECCCCCEEEECCEECCCCCCCCCCCCCCHH
SYPLSQVPDEAAGLVRALLTADRNQHYLRLRMSEEQRAAAPPPVDFRPFIIADADTGHGG
CCCHHHCCHHHHHHHHHHHHCCCCCEEEEEEECCHHCCCCCCCCCCCCEEEEECCCCCCC
DPHVRNLIRRFVEAGVPGYHIEDQRPGTKKCGHQGGKVLVPSDEQIKRLNTARFQLDIMG
CHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCEEECCCHHHHHHHHHHEEEEEEEC
VPGIIVARTDAEAANLIDSRADERDQPFLLGATNLSIPSYKSCFLAMMRSFHDAGVTALN
CCEEEEEECCCHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEC
GHLLYWLPDGEYETARAWLERHGIADVIAKAVEQWRSDGDPSNDALYDDVESQFIAAWEE
CEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHC
DAGLKTYAETVAARLEFAEGDGEAYAMGVDEWTQFAKRASLYTAGKKARELGVDVDWDCE
CCCHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
LAKTPEGYYQLRGGIPYAIAKQLAAAPFADILWMETKTADLADAREFAEAIHAEYPDKML
CCCCCCCCEEECCCCCHHHHHHHHHCCHHHHHEEECCCCHHHHHHHHHHHHHHCCCCCCE
AYNLSPSFNWDTTGMTDDEMRAFPEELGKMGFVFNFITYGGHQVDGVASEEFATALRQDG
EEECCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCEEECCCCHHHHHHHHHHCC
MLALARLQRKMRLVESPYRTPQTLVGGPRSDAALLASSGRTATTKAMGKGSTQHQHLVQT
HHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCHHHEECCCCCHHHHHHCCCCCHHHHHHHH
EVPKKLLEDWLAMWSEHYQLGEKLRVQLRPRRAGGEVLELGIYGERDGGEEKLADVLVDP
HHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHHH
IKDRYGRSILTVRDQNTYAEKLRKKRLMTLVHLWLVHRFKADAVYYVTPTDDNVYQTEKM
HHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHH
KSHGIFSDVHKDVGEIIVAEVNRARIEELLAPDREALGRLIRKED
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
>Mature Secondary Structure 
TTHAESKTGTSFDQEVAETQRYLDSPRFEGITRLYTARQVVEQRGTIPVDHTVAREAAT
CCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
AFYPRLRELFSQGKSITTFGPYSPGQAVTMKRAGIEGIYLGGWATSAKGSTDEDPGPDLA
HHHHHHHHHHHCCCCEEECCCCCCCCEEEEECCCCCEEEECCEECCCCCCCCCCCCCCHH
SYPLSQVPDEAAGLVRALLTADRNQHYLRLRMSEEQRAAAPPPVDFRPFIIADADTGHGG
CCCHHHCCHHHHHHHHHHHHCCCCCEEEEEEECCHHCCCCCCCCCCCCEEEEECCCCCCC
DPHVRNLIRRFVEAGVPGYHIEDQRPGTKKCGHQGGKVLVPSDEQIKRLNTARFQLDIMG
CHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCEEECCCHHHHHHHHHHEEEEEEEC
VPGIIVARTDAEAANLIDSRADERDQPFLLGATNLSIPSYKSCFLAMMRSFHDAGVTALN
CCEEEEEECCCHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEC
GHLLYWLPDGEYETARAWLERHGIADVIAKAVEQWRSDGDPSNDALYDDVESQFIAAWEE
CEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHC
DAGLKTYAETVAARLEFAEGDGEAYAMGVDEWTQFAKRASLYTAGKKARELGVDVDWDCE
CCCHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
LAKTPEGYYQLRGGIPYAIAKQLAAAPFADILWMETKTADLADAREFAEAIHAEYPDKML
CCCCCCCCEEECCCCCHHHHHHHHHCCHHHHHEEECCCCHHHHHHHHHHHHHHCCCCCCE
AYNLSPSFNWDTTGMTDDEMRAFPEELGKMGFVFNFITYGGHQVDGVASEEFATALRQDG
EEECCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCEEECCCCHHHHHHHHHHCC
MLALARLQRKMRLVESPYRTPQTLVGGPRSDAALLASSGRTATTKAMGKGSTQHQHLVQT
HHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCHHHEECCCCCHHHHHHCCCCCHHHHHHHH
EVPKKLLEDWLAMWSEHYQLGEKLRVQLRPRRAGGEVLELGIYGERDGGEEKLADVLVDP
HHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHHH
IKDRYGRSILTVRDQNTYAEKLRKKRLMTLVHLWLVHRFKADAVYYVTPTDDNVYQTEKM
HHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHH
KSHGIFSDVHKDVGEIIVAEVNRARIEELLAPDREALGRLIRKED
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7476188; 11234002 [H]